residueId AA Amino acid residues Amino acid properties Secondary structure (PDBe/SIFTS) Secondary structure (DSSP 3-state)* Secondary structure (DSSP 9-state)* Accessible surface area (Ų)* Phi angle (degrees)* Psi angle (degrees)* AlphaFold confidence (pLDDT) Active site (UniProt) Binding site (UniProt) Chain (UniProt) Coiled coil (UniProt) Compositional bias (UniProt) Cross-link (UniProt) Disulfide bond (UniProt) DNA binding (UniProt) Domain (UniProt) Glycosylation (UniProt) Initiator methionine (UniProt) Intramembrane (UniProt) Lipidation (UniProt) Modified residue (UniProt) Motif (UniProt) Mutagenesis (UniProt) Non-adjacent residues (UniProt) Non-standard residue (UniProt) Non-terminal residue (UniProt) Peptide (UniProt) Propeptide (UniProt) Region (UniProt) Repeat (UniProt) Sequence conflict (UniProt) Sequence uncertainty (UniProt) Signal (UniProt) Site (UniProt) Topological domain (UniProt) Transit peptide (UniProt) Transmembrane (UniProt) Zinc finger (UniProt) Molar mass (g/mol) Hydropathy Acetylation Disease-associated PTMs Methylation O-GalNAc O-GlcNAc Phosphorylation SNP-associated PTMs Regulatory sites Substrate genes SUMOylation Ubiquitination Pocket number (fpocket)* Druggability score (fpocket)* Intra-chain Hydrogen bond (PDB) Intra-chain Hydrogen bond (AlphaFold2) Intra-chain Non-bonded interaction (PDB) Intra-chain Non-bonded interaction (AlphaFold2) Intra-chain Disulfide bond (PDB) Intra-chain Disulfide bond (AlphaFold2) Intra-chain Salt bridge (PDB) Intra-chain Salt bridge (AlphaFold2) Inter-chain Hydrogen bond (PDB) Inter-chain Non-bonded interaction (PDB) Inter-chain Disulfide bond (PDB) Inter-chain Salt bridge (PDB) 1 M Methionine Aliphatic C (loop/coil) C (loop/coil) 247 360.0 99.4 38.67 Signal 149 1.9 2 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible C (loop/coil) C (loop/coil) 64 -75.2 141.3 40.45 Signal 75 -0.4 3 P Proline Special, No backbone hydrogen C (loop/coil) T (turn) 125 -82.3 40.8 51.92 Signal 115 1.6 Pocket 5: Mean pLDDT: 33.43, Volume: 178.62 ų, Druggability score: 0.02 0.0167 4 W Tryptophan Aromatic C (loop/coil) T (turn) 235 -103.2 3.3 43.65 Signal 204 -0.9 Pocket 5: Mean pLDDT: 33.43, Volume: 178.62 ų, Druggability score: 0.02 0.0167 5 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible C (loop/coil) S (bend) 51 -78.7 -15.8 48.71 Signal 75 -0.4 6 W Tryptophan Aromatic C (loop/coil) S (bend) 225 -87.4 -23.1 48.43 Signal 204 -0.9 7 K Lysine Positively-charged H (helix) H (α-helix) 178 -75.9 -24.7 49.62 Signal 147 -3.9 Pocket 5: Mean pLDDT: 33.43, Volume: 178.62 ų, Druggability score: 0.02 0.0167 K7-T11; PAE: 5.0 K7-T11; PAE: 5.0 8 L Leucine Aliphatic H (helix) H (α-helix) 124 -78.1 -24.6 51.98 Signal 131 3.8 L8-V12; PAE: 4.5 L8-V12; PAE: 4.5 9 R Arginine Positively-charged H (helix) H (α-helix) 206 -73.0 -33.5 51.86 Signal 175 -4.5 R9-A13; PAE: 5.0 R9-A13; PAE: 5.0 10 W Tryptophan Aromatic H (helix) H (α-helix) 196 -75.1 -34.9 50.05 Signal 204 -0.9 W10-L14; PAE: 4.5 W10-L14; PAE: 4.5 11 T Threonine Polar/Neutral H (helix) H (α-helix) 76 -71.3 -35.9 56.76 Signal 119 -0.7 T11-L15, T11-K7; PAE: 4.5, 5.0 T11-L15, T11-K7; PAE: 4.5, 5.0 12 V Valine Aliphatic H (helix) H (α-helix) 78 -72.9 -35.7 55.25 Signal 117 4.2 V12-L16, V12-L8; PAE: 4.5, 4.5 V12-L16, V12-L8; PAE: 4.5, 4.5 13 A Alanine Aliphatic H (helix) H (α-helix) 56 -66.6 -38.1 52.87 Signal 89 1.8 A13-A17, A13-R9; PAE: 5.0, 5.0 A13-A17, A13-R9; PAE: 5.0, 5.0 14 L Leucine Aliphatic H (helix) H (α-helix) 116 -70.7 -34.6 49.0 Signal 131 3.8 L14-A18, L14-W10; PAE: 5.0, 4.5 L14-A18, L14-W10; PAE: 5.0, 4.5 15 L Leucine Aliphatic H (helix) H (α-helix) 123 -72.9 -31.2 45.82 Signal 131 3.8 L15-A19, L15-T11; PAE: 5.5, 4.5 L15-A19, L15-T11; PAE: 5.5, 4.5 16 L Leucine Aliphatic H (helix) H (α-helix) 126 -76.9 -29.6 43.05 Signal 131 3.8 L16-V12; PAE: 4.5 L16-V12, L16-G20; PAE: 4.5, 6.0 17 A Alanine Aliphatic H (helix) H (α-helix) 75 -73.4 -33.8 43.35 Signal 89 1.8 A17-A13; PAE: 5.0 A17-A13; PAE: 5.0 18 A Alanine Aliphatic H (helix) H (α-helix) 85 -78.6 -16.3 42.38 Signal 89 1.8 A18-L14; PAE: 5.0 A18-L14; PAE: 5.0 19 A Alanine Aliphatic C (loop/coil) T (turn) 65 -94.7 7.7 39.06 Signal 89 1.8 A19-L15; PAE: 5.5 A19-L15; PAE: 5.5 20 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible C (loop/coil) C (loop/coil) 55 -70.4 69.1 35.64 Signal 75 -0.4 G20-L16; PAE: 6.0 21 T Threonine Polar/Neutral C (loop/coil) C (loop/coil) 111 -46.7 118.3 38.18 Signal 119 -0.7 22 A Alanine Aliphatic C (loop/coil) C (loop/coil) 95 -44.4 107.8 39.18 Low-density lipoprotein receptor Extracellular 89 1.8 23 V Valine Aliphatic C (loop/coil) C (loop/coil) 123 -65.0 85.2 38.93 Low-density lipoprotein receptor Extracellular 117 4.2 24 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible C (loop/coil) C (loop/coil) 45 -49.8 124.7 44.92 Low-density lipoprotein receptor Extracellular 75 -0.4 25 D Aspartic Acid Negatively-charged C (loop/coil) C (loop/coil) 141 -43.5 112.8 50.13 Low-density lipoprotein receptor LDL-receptor class A 1 Extracellular 132 -3.5 26 R Arginine Positively-charged C (loop/coil) C (loop/coil) 226 -66.6 115.3 59.32 Low-density lipoprotein receptor LDL-receptor class A 1 Extracellular 175 -4.5 R26-Q33 (PDB: 1F5Y) 27 C Cysteine Special, a very reactive sulfhydryl group C (loop/coil) C (loop/coil) 24 -47.5 150.0 74.34 Low-density lipoprotein receptor Disulfide bond 27-39 LDL-receptor class A 1 Extracellular 121 2.5 28 E Glutamic Acid Negatively-charged C (loop/coil) C (loop/coil) 145 -59.0 162.8 74.05 Low-density lipoprotein receptor LDL-receptor class A 1 Extracellular 146 -3.5 29 R Arginine Positively-charged Beta strand C (loop/coil) T (turn) 239 -58.1 -15.4 65.28 Low-density lipoprotein receptor LDL-receptor class A 1 Extracellular 175 -4.5 30 N Asparagine Polar/Neutral Beta strand C (loop/coil) T (turn) 119 -108.7 11.4 63.09 Low-density lipoprotein receptor LDL-receptor class A 1 Extracellular 132 -3.5 N30-Y42; PAE: 3.5 N30-Y42 (PDB: 1LDL) N30-Y42; PAE: 3.5 31 E Glutamic Acid Negatively-charged Beta strand B (strand) E (parallel sheets) 66 -119.6 139.9 75.25 Low-density lipoprotein receptor LDL-receptor class A 1 in Ref. 4; BAG58495 Extracellular 146 -3.5 E31-S41 (PDB: 1F5Y) E31-S41 (PDB: 1F5Y); E31-I40 (PDB: 1LDL) 32 F Phenylalanine Aromatic Beta strand B (strand) E (parallel sheets) 32 -91.2 135.6 76.58 Low-density lipoprotein receptor LDL-receptor class A 1 Extracellular 165 2.8 F32-I40 (PDB: 1F5Y); F32-I40 (PDB: 1LDL) F32-I40; PAE: 2.0 F32-I40, F32-D57 (PDB: 1F5Y); F32-I40 (PDB: 1LDL) F32-I40; PAE: 2.0 33 Q Glutamine Polar/Neutral Beta strand B (strand) E (parallel sheets) 97 -91.7 112.6 80.05 Low-density lipoprotein receptor LDL-receptor class A 1 Extracellular 146 -3.5 Q33-G37 (PDB: 1F5Y) Q33-R26 (PDB: 1F5Y) 34 C Cysteine Special, a very reactive sulfhydryl group C (loop/coil) C (loop/coil) 4 -59.3 157.8 82.23 Low-density lipoprotein receptor Disulfide bond 34-52 LDL-receptor class A 1 Extracellular 121 2.5 C34-K38 (PDB: 1F5Y); C34-K38 (PDB: 1LDL) C34-K38; PAE: 5.0 C34-S56, C34-K38 (PDB: 1F5Y); C34-S56, C34-D57 (PDB: 1LDL) 35 Q Glutamine Polar/Neutral Beta strand C (loop/coil) T (turn) 173 -70.0 -22.7 79.07 Low-density lipoprotein receptor LDL-receptor class A 1 Extracellular 146 -3.5 Q35-S56; PAE: 6.5 Q35-S56 (PDB: 1F5Y) Q35-S56; PAE: 6.5 36 D Aspartic Acid Negatively-charged Beta strand C (loop/coil) T (turn) 70 -71.8 -9.0 78.61 Low-density lipoprotein receptor LDL-receptor class A 1 Extracellular 132 -3.5 D36-D54; PAE: 7.5 D36-S56 (PDB: 1LDL) 37 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible Beta strand C (loop/coil) S (bend) 41 90.3 -0.2 78.64 Low-density lipoprotein receptor LDL-receptor class A 1 Extracellular 75 -0.4 G37-Q33 (PDB: 1F5Y) 38 K Lysine Positively-charged C (loop/coil) C (loop/coil) 109 -71.3 148.0 80.73 Low-density lipoprotein receptor LDL-receptor class A 1 Extracellular 147 -3.9 Morphology: EFQCQDGkCISYKWV; Domain: Ldl_recept_a K38-C34 (PDB: 1F5Y); K38-C34 (PDB: 1LDL) K38-Q53, K38-C34; PAE: 5.0, 5.0 K38-C34 (PDB: 1F5Y) 39 C Cysteine Special, a very reactive sulfhydryl group Beta strand B (strand) E (parallel sheets) 50 -102.2 127.1 81.31 Low-density lipoprotein receptor Disulfide bond 27-39 LDL-receptor class A 1 Extracellular 121 2.5 40 I Isoleucine Aliphatic Beta strand B (strand) E (parallel sheets) 23 -118.6 155.8 73.8 Low-density lipoprotein receptor LDL-receptor class A 1 Extracellular 131 4.5 I40-F32 (PDB: 1F5Y); I40-F32 (PDB: 1LDL) I40-F32; PAE: 2.0 I40-F32 (PDB: 1F5Y); I40-F32, I40-V45, I40-E31 (PDB: 1LDL) I40-F32; PAE: 2.0 41 S Serine Polar/Neutral Beta strand B (strand) E (parallel sheets) 38 -61.9 144.0 71.77 Low-density lipoprotein receptor LDL-receptor class A 1 Extracellular 105 -0.8 S41-E31 (PDB: 1F5Y) S41-E31, S41-V45 (PDB: 1F5Y); S41-V45 (PDB: 1LDL) 42 Y Tyrosine Aromatic Turn H (helix) G (3₁₀-helix) 132 -55.5 -19.2 69.05 Low-density lipoprotein receptor LDL-receptor class A 1 Extracellular 181 -1.3 Y42-N30; PAE: 3.5 Y42-N30 (PDB: 1LDL) Y42-N30; PAE: 3.5 43 K Lysine Positively-charged Turn H (helix) G (3₁₀-helix) 154 -65.7 -20.8 62.79 Low-density lipoprotein receptor LDL-receptor class A 1 Extracellular 147 -3.9 44 W Tryptophan Aromatic Turn H (helix) G (3₁₀-helix) 53 -105.1 22.8 65.92 Low-density lipoprotein receptor LDL-receptor class A 1 Extracellular 204 -0.9 45 V Valine Aliphatic Turn C (loop/coil) S (bend) 18 -102.7 119.0 71.09 Low-density lipoprotein receptor LDL-receptor class A 1 Extracellular 117 4.2 V45-S41 (PDB: 1F5Y); V45-S41, V45-I40 (PDB: 1LDL) 46 C Cysteine Special, a very reactive sulfhydryl group Turn C (loop/coil) S (bend) 11 67.1 35.7 67.96 Low-density lipoprotein receptor Disulfide bond 46-63 LDL-receptor class A 1 Extracellular 121 2.5 C46-D57 (PDB: 1LDL) C46-C63; PAE: 6.0 47 D Aspartic Acid Negatively-charged Beta strand C (loop/coil) S (bend) 24 -89.6 -2.4 60.58 Low-density lipoprotein receptor LDL-receptor class A 1 Extracellular 132 -3.5 D47-E58; PAE: 4.0 48 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible Beta strand C (loop/coil) S (bend) 57 92.8 -2.3 63.58 Low-density lipoprotein receptor LDL-receptor class A 1 Extracellular 75 -0.4 G48-E58 (PDB: 1F5Y) G48-E58; PAE: 4.0 49 S Serine Polar/Neutral Beta strand C (loop/coil) S (bend) 48 -114.8 144.6 62.2 Low-density lipoprotein receptor LDL-receptor class A 1 Extracellular 105 -0.8 50 A Alanine Aliphatic C (loop/coil) C (loop/coil) 70 -91.6 96.5 70.83 Low-density lipoprotein receptor LDL-receptor class A 1 Extracellular 89 1.8 A50-G55 (PDB: 1F5Y) 51 E Glutamic Acid Negatively-charged Beta strand C (loop/coil) C (loop/coil) 56 -78.4 -33.4 68.86 Low-density lipoprotein receptor LDL-receptor class A 1 Extracellular 146 -3.5 E51-D57 (PDB: 1F5Y); E51-D57 (PDB: 1LDL) E51-D57, E51-K376; PAE: 5.0, 29.5 52 C Cysteine Special, a very reactive sulfhydryl group Beta strand C (loop/coil) S (bend) 2 -73.5 129.9 78.07 Low-density lipoprotein receptor Disulfide bond 34-52 LDL-receptor class A 1 Extracellular 121 2.5 C52-D57 (PDB: 1F5Y) C52-D57; PAE: 4.0 C52-D57, C52-S56 (PDB: 1LDL) C52-D57, C52-S56; PAE: 4.0, 5.0 53 Q Glutamine Polar/Neutral Beta strand C (loop/coil) T (turn) 160 -65.7 -15.5 74.73 Low-density lipoprotein receptor LDL-receptor class A 1 Extracellular 146 -3.5 Q53-K38; PAE: 5.0 54 D Aspartic Acid Negatively-charged Beta strand C (loop/coil) T (turn) 69 -98.4 -2.5 78.37 Low-density lipoprotein receptor LDL-receptor class A 1 Extracellular 132 -3.5 D54-D36; PAE: 7.5 55 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible Beta strand C (loop/coil) S (bend) 24 68.0 21.6 74.31 Low-density lipoprotein receptor LDL-receptor class A 1 Extracellular 75 -0.4 G55-S59 (PDB: 1F5Y) G55-A50, G55-S59 (PDB: 1F5Y) G55-S59; PAE: 3.5 56 S Serine Polar/Neutral Helix C (loop/coil) C (loop/coil) 6 -65.5 -33.4 79.71 Low-density lipoprotein receptor LDL-receptor class A 1 Extracellular 105 -0.8 S56-Q35, S56-T62; PAE: 6.5, 6.5 S56-Q35, S56-C34 (PDB: 1F5Y); S56-C34, S56-C52, S56-D36 (PDB: 1LDL) S56-Q35, S56-T62, S56-C52; PAE: 6.5, 6.5, 5.0 57 D Aspartic Acid Negatively-charged Helix C (loop/coil) S (bend) 0 -64.1 -38.9 74.61 Low-density lipoprotein receptor LDL-receptor class A 1 Extracellular 132 -3.5 D57-C52, D57-E51 (PDB: 1F5Y); D57-C46, D57-E51 (PDB: 1LDL) D57-C52, D57-E51; PAE: 4.0, 5.0 D57-F32 (PDB: 1F5Y); D57-C52, D57-C34 (PDB: 1LDL) D57-C52; PAE: 4.0 58 E Glutamic Acid Negatively-charged Helix C (loop/coil) S (bend) 59 -91.0 1.9 76.52 Low-density lipoprotein receptor LDL-receptor class A 1 Extracellular 146 -3.5 E58-G48 (PDB: 1F5Y) E58-D47, E58-G48; PAE: 4.0, 4.0 59 S Serine Polar/Neutral C (loop/coil) C (loop/coil) 40 -65.7 135.9 76.62 Low-density lipoprotein receptor LDL-receptor class A 1 Extracellular 105 -0.8 S59-G55 (PDB: 1F5Y); S59-C63 (PDB: 1LDL) S59-C63; PAE: 3.0 S59-G55 (PDB: 1F5Y); S59-C63 (PDB: 1LDL) S59-G55, S59-C63; PAE: 3.5, 3.0 60 Q Glutamine Polar/Neutral Turn H (helix) H (α-helix) 143 -55.8 -31.8 68.36 Low-density lipoprotein receptor LDL-receptor class A 1 Extracellular 146 -3.5 Q60-L64 (PDB: 1LDL) Q60-L64; PAE: 3.5 Q60-L64 (PDB: 1LDL) Q60-L64; PAE: 3.5 61 E Glutamic Acid Negatively-charged Turn H (helix) H (α-helix) 166 -73.0 -44.3 69.75 Low-density lipoprotein receptor LDL-receptor class A 1 Extracellular 146 -3.5 E61-S65; PAE: 5.0 E61-S65; PAE: 5.0 62 T Threonine Polar/Neutral Turn H (helix) H (α-helix) 23 -58.8 -50.5 69.31 Low-density lipoprotein receptor LDL-receptor class A 1 Extracellular 119 -0.7 T62-S56, T62-V66; PAE: 6.5, 4.5 T62-S56, T62-V66; PAE: 6.5, 4.5 63 C Cysteine Special, a very reactive sulfhydryl group H (helix) H (α-helix) 3 -66.5 -24.5 67.23 Low-density lipoprotein receptor Disulfide bond 46-63 LDL-receptor class A 1 Extracellular 121 2.5 C63-S59 (PDB: 1LDL) C63-N80, C63-S59; PAE: 11.0, 3.0 C63-S59 (PDB: 1LDL) C63-C46, C63-N80, C63-S59; PAE: 6.0, 11.0, 3.0 64 L Leucine Aliphatic H (helix) H (α-helix) 84 -79.3 -26.1 64.0 Low-density lipoprotein receptor LDL-receptor class A 1 Extracellular 131 3.8 L64-R81 (PDB: 1F5Y); L64-Q60 (PDB: 1LDL) L64-Q60, L64-N80; PAE: 3.5, 9.0 L64-Q60 (PDB: 1LDL) L64-Q60, L64-N80; PAE: 3.5, 9.0 65 S Serine Polar/Neutral Beta strand H (helix) H (α-helix) 83 -87.0 -18.4 60.86 Low-density lipoprotein receptor LDL-receptor class A 1 Extracellular 105 -0.8 S65-C82 (PDB: 5OYL) S65-E61; PAE: 5.0 S65-C82 (PDB: 5OYL) S65-E61; PAE: 5.0 66 V Valine Aliphatic Beta strand C (loop/coil) C (loop/coil) 41 -60.7 115.1 62.92 Low-density lipoprotein receptor LDL-receptor class A 2 Extracellular 117 4.2 V66-T62; PAE: 4.5 V66-T62; PAE: 4.5 67 T Threonine Polar/Neutral Beta strand H (helix) P (polyproline helix) 129 -97.8 121.8 62.64 Low-density lipoprotein receptor LDL-receptor class A 2 Extracellular 119 -0.7 68 C Cysteine Special, a very reactive sulfhydryl group H (helix) P (polyproline helix) 30 -54.6 140.6 67.28 Low-density lipoprotein receptor Disulfide bond 68-82 LDL-receptor class A 2 Extracellular 121 2.5 C68-S74; PAE: 6.5 69 K Lysine Positively-charged H (helix) P (polyproline helix) 160 -62.5 152.8 67.43 Low-density lipoprotein receptor LDL-receptor class A 2 Extracellular 147 -3.9 70 S Serine Polar/Neutral Beta strand C (loop/coil) T (turn) 128 -58.9 109.8 63.77 Low-density lipoprotein receptor LDL-receptor class A 2 Extracellular 105 -0.8 71 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible Beta strand C (loop/coil) T (turn) 52 117.9 -4.0 66.56 Low-density lipoprotein receptor LDL-receptor class A 2 Extracellular 75 -0.4 G71-Q85; PAE: 4.5 G71-Q85; PAE: 4.5 72 D Aspartic Acid Negatively-charged Beta strand B (strand) E (parallel sheets) 62 -105.6 144.6 74.83 Low-density lipoprotein receptor LDL-receptor class A 2 Extracellular 132 -3.5 73 F Phenylalanine Aromatic B (strand) E (parallel sheets) 45 -88.2 132.8 77.5 Low-density lipoprotein receptor LDL-receptor class A 2 Extracellular 165 2.8 F73-I83 (PDB: 1F5Y); F73-I83 (PDB: 5OYL) F73-I83; PAE: 2.5 F73-I83, F73-D100 (PDB: 1F5Y); F73-I83, F73-D100 (PDB: 5OYL) F73-R88, F73-I83, F73-D100; PAE: 3.5, 2.5, 4.0 74 S Serine Polar/Neutral B (strand) E (parallel sheets) 49 -89.7 120.1 79.3 Low-density lipoprotein receptor LDL-receptor class A 2 Extracellular 105 -0.8 S74-C82 (PDB: 5OYL) S74-N80 (PDB: 5OYL) S74-C68; PAE: 6.5 75 C Cysteine Special, a very reactive sulfhydryl group C (loop/coil) C (loop/coil) 7 -60.0 -25.1 75.58 Low-density lipoprotein receptor Disulfide bond 75-95 LDL-receptor class A 2 Extracellular 121 2.5 C75-R81 (PDB: 1F5Y); C75-S99, C75-R81, C75-N97 (PDB: 5OYL) C75-S99, C75-R81, C75-N97; PAE: 5.0, 7.0, 5.0 C75-S99, C75-N80, C75-N97 (PDB: 5OYL) C75-S99, C75-N97; PAE: 5.0, 5.0 76 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible C (loop/coil) C (loop/coil) 31 62.0 143.1 70.51 Low-density lipoprotein receptor LDL-receptor class A 2 Extracellular 75 -0.4 G76-N80 (PDB: 1F5Y); G76-N80 (PDB: 5OYL) 77 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible Beta strand C (loop/coil) S (bend) 57 150.3 -160.5 62.78 Low-density lipoprotein receptor LDL-receptor class A 2 Extracellular 75 -0.4 G77-S99, G77-N97 (PDB: 2M7P) 78 R Arginine Positively-charged Beta strand C (loop/coil) S (bend) 222 -71.2 -24.6 56.79 Low-density lipoprotein receptor LDL-receptor class A 2 Extracellular 175 -4.5 R78-N97 (PDB: 1F5Y) 79 V Valine Aliphatic Beta strand C (loop/coil) S (bend) 55 -119.5 124.1 59.79 Low-density lipoprotein receptor LDL-receptor class A 2 Extracellular 117 4.2 V79-D96 (PDB: 1F5Y) 80 N Asparagine Polar/Neutral C (loop/coil) C (loop/coil) 51 -75.5 77.0 62.05 Low-density lipoprotein receptor LDL-receptor class A 2 Extracellular 132 -3.5 N80-L64, N80-C63; PAE: 9.0, 11.0 N80-G76 (PDB: 1F5Y); N80-C75, N80-S74, N80-G76 (PDB: 5OYL) N80-L64, N80-C63; PAE: 9.0, 11.0 81 R Arginine Positively-charged C (loop/coil) C (loop/coil) 33 -77.7 139.0 70.0 Low-density lipoprotein receptor LDL-receptor class A 2 Extracellular 175 -4.5 R81-C75, R81-L64 (PDB: 1F5Y); R81-C75, R81-G64 (PDB: 5OYL) R81-C75, R81-D96; PAE: 7.0, 6.0 R81-G64 (PDB: 5OYL) 82 C Cysteine Special, a very reactive sulfhydryl group B (strand) E (parallel sheets) 36 -117.4 125.1 74.3 Low-density lipoprotein receptor Disulfide bond 68-82 LDL-receptor class A 2 Extracellular 121 2.5 C82-S65, C82-S74 (PDB: 5OYL) C82-S65 (PDB: 5OYL) 83 I Isoleucine Aliphatic B (strand) E (parallel sheets) 0 -109.8 153.9 74.83 Low-density lipoprotein receptor LDL-receptor class A 2 Extracellular 131 4.5 I83-F73 (PDB: 1F5Y); I83-F74 (PDB: 2M7P); I83-F73 (PDB: 5OYL) I83-F73; PAE: 2.5 I83-F73 (PDB: 1F5Y); I83-F74 (PDB: 2M7P); I83-F73 (PDB: 5OYL) I83-F73; PAE: 2.5 84 P Proline Special, No backbone hydrogen B (strand) E (parallel sheets) 7 -59.6 147.6 75.78 Low-density lipoprotein receptor LDL-receptor class A 2 Extracellular 115 1.6 85 Q Glutamine Polar/Neutral Helix H (helix) G (3₁₀-helix) 99 -57.7 -23.5 74.73 Low-density lipoprotein receptor LDL-receptor class A 2 Extracellular 146 -3.5 Q85-G72 (PDB: 2M7P) Q85-G71; PAE: 4.5 Q85-G72, Q85-Y73, Q85-F74 (PDB: 2M7P) Q85-G71; PAE: 4.5 86 F Phenylalanine Aromatic Helix H (helix) G (3₁₀-helix) 86 -81.0 -12.7 75.67 Low-density lipoprotein receptor LDL-receptor class A 2 Extracellular 165 2.8 F86-G396; PAE: 29.0 D:F86-A:R375 (PDB: 5OYL) D:F86-A:Q31 (PDB: 5OYL) 87 W Tryptophan Aromatic Helix H (helix) G (3₁₀-helix) 4 -84.1 -7.8 77.85 Low-density lipoprotein receptor LDL-receptor class A 2 Extracellular 204 -0.9 88 R Arginine Positively-charged C (loop/coil) T (turn) 65 -75.9 125.8 78.88 Low-density lipoprotein receptor LDL-receptor class A 2 Extracellular 175 -4.5 R88-G103, R88-Q102 (PDB: 5OYL) R88-G103; PAE: 5.5 R88-C104, R88-F73; PAE: 5.5, 3.5 89 C Cysteine Special, a very reactive sulfhydryl group C (loop/coil) T (turn) 22 66.7 32.9 75.81 Low-density lipoprotein receptor Disulfide bond 89-104 LDL-receptor class A 2 Extracellular 121 2.5 C89-D100 (PDB: 1F5Y); C89-D100 (PDB: 5OYL) C89-C104 (PDB: 5OYL) D:C89-A:R375 (PDB: 5OYL) 90 D Aspartic Acid Negatively-charged Beta strand C (loop/coil) S (bend) 38 -93.1 1.3 70.08 Low-density lipoprotein receptor LDL-receptor class A 2 Extracellular 132 -3.5 D90-D100 (PDB: 1F5Y); D90-E101 (PDB: 5OYL) D90-K393, D90-E101; PAE: 29.0, 3.5 D:D90-A:Y230, D:D90-A:H29, D:D90-A:K68 (PDB: 5OYL) D:D90-A:R375 (PDB: 5OYL) D:D90-A:K68 (PDB: 5OYL) 91 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible Beta strand C (loop/coil) S (bend) 46 90.3 1.8 71.19 Low-density lipoprotein receptor LDL-receptor class A 2 Extracellular 75 -0.4 G91-E101 (PDB: 5OYL) G91-E101; PAE: 3.5 92 Q Glutamine Polar/Neutral Beta strand C (loop/coil) S (bend) 62 -109.7 153.1 71.31 Low-density lipoprotein receptor LDL-receptor class A 2 Extracellular 146 -3.5 Q92-K393; PAE: 28.5 D:Q92-A:K68 (PDB: 5OYL) D:Q92-A:M205 (PDB: 5OYL) 93 V Valine Aliphatic Beta strand C (loop/coil) C (loop/coil) 77 -93.8 95.2 77.62 Low-density lipoprotein receptor LDL-receptor class A 2 Extracellular 117 4.2 V93-Q102 (PDB: 1F5Y) D:V93-A:S204 (PDB: 5OYL) D:V93-A:I203, D:V93-A:S204 (PDB: 5OYL) 94 D Aspartic Acid Negatively-charged C (loop/coil) C (loop/coil) 1 -94.8 -19.6 74.45 Low-density lipoprotein receptor LDL-receptor class A 2 Extracellular 132 -3.5 D94-D100 (PDB: 5OYL) D94-D100, D94-K393; PAE: 4.5, 29.0 D:D94-A:K68 (PDB: 5OYL) D:D94-A:K68 (PDB: 5OYL) 95 C Cysteine Special, a very reactive sulfhydryl group Beta strand C (loop/coil) S (bend) 0 -94.6 138.7 77.66 Low-density lipoprotein receptor Disulfide bond 75-95 LDL-receptor class A 2 Extracellular 121 2.5 C95-D100 (PDB: 2M7P); C95-D100 (PDB: 5OYL) C95-D100; PAE: 3.5 C95-D100 (PDB: 2M7P); C95-D100, C95-S99 (PDB: 5OYL) C95-S99; PAE: 4.5 96 D Aspartic Acid Negatively-charged Beta strand C (loop/coil) T (turn) 96 -53.8 -27.4 71.62 Low-density lipoprotein receptor LDL-receptor class A 2 Extracellular 132 -3.5 D96-H388, D96-R81; PAE: 29.0, 6.0 D96-V79 (PDB: 1F5Y); D96-C76 (PDB: 2M7P) D96-H388; PAE: 29.0 97 N Asparagine Polar/Neutral Beta strand C (loop/coil) T (turn) 74 -101.6 0.6 76.3 Low-density lipoprotein receptor LDL-receptor class A 2 N-linked (GlcNAc...) asparagine Extracellular 132 -3.5 N97-C75, N97-Q102 (PDB: 5OYL) N97-C75, N97-Q102; PAE: 5.0, 4.0 N97-R78, N97-Q102 (PDB: 1F5Y); N97-N78, N97-I79, N97-G77 (PDB: 2M7P); N97-C75 (PDB: 5OYL) N97-C75; PAE: 5.0 98 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible C (loop/coil) C (loop/coil) 13 59.6 25.7 76.61 Low-density lipoprotein receptor LDL-receptor class A 2 Extracellular 75 -0.4 G98-Q102, G98-G103 (PDB: 1F5Y) G98-Q102; PAE: 4.0 G98-Q102, G98-G103 (PDB: 1F5Y); G98-Q102 (PDB: 2M7P); G98-Q102 (PDB: 5OYL) G98-Q102; PAE: 4.0 99 S Serine Polar/Neutral Helix C (loop/coil) C (loop/coil) 17 -72.5 -26.8 81.5 Low-density lipoprotein receptor LDL-receptor class A 2 Extracellular 105 -0.8 S99-C75 (PDB: 5OYL) S99-C75; PAE: 5.0 S99-G103 (PDB: 1F5Y); S99-G77, S99-C76 (PDB: 2M7P); S99-C95, S99-C75 (PDB: 5OYL) S99-C95, S99-C75; PAE: 4.5, 5.0 100 D Aspartic Acid Negatively-charged Helix C (loop/coil) T (turn) 0 -56.7 -39.2 78.54 Low-density lipoprotein receptor LDL-receptor class A 2 Extracellular 132 -3.5 D100-C89, D100-D90 (PDB: 1F5Y); D100-C95 (PDB: 2M7P); D100-C95, D100-D94, D100-C89 (PDB: 5OYL) D100-C95, D100-D94; PAE: 3.5, 4.5 D100-F73 (PDB: 1F5Y); D100-C95 (PDB: 2M7P); D100-C95, D100-F73 (PDB: 5OYL) D100-F73; PAE: 4.0 101 E Glutamic Acid Negatively-charged Helix C (loop/coil) T (turn) 59 -89.3 -1.3 81.24 Low-density lipoprotein receptor LDL-receptor class A 2 Extracellular 146 -3.5 E101-D90, E101-G91 (PDB: 5OYL) E101-D90, E101-G91; PAE: 3.5, 3.5 102 Q Glutamine Polar/Neutral Beta strand C (loop/coil) T (turn) 114 -89.9 134.0 78.89 Low-density lipoprotein receptor LDL-receptor class A 2 Extracellular 146 -3.5 Q102-G98 (PDB: 1F5Y); Q102-R88, Q102-N97 (PDB: 5OYL) Q102-G98, Q102-N97; PAE: 4.0, 4.0 Q102-G98, Q102-V93, Q102-N97 (PDB: 1F5Y); Q102-G98 (PDB: 2M7P); Q102-G98 (PDB: 5OYL) Q102-G98; PAE: 4.0 103 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible Beta strand C (loop/coil) T (turn) 70 62.8 31.2 70.61 Low-density lipoprotein receptor LDL-receptor class A 2 Extracellular 75 -0.4 G103-G98 (PDB: 1F5Y); G103-R88 (PDB: 5OYL) G103-R88; PAE: 5.5 G103-G98, G103-S99 (PDB: 1F5Y) 104 C Cysteine Special, a very reactive sulfhydryl group Beta strand H (helix) P (polyproline helix) 36 -55.8 138.6 72.07 Low-density lipoprotein receptor Disulfide bond 89-104 LDL-receptor class A 2 Extracellular 121 2.5 C104-R88; PAE: 5.5 C104-C89 (PDB: 5OYL) D:C104-A:E374 (PDB: 5OYL) 105 P Proline Special, No backbone hydrogen H (helix) P (polyproline helix) 91 -50.4 131.6 67.6 Low-density lipoprotein receptor LDL-receptor class A 2 Extracellular 115 1.6 dbSNP: rs13306510; Variant type: LB/B; AA change: Pro105Ser; PTM type: Phosphorylation; PTM morphology: P*PKTCsQDEFR; Var class: II 106 P Proline Special, No backbone hydrogen H (helix) P (polyproline helix) 105 -51.2 118.7 55.25 Low-density lipoprotein receptor LDL-receptor class A 2 Extracellular 115 1.6 107 K Lysine Positively-charged C (loop/coil) C (loop/coil) 100 -55.0 96.6 57.64 Low-density lipoprotein receptor LDL-receptor class A 3 Extracellular 147 -3.9 K107-E113 (PDB: 2FCW) K107-D415; PAE: 28.5 K107-E113 (PDB: 2FCW) 108 T Threonine Polar/Neutral C (loop/coil) C (loop/coil) 119 -86.1 101.2 60.64 Low-density lipoprotein receptor LDL-receptor class A 3 Extracellular 119 -0.7 109 C Cysteine Special, a very reactive sulfhydryl group C (loop/coil) C (loop/coil) 23 -47.5 135.5 71.86 Low-density lipoprotein receptor Disulfide bond 109-121 LDL-receptor class A 3 Extracellular 121 2.5 dbSNP: rs140807148; Variant type: US; AA change: Cys109Arg; PTM type: Phosphorylation; PTM morphology: PPKTC*sQDEFR; Var class: II 110 S Serine Polar/Neutral C (loop/coil) C (loop/coil) 62 -54.9 163.7 73.13 Low-density lipoprotein receptor LDL-receptor class A 3 Extracellular 105 -0.8 Morphology: GCPPKTCsQDEFRCH; Domain: Ldl_recept_a 111 Q Glutamine Polar/Neutral C (loop/coil) T (turn) 168 -60.5 -18.3 71.17 Low-density lipoprotein receptor LDL-receptor class A 3 Extracellular 146 -3.5 Q111-R124; PAE: 4.0 112 D Aspartic Acid Negatively-charged C (loop/coil) T (turn) 121 -97.5 6.1 73.92 Low-density lipoprotein receptor LDL-receptor class A 3 Extracellular 132 -3.5 D112-R124; PAE: 3.5 D112-S123, D112-R124 (PDB: 5OY9) D112-R124; PAE: 3.5 113 E Glutamic Acid Negatively-charged Beta strand B (strand) E (parallel sheets) 46 -117.3 149.4 81.12 Low-density lipoprotein receptor LDL-receptor class A 3 Extracellular 146 -3.5 E113-K107 (PDB: 2FCW) E113-R124 (PDB: 2FCW) E113-R124; PAE: 2.5 E113-K107 (PDB: 2FCW) 114 F Phenylalanine Aromatic Beta strand B (strand) E (parallel sheets) 61 -104.0 137.8 82.21 Low-density lipoprotein receptor LDL-receptor class A 3 Extracellular 165 2.8 F114-I122 (PDB: 2FCW); F114-I122 (PDB: 5OY9) F114-I122; PAE: 2.0 F114-I122 (PDB: 2FCW); F114-I122 (PDB: 5OY9) F114-I122; PAE: 2.0 115 R Arginine Positively-charged Beta strand B (strand) E (parallel sheets) 150 -94.1 112.5 82.06 Low-density lipoprotein receptor LDL-receptor class A 3 Extracellular 175 -4.5 R115-G119 (PDB: 5OY9) 116 C Cysteine Special, a very reactive sulfhydryl group C (loop/coil) C (loop/coil) 0 -60.4 163.1 82.42 Low-density lipoprotein receptor Disulfide bond 116-134 LDL-receptor class A 3 Extracellular 121 2.5 C116-K120 (PDB: 2FCW); C116-K120 (PDB: 5OY9) C116-K120; PAE: 5.0 C116-S138 (PDB: 2FCW); C116-S138 (PDB: 5OY9) 117 H Histidine Positively-charged C (loop/coil) T (turn) 157 -67.5 -32.8 81.51 Low-density lipoprotein receptor LDL-receptor class A 3 Extracellular 155 -3.2 H117-S138 (PDB: 2FCW); H117-S138 (PDB: 5OY9) H117-D136; PAE: 5.5 H117-S138 (PDB: 2FCW); H117-S138 (PDB: 5OY9) H117-S138; PAE: 6.0 118 D Aspartic Acid Negatively-charged C (loop/coil) T (turn) 74 -64.4 -12.9 78.08 Low-density lipoprotein receptor LDL-receptor class A 3 Extracellular 132 -3.5 D118-D136 (PDB: 2FCW) D118-D136; PAE: 6.5 D118-L135, D118-D136 (PDB: 2FCW); D118-L135, D118-D136 (PDB: 5OY9) 119 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible C (loop/coil) S (bend) 22 89.7 1.8 75.73 Low-density lipoprotein receptor LDL-receptor class A 3 Extracellular 75 -0.4 G119-R115 (PDB: 5OY9) 120 K Lysine Positively-charged C (loop/coil) C (loop/coil) 69 -72.9 153.3 79.27 Low-density lipoprotein receptor LDL-receptor class A 3 Extracellular 147 -3.9 K120-C116 (PDB: 2FCW); K120-C116 (PDB: 5OY9) K120-C116, K120-D415; PAE: 5.0, 28.5 121 C Cysteine Special, a very reactive sulfhydryl group Beta strand B (strand) E (parallel sheets) 5 -106.4 126.3 81.4 Low-density lipoprotein receptor Disulfide bond 109-121 LDL-receptor class A 3 Extracellular 121 2.5 C121-Y419; PAE: 27.5 122 I Isoleucine Aliphatic Beta strand B (strand) E (parallel sheets) 0 -114.1 162.0 80.94 Low-density lipoprotein receptor LDL-receptor class A 3 Extracellular 131 4.5 I122-F114 (PDB: 2FCW); I122-F114 (PDB: 5OY9) I122-F114; PAE: 2.0 I122-F114 (PDB: 2FCW); I122-F114 (PDB: 5OY9) I122-F114; PAE: 2.0 123 S Serine Polar/Neutral Beta strand B (strand) E (parallel sheets) 13 -60.3 144.6 79.91 Low-density lipoprotein receptor LDL-receptor class A 3 Extracellular 105 -0.8 S123-Y419; PAE: 27.5 S123-D112 (PDB: 5OY9) D:S123-A:A72 (PDB: 5OY9) 124 R Arginine Positively-charged Helix H (helix) G (3₁₀-helix) 156 -62.5 -18.7 77.32 Low-density lipoprotein receptor LDL-receptor class A 3 Extracellular 175 -4.5 R124-A112 (PDB: 2FCW) R124-Q111, R124-D112; PAE: 4.0, 3.5 R124-E113, R124-A112 (PDB: 2FCW); R124-D112 (PDB: 5OY9) R124-E113, R124-D112; PAE: 2.5, 3.5 125 Q Glutamine Polar/Neutral Helix H (helix) G (3₁₀-helix) 78 -70.8 -21.8 77.17 Low-density lipoprotein receptor LDL-receptor class A 3 Extracellular 146 -3.5 B:Q125-A:E290 (PDB: 2FCW); D:Q125-A:R375 (PDB: 5OY9) D:Q125-A:A72 (PDB: 5OY9) 126 F Phenylalanine Aromatic Helix H (helix) G (3₁₀-helix) 2 -88.6 30.8 81.31 Low-density lipoprotein receptor LDL-receptor class A 3 Extracellular 165 2.8 127 V Valine Aliphatic C (loop/coil) S (bend) 48 -118.7 117.0 81.02 Low-density lipoprotein receptor LDL-receptor class A 3 Extracellular 117 4.2 128 C Cysteine Special, a very reactive sulfhydryl group C (loop/coil) S (bend) 48 63.4 36.6 77.24 Low-density lipoprotein receptor Disulfide bond 128-143 LDL-receptor class A 3 Extracellular 121 2.5 C128-D139 (PDB: 2FCW) C128-E140; PAE: 2.5 C128-C143 (PDB: 5OY9) C128-C143; PAE: 7.0 D:C128-A:R375 (PDB: 5OY9) 129 D Aspartic Acid Negatively-charged Beta strand C (loop/coil) S (bend) 56 -95.7 6.4 71.26 Low-density lipoprotein receptor LDL-receptor class A 3 Extracellular 132 -3.5 D129-E140 (PDB: 2FCW) B:D129-A:K291 (PDB: 2FCW); D:D129-A:K68 (PDB: 5OY9) B:D129-A:K291 (PDB: 2FCW) 130 S Serine Polar/Neutral Beta strand C (loop/coil) S (bend) 101 77.8 -1.4 71.01 Low-density lipoprotein receptor LDL-receptor class A 3 Extracellular 105 -0.8 S130-E174, S130-E140 (PDB: 2FCW) S130-E140; PAE: 3.0 D:S130-A:T373 (PDB: 5OY9) D:S130-A:I368, D:S130-A:T371, D:S130-A:T373 (PDB: 5OY9) 131 D Aspartic Acid Negatively-charged Beta strand C (loop/coil) S (bend) 42 -105.9 139.6 72.99 Low-density lipoprotein receptor LDL-receptor class A 3 Extracellular 132 -3.5 D131-E140 (PDB: 5OY9) B:D131-A:R306, B:D131-A:K291 (PDB: 2FCW); D:D131-A:K68 (PDB: 5OY9) B:D131-A:R306, B:D131-A:K291 (PDB: 2FCW); D:D131-A:K68 (PDB: 5OY9) 132 R Arginine Positively-charged C (loop/coil) C (loop/coil) 100 -87.1 89.8 78.98 Low-density lipoprotein receptor LDL-receptor class A 3 Extracellular 175 -4.5 R132-N645; PAE: 26.0 R132-G137, R132-N645; PAE: 3.0, 26.0 B:R132-A:R306 (PDB: 2FCW) 133 D Aspartic Acid Negatively-charged C (loop/coil) C (loop/coil) 1 -90.4 -25.3 81.82 Low-density lipoprotein receptor LDL-receptor class A 3 Extracellular 132 -3.5 D133-D139 (PDB: 2FCW) D133-R416, D133-R410, D133-D139; PAE: 28.0, 26.0, 4.0 B:D133-A:K291 (PDB: 2FCW) B:D133-A:K291 (PDB: 2FCW) 134 C Cysteine Special, a very reactive sulfhydryl group C (loop/coil) S (bend) 0 -80.2 130.3 81.83 Low-density lipoprotein receptor Disulfide bond 116-134 LDL-receptor class A 3 Extracellular 121 2.5 C134-D139 (PDB: 2FCW) C134-D139; PAE: 3.0 C134-S138, C134-D139 (PDB: 2FCW); C134-S138 (PDB: 5OY9) C134-S138, C134-D139; PAE: 4.5, 3.0 135 L Leucine Aliphatic C (loop/coil) T (turn) 56 -61.3 -14.2 78.02 Low-density lipoprotein receptor LDL-receptor class A 3 Extracellular 131 3.8 L135-D118 (PDB: 2FCW); L135-D118 (PDB: 5OY9) 136 D Aspartic Acid Negatively-charged C (loop/coil) T (turn) 56 -100.3 -4.9 82.06 Low-density lipoprotein receptor LDL-receptor class A 3 Extracellular 132 -3.5 D136-D118 (PDB: 2FCW) D136-H117, D136-D118; PAE: 5.5, 6.5 D136-D118 (PDB: 2FCW); D136-D118 (PDB: 5OY9) 137 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible C (loop/coil) C (loop/coil) 17 68.3 20.8 81.29 Low-density lipoprotein receptor LDL-receptor class A 3 Extracellular 75 -0.4 G137-A141 (PDB: 2FCW) G137-A141 (PDB: 2FCW); G137-A141 (PDB: 5OY9) G137-R132, G137-A141; PAE: 3.0, 4.0 138 S Serine Polar/Neutral Turn C (loop/coil) T (turn) 36 -70.8 -26.9 86.48 Low-density lipoprotein receptor LDL-receptor class A 3 Extracellular 105 -0.8 S138-H117 (PDB: 2FCW); S138-H117 (PDB: 5OY9) S138-H117, S138-C116, S138-C134 (PDB: 2FCW); S138-H117, S138-C116, S138-C134 (PDB: 5OY9) S138-H117, S138-C134; PAE: 6.0, 4.5 139 D Aspartic Acid Negatively-charged Turn C (loop/coil) T (turn) 3 -62.1 -41.2 81.91 Low-density lipoprotein receptor LDL-receptor class A 3 Extracellular 132 -3.5 D139-C128, D139-D133, D139-C134 (PDB: 2FCW) D139-D133, D139-C134; PAE: 4.0, 3.0 D139-C134 (PDB: 2FCW) D139-C134; PAE: 3.0 140 E Glutamic Acid Negatively-charged Turn C (loop/coil) T (turn) 51 -95.4 -5.1 85.58 Low-density lipoprotein receptor LDL-receptor class A 3 Extracellular 146 -3.5 E140-S130, E140-D129 (PDB: 2FCW); E140-D131 (PDB: 5OY9) E140-S130, E140-C128; PAE: 3.0, 2.5 141 A Alanine Aliphatic Turn C (loop/coil) T (turn) 83 -69.2 -18.8 82.49 Low-density lipoprotein receptor LDL-receptor class A 3 Extracellular 89 1.8 A141-G137 (PDB: 2FCW) A141-G137 (PDB: 2FCW); A141-G137 (PDB: 5OY9) A141-G137; PAE: 4.0 142 S Serine Polar/Neutral Turn C (loop/coil) T (turn) 111 -139.3 51.1 79.01 Low-density lipoprotein receptor LDL-receptor class A 3 Extracellular 105 -0.8 S142-L146 (PDB: 2FCW) S142-L146 (PDB: 2FCW) 143 C Cysteine Special, a very reactive sulfhydryl group Helix C (loop/coil) C (loop/coil) 47 -96.1 131.6 75.84 Low-density lipoprotein receptor Disulfide bond 128-143 LDL-receptor class A 3 Extracellular 121 2.5 C143-T147 (PDB: 2FCW) C143-T147 (PDB: 2FCW) C143-C128 (PDB: 5OY9) C143-C128; PAE: 7.0 144 P Proline Special, No backbone hydrogen Helix C (loop/coil) C (loop/coil) 112 -69.7 141.0 73.0 Low-density lipoprotein receptor LDL-receptor class A 3 Extracellular 115 1.6 P144-C148 (PDB: 2FCW) P144-C148 (PDB: 2FCW) 145 V Valine Aliphatic Helix C (loop/coil) C (loop/coil) 141 -54.5 115.2 61.08 Low-density lipoprotein receptor LDL-receptor class A 3 Extracellular 117 4.2 146 L Leucine Aliphatic Helix C (loop/coil) C (loop/coil) 130 -61.0 127.4 60.66 Low-density lipoprotein receptor LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 131 3.8 L146-S142 (PDB: 2FCW) L146-S142 (PDB: 2FCW) 147 T Threonine Polar/Neutral Helix C (loop/coil) C (loop/coil) 127 -109.2 119.2 55.96 Low-density lipoprotein receptor LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 119 -0.7 T147-C143, T147-S152 (PDB: 2FCW) T147-S143 (PDB: 2LGP); T147-C143, T147-S152 (PDB: 2FCW); T147-S152 (PDB: 2KRI) 148 C Cysteine Special, a very reactive sulfhydryl group Beta strand C (loop/coil) C (loop/coil) 38 -57.0 128.7 67.49 Low-density lipoprotein receptor Disulfide bond 148-160 LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 121 2.5 C148-P144 (PDB: 2FCW) C148-S152, C148-P144 (PDB: 2FCW); C148-S152 (PDB: 2KRI) C148-S152; PAE: 6.0 C148-C160; PAE: 5.5 149 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible Beta strand C (loop/coil) C (loop/coil) 38 -82.1 176.6 71.43 Low-density lipoprotein receptor LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 75 -0.4 150 P Proline Special, No backbone hydrogen Beta strand C (loop/coil) T (turn) 144 -69.9 -15.1 68.68 Low-density lipoprotein receptor LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 115 1.6 151 A Alanine Aliphatic Beta strand C (loop/coil) T (turn) 79 -98.0 4.6 70.05 Low-density lipoprotein receptor LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 89 1.8 A151-Q163 (PDB: 2FCW); A151-Q163 (PDB: 2KRI) A151-Q163; PAE: 3.5 A151-Q163 (PDB: 2FCW); A151-Q163 (PDB: 2KRI) A151-Q163; PAE: 3.5 152 S Serine Polar/Neutral Beta strand B (strand) E (parallel sheets) 30 -113.5 140.4 77.37 Low-density lipoprotein receptor LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 105 -0.8 S152-T147 (PDB: 2FCW) S152-Q163 (PDB: 2LGP); S152-T147, S152-C148, S152-Q163 (PDB: 2FCW); S152-T147, S152-C148 (PDB: 2KRI) S152-C148; PAE: 6.0 153 F Phenylalanine Aromatic Beta strand B (strand) E (parallel sheets) 25 -84.0 139.6 79.46 Low-density lipoprotein receptor LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 165 2.8 F153-I161 (PDB: 2LGP); F153-I161 (PDB: 2FCW); F153-I161 (PDB: 2KRI) F153-I161; PAE: 2.0 F153-Q163, F153-I161 (PDB: 2LGP); F153-Q163, F153-I161 (PDB: 2FCW); F153-I161 (PDB: 2KRI) F153-D178, F153-I161; PAE: 2.5, 2.0 154 Q Glutamine Polar/Neutral Beta strand B (strand) E (parallel sheets) 108 -102.8 115.3 80.7 Low-density lipoprotein receptor LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 146 -3.5 Q154-R183, Q154-S158 (PDB: 2FCW); Q154-R183 (PDB: 2KRI) Q154-R183; PAE: 4.5 155 C Cysteine Special, a very reactive sulfhydryl group C (loop/coil) C (loop/coil) 3 -62.3 159.9 82.4 Low-density lipoprotein receptor Disulfide bond 155-173 LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 121 2.5 C155-T159 (PDB: 2LGP); C155-T159 (PDB: 2FCW); C155-T159 (PDB: 2KRI) C155-T159; PAE: 4.0 C155-T159 (PDB: 2LGP); C155-S177 (PDB: 2FCW); C155-S177 (PDB: 2KRI) C155-C173; PAE: 3.5 156 N Asparagine Polar/Neutral Turn C (loop/coil) T (turn) 81 -69.6 -26.2 81.37 Low-density lipoprotein receptor LDL-receptor class A 4 N-linked (GlcNAc...) asparagine Binding to Getah virus E1-E2 spike glycoproteins Extracellular 132 -3.5 N156-S177, N156-R183 (PDB: 2FCW); N156-S177, N156-R183 (PDB: 2KRI) N156-D175, N156-R183; PAE: 5.5, 5.0 N156-S177 (PDB: 2LGP); N156-S177 (PDB: 2FCW); N156-S177 (PDB: 2KRI) N156-S177; PAE: 4.0 157 S Serine Polar/Neutral Turn C (loop/coil) T (turn) 46 -63.2 0.4 76.62 Low-density lipoprotein receptor LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 105 -0.8 S157-E174 (PDB: 2FCW); S157-E174 (PDB: 2KRI) S157-D175; PAE: 5.0 S157-S177 (PDB: 2LGP) 158 S Serine Polar/Neutral Turn C (loop/coil) S (bend) 85 69.9 1.8 74.15 Low-density lipoprotein receptor LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 105 -0.8 S158-Q154 (PDB: 2FCW) 159 T Threonine Polar/Neutral C (loop/coil) C (loop/coil) 69 -67.4 143.8 77.98 Low-density lipoprotein receptor LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 119 -0.7 T159-C155 (PDB: 2LGP); T159-C155, T159-E174 (PDB: 2FCW); T159-C155 (PDB: 2KRI) T159-C155; PAE: 4.0 T159-C155 (PDB: 2LGP) 160 C Cysteine Special, a very reactive sulfhydryl group Beta strand B (strand) E (parallel sheets) 26 -107.2 126.5 78.62 Low-density lipoprotein receptor Disulfide bond 148-160 LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 121 2.5 C160-C148; PAE: 5.5 161 I Isoleucine Aliphatic Beta strand B (strand) E (parallel sheets) 12 -115.5 154.7 78.92 Low-density lipoprotein receptor LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 131 4.5 I161-F153 (PDB: 2LGP); I161-F153 (PDB: 2FCW); I161-F153 (PDB: 2KRI) I161-F153; PAE: 2.0 I161-F153, I161-A166 (PDB: 2LGP); I161-F153 (PDB: 2FCW); I161-F153 (PDB: 2KRI) I161-F153; PAE: 2.0 162 P Proline Special, No backbone hydrogen Beta strand B (strand) E (parallel sheets) 38 -51.2 140.3 78.74 Low-density lipoprotein receptor LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 115 1.6 P162-A166 (PDB: 2LGP) P162-A166 (PDB: 2LGP); P162-A166 (PDB: 2FCW); P162-A166 (PDB: 2KRI) P162-A166; PAE: 2.0 163 Q Glutamine Polar/Neutral Helix H (helix) G (3₁₀-helix) 104 -60.6 -19.4 78.47 Low-density lipoprotein receptor LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 146 -3.5 Q163-A151 (PDB: 2FCW); Q163-A151 (PDB: 2KRI) Q163-A151; PAE: 3.5 Q163-S152, Q163-F153 (PDB: 2LGP); Q163-S152, Q163-F153, Q163-A151 (PDB: 2FCW); Q163-A151 (PDB: 2KRI) Q163-A151; PAE: 3.5 164 L Leucine Aliphatic Helix H (helix) G (3₁₀-helix) 80 -65.8 -31.5 77.3 Low-density lipoprotein receptor LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 131 3.8 L164-R427; PAE: 14.0 165 W Tryptophan Aromatic Helix H (helix) G (3₁₀-helix) 50 -87.2 -5.7 80.08 Low-density lipoprotein receptor LDL-receptor class A 4 Mutation: W -> I. Partial loss of binding to Getah virus E2-E1 spike glycoproteins. Binding to Getah virus E1-E2 spike glycoproteins Extracellular 204 -0.9 W165-L426; PAE: 17.0 B:W165-A:K329 (PDB: 2KRI) 166 A Alanine Aliphatic C (loop/coil) T (turn) 12 -82.0 129.7 81.61 Low-density lipoprotein receptor LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 89 1.8 A166-P162 (PDB: 2LGP) A166-I161, A166-P162 (PDB: 2LGP); A166-P162 (PDB: 2FCW); A166-P162 (PDB: 2KRI) A166-P162; PAE: 2.0 167 C Cysteine Special, a very reactive sulfhydryl group C (loop/coil) T (turn) 37 66.1 41.8 80.03 Low-density lipoprotein receptor Disulfide bond 167-184 LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 121 2.5 C167-D178 (PDB: 2FCW); C167-D178 (PDB: 2KRI) C167-E179; PAE: 2.5 C167-C184; PAE: 7.5 C167-C184; PAE: 7.5 168 D Aspartic Acid Negatively-charged Beta strand C (loop/coil) S (bend) 6 -109.7 10.1 73.24 Low-density lipoprotein receptor LDL-receptor class A 4 Mutation: D -> K. Partial loss of binding to Getah virus E2-E1 spike glycoproteins. Binding to Getah virus E1-E2 spike glycoproteins Extracellular 132 -3.5 D168-E179 (PDB: 2LGP); D168-E179 (PDB: 2FCW); D168-E179 (PDB: 2KRI) D168-E179; PAE: 2.0 D168-R427; PAE: 14.0 B:D168-A:K277 (PDB: 2FCW); B:D168-A:K329, B:D168-A:K303 (PDB: 2KRI) B:D168-A:K277 (PDB: 2FCW) 169 N Asparagine Polar/Neutral Beta strand C (loop/coil) S (bend) 95 71.0 13.0 73.72 Low-density lipoprotein receptor LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 132 -3.5 N169-E179 (PDB: 2FCW); N169-E179 (PDB: 2KRI) N169-E179; PAE: 2.5 B:N169-A:K305 (PDB: 2KRI) B:N169-A:K305 (PDB: 2KRI) 170 D Aspartic Acid Negatively-charged Beta strand C (loop/coil) S (bend) 29 -116.3 128.1 73.46 Low-density lipoprotein receptor LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 132 -3.5 D170-N428; PAE: 11.0 B:D170-A:K277, B:D170-A:K274 (PDB: 2FCW); B:D170-A:H331, B:D170-A:K329 (PDB: 2KRI) B:D170-A:K277, B:D170-A:K274 (PDB: 2FCW) 171 P Proline Special, No backbone hydrogen C (loop/coil) C (loop/coil) 78 -79.4 100.0 79.83 Low-density lipoprotein receptor LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 115 1.6 B:P171-A:K338 (PDB: 2KRI) 172 D Aspartic Acid Negatively-charged C (loop/coil) C (loop/coil) 25 -95.4 -26.0 79.08 Low-density lipoprotein receptor LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 132 -3.5 D172-D178 (PDB: 2FCW); D172-D178 (PDB: 2KRI) D172-D178, D172-H407, D172-R406; PAE: 2.5, 10.5, 11.0 B:D172-A:K277, B:D172-A:Y281 (PDB: 2FCW); B:D172-A:K338, B:D172-A:K329 (PDB: 2KRI) B:D172-A:K277 (PDB: 2FCW); B:D172-A:K338, B:D172-A:K329 (PDB: 2KRI) 173 C Cysteine Special, a very reactive sulfhydryl group Beta strand C (loop/coil) S (bend) 6 -72.6 136.7 81.64 Low-density lipoprotein receptor Disulfide bond 155-173 LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 121 2.5 C173-D178 (PDB: 2LGP); C173-D178 (PDB: 2FCW); C173-D178 (PDB: 2KRI) C173-D178; PAE: 2.5 C173-S177, C173-D178 (PDB: 2LGP); C173-S177, C173-D178 (PDB: 2FCW); C173-S177, C173-D178 (PDB: 2KRI) C173-S177, C173-D178; PAE: 3.0, 2.5 C173-C155; PAE: 3.5 B:C173-A:R317 (PDB: 2FCW) 174 E Glutamic Acid Negatively-charged Beta strand C (loop/coil) T (turn) 178 -52.8 -24.8 78.05 Low-density lipoprotein receptor LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 146 -3.5 E174-S130, E174-T159, E174-S157 (PDB: 2FCW); E174-S157 (PDB: 2KRI) B:E174-A:R317 (PDB: 2FCW) 175 D Aspartic Acid Negatively-charged Beta strand C (loop/coil) T (turn) 47 -100.8 -0.5 81.36 Low-density lipoprotein receptor LDL-receptor class A 4 Mutation: D -> K. Partial loss of binding to Getah virus E2-E1 spike glycoproteins. Binding to Getah virus E1-E2 spike glycoproteins Extracellular 132 -3.5 D175-S157, D175-N156; PAE: 5.0, 5.5 176 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible Beta strand C (loop/coil) C (loop/coil) 16 60.5 22.0 81.66 Low-density lipoprotein receptor LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 75 -0.4 G176-W180 (PDB: 2LGP) G176-W180 (PDB: 2LGP); G176-W180 (PDB: 2FCW); G176-W180 (PDB: 2KRI) G176-W180; PAE: 2.5 177 S Serine Polar/Neutral Helix C (loop/coil) C (loop/coil) 0 -68.1 -27.6 84.17 Low-density lipoprotein receptor LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 105 -0.8 S177-N156 (PDB: 2FCW); S177-N156 (PDB: 2KRI) S177-N156, S177-C173, S177-S157 (PDB: 2LGP); S177-R183, S177-C155, S177-N156, S177-C173 (PDB: 2FCW); S177-C155, S177-N156, S177-C173 (PDB: 2KRI) S177-N156, S177-C173; PAE: 4.0, 3.0 178 D Aspartic Acid Negatively-charged Helix C (loop/coil) S (bend) 0 -59.1 -40.5 80.68 Low-density lipoprotein receptor LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 132 -3.5 D178-C173 (PDB: 2LGP); D178-C173, D178-C167, D178-D172 (PDB: 2FCW); D178-C173, D178-C167, D178-D172 (PDB: 2KRI) D178-C173, D178-D172; PAE: 2.5, 2.5 D178-C173 (PDB: 2LGP); D178-C173 (PDB: 2FCW); D178-C173 (PDB: 2KRI) D178-C173, D178-F153; PAE: 2.5, 2.5 179 E Glutamic Acid Negatively-charged Helix C (loop/coil) S (bend) 34 -90.7 3.7 84.5 Low-density lipoprotein receptor LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 146 -3.5 E179-D168 (PDB: 2LGP); E179-N169, E179-D168 (PDB: 2FCW); E179-N169, E179-D168 (PDB: 2KRI) E179-N169, E179-C167, E179-D168; PAE: 2.5, 2.5, 2.0 180 W Tryptophan Aromatic C (loop/coil) C (loop/coil) 121 -64.7 128.3 81.78 Low-density lipoprotein receptor LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 204 -0.9 W180-G176 (PDB: 2LGP) W180-C184; PAE: 3.0 W180-C184, W180-G176 (PDB: 2LGP); W180-C184, W180-G176 (PDB: 2FCW); W180-C184, W180-G176 (PDB: 2KRI) W180-C184, W180-G176; PAE: 3.0, 2.5 181 P Proline Special, No backbone hydrogen Helix C (loop/coil) T (turn) 91 -58.0 -19.2 73.08 Low-density lipoprotein receptor LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 115 1.6 P181-R185 (PDB: 2LGP) 182 Q Glutamine Polar/Neutral Helix C (loop/coil) T (turn) 189 -81.2 -29.3 73.24 Low-density lipoprotein receptor LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 146 -3.5 183 R Arginine Positively-charged Helix C (loop/coil) T (turn) 107 -88.5 -39.8 73.83 Low-density lipoprotein receptor LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 175 -4.5 R183-N156, R183-Q154 (PDB: 2FCW); R183-N156, R183-Q154 (PDB: 2KRI) R183-N156, R183-Q154; PAE: 5.0, 4.5 R183-S177 (PDB: 2FCW) 184 C Cysteine Special, a very reactive sulfhydryl group C (loop/coil) T (turn) 5 -74.6 91.7 73.29 Low-density lipoprotein receptor Disulfide bond 167-184 LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 121 2.5 C184-W180; PAE: 3.0 C184-Y188, C184-W180 (PDB: 2LGP); C184-W180 (PDB: 2FCW); C184-W180 (PDB: 2KRI) C184-W180, C184-C167; PAE: 3.0, 7.5 C184-C167; PAE: 7.5 185 R Arginine Positively-charged C (loop/coil) T (turn) 234 -60.5 65.6 66.8 Low-density lipoprotein receptor LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 175 -4.5 R185-P181 (PDB: 2LGP) 186 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible C (loop/coil) S (bend) 73 62.9 13.0 54.45 Low-density lipoprotein receptor LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 75 -0.4 187 L Leucine Aliphatic C (loop/coil) S (bend) 115 -80.5 98.9 46.72 Low-density lipoprotein receptor Binding to Getah virus E1-E2 spike glycoproteins Extracellular 131 3.8 188 Y Tyrosine Aromatic C (loop/coil) C (loop/coil) 160 65.1 45.7 41.57 Low-density lipoprotein receptor Binding to Getah virus E1-E2 spike glycoproteins Extracellular 181 -1.3 Y188-S194, Y188-G192, Y188-C184 (PDB: 2LGP) 189 V Valine Aliphatic Turn C (loop/coil) C (loop/coil) 82 -84.2 90.8 38.18 Low-density lipoprotein receptor Binding to Getah virus E1-E2 spike glycoproteins Extracellular 117 4.2 190 F Phenylalanine Aromatic Turn C (loop/coil) C (loop/coil) 153 -67.6 117.3 41.47 Low-density lipoprotein receptor Binding to Getah virus E1-E2 spike glycoproteins Extracellular 165 2.8 191 Q Glutamine Polar/Neutral Turn C (loop/coil) C (loop/coil) 192 -66.7 79.9 34.96 Low-density lipoprotein receptor Binding to Getah virus E1-E2 spike glycoproteins Extracellular 146 -3.5 192 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible C (loop/coil) C (loop/coil) 65 -72.8 141.7 40.07 Low-density lipoprotein receptor Binding to Getah virus E1-E2 spike glycoproteins Extracellular 75 -0.4 G192-Y188 (PDB: 2LGP) 193 D Aspartic Acid Negatively-charged C (loop/coil) C (loop/coil) 146 -46.5 133.4 38.7 Low-density lipoprotein receptor Binding to Getah virus E1-E2 spike glycoproteins Extracellular 132 -3.5 194 S Serine Polar/Neutral C (loop/coil) S (bend) 121 -78.0 56.3 46.98 Low-density lipoprotein receptor Binding to Getah virus E1-E2 spike glycoproteins Extracellular 105 -0.8 S194-Y188 (PDB: 2LGP) 195 S Serine Polar/Neutral C (loop/coil) C (loop/coil) 69 -126.9 112.9 52.94 Low-density lipoprotein receptor LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 105 -0.8 196 P Proline Special, No backbone hydrogen C (loop/coil) S (bend) 101 -62.2 -23.8 64.14 Low-density lipoprotein receptor LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 115 1.6 P196-H203 (PDB: 2LGP) P196-H203; PAE: 6.5 197 C Cysteine Special, a very reactive sulfhydryl group C (loop/coil) S (bend) 15 -127.7 152.6 71.19 Low-density lipoprotein receptor Disulfide bond 197-209 LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 121 2.5 C197-H203 (PDB: 1AJJ); C197-H203 (PDB: 2LGP) C197-H203; PAE: 5.5 C197-C209; PAE: 5.0 198 S Serine Polar/Neutral C (loop/coil) C (loop/coil) 63 -63.3 163.0 70.38 Low-density lipoprotein receptor LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 105 -0.8 Pocket 4: Mean pLDDT: 80.74, Volume: 495.81 ų, Druggability score: 0.03 0.0258 199 A Alanine Aliphatic C (loop/coil) T (turn) 98 -60.3 -15.6 66.68 Low-density lipoprotein receptor LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 89 1.8 200 F Phenylalanine Aromatic C (loop/coil) T (turn) 141 -105.6 10.3 65.63 Low-density lipoprotein receptor LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 165 2.8 Pocket 4: Mean pLDDT: 80.74, Volume: 495.81 ų, Druggability score: 0.03 0.0258 F200-S212; PAE: 3.0 F200-H211 (PDB: 2LGP) F200-H211, F200-S212; PAE: 3.0, 3.0 201 E Glutamic Acid Negatively-charged Beta strand B (strand) E (parallel sheets) 40 -118.4 139.3 74.05 Low-density lipoprotein receptor LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 146 -3.5 Pocket 4: Mean pLDDT: 80.74, Volume: 495.81 ų, Druggability score: 0.03 0.0258 E201-K518; PAE: 26.5 E201-S212 (PDB: 2LGP) E201-S212; PAE: 2.5 202 F Phenylalanine Aromatic Beta strand B (strand) E (parallel sheets) 49 -92.4 130.0 79.23 Low-density lipoprotein receptor LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 165 2.8 F202-I210 (PDB: 1AJJ); F202-I210 (PDB: 2LGP) F202-I210; PAE: 2.0 F202-D227, F202-I210, F202-R215 (PDB: 1AJJ); F202-S212, F202-I210, F202-R215 (PDB: 2LGP) F202-I210; PAE: 2.0 203 H Histidine Positively-charged Beta strand B (strand) E (parallel sheets) 83 -83.7 114.8 78.42 Low-density lipoprotein receptor LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 155 -3.2 H203-G207 (PDB: 1AJJ) H203-C197 (PDB: 1AJJ); H203-P196, H203-C197 (PDB: 2LGP) H203-P196, H203-C197; PAE: 6.5, 5.5 204 C Cysteine Special, a very reactive sulfhydryl group Beta strand C (loop/coil) C (loop/coil) 0 -63.0 150.1 81.86 Low-density lipoprotein receptor Disulfide bond 204-222 LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 121 2.5 C204-E208 (PDB: 1AJJ); C204-E208 (PDB: 2LGP) C204-E208; PAE: 4.0 C204-S226 (PDB: 1AJJ); C204-E208 (PDB: 2LGP) C204-C222; PAE: 3.5 205 L Leucine Aliphatic Turn C (loop/coil) T (turn) 144 -67.3 -18.8 78.17 Low-density lipoprotein receptor LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 131 3.8 L205-S226 (PDB: 1AJJ) L205-S226 (PDB: 1AJJ); L205-S226 (PDB: 2LGP) L205-S226; PAE: 4.0 206 S Serine Polar/Neutral Turn C (loop/coil) T (turn) 49 -70.3 -10.0 75.1 Low-density lipoprotein receptor LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 105 -0.8 S206-D224; PAE: 4.0 S206-K223, S206-D224 (PDB: 1AJJ); S206-K223, S206-D224 (PDB: 2LGP) S206-K223; PAE: 4.5 207 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible Turn C (loop/coil) S (bend) 40 102.9 -17.9 72.73 Low-density lipoprotein receptor LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 75 -0.4 G207-H203 (PDB: 1AJJ) 208 E Glutamic Acid Negatively-charged Beta strand C (loop/coil) C (loop/coil) 84 -69.3 152.5 71.71 Low-density lipoprotein receptor LDL-receptor class A 5 Mutation: E -> R. Partial loss of binding to Getah virus E2-E1 spike glycoproteins. Binding to Getah virus E1-E2 spike glycoproteins Extracellular 146 -3.5 Pocket 1: Mean pLDDT: 85.7, Volume: 528.09 ų, Druggability score: 0.11 0.1082 E208-K223, E208-C204 (PDB: 1AJJ); E208-C204 (PDB: 2LGP) E208-K223, E208-C204; PAE: 3.5, 4.0 E208-C204 (PDB: 2LGP) E208-K223; PAE: 3.5 209 C Cysteine Special, a very reactive sulfhydryl group Beta strand B (strand) E (parallel sheets) 45 -110.1 109.4 76.49 Low-density lipoprotein receptor Disulfide bond 197-209 LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 121 2.5 Pocket 1: Mean pLDDT: 85.7, Volume: 528.09 ų, Druggability score: 0.11 0.1082 C209-C197; PAE: 5.0 210 I Isoleucine Aliphatic Beta strand B (strand) E (parallel sheets) 11 -102.4 164.7 73.19 Low-density lipoprotein receptor LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 131 4.5 Pocket 1: Mean pLDDT: 85.7, Volume: 528.09 ų, Druggability score: 0.11 0.1082 I210-F202 (PDB: 1AJJ); I210-F202 (PDB: 2LGP) I210-F202; PAE: 2.0 I210-F202 (PDB: 1AJJ); I210-F202 (PDB: 2LGP) I210-F202; PAE: 2.0 211 H Histidine Positively-charged Beta strand B (strand) E (parallel sheets) 25 -71.6 147.6 72.47 Low-density lipoprotein receptor LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 155 -3.2 Pocket 4: Mean pLDDT: 80.74, Volume: 495.81 ų, Druggability score: 0.03 0.0258 H211-T538; PAE: 25.0 H211-F200, H211-R215 (PDB: 2LGP) H211-F200; PAE: 3.0 212 S Serine Polar/Neutral Helix H (helix) G (3₁₀-helix) 57 -61.5 -26.3 75.23 Low-density lipoprotein receptor LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 105 -0.8 S212-F200; PAE: 3.0 S212-F202, S212-E201 (PDB: 2LGP) S212-F200, S212-E201; PAE: 3.0, 2.5 213 S Serine Polar/Neutral Helix H (helix) G (3₁₀-helix) 69 -71.8 -8.8 73.66 Low-density lipoprotein receptor LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 105 -0.8 214 W Tryptophan Aromatic Helix H (helix) G (3₁₀-helix) 14 -103.0 0.4 72.09 Low-density lipoprotein receptor LDL-receptor class A 5 Mutation: W -> I. Partial loss of binding to Getah virus E2-E1 spike glycoproteins. Binding to Getah virus E1-E2 spike glycoproteins Extracellular 204 -0.9 Pocket 1: Mean pLDDT: 85.7, Volume: 528.09 ų, Druggability score: 0.11 0.1082 215 R Arginine Positively-charged C (loop/coil) T (turn) 111 -71.2 119.2 79.09 Low-density lipoprotein receptor LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 175 -4.5 R215-E229 (PDB: 1AJJ); R215-N230 (PDB: 2LGP) R215-N230; PAE: 5.0 R215-F202 (PDB: 1AJJ); R215-H211, R215-F202 (PDB: 2LGP) 216 C Cysteine Special, a very reactive sulfhydryl group C (loop/coil) T (turn) 27 65.6 41.1 79.3 Low-density lipoprotein receptor Disulfide bond 216-231 LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 121 2.5 C216-D227 (PDB: 1AJJ) C216-D227; PAE: 2.5 C216-C231; PAE: 7.0 217 D Aspartic Acid Negatively-charged Beta strand C (loop/coil) S (bend) 16 -92.7 -4.6 73.13 Low-density lipoprotein receptor LDL-receptor class A 5 Mutation: D -> K. Partial loss of binding to Getah virus E2-E1 spike glycoproteins. Binding to Getah virus E1-E2 spike glycoproteins Extracellular 132 -3.5 D217-E228 (PDB: 1AJJ); D217-E228 (PDB: 2LGP) D217-R237, D217-E228, D217-K581; PAE: 18.0, 3.5, 24.5 D217-R237, D217-K581; PAE: 18.0, 24.5 218 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible Beta strand C (loop/coil) S (bend) 46 100.0 -8.3 71.4 Low-density lipoprotein receptor LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 75 -0.4 G218-E228 (PDB: 1AJJ); G218-E228 (PDB: 2LGP) G218-E228; PAE: 3.5 219 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible Beta strand C (loop/coil) S (bend) 19 -120.6 139.3 74.09 Low-density lipoprotein receptor LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 75 -0.4 220 P Proline Special, No backbone hydrogen C (loop/coil) C (loop/coil) 78 -73.4 102.8 77.71 Low-density lipoprotein receptor LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 115 1.6 221 D Aspartic Acid Negatively-charged C (loop/coil) C (loop/coil) 31 -93.4 -25.7 75.82 Low-density lipoprotein receptor LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 132 -3.5 Pocket 1: Mean pLDDT: 85.7, Volume: 528.09 ų, Druggability score: 0.11 0.1082 D221-D227 (PDB: 1AJJ) D221-D227, D221-K581; PAE: 3.0, 22.5 D221-K581; PAE: 22.5 D221-K581; PAE: 22.5 222 C Cysteine Special, a very reactive sulfhydryl group Beta strand C (loop/coil) S (bend) 6 -82.3 143.9 80.45 Low-density lipoprotein receptor Disulfide bond 204-222 LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 121 2.5 C222-D227 (PDB: 1AJJ) C222-D227; PAE: 2.5 C222-S226, C222-D227 (PDB: 1AJJ) C222-S226, C222-D227; PAE: 3.0, 2.5 C222-C204; PAE: 3.5 223 K Lysine Positively-charged Beta strand C (loop/coil) T (turn) 147 -52.3 -32.0 73.42 Low-density lipoprotein receptor LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 147 -3.9 Pocket 1: Mean pLDDT: 85.7, Volume: 528.09 ų, Druggability score: 0.11 0.1082 K223-E208 (PDB: 1AJJ) K223-E208; PAE: 3.5 K223-S206 (PDB: 1AJJ); K223-S206 (PDB: 2LGP) K223-S206; PAE: 4.5 K223-E208; PAE: 3.5 224 D Aspartic Acid Negatively-charged Beta strand C (loop/coil) T (turn) 62 -101.4 5.5 81.65 Low-density lipoprotein receptor LDL-receptor class A 5 Mutation: D -> K. Partial loss of binding to Getah virus E2-E1 spike glycoproteins. Binding to Getah virus E1-E2 spike glycoproteins Extracellular 132 -3.5 D224-S206; PAE: 4.0 D224-S206 (PDB: 1AJJ); D224-S206 (PDB: 2LGP) 225 K Lysine Positively-charged C (loop/coil) C (loop/coil) 133 59.6 22.6 79.21 Low-density lipoprotein receptor LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 147 -3.9 K225-E229 (PDB: 2LGP) K225-E229 (PDB: 1AJJ); K225-E229 (PDB: 2LGP) K225-E229; PAE: 3.5 226 S Serine Polar/Neutral Helix H (helix) G (3₁₀-helix) 19 -69.2 -21.5 85.71 Low-density lipoprotein receptor LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 105 -0.8 S226-L205 (PDB: 1AJJ); S226-N230 (PDB: 2LGP) S226-L205, S226-C204, S226-C222 (PDB: 1AJJ); S226-N230, S226-L205 (PDB: 2LGP) S226-L205, S226-C222; PAE: 4.0, 3.0 227 D Aspartic Acid Negatively-charged Helix H (helix) G (3₁₀-helix) 0 -67.4 -28.7 80.81 Low-density lipoprotein receptor LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 132 -3.5 D227-D221, D227-C222, D227-C216 (PDB: 1AJJ) D227-D221, D227-C222, D227-C216; PAE: 3.0, 2.5, 2.5 D227-C222, D227-F202 (PDB: 1AJJ); D227-C231 (PDB: 2LGP) D227-C222; PAE: 2.5 228 E Glutamic Acid Negatively-charged Helix H (helix) G (3₁₀-helix) 52 -96.6 0.8 85.49 Low-density lipoprotein receptor LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 146 -3.5 E228-G218, E228-D217 (PDB: 1AJJ); E228-G218, E228-D217, E228-A232 (PDB: 2LGP) E228-G218, E228-D217; PAE: 3.5, 3.5 E228-A232 (PDB: 2LGP) 229 E Glutamic Acid Negatively-charged C (loop/coil) T (turn) 126 -83.5 134.7 79.48 Low-density lipoprotein receptor LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 146 -3.5 E229-R215 (PDB: 1AJJ); E229-K225 (PDB: 2LGP) E229-K225 (PDB: 1AJJ); E229-K225 (PDB: 2LGP) E229-K225; PAE: 3.5 230 N Asparagine Polar/Neutral C (loop/coil) T (turn) 136 59.0 53.7 75.47 Low-density lipoprotein receptor LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 132 -3.5 N230-R215, N230-S226 (PDB: 2LGP) N230-R215; PAE: 5.0 N230-S226 (PDB: 2LGP) 231 C Cysteine Special, a very reactive sulfhydryl group C (loop/coil) C (loop/coil) 43 -99.0 132.5 75.27 Low-density lipoprotein receptor Disulfide bond 216-231 LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 121 2.5 C231-D227 (PDB: 2LGP) C231-C216; PAE: 7.0 232 A Alanine Aliphatic C (loop/coil) S (bend) 105 -80.5 -33.1 67.16 Low-density lipoprotein receptor LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 89 1.8 A232-E228 (PDB: 2LGP) A232-E228 (PDB: 2LGP) 233 V Valine Aliphatic C (loop/coil) C (loop/coil) 111 -159.4 119.3 59.62 Low-density lipoprotein receptor LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 117 4.2 234 A Alanine Aliphatic C (loop/coil) C (loop/coil) 43 -67.7 121.2 56.38 Low-density lipoprotein receptor LDL-receptor class A 6 Extracellular 89 1.8 235 T Threonine Polar/Neutral C (loop/coil) C (loop/coil) 105 -110.2 112.1 62.73 Low-density lipoprotein receptor LDL-receptor class A 6 Extracellular 119 -0.7 236 C Cysteine Special, a very reactive sulfhydryl group C (loop/coil) C (loop/coil) 20 -66.1 151.4 69.19 Low-density lipoprotein receptor Disulfide bond 236-248 LDL-receptor class A 6 Extracellular 121 2.5 C236-C248; PAE: 6.0 C236-C248; PAE: 6.0 237 R Arginine Positively-charged C (loop/coil) C (loop/coil) 38 -72.6 164.0 59.37 Low-density lipoprotein receptor LDL-receptor class A 6 Extracellular 175 -4.5 R237-D217; PAE: 18.0 R237-D217; PAE: 18.0 238 P Proline Special, No backbone hydrogen C (loop/coil) T (turn) 140 -64.6 -26.4 59.2 Low-density lipoprotein receptor LDL-receptor class A 6 Extracellular 115 1.6 239 D Aspartic Acid Negatively-charged C (loop/coil) T (turn) 35 -91.9 -4.6 54.63 Low-density lipoprotein receptor LDL-receptor class A 6 Extracellular 132 -3.5 D239-G251 (PDB: 1F8Z) D239-G251; PAE: 4.5 D239-H250, D239-G251 (PDB: 1F8Z) D239-G251; PAE: 4.5 240 E Glutamic Acid Negatively-charged B (strand) E (parallel sheets) 53 -106.7 142.6 71.51 Low-density lipoprotein receptor LDL-receptor class A 6 Extracellular 146 -3.5 E240-I249 (PDB: 1F8Z) 241 F Phenylalanine Aromatic Beta strand B (strand) E (parallel sheets) 47 -86.4 124.0 77.12 Low-density lipoprotein receptor LDL-receptor class A 6 Extracellular 165 2.8 F241-I249 (PDB: 1F8Z) F241-I249; PAE: 2.5 F241-Q254, F241-I249 (PDB: 1F8Z) F241-Q254, F241-D266, F241-I249; PAE: 3.5, 3.5, 2.5 242 Q Glutamine Polar/Neutral Beta strand B (strand) E (parallel sheets) 102 -79.3 110.5 79.22 Low-density lipoprotein receptor LDL-receptor class A 6 Extracellular 146 -3.5 243 C Cysteine Special, a very reactive sulfhydryl group Beta strand C (loop/coil) C (loop/coil) 2 -58.2 155.1 82.42 Low-density lipoprotein receptor Disulfide bond 243-261 LDL-receptor class A 6 Extracellular 121 2.5 C243-N247 (PDB: 1F8Z) C243-N247; PAE: 4.0 C243-S265, C243-D266 (PDB: 1F8Z) C243-C261; PAE: 4.0 244 S Serine Polar/Neutral Turn C (loop/coil) T (turn) 97 -65.7 -25.5 79.35 Low-density lipoprotein receptor LDL-receptor class A 6 Extracellular 105 -0.8 S244-D263, S244-S265; PAE: 5.5, 5.0 S244-S265 (PDB: 1F8Z) S244-S265; PAE: 5.0 245 D Aspartic Acid Negatively-charged Turn C (loop/coil) T (turn) 97 -68.5 -12.0 77.99 Low-density lipoprotein receptor LDL-receptor class A 6 Extracellular 132 -3.5 D245-D263; PAE: 6.0 D245-D263 (PDB: 1F8Z) D245-D263; PAE: 6.0 246 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible Turn C (loop/coil) S (bend) 25 92.2 -1.6 74.41 Low-density lipoprotein receptor LDL-receptor class A 6 Extracellular 75 -0.4 247 N Asparagine Polar/Neutral Beta strand C (loop/coil) C (loop/coil) 77 -72.2 151.8 78.06 Low-density lipoprotein receptor LDL-receptor class A 6 Extracellular 132 -3.5 N247-C243 (PDB: 1F8Z) N247-C243; PAE: 4.0 248 C Cysteine Special, a very reactive sulfhydryl group Beta strand B (strand) E (parallel sheets) 41 -110.1 133.1 78.63 Low-density lipoprotein receptor Disulfide bond 236-248 LDL-receptor class A 6 Extracellular 121 2.5 C248-C236; PAE: 6.0 C248-C236; PAE: 6.0 249 I Isoleucine Aliphatic Beta strand B (strand) E (parallel sheets) 16 -119.4 155.0 76.69 Low-density lipoprotein receptor LDL-receptor class A 6 Extracellular 131 4.5 I249-F241 (PDB: 1F8Z) I249-F241; PAE: 2.5 I249-Q254, I249-E240, I249-F241 (PDB: 1F8Z) I249-F241; PAE: 2.5 250 H Histidine Positively-charged B (strand) E (parallel sheets) 54 -63.8 143.1 72.48 Low-density lipoprotein receptor LDL-receptor class A 6 Extracellular 155 -3.2 H250-D239, H250-Q254 (PDB: 1F8Z) 251 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible Helix H (helix) G (3₁₀-helix) 34 -62.3 -16.6 70.74 Low-density lipoprotein receptor LDL-receptor class A 6 Extracellular 75 -0.4 G251-D239 (PDB: 1F8Z) G251-D239; PAE: 4.5 G251-D239 (PDB: 1F8Z) G251-D239; PAE: 4.5 252 S Serine Polar/Neutral Helix H (helix) G (3₁₀-helix) 71 -73.0 -22.6 72.75 Low-density lipoprotein receptor LDL-receptor class A 6 Extracellular 105 -0.8 253 R Arginine Positively-charged Helix H (helix) G (3₁₀-helix) 71 -86.1 8.4 78.48 Low-density lipoprotein receptor LDL-receptor class A 6 Extracellular 175 -4.5 R253-E258 (PDB: 1F8Z) 254 Q Glutamine Polar/Neutral Beta strand C (loop/coil) S (bend) 93 -89.3 122.0 75.17 Low-density lipoprotein receptor LDL-receptor class A 6 Extracellular 146 -3.5 Q254-I249, Q254-F241, Q254-H250 (PDB: 1F8Z) Q254-F241; PAE: 3.5 255 C Cysteine Special, a very reactive sulfhydryl group Beta strand C (loop/coil) S (bend) 58 64.0 35.5 76.7 Low-density lipoprotein receptor Disulfide bond 255-270 LDL-receptor class A 6 Extracellular 121 2.5 C255-E267 (PDB: 1F8Z) C255-D266; PAE: 3.0 C255-C270; PAE: 7.0 256 D Aspartic Acid Negatively-charged Beta strand C (loop/coil) S (bend) 65 -93.4 1.8 71.92 Low-density lipoprotein receptor LDL-receptor class A 6 Extracellular 132 -3.5 D256-E267 (PDB: 1F8Z) D256-E267; PAE: 4.0 257 R Arginine Positively-charged Beta strand C (loop/coil) S (bend) 211 78.1 2.9 69.81 Low-density lipoprotein receptor LDL-receptor class A 6 Extracellular 175 -4.5 R257-E267 (PDB: 1F8Z) R257-E267; PAE: 3.0 258 E Glutamic Acid Negatively-charged Beta strand C (loop/coil) S (bend) 132 -103.0 157.0 75.87 Low-density lipoprotein receptor LDL-receptor class A 6 Extracellular 146 -3.5 E258-R253 (PDB: 1F8Z) 259 Y Tyrosine Aromatic C (loop/coil) C (loop/coil) 154 -103.0 86.4 81.35 Low-density lipoprotein receptor LDL-receptor class A 6 Extracellular 181 -1.3 Y259-M264 (PDB: 1F8Z) 260 D Aspartic Acid Negatively-charged Beta strand C (loop/coil) C (loop/coil) 60 -83.2 -33.5 79.81 Low-density lipoprotein receptor LDL-receptor class A 6 Extracellular 132 -3.5 D260-D266; PAE: 4.0 261 C Cysteine Special, a very reactive sulfhydryl group Beta strand C (loop/coil) S (bend) 3 -74.8 132.6 82.16 Low-density lipoprotein receptor Disulfide bond 243-261 LDL-receptor class A 6 Extracellular 121 2.5 C261-D266 (PDB: 1F8Z) C261-D266; PAE: 3.5 C261-D266, C261-S265; PAE: 3.5, 5.0 C261-C243; PAE: 4.0 262 K Lysine Positively-charged Beta strand C (loop/coil) T (turn) 186 -60.1 -26.8 79.57 Low-density lipoprotein receptor LDL-receptor class A 6 Extracellular 147 -3.9 263 D Aspartic Acid Negatively-charged Beta strand C (loop/coil) T (turn) 40 -94.2 3.7 83.41 Low-density lipoprotein receptor LDL-receptor class A 6 Extracellular 132 -3.5 D263-S244, D263-D245; PAE: 5.5, 6.0 D263-D245 (PDB: 1F8Z) D263-D245; PAE: 6.0 264 M Methionine Aliphatic Beta strand C (loop/coil) C (loop/coil) 99 62.2 19.1 79.05 Low-density lipoprotein receptor LDL-receptor class A 6 Extracellular 149 1.9 M264-Y259, M264-V268 (PDB: 1F8Z) M264-V268; PAE: 3.0 265 S Serine Polar/Neutral Helix H (helix) G (3₁₀-helix) 16 -62.3 -31.0 85.28 Low-density lipoprotein receptor LDL-receptor class A 6 Extracellular 105 -0.8 S265-S244; PAE: 5.0 S265-S244, S265-C243 (PDB: 1F8Z) S265-C261, S265-S244; PAE: 5.0, 5.0 266 D Aspartic Acid Negatively-charged Helix H (helix) G (3₁₀-helix) 1 -60.6 -33.0 81.17 Low-density lipoprotein receptor LDL-receptor class A 6 Extracellular 132 -3.5 D266-C261 (PDB: 1F8Z) D266-C261, D266-C255, D266-D260; PAE: 3.5, 3.0, 4.0 D266-C243 (PDB: 1F8Z) D266-C261, D266-F241; PAE: 3.5, 3.5 267 E Glutamic Acid Negatively-charged Helix H (helix) G (3₁₀-helix) 34 -98.0 -2.0 83.69 Low-density lipoprotein receptor LDL-receptor class A 6 Extracellular 146 -3.5 E267-R257, E267-C255, E267-D256 (PDB: 1F8Z) E267-R257, E267-D256; PAE: 3.0, 4.0 268 V Valine Aliphatic Beta strand C (loop/coil) T (turn) 107 -91.7 125.7 78.43 Low-density lipoprotein receptor LDL-receptor class A 6 Extracellular 117 4.2 V268-N272, V268-M264 (PDB: 1F8Z) V268-M264; PAE: 3.0 269 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible Beta strand C (loop/coil) T (turn) 75 84.5 5.2 72.21 Low-density lipoprotein receptor LDL-receptor class A 6 Extracellular 75 -0.4 270 C Cysteine Special, a very reactive sulfhydryl group Beta strand C (loop/coil) C (loop/coil) 21 -54.1 135.8 70.37 Low-density lipoprotein receptor Disulfide bond 255-270 LDL-receptor class A 6 Extracellular 121 2.5 C270-C255; PAE: 7.0 271 V Valine Aliphatic C (loop/coil) C (loop/coil) 139 -69.9 83.4 65.63 Low-density lipoprotein receptor LDL-receptor class A 6 Extracellular 117 4.2 272 N Asparagine Polar/Neutral C (loop/coil) C (loop/coil) 129 -70.1 91.5 46.22 Low-density lipoprotein receptor LDL-receptor class A 6 N-linked (GlcNAc...) asparagine Extracellular 132 -3.5 N272-V268 (PDB: 1F8Z) 273 V Valine Aliphatic C (loop/coil) C (loop/coil) 105 -60.4 106.1 43.47 Low-density lipoprotein receptor Extracellular 117 4.2 274 T Threonine Polar/Neutral C (loop/coil) C (loop/coil) 129 -70.2 76.3 42.57 Low-density lipoprotein receptor LDL-receptor class A 7 Extracellular 119 -0.7 275 L Leucine Aliphatic C (loop/coil) C (loop/coil) 105 -69.7 137.5 51.9 Low-density lipoprotein receptor LDL-receptor class A 7 Extracellular 131 3.8 276 C Cysteine Special, a very reactive sulfhydryl group C (loop/coil) C (loop/coil) 31 -66.9 78.9 63.57 Low-density lipoprotein receptor Disulfide bond 276-289 LDL-receptor class A 7 Extracellular 121 2.5 C276-C289 (PDB: 3M0C) C276-C289 (PDB: 3M0C) C276-C289; PAE: 5.5 277 E Glutamic Acid Negatively-charged C (loop/coil) C (loop/coil) 142 -83.6 123.0 58.53 Low-density lipoprotein receptor LDL-receptor class A 7 Extracellular 146 -3.5 278 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible C (loop/coil) S (bend) 36 164.0 138.4 63.96 Low-density lipoprotein receptor LDL-receptor class A 7 Extracellular 75 -0.4 279 P Proline Special, No backbone hydrogen C (loop/coil) T (turn) 125 -61.0 -15.9 65.61 Low-density lipoprotein receptor LDL-receptor class A 7 Extracellular 115 1.6 280 N Asparagine Polar/Neutral C (loop/coil) T (turn) 106 -118.4 23.1 72.18 Low-density lipoprotein receptor LDL-receptor class A 7 Extracellular 132 -3.5 N280-L292 (PDB: 1XFE) N280-L292; PAE: 4.0 N280-L292 (PDB: 1XFE); N280-T291 (PDB: 3M0C) N280-L292; PAE: 4.0 281 K Lysine Positively-charged Beta strand B (strand) E (parallel sheets) 123 -118.6 134.3 77.49 Low-density lipoprotein receptor LDL-receptor class A 7 Extracellular 147 -3.9 K281-T291 (PDB: 3M0C) 282 F Phenylalanine Aromatic Beta strand B (strand) E (parallel sheets) 48 -110.1 133.6 79.16 Low-density lipoprotein receptor LDL-receptor class A 7 Extracellular 165 2.8 F282-I290 (PDB: 1XFE) F282-I290; PAE: 2.0 F282-I290, F282-L292 (PDB: 1XFE); F282-I290, F282-C289, F282-T291 (PDB: 3M0C) F282-I290; PAE: 2.0 283 K Lysine Positively-charged Beta strand B (strand) E (parallel sheets) 127 -91.9 113.9 79.42 Low-density lipoprotein receptor LDL-receptor class A 7 Extracellular 147 -3.9 284 C Cysteine Special, a very reactive sulfhydryl group C (loop/coil) C (loop/coil) 1 -61.4 146.9 79.55 Low-density lipoprotein receptor Disulfide bond 284-302 LDL-receptor class A 7 Extracellular 121 2.5 C284-E288 (PDB: 1XFE); C284-E288 (PDB: 3M0C) C284-E288; PAE: 6.5 C284-E288 (PDB: 1XFE); C284-E288 (PDB: 3M0C) C284-C302 (PDB: 3M0C) C284-C302; PAE: 3.5 285 H Histidine Positively-charged C (loop/coil) T (turn) 174 -61.2 -24.8 79.44 Low-density lipoprotein receptor LDL-receptor class A 7 Extracellular 155 -3.2 H285-S306 (PDB: 1XFE); H285-S306 (PDB: 3M0C) H285-S306; PAE: 4.5 286 S Serine Polar/Neutral C (loop/coil) T (turn) 52 -72.0 -5.0 78.14 Low-density lipoprotein receptor LDL-receptor class A 7 Extracellular 105 -0.8 S286-D304; PAE: 4.5 S286-R303; PAE: 5.0 287 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible C (loop/coil) S (bend) 47 93.5 -3.6 76.99 Low-density lipoprotein receptor LDL-receptor class A 7 Extracellular 75 -0.4 288 E Glutamic Acid Negatively-charged C (loop/coil) C (loop/coil) 89 -78.6 143.4 76.52 Low-density lipoprotein receptor LDL-receptor class A 7 Extracellular 146 -3.5 E288-C284 (PDB: 1XFE); E288-C284 (PDB: 3M0C) E288-C284; PAE: 6.5 E288-C284 (PDB: 1XFE); E288-C284 (PDB: 3M0C) E288-R303; PAE: 4.5 289 C Cysteine Special, a very reactive sulfhydryl group Beta strand B (strand) E (parallel sheets) 69 -102.3 118.4 81.21 Low-density lipoprotein receptor Disulfide bond 276-289 LDL-receptor class A 7 Extracellular 121 2.5 C289-F282, C289-C276 (PDB: 3M0C) C289-C276 (PDB: 3M0C) C289-C276; PAE: 5.5 290 I Isoleucine Aliphatic Beta strand B (strand) E (parallel sheets) 18 -106.1 170.4 80.36 Low-density lipoprotein receptor LDL-receptor class A 7 Extracellular 131 4.5 I290-F282 (PDB: 1XFE) I290-F282; PAE: 2.0 I290-F282 (PDB: 1XFE); I290-F282 (PDB: 3M0C) I290-F282; PAE: 2.0 291 T Threonine Polar/Neutral Beta strand B (strand) E (parallel sheets) 63 -88.6 144.5 81.57 Low-density lipoprotein receptor LDL-receptor class A 7 Extracellular 119 -0.7 T291-N280, T291-F282, T291-K281 (PDB: 3M0C) T291-V295; PAE: 3.0 292 L Leucine Aliphatic Beta strand H (helix) G (3₁₀-helix) 67 -56.6 -26.3 80.15 Low-density lipoprotein receptor LDL-receptor class A 7 Extracellular 131 3.8 L292-N280 (PDB: 1XFE) L292-N280; PAE: 4.0 L292-F282, L292-N280 (PDB: 1XFE) L292-N280; PAE: 4.0 293 D Aspartic Acid Negatively-charged Turn H (helix) G (3₁₀-helix) 116 -65.6 -19.0 82.31 Low-density lipoprotein receptor LDL-receptor class A 7 Extracellular 132 -3.5 294 K Lysine Positively-charged Turn H (helix) G (3₁₀-helix) 74 -92.3 -6.3 82.99 Low-density lipoprotein receptor LDL-receptor class A 7 Extracellular 147 -3.9 K294-D301; PAE: 4.0 K294-D301 (PDB: 3M0C) K294-D301; PAE: 4.0 295 V Valine Aliphatic Turn C (loop/coil) T (turn) 8 -80.4 128.2 83.33 Low-density lipoprotein receptor LDL-receptor class A 7 Extracellular 117 4.2 V295-T291; PAE: 3.0 296 C Cysteine Special, a very reactive sulfhydryl group Turn C (loop/coil) T (turn) 33 61.1 42.6 82.96 Low-density lipoprotein receptor Disulfide bond 296-313 LDL-receptor class A 7 Extracellular 121 2.5 C296-D307; PAE: 3.0 C296-G314; PAE: 5.5 C296-C313 (PDB: 3M0C) C296-C313; PAE: 5.0 297 N Asparagine Polar/Neutral C (loop/coil) S (bend) 65 -104.6 9.3 84.36 Low-density lipoprotein receptor LDL-receptor class A 7 Extracellular 132 -3.5 N297-D301 (PDB: 1XFE); N297-E308 (PDB: 3M0C) N297-D301; PAE: 3.0 298 M Methionine Aliphatic C (loop/coil) S (bend) 178 64.8 19.6 78.03 Low-density lipoprotein receptor LDL-receptor class A 7 Extracellular 149 1.9 M298-E308; PAE: 4.5 299 A Alanine Aliphatic C (loop/coil) S (bend) 43 -129.6 136.7 81.31 Low-density lipoprotein receptor LDL-receptor class A 7 Extracellular 89 1.8 A299-E308 (PDB: 3M0C) A299-E308; PAE: 3.5 300 R Arginine Positively-charged C (loop/coil) C (loop/coil) 131 -75.3 92.2 83.53 Low-density lipoprotein receptor LDL-receptor class A 7 Extracellular 175 -4.5 R300-W305 (PDB: 1XFE) R300-W305; PAE: 2.5 301 D Aspartic Acid Negatively-charged C (loop/coil) C (loop/coil) 53 -92.0 -31.4 83.5 Low-density lipoprotein receptor LDL-receptor class A 7 Extracellular 132 -3.5 D301-N297 (PDB: 1XFE); D301-D307 (PDB: 3M0C) D301-K294, D301-N297, D301-D307; PAE: 4.0, 3.0, 3.5 D301-K294 (PDB: 3M0C) D301-K294; PAE: 4.0 302 C Cysteine Special, a very reactive sulfhydryl group C (loop/coil) S (bend) 0 -86.0 145.5 82.07 Low-density lipoprotein receptor Disulfide bond 284-302 LDL-receptor class A 7 Extracellular 121 2.5 C302-D307, C302-S306; PAE: 3.0, 4.0 C302-C284 (PDB: 3M0C) C302-C284; PAE: 3.5 303 R Arginine Positively-charged C (loop/coil) T (turn) 188 -64.1 -29.3 78.89 Low-density lipoprotein receptor LDL-receptor class A 7 Extracellular 175 -4.5 R303-E288, R303-S286; PAE: 4.5, 5.0 304 D Aspartic Acid Negatively-charged C (loop/coil) T (turn) 55 -103.7 6.4 82.02 Low-density lipoprotein receptor LDL-receptor class A 7 Extracellular 132 -3.5 D304-S286; PAE: 4.5 305 W Tryptophan Aromatic C (loop/coil) S (bend) 152 64.0 19.1 76.66 Low-density lipoprotein receptor LDL-receptor class A 7 Extracellular 204 -0.9 W305-R300 (PDB: 1XFE) W305-R300; PAE: 2.5 306 S Serine Polar/Neutral Beta strand C (loop/coil) T (turn) 34 -63.4 -21.3 81.14 Low-density lipoprotein receptor LDL-receptor class A 7 Extracellular 105 -0.8 S306-H285 (PDB: 1XFE); S306-H285 (PDB: 3M0C) S306-H285, S306-C302; PAE: 4.5, 4.0 307 D Aspartic Acid Negatively-charged Beta strand C (loop/coil) T (turn) 0 -78.5 -16.4 81.8 Low-density lipoprotein receptor LDL-receptor class A 7 Extracellular 132 -3.5 D307-D301 (PDB: 3M0C) D307-D301, D307-C296; PAE: 3.5, 3.0 D307-C302; PAE: 3.0 308 E Glutamic Acid Negatively-charged Beta strand C (loop/coil) C (loop/coil) 26 -135.7 61.7 84.47 Low-density lipoprotein receptor LDL-receptor class A 7 Extracellular 146 -3.5 E308-N297, E308-A299 (PDB: 3M0C) E308-A299, E308-M298; PAE: 3.5, 4.5 309 P Proline Special, No backbone hydrogen C (loop/coil) C (loop/coil) 36 -68.3 121.2 78.24 Low-density lipoprotein receptor LDL-receptor class A 7 Extracellular 115 1.6 P309-C313 (PDB: 1XFE) P309-C313; PAE: 4.5 P309-C313 (PDB: 1XFE) P309-C313; PAE: 4.5 310 I Isoleucine Aliphatic Turn C (loop/coil) T (turn) 182 -53.8 -28.2 75.28 Low-density lipoprotein receptor LDL-receptor class A 7 Extracellular 131 4.5 I310-T315 (PDB: 3M0C) 311 K Lysine Positively-charged Turn C (loop/coil) T (turn) 165 -106.3 -33.3 75.31 Low-density lipoprotein receptor LDL-receptor class A 7 Extracellular 147 -3.9 K311-T315; PAE: 5.0 K311-T315 (PDB: 1XFE) K311-T315; PAE: 5.0 312 E Glutamic Acid Negatively-charged Turn C (loop/coil) T (turn) 84 -98.8 -11.6 72.75 Low-density lipoprotein receptor LDL-receptor class A 7 Extracellular 146 -3.5 E312-G335 (PDB: 3M0C) E312-I334, E312-K333 (PDB: 1XFE); E312-G335 (PDB: 3M0C) 313 C Cysteine Special, a very reactive sulfhydryl group B (strand) B (beta bridge) 39 -73.5 112.4 82.17 Low-density lipoprotein receptor Disulfide bond 296-313 LDL-receptor class A 7 Extracellular 121 2.5 C313-P309 (PDB: 1XFE) C313-P309; PAE: 4.5 C313-P309 (PDB: 1XFE) C313-P309; PAE: 4.5 C313-C296 (PDB: 3M0C) C313-C296; PAE: 5.0 314 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible C (loop/coil) T (turn) 58 70.3 12.9 77.25 Low-density lipoprotein receptor EGF-like 1 Extracellular 75 -0.4 G314-K333, G314-Y336 (PDB: 1HZ8); G314-K333 (PDB: 2W2M); G314-K333 (PDB: 2W2P); G314-K333 (PDB: 3M0C) G314-K333; PAE: 4.5 G314-C296; PAE: 5.5 315 T Threonine Polar/Neutral C (loop/coil) C (loop/coil) 65 -79.3 134.1 82.27 Low-density lipoprotein receptor EGF-like 1 Extracellular 119 -0.7 T315-Y336 (PDB: 1I0U) T315-K311; PAE: 5.0 T315-K311 (PDB: 1XFE); T315-I310 (PDB: 3M0C) T315-K311; PAE: 5.0 316 N Asparagine Polar/Neutral C (loop/coil) C (loop/coil) 62 -97.3 96.1 82.79 Low-density lipoprotein receptor EGF-like 1 Extracellular 132 -3.5 N316-D331; PAE: 2.5 N316-D320 (PDB: 1XFE) E:N316-A:D259 (PDB: 2W2M); E:N316-A:D259 (PDB: 2W2O); E:N316-A:D259 (PDB: 2W2P); E:N316-A:D259 (PDB: 2W2Q); E:N316-A:D259 (PDB: 3BPS); E:N316-A:D259 (PDB: 3GCX); C:N316-B:D259 (PDB: 3M0C); D:N316-B:D551 (PDB: 4NE9) E:N316-A:D259 (PDB: 2W2M); E:N316-A:D259 (PDB: 2W2O); E:N316-A:D259 (PDB: 2W2P); E:N316-A:D259 (PDB: 2W2Q); E:N316-A:D259 (PDB: 3BPS); E:N316-A:D259 (PDB: 3GCX); D:N316-B:D551 (PDB: 4NE9) 317 E Glutamic Acid Negatively-charged Helix H (helix) G (3₁₀-helix) 30 -70.8 -20.7 85.15 Low-density lipoprotein receptor EGF-like 1 Extracellular 146 -3.5 E317-G323 (PDB: 1HZ8); E317-G323 (PDB: 1I0U) E317-G323 (PDB: 1HJ7); E317-G323 (PDB: 1HZ8); E317-G323 (PDB: 1I0U); E317-Y336 (PDB: 1XFE); E317-G323 (PDB: 2MG9); E317-G323 (PDB: 2W2M); E317-G323 (PDB: 2W2O); E317-G323 (PDB: 2W2P); E317-G323 (PDB: 2W2Q); E317-G323 (PDB: 3BPS); E317-G335, E317-G323 (PDB: 3GCX); E317-G323 (PDB: 3M0C); E317-G323 (PDB: 4NE9) E317-G323; PAE: 4.5 318 C Cysteine Special, a very reactive sulfhydryl group Helix H (helix) G (3₁₀-helix) 24 -64.6 -19.6 87.13 Low-density lipoprotein receptor Disulfide bond 318-329 EGF-like 1 Extracellular 121 2.5 C318-G324, C318-D331 (PDB: 1XFE); C318-N322 (PDB: 2W2O); C318-N322 (PDB: 2W2P); C318-N322 (PDB: 3BPS); C318-N322 (PDB: 3GCX); C318-N322 (PDB: 3M0C); C318-N322 (PDB: 4NE9) C318-N330, C318-D331 (PDB: 1HJ7); C318-N330, C318-G324, C318-D331 (PDB: 1XFE); C318-G323, C318-N322, C318-N330, C318-D331 (PDB: 2MG9); C318-G323, C318-N322, C318-D331 (PDB: 2W2M); C318-G323, C318-N322, C318-N330, C318-D331 (PDB: 2W2O); C318-G323, C318-N322, C318-D331 (PDB: 2W2P); C318-G323, C318-N322, C318-D331 (PDB: 2W2Q); C318-G323, C318-N322, C318-D331 (PDB: 3BPS); C318-G323, C318-N322, C318-N330 (PDB: 3GCX); C318-G323, C318-N322, C318-N330, C318-D331 (PDB: 3M0C); C318-G323, C318-N322, C318-D331 (PDB: 4NE9) C318-G323, C318-N322, C318-D331; PAE: 3.0, 2.5, 2.5 C318-C329 (PDB: 3BPS); C318-C329 (PDB: 3GCX); C318-C329 (PDB: 3M0C); C318-C329 (PDB: 4NE9) C318-C329; PAE: 2.5 319 L Leucine Aliphatic Helix H (helix) G (3₁₀-helix) 155 -71.9 -21.7 87.2 Low-density lipoprotein receptor EGF-like 1 Extracellular 131 3.8 320 D Aspartic Acid Negatively-charged C (loop/coil) T (turn) 132 -103.5 107.4 86.55 Low-density lipoprotein receptor EGF-like 1 Extracellular 132 -3.5 D320-N316 (PDB: 1XFE); D320-G324 (PDB: 2W2M); D320-G324 (PDB: 2W2O); D320-G324 (PDB: 3M0C) E:D320-A:S174 (PDB: 2W2O) E:D320-A:S174 (PDB: 3BPS); C:D320-B:S174 (PDB: 3M0C) 321 N Asparagine Polar/Neutral Helix H (helix) G (3₁₀-helix) 135 47.9 37.6 87.43 Low-density lipoprotein receptor EGF-like 1 Extracellular 132 -3.5 N321-C325 (PDB: 1XFE); N321-C325 (PDB: 2W2O); N321-C325 (PDB: 3M0C) E:N321-A:I390 (PDB: 2W2P); E:N321-A:I390 (PDB: 2W2Q); E:N321-A:I390 (PDB: 3GCX); D:N321-B:I682 (PDB: 4NE9) 322 N Asparagine Polar/Neutral Helix H (helix) G (3₁₀-helix) 58 55.2 32.6 85.26 Low-density lipoprotein receptor EGF-like 1 Extracellular 132 -3.5 N322-C329 (PDB: 1I0U); N322-H327 (PDB: 2MG9); N322-C318 (PDB: 2W2O); N322-C318 (PDB: 2W2P); N322-H327 (PDB: 2W2Q); N322-H327, N322-C318 (PDB: 3BPS); N322-H327, N322-C318 (PDB: 3GCX); N322-C318 (PDB: 3M0C); N322-H327, N322-C318 (PDB: 4NE9) N322-H327; PAE: 3.0 N322-H327, N322-S326, N322-V328, N322-C329 (PDB: 1HZ8); N322-H327, N322-S326, N322-V328, N322-C329 (PDB: 1I0U); N322-S326 (PDB: 1XFE); N322-C318, N322-C329 (PDB: 2MG9); N322-C318, N322-C329 (PDB: 2W2M); N322-C318, N322-C329 (PDB: 2W2O); N322-C318 (PDB: 2W2P); N322-C318, N322-C329 (PDB: 2W2Q); N322-C318, N322-C329 (PDB: 3BPS); N322-C318 (PDB: 3GCX); N322-C318, N322-C329 (PDB: 3M0C); N322-C318, N322-C329 (PDB: 4NE9) N322-C318, N322-C329; PAE: 2.5, 2.0 E:N322-A:F400, E:N322-A:I390 (PDB: 2W2M); E:N322-A:I390 (PDB: 2W2O); E:N322-A:I390 (PDB: 2W2P); E:N322-A:F400, E:N322-A:I390 (PDB: 2W2Q); E:N322-A:I390 (PDB: 3BPS); E:N322-A:I390 (PDB: 3GCX); C:N322-B:F400, C:N322-B:I390 (PDB: 3M0C); D:N322-B:I682, D:N322-B:F692 (PDB: 4NE9) 323 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible Helix H (helix) G (3₁₀-helix) 11 64.2 5.9 82.9 Low-density lipoprotein receptor EGF-like 1 Extracellular 75 -0.4 G323-R350 (PDB: 1HJ7); G323-E317 (PDB: 1HZ8); G323-E317 (PDB: 1I0U); G323-C329 (PDB: 1XFE); G323-Y336 (PDB: 2MG9); G323-Y336 (PDB: 2W2M); G323-Y336 (PDB: 2W2O); G323-Y336 (PDB: 2W2P); G323-Y336 (PDB: 2W2Q); G323-Y336 (PDB: 3BPS); G323-Y336 (PDB: 3GCX); G323-Y336 (PDB: 3M0C); G323-Y336 (PDB: 4NE9) G323-E317, G323-Y336 (PDB: 1HJ7); G323-E317 (PDB: 1HZ8); G323-E317 (PDB: 1I0U); G323-C329 (PDB: 1XFE); G323-E317, G323-C318, G323-Y336 (PDB: 2MG9); G323-E317, G323-C318, G323-Y336 (PDB: 2W2M); G323-E317, G323-C318, G323-Y336 (PDB: 2W2O); G323-E317, G323-C318, G323-Y336 (PDB: 2W2P); G323-E317, G323-C318, G323-Y336 (PDB: 2W2Q); G323-E317, G323-C318, G323-Y336 (PDB: 3BPS); G323-E317, G323-C318, G323-Y336 (PDB: 3GCX); G323-E317, G323-C318, G323-Y336 (PDB: 3M0C); G323-E317, G323-C318, G323-Y336 (PDB: 4NE9) G323-E317, G323-C318, G323-Y336; PAE: 4.5, 3.0, 2.5 324 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible Helix H (helix) G (3₁₀-helix) 27 78.1 11.6 84.4 Low-density lipoprotein receptor EGF-like 1 Extracellular 75 -0.4 G324-C318, G324-R350 (PDB: 1XFE) G324-R350 (PDB: 1HJ7); G324-C318, G324-R350 (PDB: 1XFE); G324-D320 (PDB: 2W2M); G324-D320 (PDB: 2W2O); G324-R350 (PDB: 3BPS); G324-D320 (PDB: 3M0C) 325 C Cysteine Special, a very reactive sulfhydryl group C (loop/coil) C (loop/coil) 10 -75.5 139.7 87.57 Low-density lipoprotein receptor Disulfide bond 325-338 EGF-like 1 Extracellular 121 2.5 C325-L339 (PDB: 1HJ7); C325-N321 (PDB: 1XFE); C325-N321 (PDB: 2W2O); C325-N321 (PDB: 3M0C) C325-C338 (PDB: 3BPS); C325-C338 (PDB: 3GCX); C325-C338 (PDB: 3M0C); C325-C338 (PDB: 4NE9) C325-C338; PAE: 3.5 326 S Serine Polar/Neutral Beta strand C (loop/coil) S (bend) 60 -66.9 -38.0 86.21 Low-density lipoprotein receptor EGF-like 1 Extracellular 105 -0.8 S326-R350 (PDB: 2W2M); S326-R350 (PDB: 2W2O); S326-R350 (PDB: 2W2P); S326-C352, S326-R350 (PDB: 2W2Q); S326-R350 (PDB: 3BPS); S326-R350 (PDB: 3GCX); S326-R350 (PDB: 3M0C) S326-C352, S326-R350; PAE: 3.5, 3.5 S326-N322 (PDB: 1HZ8); S326-N322 (PDB: 1I0U); S326-C352, S326-N322, S326-R351 (PDB: 1XFE); S326-C352 (PDB: 2W2M); S326-C352 (PDB: 2W2O); S326-C352 (PDB: 2W2P); S326-C352 (PDB: 2W2Q); S326-C352 (PDB: 3BPS); S326-C352 (PDB: 3GCX) S326-C352; PAE: 3.5 327 H Histidine Positively-charged Beta strand C (loop/coil) S (bend) 82 -122.3 -101.3 87.75 Low-density lipoprotein receptor EGF-like 1 Extracellular 155 -3.2 H327-N322 (PDB: 2MG9); H327-N322 (PDB: 2W2Q); H327-N322 (PDB: 3BPS); H327-N322 (PDB: 3GCX); H327-N322 (PDB: 4NE9) H327-N322; PAE: 3.0 H327-N322 (PDB: 1HZ8); H327-N322 (PDB: 1I0U) 328 V Valine Aliphatic Beta strand B (strand) E (parallel sheets) 78 -95.0 127.0 89.29 Low-density lipoprotein receptor EGF-like 1 Extracellular 117 4.2 V328-L339 (PDB: 1HJ7); V328-L339 (PDB: 1I0U); V328-L339 (PDB: 1XFE); V328-L339 (PDB: 2MG9); V328-L339 (PDB: 2W2M); V328-L339 (PDB: 2W2O); V328-L339 (PDB: 2W2P); V328-L339 (PDB: 2W2Q); V328-L339 (PDB: 3BPS); V328-L339 (PDB: 3GCX); V328-L339 (PDB: 3M0C); V328-L339 (PDB: 4NE9) V328-L339; PAE: 2.0 V328-L339 (PDB: 1HJ7); V328-N322, V328-C340, V328-L339 (PDB: 1HZ8); V328-N322, V328-C340, V328-L339, V328-C338 (PDB: 1I0U); V328-L339 (PDB: 1XFE); V328-L339 (PDB: 2MG9); V328-L339 (PDB: 2W2M); V328-L339 (PDB: 2W2O); V328-L339 (PDB: 2W2P); V328-L339 (PDB: 2W2Q); V328-L339 (PDB: 3BPS); V328-L339 (PDB: 3GCX); V328-L339 (PDB: 3M0C); V328-L339 (PDB: 4NE9) V328-L339; PAE: 2.0 329 C Cysteine Special, a very reactive sulfhydryl group Beta strand B (strand) E (parallel sheets) 20 -101.7 116.9 89.64 Low-density lipoprotein receptor Disulfide bond 318-329 EGF-like 1 Extracellular 121 2.5 C329-N322 (PDB: 1I0U); C329-G323 (PDB: 1XFE) C329-N322 (PDB: 1HZ8); C329-N322 (PDB: 1I0U); C329-G323 (PDB: 1XFE); C329-N322 (PDB: 2MG9); C329-N322 (PDB: 2W2M); C329-N322 (PDB: 2W2O); C329-N322 (PDB: 2W2Q); C329-N322 (PDB: 3BPS); C329-N322 (PDB: 3M0C); C329-N322 (PDB: 4NE9) C329-N322; PAE: 2.0 C329-C318 (PDB: 3BPS); C329-C318 (PDB: 3GCX); C329-C318 (PDB: 3M0C); C329-C318 (PDB: 4NE9) C329-C318; PAE: 2.5 E:C329-A:F400 (PDB: 2W2M); E:C329-A:F400 (PDB: 2W2O); E:C329-A:F400 (PDB: 2W2P); E:C329-A:F400 (PDB: 2W2Q); E:C329-A:F400 (PDB: 3BPS); E:C329-A:F400 (PDB: 3GCX); C:C329-B:F400 (PDB: 3M0C); D:C329-B:F692 (PDB: 4NE9) E:C329-A:F400 (PDB: 2W2M); E:C329-A:F400 (PDB: 2W2O); E:C329-A:F400 (PDB: 2W2P); E:C329-A:F400 (PDB: 2W2Q); E:C329-A:F400 (PDB: 3BPS); E:C329-A:F400 (PDB: 3GCX); C:C329-B:F400 (PDB: 3M0C); D:C329-B:F692 (PDB: 4NE9) 330 N Asparagine Polar/Neutral Beta strand B (strand) E (parallel sheets) 62 -98.5 121.7 87.52 Low-density lipoprotein receptor EGF-like 1 Extracellular 132 -3.5 N330-E337 (PDB: 1HJ7); N330-E337 (PDB: 1HZ8); N330-E337 (PDB: 1I0U); N330-E337 (PDB: 1XFE); N330-E337 (PDB: 2MG9); N330-E337 (PDB: 2W2M); N330-E337 (PDB: 2W2O); N330-E337 (PDB: 2W2P); N330-E337 (PDB: 2W2Q); N330-E337 (PDB: 3BPS); N330-E337 (PDB: 3GCX); N330-E337 (PDB: 3M0C); N330-E337 (PDB: 4NE9) N330-E337; PAE: 2.0 N330-C318, N330-E337 (PDB: 1HJ7); N330-E337 (PDB: 1HZ8); N330-E337 (PDB: 1I0U); N330-C318, N330-E337 (PDB: 1XFE); N330-C318, N330-E337 (PDB: 2MG9); N330-E337 (PDB: 2W2M); N330-C318, N330-E337 (PDB: 2W2O); N330-E337 (PDB: 2W2P); N330-E337 (PDB: 2W2Q); N330-E337 (PDB: 3BPS); N330-C318, N330-E337 (PDB: 3GCX); N330-C318, N330-E337 (PDB: 3M0C); N330-E337 (PDB: 4NE9) N330-E337; PAE: 2.0 E:N330-A:T398 (PDB: 2W2M); E:N330-A:T398 (PDB: 2W2O); E:N330-A:T398 (PDB: 2W2P); E:N330-A:T398 (PDB: 2W2Q); E:N330-A:T398 (PDB: 3BPS); E:N330-A:T398 (PDB: 3GCX); C:N330-B:T398 (PDB: 3M0C); D:N330-B:T690 (PDB: 4NE9) E:N330-A:C399, E:N330-A:T398, E:N330-A:C396 (PDB: 2W2M); E:N330-A:C399, E:N330-A:T398, E:N330-A:C396 (PDB: 2W2O); E:N330-A:C399, E:N330-A:T398, E:N330-A:C396 (PDB: 2W2P); E:N330-A:T398, E:N330-A:C396 (PDB: 2W2Q); C:N330-B:T398 (PDB: 3M0C) 331 D Aspartic Acid Negatively-charged B (strand) E (parallel sheets) 57 -82.7 117.2 84.17 Low-density lipoprotein receptor EGF-like 1 Extracellular 132 -3.5 D331-C318 (PDB: 1XFE) D331-N316; PAE: 2.5 D331-C318 (PDB: 1HJ7); D331-C318 (PDB: 1XFE); D331-C318 (PDB: 2MG9); D331-C318 (PDB: 2W2M); D331-C318 (PDB: 2W2O); D331-C318 (PDB: 2W2P); D331-C318 (PDB: 2W2Q); D331-C318 (PDB: 3BPS); D331-C318 (PDB: 3M0C); D331-C318 (PDB: 4NE9) D331-C318; PAE: 2.5 E:D331-A:R215, E:D331-A:T398 (PDB: 2W2M); E:D331-A:R215, E:D331-A:T398 (PDB: 2W2O); E:D331-A:R215, E:D331-A:T398 (PDB: 2W2P); E:D331-A:R215, E:D331-A:T398 (PDB: 2W2Q); E:D331-A:R215, E:D331-A:T398 (PDB: 3BPS); E:D331-A:R215, E:D331-A:T398 (PDB: 3GCX); D:D331-B:T690, D:D331-B:R507 (PDB: 4NE9) E:D331-A:T398 (PDB: 2W2M); E:D331-A:T398 (PDB: 2W2O); E:D331-A:T398 (PDB: 2W2P); E:D331-A:T398 (PDB: 2W2Q); E:D331-A:T398 (PDB: 3BPS); E:D331-A:T398 (PDB: 3GCX); C:D331-B:T398 (PDB: 3M0C); D:D331-B:T690 (PDB: 4NE9) E:D331-A:R215 (PDB: 2W2M); E:D331-A:R215 (PDB: 2W2O); E:D331-A:R215 (PDB: 2W2P); E:D331-A:R215 (PDB: 2W2Q); E:D331-A:R215 (PDB: 3BPS); E:D331-A:R215 (PDB: 3GCX); D:D331-B:R507 (PDB: 4NE9) 332 L Leucine Aliphatic H (helix) P (polyproline helix) 70 -95.0 166.4 83.01 Low-density lipoprotein receptor EGF-like 1 Extracellular 131 3.8 L332-E337 (PDB: 1HJ7); L332-Y336 (PDB: 1HZ8); L332-Y336 (PDB: 1I0U) 333 K Lysine Positively-charged Beta strand C (loop/coil) S (bend) 135 -61.9 -27.3 80.97 Low-density lipoprotein receptor EGF-like 1 Extracellular 147 -3.9 K333-G314 (PDB: 1HZ8); K333-G314 (PDB: 2W2M); K333-G314 (PDB: 2W2P); K333-G314 (PDB: 3M0C) K333-G314; PAE: 4.5 K333-E312 (PDB: 1XFE) 334 I Isoleucine Aliphatic Beta strand B (strand) B (beta bridge) 49 -132.9 113.9 77.88 Low-density lipoprotein receptor EGF-like 1 Extracellular 131 4.5 I334-E312 (PDB: 1XFE) 335 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible Beta strand C (loop/coil) S (bend) 14 72.4 -164.7 82.75 Low-density lipoprotein receptor EGF-like 1 Extracellular 75 -0.4 G335-A312 (PDB: 2W2M); G335-A312 (PDB: 2W2O); G335-A312 (PDB: 2W2P); G335-E312 (PDB: 3M0C) G335-Q310, G335-A312 (PDB: 2W2M); G335-Q310, G335-A312 (PDB: 2W2O); G335-Q310, G335-A312 (PDB: 2W2P); G335-M313 (PDB: 3BPS); G335-E317 (PDB: 3GCX); G335-E312 (PDB: 3M0C) 336 Y Tyrosine Aromatic B (strand) E (parallel sheets) 75 -138.7 156.8 84.82 Low-density lipoprotein receptor EGF-like 1 Extracellular 181 -1.3 Y336-R350 (PDB: 1HJ7); Y336-G314 (PDB: 1HZ8); Y336-T315 (PDB: 1I0U); Y336-G323 (PDB: 2MG9); Y336-G323 (PDB: 2W2M); Y336-G323 (PDB: 2W2O); Y336-G323 (PDB: 2W2P); Y336-G323 (PDB: 2W2Q); Y336-G323 (PDB: 3BPS); Y336-G323 (PDB: 3GCX); Y336-G323 (PDB: 3M0C); Y336-G323 (PDB: 4NE9) Y336-R350; PAE: 4.0 Y336-G323 (PDB: 1HJ7); Y336-L332 (PDB: 1HZ8); Y336-L332 (PDB: 1I0U); Y336-E317 (PDB: 1XFE); Y336-G323 (PDB: 2MG9); Y336-G323 (PDB: 2W2M); Y336-G323 (PDB: 2W2O); Y336-G323 (PDB: 2W2P); Y336-G323 (PDB: 2W2Q); Y336-G323 (PDB: 3BPS); Y336-G323 (PDB: 3GCX); Y336-G323 (PDB: 3M0C); Y336-G323 (PDB: 4NE9) Y336-G323; PAE: 2.5 337 E Glutamic Acid Negatively-charged Beta strand B (strand) E (parallel sheets) 81 -125.0 143.0 85.69 Low-density lipoprotein receptor EGF-like 1 Extracellular 146 -3.5 E337-N330 (PDB: 1HJ7); E337-N330 (PDB: 1HZ8); E337-N330 (PDB: 1I0U); E337-N330 (PDB: 1XFE); E337-N330 (PDB: 2MG9); E337-N330 (PDB: 2W2M); E337-N330 (PDB: 2W2O); E337-N330 (PDB: 2W2P); E337-N330 (PDB: 2W2Q); E337-N330 (PDB: 3BPS); E337-N330 (PDB: 3GCX); E337-N330 (PDB: 3M0C); E337-N330 (PDB: 4NE9) E337-N330; PAE: 2.0 E337-N330, E337-L332 (PDB: 1HJ7); E337-N330 (PDB: 1HZ8); E337-N330 (PDB: 1I0U); E337-N330 (PDB: 1XFE); E337-N330 (PDB: 2MG9); E337-N330 (PDB: 2W2M); E337-N330 (PDB: 2W2O); E337-N330 (PDB: 2W2P); E337-N330 (PDB: 2W2Q); E337-N330 (PDB: 3BPS); E337-N330 (PDB: 3GCX); E337-N330 (PDB: 3M0C); E337-N330 (PDB: 4NE9) E337-N330; PAE: 2.0 338 C Cysteine Special, a very reactive sulfhydryl group Beta strand B (strand) E (parallel sheets) 10 -90.6 129.4 89.58 Low-density lipoprotein receptor Disulfide bond 325-338 EGF-like 1 Extracellular 121 2.5 C338-V328 (PDB: 1I0U) C338-C325 (PDB: 3BPS); C338-C325 (PDB: 3GCX); C338-C325 (PDB: 3M0C); C338-C325 (PDB: 4NE9) C338-C325; PAE: 3.5 339 L Leucine Aliphatic Beta strand B (strand) E (parallel sheets) 74 -110.5 142.1 87.53 Low-density lipoprotein receptor EGF-like 1 Extracellular 131 3.8 L339-V328 (PDB: 1HJ7); L339-V328 (PDB: 1I0U); L339-V328 (PDB: 1XFE); L339-V328 (PDB: 2MG9); L339-V328 (PDB: 2W2M); L339-V328 (PDB: 2W2O); L339-V328 (PDB: 2W2P); L339-V328 (PDB: 2W2Q); L339-V328 (PDB: 3BPS); L339-V328 (PDB: 3GCX); L339-V328 (PDB: 3M0C); L339-V328 (PDB: 4NE9) L339-V328; PAE: 2.0 L339-C325, L339-V328 (PDB: 1HJ7); L339-V328 (PDB: 1HZ8); L339-V328 (PDB: 1I0U); L339-V328 (PDB: 1XFE); L339-V328 (PDB: 2MG9); L339-V328 (PDB: 2W2M); L339-V328 (PDB: 2W2O); L339-V328 (PDB: 2W2P); L339-V328 (PDB: 2W2Q); L339-V328 (PDB: 3BPS); L339-V328 (PDB: 3GCX); L339-V328 (PDB: 3M0C); L339-V328 (PDB: 4NE9) L339-V328; PAE: 2.0 340 C Cysteine Special, a very reactive sulfhydryl group H (helix) P (polyproline helix) 31 -95.9 148.3 88.8 Low-density lipoprotein receptor Disulfide bond 340-352 EGF-like 1 Extracellular 121 2.5 C340-V328, C340-Q345, C340-L346 (PDB: 1HZ8); C340-V328, C340-L346 (PDB: 1I0U); C340-L346 (PDB: 2W2M); C340-L346 (PDB: 2W2Q); C340-L346 (PDB: 3BPS) C340-L346; PAE: 2.0 C340-C352 (PDB: 3BPS); C340-C352 (PDB: 3GCX); C340-C352 (PDB: 3M0C) C340-C352; PAE: 2.5 C:C340-B:Y395 (PDB: 3M0C) 341 P Proline Special, No backbone hydrogen Beta strand H (helix) P (polyproline helix) 49 -58.2 161.8 87.14 Low-density lipoprotein receptor EGF-like 1 Extracellular 115 1.6 342 D Aspartic Acid Negatively-charged Beta strand C (loop/coil) T (turn) 158 -54.3 140.7 83.61 Low-density lipoprotein receptor EGF-like 1 Extracellular 132 -3.5 343 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible Beta strand C (loop/coil) T (turn) 17 84.7 1.3 83.31 Low-density lipoprotein receptor EGF-like 1 Extracellular 75 -0.4 G343-I355 (PDB: 1HJ7) G343-I355; PAE: 3.0 G343-I355 (PDB: 1HJ7); G343-D354 (PDB: 3M0C) G343-I355; PAE: 3.0 344 F Phenylalanine Aromatic B (strand) E (parallel sheets) 37 -127.3 141.9 88.62 Low-density lipoprotein receptor EGF-like 1 Extracellular 165 2.8 F344-D354, F344-I355 (PDB: 1HJ7); F344-D354, F344-G373, F344-E353 (PDB: 1HZ8); F344-D354, F344-E353 (PDB: 1I0U); F344-E353 (PDB: 2W2M); F344-E353 (PDB: 2W2O); F344-E353 (PDB: 2W2P); F344-E353 (PDB: 2W2Q); F344-D354, F344-E353 (PDB: 3M0C) F344-D354, F344-G373; PAE: 1.0, 2.5 345 Q Glutamine Polar/Neutral Beta strand B (strand) E (parallel sheets) 131 -103.0 136.8 84.75 Low-density lipoprotein receptor EGF-like 1 Extracellular 146 -3.5 Q345-E353 (PDB: 1HJ7); Q345-E353 (PDB: 1HZ8); Q345-E353 (PDB: 1I0U); Q345-E353 (PDB: 1XFE); Q345-E353 (PDB: 2W2M); Q345-E353 (PDB: 2W2O); Q345-E353 (PDB: 2W2P); Q345-E353 (PDB: 2W2Q); Q345-E353 (PDB: 3BPS); Q345-E353 (PDB: 3GCX) Q345-E353; PAE: 2.0 Q345-E353 (PDB: 1HJ7); Q345-C340, Q345-I355, Q345-E353 (PDB: 1HZ8); Q345-E353 (PDB: 1I0U); Q345-E353 (PDB: 1XFE); Q345-E353 (PDB: 2W2M); Q345-E353 (PDB: 2W2O); Q345-E353 (PDB: 2W2P); Q345-E353 (PDB: 2W2Q); Q345-E353 (PDB: 3BPS); Q345-E353 (PDB: 3GCX); Q345-E353 (PDB: 3M0C) Q345-E353; PAE: 2.0 346 L Leucine Aliphatic Beta strand B (strand) E (parallel sheets) 70 -76.0 104.1 85.32 Low-density lipoprotein receptor EGF-like 1 Extracellular 131 3.8 L346-C340 (PDB: 1HZ8); L346-C340 (PDB: 1I0U); L346-R351, L346-C352, L346-R350 (PDB: 1XFE); L346-C340, L346-R351, L346-R350 (PDB: 2W2M); L346-R350 (PDB: 2W2O); L346-R350 (PDB: 2W2P); L346-C340, L346-R351, L346-R350 (PDB: 2W2Q); L346-C340 (PDB: 3BPS); L346-R350 (PDB: 3M0C) L346-C340, L346-R350; PAE: 2.0, 2.0 347 V Valine Aliphatic Beta strand B (strand) E (parallel sheets) 47 -94.4 132.6 84.98 Low-density lipoprotein receptor EGF-like 1 Extracellular 117 4.2 V347-R351 (PDB: 1XFE); V347-R351 (PDB: 2W2M); V347-R351 (PDB: 2W2O); V347-R351 (PDB: 2W2P); V347-R351 (PDB: 2W2Q); V347-R351 (PDB: 3BPS); V347-R351 (PDB: 3GCX); V347-R351 (PDB: 3M0C) V347-R351; PAE: 3.5 V347-E353 (PDB: 1HJ7); V347-R351 (PDB: 1XFE); V347-R351 (PDB: 2W2M); V347-R351 (PDB: 2W2O); V347-R351 (PDB: 2W2P); V347-R351 (PDB: 2W2Q); V347-R351 (PDB: 3BPS); V347-R351 (PDB: 3GCX); V347-R351 (PDB: 3M0C) V347-R351; PAE: 3.5 348 A Alanine Aliphatic Turn C (loop/coil) T (turn) 67 53.3 35.0 83.07 Low-density lipoprotein receptor EGF-like 1 Extracellular 89 1.8 349 Q Glutamine Polar/Neutral Turn C (loop/coil) T (turn) 161 61.1 5.8 79.78 Low-density lipoprotein receptor EGF-like 1 Extracellular 146 -3.5 350 R Arginine Positively-charged Turn C (loop/coil) T (turn) 125 -143.5 -34.8 84.86 Low-density lipoprotein receptor EGF-like 1 Extracellular 175 -4.5 R350-Y336, R350-G323 (PDB: 1HJ7); R350-G324 (PDB: 1XFE); R350-S326 (PDB: 2W2M); R350-S326 (PDB: 2W2O); R350-S326 (PDB: 2W2P); R350-S326 (PDB: 2W2Q); R350-S326 (PDB: 3BPS); R350-S326 (PDB: 3GCX); R350-S326 (PDB: 3M0C) R350-Y336, R350-S326; PAE: 4.0, 3.5 R350-G324 (PDB: 1HJ7); R350-L346, R350-G324 (PDB: 1XFE); R350-L346 (PDB: 2W2M); R350-L346 (PDB: 2W2O); R350-L346 (PDB: 2W2P); R350-L346 (PDB: 2W2Q); R350-G324 (PDB: 3BPS); R350-L346 (PDB: 3M0C) R350-L346; PAE: 2.0 351 R Arginine Positively-charged Beta strand B (strand) E (parallel sheets) 155 -95.7 142.8 86.18 Low-density lipoprotein receptor EGF-like 1 Extracellular 175 -4.5 R351-V347 (PDB: 1XFE); R351-V347 (PDB: 2W2M); R351-V347 (PDB: 2W2O); R351-V347 (PDB: 2W2P); R351-V347 (PDB: 2W2Q); R351-V347 (PDB: 3BPS); R351-V347 (PDB: 3GCX); R351-V347 (PDB: 3M0C) R351-V347; PAE: 3.5 R351-L346, R351-S326, R351-V347 (PDB: 1XFE); R351-V347, R351-L346 (PDB: 2W2M); R351-V347 (PDB: 2W2O); R351-V347 (PDB: 2W2P); R351-L346, R351-V347 (PDB: 2W2Q); R351-V347 (PDB: 3BPS); R351-V347 (PDB: 3GCX); R351-V347 (PDB: 3M0C) R351-V347; PAE: 3.5 352 C Cysteine Special, a very reactive sulfhydryl group Beta strand B (strand) E (parallel sheets) 19 -105.8 119.7 87.48 Low-density lipoprotein receptor Disulfide bond 340-352 EGF-like 1 Extracellular 121 2.5 C352-S326 (PDB: 2W2Q) C352-S326; PAE: 3.5 C352-L346, C352-S326 (PDB: 1XFE); C352-S326 (PDB: 2W2M); C352-S326 (PDB: 2W2O); C352-S326 (PDB: 2W2P); C352-S326 (PDB: 2W2Q); C352-S326 (PDB: 3BPS); C352-S326 (PDB: 3GCX) C352-S326; PAE: 3.5 C352-C340 (PDB: 3BPS); C352-C340 (PDB: 3GCX); C352-C340 (PDB: 3M0C) C352-C340; PAE: 2.5 353 E Glutamic Acid Negatively-charged Beta strand B (strand) E (parallel sheets) 102 -105.6 147.3 87.27 Low-density lipoprotein receptor EGF-like 1 Extracellular 146 -3.5 E353-Q345 (PDB: 1HJ7); E353-Q345 (PDB: 1HZ8); E353-Q345 (PDB: 1I0U); E353-Q345 (PDB: 1XFE); E353-Q345 (PDB: 2W2M); E353-Q345 (PDB: 2W2O); E353-Q345 (PDB: 2W2P); E353-Q345 (PDB: 2W2Q); E353-Q345 (PDB: 3BPS); E353-Q345 (PDB: 3GCX) E353-Q345; PAE: 2.0 E353-Q345, E353-V347 (PDB: 1HJ7); E353-E372, E353-Q345, E353-F344 (PDB: 1HZ8); E353-Q345, E353-F344 (PDB: 1I0U); E353-Q345 (PDB: 1XFE); E353-Q345, E353-F344 (PDB: 2W2M); E353-Q345, E353-F344 (PDB: 2W2O); E353-Q345, E353-F344 (PDB: 2W2P); E353-Q345, E353-F344 (PDB: 2W2Q); E353-Q345 (PDB: 3BPS); E353-Q345 (PDB: 3GCX); E353-Q345, E353-F344 (PDB: 3M0C) E353-Q345; PAE: 2.0 354 D Aspartic Acid Negatively-charged B (strand) E (parallel sheets) 50 -60.6 134.8 87.81 Low-density lipoprotein receptor EGF-like 2; calcium-binding Extracellular 132 -3.5 D354-G373, D354-N370; PAE: 3.5, 2.5 D354-F344 (PDB: 1HJ7); D354-F344 (PDB: 1HZ8); D354-F344 (PDB: 1I0U); D354-G373, D354-F344, D354-G343 (PDB: 3M0C) D354-G373, D354-F344; PAE: 3.5, 1.0 355 I Isoleucine Aliphatic C (loop/coil) C (loop/coil) 66 -81.0 114.9 87.07 Low-density lipoprotein receptor EGF-like 2; calcium-binding Extracellular 131 4.5 I355-G343 (PDB: 1HJ7) I355-G343; PAE: 3.0 I355-F344, I355-G343 (PDB: 1HJ7); I355-Q345 (PDB: 1HZ8) I355-G343; PAE: 3.0 356 D Aspartic Acid Negatively-charged C (loop/coil) C (loop/coil) 60 -74.8 88.3 83.93 Low-density lipoprotein receptor EGF-like 2; calcium-binding Extracellular 132 -3.5 D356-N370 (PDB: 1HJ7); D356-N370 (PDB: 1HZ8); D356-D360, D356-N370 (PDB: 1I0U); D356-N370 (PDB: 3M0C) D356-N370; PAE: 2.0 357 E Glutamic Acid Negatively-charged Helix H (helix) G (3₁₀-helix) 32 -64.9 -18.5 86.03 Low-density lipoprotein receptor EGF-like 2; calcium-binding Extracellular 146 -3.5 E357-T363 (PDB: 1I0U) E357-T363; PAE: 4.5 E357-T363 (PDB: 1HJ7); E357-T363 (PDB: 1HZ8); E357-T363 (PDB: 1I0U); E357-N370 (PDB: 3M0C) E357-Y375, E357-T363; PAE: 2.0, 4.5 358 C Cysteine Special, a very reactive sulfhydryl group Helix H (helix) G (3₁₀-helix) 35 -72.6 -8.1 84.32 Low-density lipoprotein receptor Disulfide bond 358-368 EGF-like 2; calcium-binding Extracellular 121 2.5 C358-N370, C358-V369, C358-T363 (PDB: 1HJ7); C358-N370, C358-V369, C358-T363 (PDB: 1HZ8); C358-N370, C358-V369, C358-T363 (PDB: 1I0U); C358-N370, C358-V369, C358-T363 (PDB: 3M0C) C358-N370, C358-V369; PAE: 2.0, 1.5 C358-C368 (PDB: 3M0C) C358-C368; PAE: 2.5 359 Q Glutamine Polar/Neutral Helix H (helix) G (3₁₀-helix) 145 -73.3 -22.9 82.25 Low-density lipoprotein receptor EGF-like 2; calcium-binding Extracellular 146 -3.5 Q359-T363 (PDB: 3M0C) 360 D Aspartic Acid Negatively-charged C (loop/coil) S (bend) 79 -85.3 116.5 77.25 Low-density lipoprotein receptor EGF-like 2; calcium-binding Extracellular 132 -3.5 D360-D356 (PDB: 1I0U) 361 P Proline Special, No backbone hydrogen C (loop/coil) T (turn) 54 -63.4 -14.7 70.22 Low-density lipoprotein receptor EGF-like 2; calcium-binding Extracellular 115 1.6 362 D Aspartic Acid Negatively-charged C (loop/coil) T (turn) 53 -82.2 -11.9 72.04 Low-density lipoprotein receptor EGF-like 2; calcium-binding Extracellular 132 -3.5 D362-K596; PAE: 7.0 363 T Threonine Polar/Neutral Beta strand C (loop/coil) S (bend) 26 -66.9 -39.4 79.41 Low-density lipoprotein receptor EGF-like 2; calcium-binding Extracellular 119 -0.7 T363-E357 (PDB: 1I0U) T363-E357; PAE: 4.5 T363-E357, T363-C358 (PDB: 1HJ7); T363-E357, T363-C358 (PDB: 1HZ8); T363-E357, T363-C358 (PDB: 1I0U); T363-Q359, T363-C358 (PDB: 3M0C) T363-E357; PAE: 4.5 364 C Cysteine Special, a very reactive sulfhydryl group Beta strand C (loop/coil) C (loop/coil) 11 -133.8 146.4 79.39 Low-density lipoprotein receptor Disulfide bond 364-377 EGF-like 2; calcium-binding Extracellular 121 2.5 C364-C392 (PDB: 1I0U); C364-C368, C364-C377 (PDB: 3M0C) C364-C377; PAE: 3.5 C364-C377 (PDB: 3M0C) C364-C377; PAE: 3.5 365 S Serine Polar/Neutral Beta strand C (loop/coil) S (bend) 9 -58.0 -40.7 77.64 Low-density lipoprotein receptor EGF-like 2; calcium-binding Extracellular 105 -0.8 S365-R633; PAE: 5.0 S365-C392; PAE: 4.5 366 Q Glutamine Polar/Neutral Beta strand C (loop/coil) S (bend) 45 -131.5 -102.8 83.35 Low-density lipoprotein receptor EGF-like 2; calcium-binding Extracellular 146 -3.5 Pocket 2: Mean pLDDT: 89.82, Volume: 512.1 ų, Druggability score: 0.1 0.0983 Q366-C392 (PDB: 1HZ8) Q366-E380; PAE: 3.5 Q366-C392, Q366-E380, Q366-Q378 (PDB: 1HZ8) Q366-E380; PAE: 3.5 367 L Leucine Aliphatic Beta strand B (strand) E (parallel sheets) 92 -89.6 121.6 84.14 Low-density lipoprotein receptor EGF-like 2; calcium-binding Extracellular 131 3.8 Pocket 2: Mean pLDDT: 89.82, Volume: 512.1 ų, Druggability score: 0.1 0.0983 L367-Q378 (PDB: 1HJ7); L367-Q378 (PDB: 1HZ8); L367-Q378 (PDB: 1I0U); L367-Q378 (PDB: 3M0C) L367-Q378; PAE: 2.0 L367-Q378 (PDB: 1HJ7); L367-Q378 (PDB: 1HZ8); L367-Q378, L367-C379 (PDB: 1I0U); L367-Q378 (PDB: 3M0C) L367-Q378; PAE: 2.0 368 C Cysteine Special, a very reactive sulfhydryl group Beta strand B (strand) E (parallel sheets) 32 -98.1 131.8 84.54 Low-density lipoprotein receptor Disulfide bond 358-368 EGF-like 2; calcium-binding Extracellular 121 2.5 C368-Q378 (PDB: 1I0U); C368-C364 (PDB: 3M0C) C368-C358 (PDB: 3M0C) C368-C358; PAE: 2.5 369 V Valine Aliphatic Beta strand B (strand) E (parallel sheets) 49 -116.5 115.4 84.94 Low-density lipoprotein receptor EGF-like 2; calcium-binding Extracellular 117 4.2 V369-K376 (PDB: 1HJ7); V369-K376 (PDB: 1HZ8); V369-K376 (PDB: 1I0U) V369-K376; PAE: 1.5 V369-K376, V369-Q378, V369-C358 (PDB: 1HJ7); V369-C358, V369-K376 (PDB: 1HZ8); V369-K376, V369-C358 (PDB: 1I0U); V369-C358, V369-K376 (PDB: 3M0C) V369-C358, V369-Q378, V369-K376; PAE: 1.5, 3.0, 1.5 370 N Asparagine Polar/Neutral B (strand) E (parallel sheets) 54 -73.7 132.6 84.26 Low-density lipoprotein receptor EGF-like 2; calcium-binding Extracellular 132 -3.5 N370-D354; PAE: 2.5 N370-C358, N370-D356 (PDB: 1HJ7); N370-C358, N370-D356 (PDB: 1HZ8); N370-C358, N370-D356 (PDB: 1I0U); N370-C358, N370-E357, N370-D356 (PDB: 3M0C) N370-C358, N370-D356; PAE: 2.0, 2.0 371 L Leucine Aliphatic B (strand) E (parallel sheets) 87 -122.9 156.0 85.69 Low-density lipoprotein receptor EGF-like 2; calcium-binding Extracellular 131 3.8 L371-Y375 (PDB: 1HZ8); L371-Y375 (PDB: 1I0U) 372 E Glutamic Acid Negatively-charged Beta strand C (loop/coil) T (turn) 175 -68.0 110.8 81.82 Low-density lipoprotein receptor EGF-like 2; calcium-binding Extracellular 146 -3.5 E372-E353 (PDB: 1HZ8) 373 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible Beta strand C (loop/coil) T (turn) 29 91.6 12.9 80.41 Low-density lipoprotein receptor EGF-like 2; calcium-binding Extracellular 75 -0.4 G373-D354; PAE: 3.5 G373-F344 (PDB: 1HZ8); G373-D354 (PDB: 3M0C) G373-D354, G373-F344; PAE: 3.5, 2.5 374 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible Beta strand B (strand) E (parallel sheets) 17 162.8 -170.6 82.31 Low-density lipoprotein receptor EGF-like 2; calcium-binding Extracellular 75 -0.4 375 Y Tyrosine Aromatic B (strand) E (parallel sheets) 115 -128.3 161.7 85.01 Low-density lipoprotein receptor EGF-like 2; calcium-binding Extracellular 181 -1.3 Y375-L371 (PDB: 1HZ8); Y375-L371 (PDB: 1I0U) Y375-E357; PAE: 2.0 376 K Lysine Positively-charged Beta strand B (strand) E (parallel sheets) 37 -127.4 126.1 77.32 Low-density lipoprotein receptor EGF-like 2; calcium-binding Extracellular 147 -3.9 K376-V369 (PDB: 1HJ7); K376-V369 (PDB: 1HZ8); K376-V369 (PDB: 1I0U) K376-V369, K376-E51; PAE: 1.5, 29.5 K376-V369 (PDB: 1HJ7); K376-V369 (PDB: 1HZ8); K376-V369 (PDB: 1I0U); K376-V369 (PDB: 3M0C) K376-V369; PAE: 1.5 377 C Cysteine Special, a very reactive sulfhydryl group Beta strand B (strand) E (parallel sheets) 26 -87.0 138.0 83.64 Low-density lipoprotein receptor Disulfide bond 364-377 EGF-like 2; calcium-binding Extracellular 121 2.5 C377-C364 (PDB: 3M0C) C377-C364; PAE: 3.5 C377-C364 (PDB: 3M0C) C377-C364; PAE: 3.5 378 Q Glutamine Polar/Neutral Beta strand B (strand) E (parallel sheets) 72 -126.1 151.0 82.53 Low-density lipoprotein receptor EGF-like 2; calcium-binding Extracellular 146 -3.5 Q378-L367 (PDB: 1HJ7); Q378-L367 (PDB: 1HZ8); Q378-L367 (PDB: 1I0U); Q378-L367 (PDB: 3M0C) Q378-L367; PAE: 2.0 Q378-L367, Q378-V369 (PDB: 1HJ7); Q378-L367, Q378-Q366 (PDB: 1HZ8); Q378-L367, Q378-C368 (PDB: 1I0U); Q378-L367 (PDB: 3M0C) Q378-L367, Q378-V369; PAE: 2.0, 3.0 379 C Cysteine Special, a very reactive sulfhydryl group H (helix) P (polyproline helix) 34 -101.1 146.7 85.04 Low-density lipoprotein receptor Disulfide bond 379-392 EGF-like 2; calcium-binding Extracellular 121 2.5 C379-L385, C379-Q384 (PDB: 1HZ8); C379-Q384, C379-L367 (PDB: 1I0U); C379-L385, C379-Q384 (PDB: 3M0C) C379-L385; PAE: 3.0 C379-C392 (PDB: 3M0C) C379-C392; PAE: 3.5 380 E Glutamic Acid Negatively-charged H (helix) P (polyproline helix) 86 -76.1 171.0 83.87 Low-density lipoprotein receptor EGF-like 2; calcium-binding Extracellular 146 -3.5 Pocket 2: Mean pLDDT: 89.82, Volume: 512.1 ų, Druggability score: 0.1 0.0983 E380-Q366; PAE: 3.5 E380-Q366 (PDB: 1HZ8) E380-Q366; PAE: 3.5 381 E Glutamic Acid Negatively-charged Beta strand C (loop/coil) T (turn) 185 -59.5 126.7 82.81 Low-density lipoprotein receptor EGF-like 2; calcium-binding Extracellular 146 -3.5 382 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible Beta strand C (loop/coil) T (turn) 28 94.2 -8.8 81.3 Low-density lipoprotein receptor EGF-like 2; calcium-binding Extracellular 75 -0.4 G382-V395 (PDB: 1HZ8); G382-V395 (PDB: 1I0U) G382-V395; PAE: 5.0 G382-V395 (PDB: 1HZ8); G382-V395 (PDB: 1I0U) G382-V395; PAE: 5.0 383 F Phenylalanine Aromatic Beta strand B (strand) E (parallel sheets) 18 -108.7 149.9 85.62 Low-density lipoprotein receptor EGF-like 2; calcium-binding Extracellular 165 2.8 Pocket 2: Mean pLDDT: 89.82, Volume: 512.1 ų, Druggability score: 0.1 0.0983 F383-K393 (PDB: 1HJ7); F383-V395, F383-A394, F383-K393 (PDB: 1HZ8); F383-V395, F383-A394, F383-K393 (PDB: 1I0U) F383-A394; PAE: 1.5 384 Q Glutamine Polar/Neutral Beta strand B (strand) E (parallel sheets) 74 -124.3 139.6 79.19 Low-density lipoprotein receptor EGF-like 2; calcium-binding Extracellular 146 -3.5 Q384-K393 (PDB: 1HJ7); Q384-K393 (PDB: 1HZ8); Q384-K393 (PDB: 1I0U) Q384-K393; PAE: 2.0 Q384-K393 (PDB: 1HJ7); Q384-K393, Q384-C379 (PDB: 1HZ8); Q384-K393, Q384-C379 (PDB: 1I0U); Q384-K393, Q384-C379 (PDB: 3M0C) Q384-K393; PAE: 2.0 385 L Leucine Aliphatic Beta strand B (strand) E (parallel sheets) 51 -67.8 121.1 77.64 Low-density lipoprotein receptor EGF-like 2; calcium-binding Extracellular 131 3.8 L385-C379 (PDB: 1HZ8); L385-A391, L385-C379 (PDB: 3M0C) L385-C379; PAE: 3.0 386 D Aspartic Acid Negatively-charged C (loop/coil) C (loop/coil) 1 -69.2 116.2 72.05 Low-density lipoprotein receptor EGF-like 2; calcium-binding Extracellular 132 -3.5 D386-A391 (PDB: 1HJ7); D386-A391, D386-K390 (PDB: 1HZ8); D386-A391, D386-K390 (PDB: 1I0U) D386-A391, D386-K390; PAE: 2.5, 2.0 D386-A391, D386-K390 (PDB: 1HJ7); D386-A391, D386-K390 (PDB: 1HZ8); D386-A391, D386-K390 (PDB: 1I0U) D386-A391, D386-K390; PAE: 2.5, 2.0 387 P Proline Special, No backbone hydrogen Turn C (loop/coil) T (turn) 34 -64.3 -20.9 66.16 Low-density lipoprotein receptor EGF-like 2; calcium-binding Extracellular 115 1.6 388 H Histidine Positively-charged Turn C (loop/coil) T (turn) 81 -84.7 -56.6 62.18 Low-density lipoprotein receptor EGF-like 2; calcium-binding Extracellular 155 -3.2 H388-D96; PAE: 29.0 H388-D96; PAE: 29.0 389 T Threonine Polar/Neutral Turn C (loop/coil) T (turn) 79 -82.4 -12.8 69.71 Low-density lipoprotein receptor EGF-like 2; calcium-binding Extracellular 119 -0.7 390 K Lysine Positively-charged C (loop/coil) C (loop/coil) 139 56.3 18.7 71.49 Low-density lipoprotein receptor EGF-like 2; calcium-binding Extracellular 147 -3.9 Morphology: FQLDPHTkACKAVGS; Domain: EGF_CA K390-D386 (PDB: 1HZ8); K390-D386 (PDB: 1I0U) K390-D386; PAE: 2.0 K390-D386 (PDB: 1HJ7); K390-D386 (PDB: 1HZ8); K390-D386 (PDB: 1I0U) K390-D386; PAE: 2.0 391 A Alanine Aliphatic C (loop/coil) C (loop/coil) 22 -87.9 152.7 77.62 Low-density lipoprotein receptor EGF-like 2; calcium-binding Extracellular 89 1.8 dbSNP: rs11669576; Variant type: LB/B; AA change: Ala391Thr; PTM type: Ubiquitylation; PTM morphology: LDPHTkA*CKAV; Var class: II A391-D386 (PDB: 1HJ7); A391-D386 (PDB: 1HZ8); A391-D386 (PDB: 1I0U) A391-D386; PAE: 2.5 A391-D386 (PDB: 1HJ7); A391-D386 (PDB: 1HZ8); A391-D386 (PDB: 1I0U); A391-L385 (PDB: 3M0C) A391-D386; PAE: 2.5 392 C Cysteine Special, a very reactive sulfhydryl group Beta strand B (strand) E (parallel sheets) 0 -91.5 111.2 85.08 Low-density lipoprotein receptor Disulfide bond 379-392 EGF-like 2; calcium-binding Extracellular 121 2.5 C392-Q366 (PDB: 1HZ8) C392-Q366 (PDB: 1HZ8); C392-C364 (PDB: 1I0U) C392-S365; PAE: 4.5 C392-C379 (PDB: 3M0C) C392-C379; PAE: 3.5 393 K Lysine Positively-charged Beta strand B (strand) E (parallel sheets) 13 -108.4 141.2 83.23 Low-density lipoprotein receptor EGF-like 2; calcium-binding Extracellular 147 -3.9 K393-Q384 (PDB: 1HJ7); K393-Q384 (PDB: 1HZ8); K393-Q384 (PDB: 1I0U) K393-Q384, K393-D94, K393-D90, K393-Q92; PAE: 2.0, 29.0, 29.0, 28.5 K393-Q384, K393-F383 (PDB: 1HJ7); K393-Q384, K393-F383 (PDB: 1HZ8); K393-Q384, K393-F383 (PDB: 1I0U); K393-Q384 (PDB: 3M0C) K393-Q384; PAE: 2.0 394 A Alanine Aliphatic Beta strand B (strand) E (parallel sheets) 8 -70.2 149.2 86.01 Low-density lipoprotein receptor Extracellular 89 1.8 A394-E615; PAE: 3.5 A394-F383 (PDB: 1HZ8); A394-F383 (PDB: 1I0U) A394-F383; PAE: 1.5 395 V Valine Aliphatic C (loop/coil) C (loop/coil) 48 -107.0 125.3 79.91 Low-density lipoprotein receptor Extracellular 117 4.2 V395-G382 (PDB: 1HZ8); V395-G382 (PDB: 1I0U) V395-G382; PAE: 5.0 V395-G382, V395-F383 (PDB: 1HZ8); V395-G382, V395-F383 (PDB: 1I0U) V395-G382; PAE: 5.0 396 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible C (loop/coil) S (bend) 57 97.4 -24.2 73.95 Low-density lipoprotein receptor Extracellular 75 -0.4 G396-H656 (PDB: 3M0C) G396-H656 (PDB: 3M0C) G396-F86; PAE: 29.0 397 S Serine Polar/Neutral C (loop/coil) S (bend) 54 -124.0 145.3 79.95 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 105 -0.8 S397-N657, S397-H656; PAE: 6.0, 3.5 S397-N657, S397-H656; PAE: 6.0, 3.5 398 I Isoleucine Aliphatic C (loop/coil) C (loop/coil) 114 -79.1 132.5 85.57 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 131 4.5 399 A Alanine Aliphatic C (loop/coil) C (loop/coil) 9 -85.8 135.8 92.29 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 89 1.8 A399-L414 (PDB: 1IJQ); A399-L414 (PDB: 3M0C) A399-L414; PAE: 2.0 400 Y Tyrosine Aromatic Beta strand B (strand) E (parallel sheets) 48 -120.9 143.7 94.91 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 181 -1.3 Y400-F655 (PDB: 1IJQ); Y400-F655 (PDB: 3M0C) Y400-E418, Y400-F655; PAE: 2.5, 1.0 Y400-F655 (PDB: 1IJQ); Y400-F655 (PDB: 3M0C) Y400-F655; PAE: 1.0 401 L Leucine Aliphatic Beta strand B (strand) E (parallel sheets) 0 -96.3 124.7 97.03 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 131 3.8 L401-M412 (PDB: 1IJQ); L401-M412 (PDB: 3M0C) L401-M412; PAE: 1.0 L401-M412 (PDB: 1IJQ); L401-M412 (PDB: 3M0C) L401-M412; PAE: 1.0 402 F Phenylalanine Aromatic Beta strand B (strand) E (parallel sheets) 7 -106.2 129.6 96.89 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 165 2.8 F402-V653 (PDB: 1IJQ); F402-V653 (PDB: 3M0C) F402-V653; PAE: 1.0 F402-V653 (PDB: 1IJQ); F402-V653 (PDB: 3M0C) F402-V653; PAE: 1.0 403 F Phenylalanine Aromatic Beta strand B (strand) E (parallel sheets) 0 -144.5 154.3 97.27 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 165 2.8 F403-R410 (PDB: 1IJQ); F403-R410 (PDB: 3M0C) F403-R410; PAE: 1.0 F403-R410 (PDB: 1IJQ); F403-R410 (PDB: 3M0C) F403-R410; PAE: 1.0 404 T Threonine Polar/Neutral Beta strand B (strand) E (parallel sheets) 0 -77.8 147.2 95.76 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 119 -0.7 T404-D651 (PDB: 1IJQ); T404-D651 (PDB: 3M0C) T404-D651, T404-E650; PAE: 1.0, 2.0 T404-E650, T404-D651 (PDB: 1IJQ); T404-E650, T404-D651 (PDB: 3M0C) T404-E650, T404-D651; PAE: 2.0, 1.0 405 N Asparagine Polar/Neutral C (loop/coil) C (loop/coil) 5 -141.9 58.3 92.75 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 132 -3.5 N405-L647 (PDB: 1IJQ); N405-L647 (PDB: 3M0C) N405-L647; PAE: 2.0 N405-L647, N405-R410 (PDB: 1IJQ); N405-L647, N405-R410 (PDB: 3M0C) N405-L647, N405-R410; PAE: 2.0, 1.5 406 R Arginine Positively-charged Beta strand C (loop/coil) S (bend) 67 54.7 -69.0 87.99 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 175 -4.5 R406-V429, R406-S648 (PDB: 1IJQ); R406-V429, R406-S648 (PDB: 3M0C) R406-V429, R406-D172; PAE: 1.5, 11.0 R406-V429, R406-N428, R406-S648 (PDB: 1IJQ); R406-V429, R406-N428, R406-S648 (PDB: 3M0C) R406-V429; PAE: 1.5 407 H Histidine Positively-charged Beta strand C (loop/coil) S (bend) 9 -102.6 7.1 88.34 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 155 -3.2 H407-L426 (PDB: 1IJQ); H407-L426 (PDB: 3M0C) H407-L426, H407-D172, H407-R427; PAE: 1.5, 10.5, 2.0 H407-L426, H407-N425 (PDB: 1IJQ); H407-L426, H407-N425 (PDB: 3M0C) H407-L426, H407-N425; PAE: 1.5, 2.0 408 E Glutamic Acid Negatively-charged Beta strand C (loop/coil) C (loop/coil) 25 -154.5 165.5 89.43 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 146 -3.5 E408-S421 (PDB: 1IJQ); E408-S421 (PDB: 3M0C) E408-S421; PAE: 2.0 E408-S421 (PDB: 1IJQ); E408-S421 (PDB: 3M0C) E408-S421; PAE: 2.0 E408-R410 (PDB: 3M0C) E408-R410; PAE: 1.5 409 V Valine Aliphatic Beta strand B (strand) E (parallel sheets) 0 -106.0 125.7 93.76 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 117 4.2 V409-I423, V409-L422 (PDB: 1IJQ); V409-I423, V409-L422 (PDB: 3M0C) V409-I423, V409-L422; PAE: 1.0, 1.0 V409-I423, V409-L422 (PDB: 1IJQ); V409-I423, V409-L422 (PDB: 3M0C) V409-S421, V409-I423, V409-L422; PAE: 1.5, 1.0, 1.0 410 R Arginine Positively-charged Beta strand B (strand) E (parallel sheets) 1 -98.9 156.1 93.25 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 175 -4.5 R410-F403 (PDB: 1IJQ); R410-F403 (PDB: 3M0C) R410-Y419, R410-D133, R410-F403; PAE: 1.5, 26.0, 1.0 R410-Y419, R410-T420, R410-N405, R410-F403, R410-S421 (PDB: 1IJQ); R410-N405, R410-F403 (PDB: 3M0C) R410-Y419, R410-N405, R410-F403; PAE: 1.5, 1.5, 1.0 R410-E408 (PDB: 3M0C) R410-E408; PAE: 1.5 411 K Lysine Positively-charged Beta strand B (strand) E (parallel sheets) 39 -126.5 140.3 93.01 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 147 -3.9 K411-T420 (PDB: 1IJQ); K411-T420 (PDB: 3M0C) K411-E418, K411-T420; PAE: 2.5, 2.0 K411-T420 (PDB: 1IJQ); K411-T420 (PDB: 3M0C) K411-T420; PAE: 2.0 K411-E418; PAE: 2.5 412 M Methionine Aliphatic Beta strand B (strand) E (parallel sheets) 1 -146.1 153.8 92.43 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 149 1.9 M412-L401 (PDB: 1IJQ); M412-L401 (PDB: 3M0C) M412-L401; PAE: 1.0 M412-L401 (PDB: 1IJQ); M412-L401 (PDB: 3M0C) M412-L401; PAE: 1.0 413 T Threonine Polar/Neutral Beta strand B (strand) E (parallel sheets) 6 -76.7 159.2 91.14 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 119 -0.7 T413-E418, T413-S417 (PDB: 1IJQ); T413-S417 (PDB: 3M0C) T413-E418, T413-S417; PAE: 2.0, 3.0 T413-E418, T413-S417 (PDB: 1IJQ); T413-S417 (PDB: 3M0C) T413-E418, T413-S417; PAE: 2.0, 3.0 414 L Leucine Aliphatic C (loop/coil) T (turn) 34 -62.0 -26.7 90.53 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 131 3.8 L414-A399 (PDB: 1IJQ); L414-A399 (PDB: 3M0C) L414-A399; PAE: 2.0 415 D Aspartic Acid Negatively-charged C (loop/coil) T (turn) 39 -90.9 2.5 82.43 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 132 -3.5 D415-K120, D415-K107; PAE: 28.5, 28.5 416 R Arginine Positively-charged C (loop/coil) S (bend) 12 57.3 21.7 84.09 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 175 -4.5 R416-L641, R416-E644 (PDB: 1IJQ); R416-L641, R416-E644 (PDB: 3M0C) R416-D133, R416-L642; PAE: 28.0, 4.0 R416-A643 (PDB: 1IJQ); R416-A643 (PDB: 3M0C) R416-E644 (PDB: 3M0C) 417 S Serine Polar/Neutral C (loop/coil) S (bend) 20 -71.3 -30.0 77.67 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 105 -0.8 S417-T413 (PDB: 1IJQ); S417-T413 (PDB: 3M0C) S417-T413; PAE: 3.0 S417-T413 (PDB: 1IJQ); S417-T413 (PDB: 3M0C) S417-T413; PAE: 3.0 418 E Glutamic Acid Negatively-charged B (strand) E (parallel sheets) 43 -114.6 126.8 83.15 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 146 -3.5 E418-T413 (PDB: 1IJQ) E418-T413, E418-K411, E418-Y400; PAE: 2.0, 2.5, 2.5 E418-T413 (PDB: 1IJQ) E418-T413; PAE: 2.0 E418-K411; PAE: 2.5 419 Y Tyrosine Aromatic B (strand) E (parallel sheets) 1 -141.0 109.6 88.67 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 181 -1.3 Y419-L642 (PDB: 1IJQ); Y419-L642 (PDB: 3M0C) Y419-S123, Y419-R410; PAE: 27.5, 1.5 Y419-R410 (PDB: 1IJQ) Y419-C121, Y419-R410; PAE: 27.5, 1.5 420 T Threonine Polar/Neutral Beta strand B (strand) E (parallel sheets) 8 -148.7 159.1 88.14 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 119 -0.7 T420-K411 (PDB: 1IJQ); T420-K411 (PDB: 3M0C) T420-K411; PAE: 2.0 T420-R410, T420-K411 (PDB: 1IJQ); T420-K411 (PDB: 3M0C) T420-K411; PAE: 2.0 421 S Serine Polar/Neutral Beta strand B (strand) E (parallel sheets) 0 -76.1 129.8 87.74 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 105 -0.8 S421-E408 (PDB: 1IJQ); S421-E408 (PDB: 3M0C) S421-E408; PAE: 2.0 S421-E408, S421-R410 (PDB: 1IJQ); S421-E408 (PDB: 3M0C) S421-E408, S421-H460, S421-V409; PAE: 2.0, 8.0, 1.5 422 L Leucine Aliphatic Beta strand B (strand) E (parallel sheets) 9 -90.4 -47.6 90.84 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 131 3.8 L422-V409 (PDB: 1IJQ); L422-V409 (PDB: 3M0C) L422-V409; PAE: 1.0 L422-V409 (PDB: 1IJQ); L422-V409 (PDB: 3M0C) L422-H460, L422-V409; PAE: 7.5, 1.0 423 I Isoleucine Aliphatic Beta strand B (strand) E (parallel sheets) 0 -128.5 99.2 91.0 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 131 4.5 I423-V409 (PDB: 1IJQ); I423-V409 (PDB: 3M0C) I423-V409; PAE: 1.0 I423-V409 (PDB: 1IJQ); I423-V409 (PDB: 3M0C) I423-V409; PAE: 1.0 424 P Proline Special, No backbone hydrogen C (loop/coil) C (loop/coil) 21 -84.8 165.7 86.13 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 115 1.6 P424-Y465 (PDB: 1IJQ); P424-Y465 (PDB: 3M0C) 425 N Asparagine Polar/Neutral C (loop/coil) S (bend) 97 59.5 40.0 81.78 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 132 -3.5 N425-H407 (PDB: 1IJQ); N425-H407 (PDB: 3M0C) N425-H407; PAE: 2.0 426 L Leucine Aliphatic C (loop/coil) C (loop/coil) 8 -79.7 172.8 87.95 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 131 3.8 L426-H407 (PDB: 1IJQ); L426-H407 (PDB: 3M0C) L426-H407, L426-W165; PAE: 1.5, 17.0 L426-H407 (PDB: 1IJQ); L426-H407 (PDB: 3M0C) L426-H407; PAE: 1.5 427 R Arginine Positively-charged Beta strand C (loop/coil) S (bend) 64 -97.6 -68.5 84.49 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 175 -4.5 R427-S447, R427-Q448, R427-D445 (PDB: 1IJQ); R427-S447, R427-Q448, R427-D445 (PDB: 3M0C) R427-H407; PAE: 2.0 R427-S447 (PDB: 1IJQ); R427-S447 (PDB: 3M0C) R427-D168, R427-L164, R427-Q448, R427-S447; PAE: 14.0, 14.0, 2.5, 3.0 428 N Asparagine Polar/Neutral Beta strand C (loop/coil) C (loop/coil) 22 -146.2 90.3 88.57 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 132 -3.5 N428-D445, N428-S447, N428-L446 (PDB: 1IJQ); N428-L446 (PDB: 3M0C) N428-L446; PAE: 2.0 N428-R406, N428-S447, N428-L446 (PDB: 1IJQ); N428-R406, N428-S447, N428-L446 (PDB: 3M0C) N428-D170, N428-L446; PAE: 11.0, 2.0 429 V Valine Aliphatic Beta strand B (strand) E (parallel sheets) 0 -87.7 126.0 93.51 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 117 4.2 V429-R406 (PDB: 1IJQ); V429-R406 (PDB: 3M0C) V429-R406; PAE: 1.5 V429-R406 (PDB: 1IJQ); V429-R406 (PDB: 3M0C) V429-R406; PAE: 1.5 430 V Valine Aliphatic Beta strand B (strand) E (parallel sheets) 2 -118.5 -49.8 93.23 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 117 4.2 V430-S444 (PDB: 1IJQ); V430-S444 (PDB: 3M0C) V430-S444; PAE: 2.0 V430-D651; PAE: 1.5 431 A Alanine Aliphatic Beta strand B (strand) E (parallel sheets) 0 -121.0 150.1 96.67 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 89 1.8 A431-S444 (PDB: 1IJQ); A431-S444 (PDB: 3M0C) A431-S444; PAE: 1.0 A431-S444 (PDB: 1IJQ); A431-S444 (PDB: 3M0C) A431-G478, A431-S444; PAE: 2.0, 1.0 432 L Leucine Aliphatic Beta strand B (strand) E (parallel sheets) 0 -146.4 154.1 96.7 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 131 3.8 L432-D651 (PDB: 1IJQ); L432-D651 (PDB: 3M0C) L432-D651; PAE: 2.0 L432-M652 (PDB: 1IJQ) 433 D Aspartic Acid Negatively-charged Beta strand B (strand) E (parallel sheets) 23 -155.8 166.5 97.67 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 132 -3.5 D433-Y442, D433-V481 (PDB: 1IJQ); D433-Y442, D433-V481 (PDB: 3M0C) D433-Y442, D433-V481; PAE: 1.0, 1.0 D433-Y442, D433-V481 (PDB: 1IJQ); D433-Y442, D433-V481 (PDB: 3M0C) D433-Y442, D433-V481; PAE: 1.0, 1.0 434 T Threonine Polar/Neutral Beta strand B (strand) E (parallel sheets) 1 -130.3 155.8 96.59 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 119 -0.7 T434-Q660 (PDB: 1IJQ); T434-Q660 (PDB: 3M0C) T434-Q660; PAE: 1.5 435 E Glutamic Acid Negatively-charged Beta strand B (strand) E (parallel sheets) 15 -115.1 99.4 96.14 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 146 -3.5 E435-Y442, E435-N439, E435-R440 (PDB: 1IJQ); E435-Y442, E435-N439, E435-R440 (PDB: 3M0C) E435-Y442, E435-R440; PAE: 1.0, 1.0 E435-N439, E435-R440 (PDB: 1IJQ); E435-N439, E435-R440 (PDB: 3M0C) E435-N439, E435-R440; PAE: 1.0, 1.0 E435-R440 (PDB: 3M0C) 436 V Valine Aliphatic Turn C (loop/coil) T (turn) 10 -63.5 -46.6 94.33 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 117 4.2 V436-Q660 (PDB: 1IJQ); V436-Q660 (PDB: 3M0C) V436-Q660; PAE: 2.0 V436-N657 (PDB: 1IJQ); V436-N657 (PDB: 3M0C) 437 A Alanine Aliphatic Turn C (loop/coil) T (turn) 91 -62.5 -34.7 92.34 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 89 1.8 438 S Serine Polar/Neutral Turn C (loop/coil) T (turn) 54 -93.4 1.5 92.44 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 105 -0.8 S438-Q455 (PDB: 1IJQ); S438-Q455 (PDB: 3M0C) S438-Q455; PAE: 2.0 439 N Asparagine Polar/Neutral Turn C (loop/coil) T (turn) 39 50.3 44.8 93.48 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 132 -3.5 N439-E435, N439-L456 (PDB: 1IJQ); N439-E435, N439-L456 (PDB: 3M0C) N439-L456; PAE: 2.0 N439-E435, N439-L456, N439-Q455 (PDB: 1IJQ); N439-E435, N439-L456, N439-Q455 (PDB: 3M0C) N439-D457, N439-E435, N439-L456, N439-Q455; PAE: 3.5, 1.0, 2.0, 2.0 440 R Arginine Positively-charged Beta strand B (strand) E (parallel sheets) 32 -122.9 143.8 94.33 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 175 -4.5 R440-Q455, R440-E435 (PDB: 1IJQ); R440-Q455, R440-E435 (PDB: 3M0C) R440-D466, R440-E435, R440-S453; PAE: 2.5, 1.0, 1.5 R440-Q455, R440-E435 (PDB: 1IJQ); R440-Q455, R440-E435 (PDB: 3M0C) R440-E435, R440-S453; PAE: 1.0, 1.5 R440-E435 (PDB: 3M0C) R440-D466; PAE: 2.5 441 I Isoleucine Aliphatic Beta strand B (strand) E (parallel sheets) 0 -120.2 143.1 95.78 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 131 4.5 I441-T454 (PDB: 1IJQ); I441-T454 (PDB: 3M0C) I441-T454; PAE: 1.0 I441-T454 (PDB: 1IJQ); I441-T454 (PDB: 3M0C) I441-T454; PAE: 1.0 442 Y Tyrosine Aromatic Beta strand B (strand) E (parallel sheets) 1 -122.0 142.3 97.05 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 181 -1.3 Y442-E435, Y442-D433 (PDB: 1IJQ); Y442-E435, Y442-D433 (PDB: 3M0C) Y442-E435, Y442-D433; PAE: 1.0, 1.0 Y442-D433 (PDB: 1IJQ); Y442-D433 (PDB: 3M0C) Y442-D433; PAE: 1.0 443 W Tryptophan Aromatic Beta strand B (strand) E (parallel sheets) 2 -147.8 155.4 96.58 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 204 -0.9 W443-C452 (PDB: 1IJQ); W443-C452 (PDB: 3M0C) W443-C452; PAE: 1.0 W443-C452 (PDB: 1IJQ); W443-C452 (PDB: 3M0C) W443-S453, W443-C452; PAE: 1.5, 1.0 444 S Serine Polar/Neutral Beta strand B (strand) E (parallel sheets) 0 -100.6 140.6 95.45 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 105 -0.8 S444-V430, S444-A431, S444-P476 (PDB: 1IJQ); S444-V430, S444-P476, S444-A431 (PDB: 3M0C) S444-V430, S444-P476, S444-A431; PAE: 2.0, 2.0, 1.0 S444-A431 (PDB: 1IJQ); S444-A431 (PDB: 3M0C) S444-A431; PAE: 1.0 445 D Aspartic Acid Negatively-charged Beta strand B (strand) E (parallel sheets) 1 -119.1 116.5 90.86 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 132 -3.5 D445-N428, D445-M450, D445-R427, D445-R449 (PDB: 1IJQ); D445-M450, D445-R427 (PDB: 3M0C) D445-M450, D445-R449; PAE: 1.0, 1.0 D445-M450, D445-R449 (PDB: 1IJQ); D445-M450, D445-R449 (PDB: 3M0C) D445-M450, D445-R449; PAE: 1.0, 1.0 446 L Leucine Aliphatic Turn C (loop/coil) T (turn) 49 -72.2 -38.1 87.86 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 131 3.8 L446-N428 (PDB: 1IJQ); L446-N428 (PDB: 3M0C) L446-N428; PAE: 2.0 L446-N428 (PDB: 1IJQ); L446-N428 (PDB: 3M0C) L446-N428; PAE: 2.0 447 S Serine Polar/Neutral Turn C (loop/coil) T (turn) 25 -62.4 -40.3 84.06 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 105 -0.8 S447-R427, S447-N428 (PDB: 1IJQ); S447-R427 (PDB: 3M0C) S447-R427, S447-N428 (PDB: 1IJQ); S447-R427, S447-N428 (PDB: 3M0C) S447-R427; PAE: 3.0 448 Q Glutamine Polar/Neutral Turn C (loop/coil) T (turn) 88 -90.2 -16.4 83.87 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 146 -3.5 Q448-R427 (PDB: 1IJQ); Q448-R427 (PDB: 3M0C) Q448-R427; PAE: 2.5 449 R Arginine Positively-charged Turn C (loop/coil) T (turn) 104 51.9 55.7 89.67 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 175 -4.5 R449-I473, R449-D445 (PDB: 1IJQ); R449-I473 (PDB: 3M0C) R449-D445; PAE: 1.0 R449-D445 (PDB: 1IJQ); R449-D445 (PDB: 3M0C) R449-D445; PAE: 1.0 450 M Methionine Aliphatic Beta strand B (strand) E (parallel sheets) 34 -140.1 158.1 93.05 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 149 1.9 M450-D445 (PDB: 1IJQ); M450-D445 (PDB: 3M0C) M450-D445; PAE: 1.0 M450-T467, M450-D445 (PDB: 1IJQ); M450-D445 (PDB: 3M0C) M450-D445; PAE: 1.0 451 I Isoleucine Aliphatic Beta strand B (strand) E (parallel sheets) 0 -109.7 127.3 96.08 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 131 4.5 I451-I469, I451-V468 (PDB: 1IJQ); I451-I469, I451-V468 (PDB: 3M0C) I451-I469, I451-V468; PAE: 1.0, 1.0 I451-I469, I451-V468 (PDB: 1IJQ); I451-I469, I451-V468 (PDB: 3M0C) I451-I469, I451-V468; PAE: 1.0, 1.0 452 C Cysteine Special, a very reactive sulfhydryl group Beta strand B (strand) E (parallel sheets) 4 -118.0 161.5 94.49 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 121 2.5 C452-W443 (PDB: 1IJQ); C452-W443 (PDB: 3M0C) C452-W443; PAE: 1.0 C452-W443 (PDB: 1IJQ); C452-W443 (PDB: 3M0C) C452-W443; PAE: 1.0 453 S Serine Polar/Neutral Beta strand B (strand) E (parallel sheets) 4 -144.4 156.2 94.58 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 105 -0.8 S453-D466 (PDB: 1IJQ); S453-D466 (PDB: 3M0C) S453-D466, S453-R440; PAE: 2.0, 1.5 S453-D466 (PDB: 1IJQ); S453-D466 (PDB: 3M0C) S453-R440, S453-D466, S453-W443; PAE: 1.5, 2.0, 1.5 454 T Threonine Polar/Neutral Beta strand B (strand) E (parallel sheets) 4 -153.3 160.0 93.9 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 119 -0.7 T454-I441 (PDB: 1IJQ); T454-I441 (PDB: 3M0C) T454-I441; PAE: 1.0 T454-I441 (PDB: 1IJQ); T454-I441 (PDB: 3M0C) T454-I441; PAE: 1.0 455 Q Glutamine Polar/Neutral Beta strand B (strand) E (parallel sheets) 45 -74.0 130.6 92.91 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 146 -3.5 Q455-R440, Q455-S438 (PDB: 1IJQ); Q455-R440, Q455-S438 (PDB: 3M0C) Q455-S438; PAE: 2.0 Q455-R440, Q455-N439 (PDB: 1IJQ); Q455-R440, Q455-N439 (PDB: 3M0C) Q455-N439, Q455-A459; PAE: 2.0, 5.0 456 L Leucine Aliphatic H (helix) G (3₁₀-helix) 15 -58.5 -39.0 90.06 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 131 3.8 L456-N439 (PDB: 1IJQ); L456-N439 (PDB: 3M0C) L456-N439; PAE: 2.0 L456-N439 (PDB: 1IJQ); L456-N439 (PDB: 3M0C) L456-N439; PAE: 2.0 457 D Aspartic Acid Negatively-charged H (helix) G (3₁₀-helix) 134 -60.7 -20.3 85.89 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 132 -3.5 D457-N439; PAE: 3.5 458 R Arginine Positively-charged H (helix) G (3₁₀-helix) 142 -100.2 -10.2 80.31 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 175 -4.5 R458-V462; PAE: 8.0 459 A Alanine Aliphatic H (helix) G (3₁₀-helix) 1 -54.7 -44.1 76.14 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 89 1.8 A459-Q455; PAE: 5.0 460 H Histidine Positively-charged H (helix) G (3₁₀-helix) 102 -66.5 -11.9 70.52 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 155 -3.2 H460-S421, H460-L422; PAE: 8.0, 7.5 461 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible H (helix) G (3₁₀-helix) 75 -141.3 6.9 65.58 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 75 -0.4 462 V Valine Aliphatic C (loop/coil) C (loop/coil) 25 -96.5 134.6 66.61 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 117 4.2 V462-R458; PAE: 8.0 463 S Serine Polar/Neutral C (loop/coil) S (bend) 128 -84.9 -0.1 64.71 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 105 -0.8 464 S Serine Polar/Neutral C (loop/coil) C (loop/coil) 77 -145.7 128.1 76.35 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 105 -0.8 465 Y Tyrosine Aromatic C (loop/coil) C (loop/coil) 62 -108.1 160.7 86.82 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 181 -1.3 Morphology: RAHGVSSyDTVIsRD; Domain: Ldl_recept_b Y465-P424 (PDB: 1IJQ); Y465-P424 (PDB: 3M0C) 466 D Aspartic Acid Negatively-charged Beta strand B (strand) E (parallel sheets) 79 -79.8 114.6 91.09 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 132 -3.5 D466-S453 (PDB: 1IJQ); D466-S453 (PDB: 3M0C) D466-R440, D466-S453; PAE: 2.5, 2.0 D466-S453 (PDB: 1IJQ); D466-S453 (PDB: 3M0C) D466-S453; PAE: 2.0 D466-R440; PAE: 2.5 467 T Threonine Polar/Neutral Beta strand B (strand) E (parallel sheets) 73 -75.6 119.5 92.01 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 119 -0.7 T467-M450 (PDB: 1IJQ) 468 V Valine Aliphatic Beta strand B (strand) E (parallel sheets) 12 -87.3 -56.5 93.96 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 117 4.2 dbSNP: rs5932; Variant type: LB/B; AA change: Val468Ile; PTM type: Phosphorylation; PTM morphology: HGVSSyDTV*Is; Var class: II&rs5932 V468-I451 (PDB: 1IJQ); V468-I451 (PDB: 3M0C) V468-I451; PAE: 1.0 V468-I451, V468-G505 (PDB: 1IJQ); V468-I451, V468-G505 (PDB: 3M0C) V468-I451, V468-G505; PAE: 1.0, 2.0 469 I Isoleucine Aliphatic Beta strand B (strand) E (parallel sheets) 6 -126.2 134.9 94.93 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 131 4.5 I469-I451 (PDB: 1IJQ); I469-I451 (PDB: 3M0C) I469-I451; PAE: 1.0 I469-I451 (PDB: 1IJQ); I469-I451 (PDB: 3M0C) I469-I451; PAE: 1.0 470 S Serine Polar/Neutral C (loop/coil) C (loop/coil) 70 -135.3 2.5 90.02 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 105 -0.8 Morphology: SSyDTVIsRDIQAPD; Domain: Ldl_recept_b 471 R Arginine Positively-charged C (loop/coil) S (bend) 187 -141.3 149.6 87.86 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 175 -4.5 dbSNP: rs879254891; Variant type: US; AA change: Arg471Gly; PTM type: Phosphorylation; PTM morphology: yDTVIsR*DIQA; Var class: II R471-R508 (PDB: 1IJQ); R471-R508 (PDB: 3M0C) 472 D Aspartic Acid Negatively-charged C (loop/coil) S (bend) 111 51.7 43.6 85.88 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 132 -3.5 D472-R508 (PDB: 1IJQ); D472-R508 (PDB: 3M0C) D472-R508; PAE: 4.0 D472-R508; PAE: 4.0 473 I Isoleucine Aliphatic C (loop/coil) C (loop/coil) 4 -133.1 136.3 90.7 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 131 4.5 I473-R449 (PDB: 1IJQ); I473-R449 (PDB: 3M0C) 474 Q Glutamine Polar/Neutral C (loop/coil) S (bend) 70 -120.1 -61.8 90.0 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 146 -3.5 Q474-D492 (PDB: 1IJQ); Q474-D492 (PDB: 3M0C) Q474-D492; PAE: 2.0 475 A Alanine Aliphatic C (loop/coil) C (loop/coil) 13 -137.7 80.8 90.03 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 89 1.8 A475-S493, A475-D492 (PDB: 1IJQ); A475-S493, A475-D492 (PDB: 3M0C) A475-S493; PAE: 2.0 A475-S493 (PDB: 1IJQ); A475-S493 (PDB: 3M0C) A475-S493; PAE: 2.0 476 P Proline Special, No backbone hydrogen C (loop/coil) C (loop/coil) 0 -76.5 83.3 93.88 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 115 1.6 P476-S444 (PDB: 1IJQ); P476-S444 (PDB: 3M0C) P476-S444; PAE: 2.0 477 D Aspartic Acid Negatively-charged C (loop/coil) C (loop/coil) 25 -83.6 -2.3 93.13 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 132 -3.5 D477-S493, D477-R520 (PDB: 1IJQ); D477-S493, D477-R520 (PDB: 3M0C) D477-S493; PAE: 2.5 D477-S493, D477-R520 (PDB: 1IJQ); D477-S493, D477-R520 (PDB: 3M0C) D477-T491, D477-S493; PAE: 2.0, 2.5 D477-R520 (PDB: 3M0C) 478 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible Beta strand B (strand) E (parallel sheets) 2 -154.9 140.3 96.35 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 75 -0.4 G478-T491 (PDB: 1IJQ); G478-T491 (PDB: 3M0C) G478-T491; PAE: 1.0 G478-T491 (PDB: 1IJQ); G478-T491 (PDB: 3M0C) G478-T491, G478-A431; PAE: 1.0, 2.0 479 L Leucine Aliphatic Beta strand B (strand) E (parallel sheets) 8 -127.5 142.4 97.73 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 131 3.8 480 A Alanine Aliphatic Beta strand B (strand) E (parallel sheets) 2 -145.5 131.5 98.26 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 89 1.8 A480-Y489 (PDB: 1IJQ); A480-Y489 (PDB: 3M0C) A480-Y489; PAE: 1.0 A480-Y489 (PDB: 1IJQ); A480-Y489 (PDB: 3M0C) A480-Y489; PAE: 1.0 481 V Valine Aliphatic Beta strand B (strand) E (parallel sheets) 0 -105.2 127.0 97.79 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 117 4.2 V481-D433 (PDB: 1IJQ); V481-D433 (PDB: 3M0C) V481-D433; PAE: 1.0 V481-D433 (PDB: 1IJQ); V481-D433 (PDB: 3M0C) V481-D433; PAE: 1.0 482 D Aspartic Acid Negatively-charged Beta strand B (strand) E (parallel sheets) 0 -86.3 97.6 97.13 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 132 -3.5 D482-S486, D482-N487 (PDB: 1IJQ); D482-S486, D482-N487 (PDB: 3M0C) D482-S486, D482-N487; PAE: 1.0, 1.0 D482-S486, D482-N487 (PDB: 1IJQ); D482-S486, D482-N487 (PDB: 3M0C) D482-S486, D482-N487; PAE: 1.0, 1.0 483 W Tryptophan Aromatic Turn C (loop/coil) T (turn) 39 -71.4 -13.5 96.15 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 204 -0.9 W483-P661 (PDB: 1IJQ); W483-P661 (PDB: 3M0C) W483-P661; PAE: 2.0 W483-Q660 (PDB: 1IJQ); W483-Q660 (PDB: 3M0C) W483-Q660; PAE: 1.5 484 I Isoleucine Aliphatic Turn C (loop/coil) T (turn) 16 -85.8 -45.1 95.91 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 131 4.5 I484-N665 (PDB: 3M0C) I484-N665, I484-G663 (PDB: 1IJQ); I484-N665 (PDB: 3M0C) I484-N665, I484-G663; PAE: 2.0, 2.0 485 H Histidine Positively-charged Turn C (loop/coil) T (turn) 16 -103.7 1.0 95.36 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 155 -3.2 H485-W666 (PDB: 1IJQ); H485-C667 (PDB: 3M0C) H485-N665, H485-W666 (PDB: 1IJQ); H485-C667, H485-N665 (PDB: 3M0C) H485-N665, H485-W666; PAE: 1.5, 2.0 486 S Serine Polar/Neutral Turn C (loop/coil) T (turn) 47 57.4 47.9 95.01 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 105 -0.8 S486-D482, S486-T503 (PDB: 1IJQ); S486-D482, S486-T503 (PDB: 3M0C) S486-D482, S486-T503; PAE: 1.0, 2.0 S486-D482, S486-T503 (PDB: 1IJQ); S486-D482, S486-T503 (PDB: 3M0C) S486-D482, S486-T503; PAE: 1.0, 2.0 487 N Asparagine Polar/Neutral Beta strand B (strand) E (parallel sheets) 7 -113.8 156.3 97.08 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 132 -3.5 N487-D482 (PDB: 1IJQ); N487-D482 (PDB: 3M0C) N487-D482; PAE: 1.0 N487-D502, N487-D482 (PDB: 1IJQ); N487-D502, N487-D482 (PDB: 3M0C) N487-D482; PAE: 1.0 488 I Isoleucine Aliphatic Beta strand B (strand) E (parallel sheets) 0 -123.5 132.9 97.66 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 131 4.5 I488-A501 (PDB: 1IJQ); I488-A501 (PDB: 3M0C) I488-A501; PAE: 1.0 I488-A501 (PDB: 1IJQ); I488-A501 (PDB: 3M0C) I488-A501; PAE: 1.0 489 Y Tyrosine Aromatic Beta strand B (strand) E (parallel sheets) 0 -112.9 141.7 98.36 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 181 -1.3 Y489-A480, Y489-L547 (PDB: 1IJQ); Y489-A480, Y489-L547 (PDB: 3M0C) Y489-A480, Y489-L547; PAE: 1.0, 1.0 Y489-A480 (PDB: 1IJQ); Y489-A480 (PDB: 3M0C) Y489-A480; PAE: 1.0 490 W Tryptophan Aromatic Beta strand B (strand) E (parallel sheets) 5 -144.7 149.7 98.02 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 204 -0.9 W490-S499 (PDB: 1IJQ); W490-S499 (PDB: 3M0C) W490-S499; PAE: 1.0 W490-S499 (PDB: 1IJQ); W490-S499 (PDB: 3M0C) W490-V500, W490-S499; PAE: 1.0, 1.0 491 T Threonine Polar/Neutral Beta strand B (strand) E (parallel sheets) 0 -93.4 149.6 97.3 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 119 -0.7 T491-G478, T491-R520 (PDB: 1IJQ); T491-G478, T491-R520 (PDB: 3M0C) T491-G478, T491-R520; PAE: 1.0, 1.5 T491-G478, T491-R520 (PDB: 1IJQ); T491-G478 (PDB: 3M0C) T491-G478, T491-D477; PAE: 1.0, 2.0 492 D Aspartic Acid Negatively-charged Beta strand B (strand) E (parallel sheets) 0 -130.8 114.1 95.68 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 132 -3.5 D492-A475, D492-G496, D492-T497, D492-Q474 (PDB: 1IJQ); D492-A475, D492-G496, D492-T497, D492-Q474 (PDB: 3M0C) D492-G496, D492-T497, D492-Q474; PAE: 1.0, 1.0, 2.0 D492-G496, D492-T497 (PDB: 1IJQ); D492-G496, D492-T497 (PDB: 3M0C) D492-G496, D492-T497; PAE: 1.0, 1.0 493 S Serine Polar/Neutral Turn C (loop/coil) T (turn) 18 -75.2 -26.4 91.62 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 105 -0.8 S493-A475, S493-D477 (PDB: 1IJQ); S493-A475, S493-D477 (PDB: 3M0C) S493-A475, S493-D477; PAE: 2.0, 2.5 S493-A475, S493-D477 (PDB: 1IJQ); S493-A475, S493-D477 (PDB: 3M0C) S493-A475, S493-D477; PAE: 2.0, 2.5 494 V Valine Aliphatic Turn C (loop/coil) T (turn) 100 -82.4 -40.3 89.81 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 117 4.2 495 L Leucine Aliphatic Turn C (loop/coil) T (turn) 55 -82.1 -15.2 91.79 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 131 3.8 L495-R513; PAE: 2.0 496 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible Turn C (loop/coil) T (turn) 2 62.3 43.2 94.18 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 75 -0.4 G496-E514, G496-D492 (PDB: 1IJQ); G496-E514, G496-D492 (PDB: 3M0C) G496-E514, G496-D492; PAE: 2.0, 1.0 G496-E514, G496-D492, G496-S517 (PDB: 1IJQ); G496-E514, G496-D492, G496-S517 (PDB: 3M0C) G496-E514, G496-D492, G496-S517; PAE: 2.0, 1.0, 3.0 497 T Threonine Polar/Neutral Beta strand B (strand) E (parallel sheets) 2 -126.5 152.9 96.03 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 119 -0.7 T497-D492 (PDB: 1IJQ); T497-D492 (PDB: 3M0C) T497-D492; PAE: 1.0 T497-D492, T497-R513 (PDB: 1IJQ); T497-D492, T497-R513 (PDB: 3M0C) T497-D492, T497-R513; PAE: 1.0, 1.5 498 V Valine Aliphatic Beta strand B (strand) E (parallel sheets) 0 -114.1 125.3 97.78 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 117 4.2 V498-F512, V498-L511 (PDB: 1IJQ); V498-F512, V498-L511 (PDB: 3M0C) V498-F512, V498-L511; PAE: 1.0, 1.0 V498-F512, V498-L511 (PDB: 1IJQ); V498-F512, V498-L511 (PDB: 3M0C) V498-F512, V498-L511; PAE: 1.0, 1.0 499 S Serine Polar/Neutral Beta strand B (strand) E (parallel sheets) 6 -126.5 158.2 97.26 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 105 -0.8 S499-W490 (PDB: 1IJQ); S499-W490 (PDB: 3M0C) S499-T510, S499-W490; PAE: 1.0, 1.0 S499-W490 (PDB: 1IJQ); S499-W490 (PDB: 3M0C) S499-T510, S499-W490; PAE: 1.0, 1.0 500 V Valine Aliphatic Beta strand B (strand) E (parallel sheets) 0 -129.7 146.3 97.51 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 117 4.2 V500-K509 (PDB: 1IJQ); V500-K509 (PDB: 3M0C) V500-K509; PAE: 1.0 V500-K509 (PDB: 1IJQ); V500-K509 (PDB: 3M0C) V500-K509, V500-W490; PAE: 1.0, 1.0 501 A Alanine Aliphatic Beta strand B (strand) E (parallel sheets) 0 -140.9 166.7 96.8 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 89 1.8 A501-I488 (PDB: 1IJQ); A501-I488 (PDB: 3M0C) A501-I488; PAE: 1.0 A501-I488 (PDB: 1IJQ); A501-I488 (PDB: 3M0C) A501-I488; PAE: 1.0 502 D Aspartic Acid Negatively-charged Beta strand B (strand) E (parallel sheets) 28 -66.8 156.2 94.89 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 132 -3.5 D502-K507, D502-V506 (PDB: 1IJQ); D502-K507, D502-V506 (PDB: 3M0C) D502-K507, D502-V506; PAE: 1.5, 1.5 D502-K507, D502-N487, D502-V506 (PDB: 1IJQ); D502-K507, D502-N487, D502-V506 (PDB: 3M0C) D502-K507, D502-V506; PAE: 1.5, 1.5 503 T Threonine Polar/Neutral C (loop/coil) T (turn) 16 -61.7 -10.8 94.46 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 119 -0.7 T503-S486 (PDB: 1IJQ); T503-S486 (PDB: 3M0C) T503-S486; PAE: 2.0 T503-S486 (PDB: 1IJQ); T503-S486 (PDB: 3M0C) T503-S486; PAE: 2.0 504 K Lysine Positively-charged C (loop/coil) T (turn) 128 -95.6 -6.7 92.73 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 147 -3.9 505 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible Beta strand C (loop/coil) S (bend) 20 68.2 12.8 92.16 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 75 -0.4 G505-V468 (PDB: 1IJQ); G505-V468 (PDB: 3M0C) G505-V468; PAE: 2.0 506 V Valine Aliphatic Beta strand C (loop/coil) S (bend) 110 -73.5 -37.2 92.61 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 117 4.2 V506-D502 (PDB: 1IJQ); V506-D502 (PDB: 3M0C) V506-D502; PAE: 1.5 V506-D502 (PDB: 1IJQ); V506-D502 (PDB: 3M0C) V506-D502; PAE: 1.5 507 K Lysine Positively-charged Beta strand C (loop/coil) S (bend) 61 -123.9 124.0 94.16 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 147 -3.9 K507-D502 (PDB: 1IJQ); K507-D502 (PDB: 3M0C) K507-Y679, K507-D502; PAE: 1.0, 1.5 K507-Y679, K507-D502 (PDB: 1IJQ); K507-Y679, K507-D502 (PDB: 3M0C) K507-Y679, K507-D502; PAE: 1.0, 1.5 508 R Arginine Positively-charged Beta strand B (strand) E (parallel sheets) 76 -140.0 160.6 94.79 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 175 -4.5 R508-D472, R508-R471, R508-Y679 (PDB: 1IJQ); R508-D472, R508-Y679, R508-R471 (PDB: 3M0C) R508-D472, R508-Y679; PAE: 4.0, 2.0 R508-D472; PAE: 4.0 509 K Lysine Positively-charged Beta strand B (strand) E (parallel sheets) 48 -155.7 140.4 94.95 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 147 -3.9 K509-V500, K509-C698 (PDB: 1IJQ); K509-V500, K509-C698 (PDB: 3M0C) K509-V500, K509-C698; PAE: 1.0, 1.5 K509-V500 (PDB: 1IJQ); K509-V500, K509-D700 (PDB: 3M0C) K509-V500; PAE: 1.0 510 T Threonine Polar/Neutral Beta strand B (strand) E (parallel sheets) 27 -79.9 122.7 95.75 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 119 -0.7 T510-D700 (PDB: 1IJQ); T510-D700 (PDB: 3M0C) T510-D700, T510-S499; PAE: 2.0, 1.0 T510-S499; PAE: 1.0 511 L Leucine Aliphatic Beta strand B (strand) E (parallel sheets) 23 -90.6 -35.8 96.07 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 131 3.8 L511-V498 (PDB: 1IJQ); L511-V498 (PDB: 3M0C) L511-V498; PAE: 1.0 L511-V498 (PDB: 1IJQ); L511-V498 (PDB: 3M0C) L511-V498; PAE: 1.0 512 F Phenylalanine Aromatic Beta strand B (strand) E (parallel sheets) 25 -138.8 140.0 96.42 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 165 2.8 F512-V498 (PDB: 1IJQ); F512-V498 (PDB: 3M0C) F512-V498; PAE: 1.0 F512-V498 (PDB: 1IJQ); F512-V498 (PDB: 3M0C) F512-V498; PAE: 1.0 513 R Arginine Positively-charged Beta strand B (strand) E (parallel sheets) 135 -149.0 121.5 95.33 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 175 -4.5 R513-T497 (PDB: 1IJQ); R513-T497 (PDB: 3M0C) R513-T497, R513-L495; PAE: 1.5, 2.0 514 E Glutamic Acid Negatively-charged C (loop/coil) C (loop/coil) 72 -138.1 122.2 92.85 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 146 -3.5 Pocket 4: Mean pLDDT: 80.74, Volume: 495.81 ų, Druggability score: 0.03 0.0258 E514-G496, E514-K543 (PDB: 1IJQ); E514-G496, E514-K543 (PDB: 3M0C) E514-G496, E514-K543, E514-K541; PAE: 2.0, 2.5, 3.0 E514-G496 (PDB: 1IJQ); E514-G496 (PDB: 3M0C) E514-G496; PAE: 2.0 E514-K543 (PDB: 3M0C) E514-K543, E514-K541; PAE: 2.5, 3.0 515 N Asparagine Polar/Neutral C (loop/coil) T (turn) 151 -66.5 126.8 86.3 Low-density lipoprotein receptor N-linked (GlcNAc...) asparagine LDL-receptor class B 3 Extracellular 132 -3.5 Pocket 4: Mean pLDDT: 80.74, Volume: 495.81 ų, Druggability score: 0.03 0.0258 516 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible C (loop/coil) T (turn) 66 87.4 -6.1 83.91 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 75 -0.4 Pocket 4: Mean pLDDT: 80.74, Volume: 495.81 ų, Druggability score: 0.03 0.0258 517 S Serine Polar/Neutral C (loop/coil) C (loop/coil) 4 -69.0 143.4 91.0 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 105 -0.8 Morphology: TLFRENGsKPRAIVV; Domain: Ldl_recept_b Pocket 4: Mean pLDDT: 80.74, Volume: 495.81 ų, Druggability score: 0.03 0.0258 S517-G496 (PDB: 1IJQ); S517-G496 (PDB: 3M0C) S517-G496; PAE: 3.0 518 K Lysine Positively-charged C (loop/coil) C (loop/coil) 48 -126.2 70.9 93.43 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 147 -3.9 Pocket 4: Mean pLDDT: 80.74, Volume: 495.81 ų, Druggability score: 0.03 0.0258 K518-D535, K518-W536 (PDB: 1IJQ); K518-D535, K518-W536 (PDB: 3M0C) K518-D535, K518-W536, K518-E201; PAE: 1.0, 1.5, 26.5 K518-W536, K518-G537 (PDB: 1IJQ); K518-W536, K518-G537 (PDB: 3M0C) K518-W536, K518-G537; PAE: 1.5, 1.5 519 P Proline Special, No backbone hydrogen Beta strand B (strand) E (parallel sheets) 0 -67.0 142.8 96.7 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 115 1.6 520 R Arginine Positively-charged Beta strand B (strand) E (parallel sheets) 29 -127.5 -106.5 95.43 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 175 -4.5 Pocket 1: Mean pLDDT: 85.7, Volume: 528.09 ų, Druggability score: 0.11 0.1082 R520-T491, R520-N564, R520-T534, R520-D477 (PDB: 1IJQ); R520-T491, R520-T534, R520-D477 (PDB: 3M0C) R520-T491, R520-T534; PAE: 1.5, 1.0 R520-W536, R520-T491, R520-T534, R520-D477 (PDB: 1IJQ); R520-T534, R520-D477 (PDB: 3M0C) R520-W536, R520-N564, R520-T534; PAE: 2.5, 2.0, 1.0 R520-D477 (PDB: 3M0C) 521 A Alanine Aliphatic Beta strand B (strand) E (parallel sheets) 15 -65.8 143.5 97.69 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 89 1.8 A521-T534 (PDB: 1IJQ); A521-T534 (PDB: 3M0C) A521-T534; PAE: 1.0 A521-T534, A521-I566 (PDB: 1IJQ); A521-T534, A521-I566 (PDB: 3M0C) A521-T534, A521-I566; PAE: 1.0, 2.0 522 I Isoleucine Aliphatic Beta strand B (strand) E (parallel sheets) 6 -136.7 141.1 98.36 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 131 4.5 523 V Valine Aliphatic Beta strand B (strand) E (parallel sheets) 24 -135.0 150.9 98.25 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 117 4.2 V523-Y532 (PDB: 1IJQ); V523-Y532 (PDB: 3M0C) V523-Y532; PAE: 1.0 V523-Y532 (PDB: 1IJQ); V523-Y532 (PDB: 3M0C) V523-Y532; PAE: 1.0 524 V Valine Aliphatic Beta strand B (strand) E (parallel sheets) 9 -120.4 146.2 97.88 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 117 4.2 525 D Aspartic Acid Negatively-charged Beta strand B (strand) E (parallel sheets) 7 -115.9 90.0 96.89 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 132 -3.5 D525-G529, D525-F530 (PDB: 1IJQ); D525-G529, D525-F530 (PDB: 3M0C) D525-G529, D525-F530; PAE: 1.0, 1.0 D525-G529, D525-F530 (PDB: 1IJQ); D525-G529, D525-F530 (PDB: 3M0C) D525-G529, D525-F530; PAE: 1.0, 1.0 526 P Proline Special, No backbone hydrogen Turn C (loop/coil) T (turn) 3 -65.5 -21.1 95.7 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 115 1.6 P526-N665 (PDB: 3M0C) 527 V Valine Aliphatic Turn C (loop/coil) T (turn) 62 -77.6 -46.3 93.73 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 117 4.2 V527-W666 (PDB: 3M0C) 528 H Histidine Positively-charged Turn C (loop/coil) T (turn) 93 -96.7 -9.1 93.52 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 155 -3.2 H528-Q686 (PDB: 1IJQ) H528-Q686; PAE: 2.0 H528-Q686 (PDB: 1IJQ) H528-Q686; PAE: 2.0 529 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible Turn C (loop/coil) T (turn) 2 85.5 27.4 95.37 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 75 -0.4 G529-D525, G529-L547 (PDB: 1IJQ); G529-D525, G529-L547 (PDB: 3M0C) G529-D525, G529-L547; PAE: 1.0, 2.0 G529-D525, G529-L547 (PDB: 1IJQ); G529-D525, G529-L547 (PDB: 3M0C) G529-D525, G529-L547; PAE: 1.0, 2.0 530 F Phenylalanine Aromatic Beta strand B (strand) E (parallel sheets) 22 -116.1 158.4 97.45 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 165 2.8 F530-D525 (PDB: 1IJQ); F530-D525 (PDB: 3M0C) F530-D525; PAE: 1.0 F530-Q686, F530-D525 (PDB: 1IJQ); F530-D525 (PDB: 3M0C) F530-D525; PAE: 1.0 531 M Methionine Aliphatic Beta strand B (strand) E (parallel sheets) 0 -134.6 150.4 97.71 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 149 1.9 M531-G545 (PDB: 1IJQ); M531-G545 (PDB: 3M0C) M531-G545; PAE: 1.0 M531-G545 (PDB: 1IJQ); M531-G545 (PDB: 3M0C) M531-G545; PAE: 1.0 532 Y Tyrosine Aromatic Beta strand B (strand) E (parallel sheets) 2 -133.6 136.0 98.5 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 181 -1.3 Y532-V523 (PDB: 1IJQ); Y532-V523 (PDB: 3M0C) Y532-V523; PAE: 1.0 Y532-K544, Y532-V523 (PDB: 1IJQ); Y532-K544, Y532-V523 (PDB: 3M0C) Y532-V523; PAE: 1.0 533 W Tryptophan Aromatic Beta strand B (strand) E (parallel sheets) 0 -145.6 152.3 98.34 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 204 -0.9 W533-K543 (PDB: 1IJQ); W533-K543 (PDB: 3M0C) W533-K543; PAE: 1.0 W533-K543 (PDB: 1IJQ); W533-K543 (PDB: 3M0C) W533-K543; PAE: 1.0 534 T Threonine Polar/Neutral Beta strand B (strand) E (parallel sheets) 0 -86.8 143.1 97.95 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 119 -0.7 T534-A521, T534-N564, T534-P563, T534-R520 (PDB: 1IJQ); T534-A521, T534-N564, T534-R520 (PDB: 3M0C) T534-A521, T534-N564, T534-P563, T534-R520; PAE: 1.0, 2.0, 1.5, 1.0 T534-A521, T534-R520 (PDB: 1IJQ); T534-A521, T534-R520 (PDB: 3M0C) T534-A521, T534-R520; PAE: 1.0, 1.0 535 D Aspartic Acid Negatively-charged Beta strand B (strand) E (parallel sheets) 1 -134.7 112.4 96.21 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 132 -3.5 Pocket 4: Mean pLDDT: 80.74, Volume: 495.81 ų, Druggability score: 0.03 0.0258 D535-K541, D535-K543, D535-K518 (PDB: 1IJQ); D535-K541, D535-K518 (PDB: 3M0C) D535-K541, D535-K518; PAE: 1.0, 1.0 D535-K541, D535-K543 (PDB: 1IJQ); D535-K541, D535-K543 (PDB: 3M0C) D535-K541; PAE: 1.0 536 W Tryptophan Aromatic C (loop/coil) C (loop/coil) 42 -94.0 11.1 93.36 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 204 -0.9 Pocket 1: Mean pLDDT: 85.7, Volume: 528.09 ų, Druggability score: 0.11 0.1082 W536-K518 (PDB: 1IJQ); W536-K518 (PDB: 3M0C) W536-K518; PAE: 1.5 W536-K518, W536-R520 (PDB: 1IJQ); W536-K518 (PDB: 3M0C) W536-K518, W536-R520; PAE: 1.5, 2.5 537 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible Beta strand C (loop/coil) S (bend) 6 -62.6 -179.6 88.78 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 75 -0.4 Pocket 4: Mean pLDDT: 80.74, Volume: 495.81 ų, Druggability score: 0.03 0.0258 G537-K518 (PDB: 1IJQ); G537-K518 (PDB: 3M0C) G537-K518; PAE: 1.5 538 T Threonine Polar/Neutral Beta strand C (loop/coil) S (bend) 85 -107.7 109.1 85.55 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 119 -0.7 Pocket 4: Mean pLDDT: 80.74, Volume: 495.81 ų, Druggability score: 0.03 0.0258 T538-H211; PAE: 25.0 539 P Proline Special, No backbone hydrogen Beta strand C (loop/coil) S (bend) 97 -82.2 148.3 89.94 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 115 1.6 Pocket 4: Mean pLDDT: 80.74, Volume: 495.81 ų, Druggability score: 0.03 0.0258 540 A Alanine Aliphatic C (loop/coil) C (loop/coil) 14 -74.6 144.8 93.54 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 89 1.8 541 K Lysine Positively-charged Beta strand B (strand) E (parallel sheets) 17 -162.3 154.8 95.71 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 147 -3.9 Pocket 4: Mean pLDDT: 80.74, Volume: 495.81 ų, Druggability score: 0.03 0.0258 K541-D535 (PDB: 1IJQ); K541-D535 (PDB: 3M0C) K541-E514, K541-D535; PAE: 3.0, 1.0 K541-S554, K541-D535 (PDB: 1IJQ); K541-S554, K541-D535 (PDB: 3M0C) K541-S554, K541-D535; PAE: 2.0, 1.0 K541-E514; PAE: 3.0 542 I Isoleucine Aliphatic Beta strand B (strand) E (parallel sheets) 1 -103.1 126.9 97.99 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 131 4.5 I542-V556, I542-L555 (PDB: 1IJQ); I542-V556, I542-L555 (PDB: 3M0C) I542-V556, I542-L555; PAE: 1.0, 1.0 I542-L555, I542-V556 (PDB: 1IJQ); I542-L555, I542-V556 (PDB: 3M0C) I542-L555, I542-V556; PAE: 1.0, 1.0 543 K Lysine Positively-charged Beta strand B (strand) E (parallel sheets) 12 -101.5 148.1 97.63 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 147 -3.9 K543-W533, K543-E514, K543-D535 (PDB: 1IJQ); K543-W533, K543-E514 (PDB: 3M0C) K543-W533, K543-E514; PAE: 1.0, 2.5 K543-W533, K543-S554, K543-D535 (PDB: 1IJQ); K543-W533, K543-D535 (PDB: 3M0C) K543-W533; PAE: 1.0 K543-E514 (PDB: 3M0C) K543-E514; PAE: 2.5 544 K Lysine Positively-charged Beta strand B (strand) E (parallel sheets) 12 -121.4 140.7 97.45 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 147 -3.9 K544-V590, K544-Y553 (PDB: 1IJQ); K544-V590, K544-Y553 (PDB: 3M0C) K544-V590, K544-Y553; PAE: 2.0, 1.0 K544-Y553, K544-Y532 (PDB: 1IJQ); K544-Y553, K544-Y532 (PDB: 3M0C) K544-Y553; PAE: 1.0 545 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible Beta strand B (strand) E (parallel sheets) 0 -159.6 168.8 96.16 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 75 -0.4 G545-M531 (PDB: 1IJQ); G545-M531 (PDB: 3M0C) G545-M531; PAE: 1.0 G545-M531 (PDB: 1IJQ); G545-M531 (PDB: 3M0C) G545-M531; PAE: 1.0 546 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible Beta strand B (strand) E (parallel sheets) 0 -69.9 149.5 96.37 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 75 -0.4 G546-D551, G546-V550 (PDB: 1IJQ); G546-D551 (PDB: 3M0C) G546-V550; PAE: 1.5 547 L Leucine Aliphatic C (loop/coil) T (turn) 0 -62.1 -12.5 97.16 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 131 3.8 L547-Y489, L547-G529 (PDB: 1IJQ); L547-Y489, L547-G529 (PDB: 3M0C) L547-Y489, L547-G529; PAE: 1.0, 2.0 L547-G529 (PDB: 1IJQ); L547-G529 (PDB: 3M0C) L547-G529; PAE: 2.0 548 N Asparagine Polar/Neutral C (loop/coil) T (turn) 19 -96.9 3.8 94.54 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 132 -3.5 N548-T695 (PDB: 1IJQ); N548-T695 (PDB: 3M0C) N548-T695; PAE: 2.0 N548-T695 (PDB: 1IJQ); N548-T695 (PDB: 3M0C) N548-T695; PAE: 2.0 549 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible C (loop/coil) S (bend) 21 81.1 10.3 93.74 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 75 -0.4 550 V Valine Aliphatic C (loop/coil) C (loop/coil) 79 -90.6 149.6 91.73 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 117 4.2 V550-G546 (PDB: 1IJQ) V550-G546; PAE: 1.5 551 D Aspartic Acid Negatively-charged C (loop/coil) S (bend) 84 57.2 47.4 91.3 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 132 -3.5 D551-G546 (PDB: 1IJQ); D551-G546 (PDB: 3M0C) 552 I Isoleucine Aliphatic Beta strand C (loop/coil) C (loop/coil) 47 -81.3 122.8 95.94 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 131 4.5 553 Y Tyrosine Aromatic Beta strand B (strand) E (parallel sheets) 93 -143.0 164.5 94.8 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 181 -1.3 Y553-K544 (PDB: 1IJQ); Y553-K544 (PDB: 3M0C) Y553-K544; PAE: 1.0 Y553-K544 (PDB: 1IJQ); Y553-K544 (PDB: 3M0C) Y553-K544; PAE: 1.0 554 S Serine Polar/Neutral Beta strand B (strand) E (parallel sheets) 52 -80.9 117.5 95.41 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 105 -0.8 S554-K541, S554-K543 (PDB: 1IJQ); S554-K541 (PDB: 3M0C) S554-K541; PAE: 2.0 555 L Leucine Aliphatic Beta strand B (strand) E (parallel sheets) 25 -80.3 -43.9 95.77 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 131 3.8 L555-I542 (PDB: 1IJQ); L555-I542 (PDB: 3M0C) L555-I542; PAE: 1.0 L555-I542, L555-G592 (PDB: 1IJQ); L555-I542, L555-G592 (PDB: 3M0C) L555-I542, L555-G592; PAE: 1.0, 2.5 556 V Valine Aliphatic Beta strand B (strand) E (parallel sheets) 6 -125.5 128.1 95.95 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 117 4.2 V556-I542 (PDB: 1IJQ); V556-I542 (PDB: 3M0C) V556-I542; PAE: 1.0 V556-I542 (PDB: 1IJQ); V556-I542 (PDB: 3M0C) V556-I542; PAE: 1.0 557 T Threonine Polar/Neutral C (loop/coil) C (loop/coil) 89 -135.7 -6.2 92.79 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 119 -0.7 558 E Glutamic Acid Negatively-charged C (loop/coil) S (bend) 143 -109.1 150.9 89.39 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 146 -3.5 E558-R595 (PDB: 1IJQ); E558-R595 (PDB: 3M0C) E558-R595; PAE: 2.5 559 N Asparagine Polar/Neutral C (loop/coil) S (bend) 84 42.3 50.8 88.44 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 132 -3.5 N559-R595 (PDB: 1IJQ); N559-R595 (PDB: 3M0C) N559-R595; PAE: 2.5 560 I Isoleucine Aliphatic C (loop/coil) C (loop/coil) 8 -144.3 131.2 91.87 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 131 4.5 561 Q Glutamine Polar/Neutral C (loop/coil) S (bend) 50 -131.6 -72.5 89.47 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 146 -3.5 Q561-D579 (PDB: 1IJQ); Q561-D579 (PDB: 3M0C) Q561-D579; PAE: 1.5 562 W Tryptophan Aromatic C (loop/coil) C (loop/coil) 20 -118.0 73.5 90.44 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 204 -0.9 Pocket 1: Mean pLDDT: 85.7, Volume: 528.09 ų, Druggability score: 0.11 0.1082 W562-S580, W562-D579 (PDB: 1IJQ); W562-S580, W562-D579 (PDB: 3M0C) W562-S580, W562-D579; PAE: 2.0, 1.0 W562-K581, W562-S580 (PDB: 1IJQ); W562-K581, W562-S580 (PDB: 3M0C) W562-S580; PAE: 2.0 563 P Proline Special, No backbone hydrogen Beta strand B (strand) E (parallel sheets) 0 -68.3 103.5 96.5 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 115 1.6 P563-T534 (PDB: 1IJQ) P563-T534; PAE: 1.5 564 N Asparagine Polar/Neutral Beta strand B (strand) E (parallel sheets) 2 -88.0 -76.9 95.21 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 132 -3.5 Pocket 1: Mean pLDDT: 85.7, Volume: 528.09 ų, Druggability score: 0.11 0.1082 N564-T534, N564-V578, N564-R520, N564-S580 (PDB: 1IJQ); N564-T534, N564-V578, N564-S580 (PDB: 3M0C) N564-T534, N564-V578, N564-P608; PAE: 2.0, 2.0, 1.5 N564-S580 (PDB: 1IJQ); N564-S580 (PDB: 3M0C) N564-R520, N564-S580; PAE: 2.0, 2.0 565 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible Beta strand B (strand) E (parallel sheets) 1 -89.7 144.8 96.31 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 75 -0.4 G565-V578, G565-F609 (PDB: 1IJQ); G565-V578, G565-F609 (PDB: 3M0C) G565-V578; PAE: 1.5 G565-V578 (PDB: 1IJQ); G565-V578 (PDB: 3M0C) G565-V578; PAE: 1.5 566 I Isoleucine Aliphatic Beta strand B (strand) E (parallel sheets) 8 -135.7 141.1 98.02 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 131 4.5 I566-A521 (PDB: 1IJQ); I566-A521 (PDB: 3M0C) I566-A521; PAE: 2.0 567 T Threonine Polar/Neutral Beta strand B (strand) E (parallel sheets) 23 -133.7 152.3 97.67 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 119 -0.7 T567-Y576 (PDB: 1IJQ); T567-Y576 (PDB: 3M0C) T567-Y576; PAE: 1.0 T567-Y576 (PDB: 1IJQ); T567-Y576 (PDB: 3M0C) T567-Y576; PAE: 1.0 568 L Leucine Aliphatic Beta strand B (strand) E (parallel sheets) 23 -118.9 120.8 96.47 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 131 3.8 Pocket 2: Mean pLDDT: 89.82, Volume: 512.1 ų, Druggability score: 0.1 0.0983 569 D Aspartic Acid Negatively-charged Beta strand B (strand) E (parallel sheets) 25 -81.9 100.7 93.37 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 132 -3.5 Pocket 2: Mean pLDDT: 89.82, Volume: 512.1 ų, Druggability score: 0.1 0.0983 D569-G573, D569-R574 (PDB: 1IJQ); D569-G573, D569-R574 (PDB: 3M0C) D569-G573, D569-R574, D569-R633; PAE: 1.5, 1.0, 3.0 D569-G573, D569-R574 (PDB: 1IJQ); D569-G573, D569-R574 (PDB: 3M0C) D569-G573, D569-R574; PAE: 1.5, 1.0 D569-R633; PAE: 3.0 570 L Leucine Aliphatic Turn C (loop/coil) T (turn) 31 -62.5 -27.9 91.37 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 131 3.8 Pocket 2: Mean pLDDT: 89.82, Volume: 512.1 ų, Druggability score: 0.1 0.0983 571 L Leucine Aliphatic Turn C (loop/coil) T (turn) 62 -78.9 -49.9 85.73 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 131 3.8 Pocket 2: Mean pLDDT: 89.82, Volume: 512.1 ų, Druggability score: 0.1 0.0983 572 S Serine Polar/Neutral Turn C (loop/coil) T (turn) 60 -79.9 -13.5 85.76 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 105 -0.8 Pocket 2: Mean pLDDT: 89.82, Volume: 512.1 ų, Druggability score: 0.1 0.0983 573 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible Turn C (loop/coil) T (turn) 21 64.1 40.5 91.22 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 75 -0.4 G573-D569, G573-V590 (PDB: 1IJQ); G573-D569, G573-V590 (PDB: 3M0C) G573-D569, G573-V590; PAE: 1.5, 2.0 G573-D569, G573-V590 (PDB: 1IJQ); G573-D569, G573-V590 (PDB: 3M0C) G573-D569, G573-V590; PAE: 1.5, 2.0 574 R Arginine Positively-charged Beta strand B (strand) E (parallel sheets) 19 -125.6 134.2 93.0 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 175 -4.5 R574-D569, R574-N594, R574-D589, R574-S587 (PDB: 1IJQ); R574-D569, R574-N594, R574-D589, R574-S587 (PDB: 3M0C) R574-D569, R574-N594, R574-D589, R574-S587; PAE: 1.0, 2.0, 1.0, 1.0 R574-I588, R574-D569, R574-D589, R574-S587 (PDB: 1IJQ); R574-I588, R574-D569, R574-D589, R574-S587 (PDB: 3M0C) R574-I588, R574-D569, R574-S587; PAE: 1.0, 1.0, 1.0 R574-D589 (PDB: 1IJQ); R574-D589 (PDB: 3M0C) R574-D589; PAE: 1.0 575 L Leucine Aliphatic Beta strand B (strand) E (parallel sheets) 1 -94.2 141.3 97.18 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 131 3.8 L575-I588 (PDB: 1IJQ); L575-I588 (PDB: 3M0C) L575-I588; PAE: 1.0 L575-I588 (PDB: 1IJQ); L575-I588 (PDB: 3M0C) L575-I588; PAE: 1.0 576 Y Tyrosine Aromatic Beta strand B (strand) E (parallel sheets) 4 -124.5 139.5 97.74 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 181 -1.3 Y576-T567, Y576-R633 (PDB: 1IJQ); Y576-T567, Y576-R633 (PDB: 3M0C) Y576-T567, Y576-R633; PAE: 1.0, 1.5 Y576-T567 (PDB: 1IJQ); Y576-T567 (PDB: 3M0C) Y576-T567; PAE: 1.0 577 W Tryptophan Aromatic Beta strand B (strand) E (parallel sheets) 1 -143.0 155.1 98.15 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 204 -0.9 W577-S586 (PDB: 1IJQ); W577-S586 (PDB: 3M0C) W577-S586; PAE: 1.0 W577-S586, W577-S587 (PDB: 1IJQ); W577-S586, W577-S587 (PDB: 3M0C) W577-S586, W577-S587; PAE: 1.0, 1.0 578 V Valine Aliphatic Beta strand B (strand) E (parallel sheets) 0 -99.9 139.3 97.73 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 117 4.2 V578-N564, V578-G565 (PDB: 1IJQ); V578-N564, V578-G565 (PDB: 3M0C) V578-N564, V578-G565; PAE: 2.0, 1.5 V578-G565 (PDB: 1IJQ); V578-G565 (PDB: 3M0C) V578-G565; PAE: 1.5 579 D Aspartic Acid Negatively-charged Beta strand B (strand) E (parallel sheets) 0 -119.4 115.9 95.92 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 132 -3.5 D579-W562, D579-H583, D579-Q561, D579-S584 (PDB: 1IJQ); D579-W562, D579-H583, D579-Q561, D579-S584 (PDB: 3M0C) D579-W562, D579-Q561, D579-S584; PAE: 1.0, 1.5, 1.0 D579-H583, D579-S584 (PDB: 1IJQ); D579-H583, D579-S584 (PDB: 3M0C) D579-H583, D579-S584; PAE: 1.0, 1.0 580 S Serine Polar/Neutral Turn C (loop/coil) T (turn) 2 -77.1 -24.8 93.34 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 105 -0.8 S580-N564, S580-P608, S580-W562 (PDB: 1IJQ); S580-N564, S580-P608, S580-W562 (PDB: 3M0C) S580-P608, S580-W562; PAE: 1.5, 2.0 S580-H607, S580-N564, S580-W562 (PDB: 1IJQ); S580-H607, S580-N564, S580-W562 (PDB: 3M0C) S580-N564, S580-W562; PAE: 2.0, 2.0 581 K Lysine Positively-charged Turn C (loop/coil) T (turn) 22 -83.8 -33.1 85.81 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 147 -3.9 K581-D217, K581-D221; PAE: 24.5, 22.5 K581-W562 (PDB: 1IJQ); K581-W562 (PDB: 3M0C) K581-D221; PAE: 22.5 K581-D217, K581-D221; PAE: 24.5, 22.5 582 L Leucine Aliphatic Turn C (loop/coil) T (turn) 34 -84.9 -1.0 90.07 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 131 3.8 583 H Histidine Positively-charged Turn C (loop/coil) T (turn) 56 47.8 41.3 93.68 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 155 -3.2 H583-D579, H583-D601 (PDB: 1IJQ); H583-D579, H583-D601 (PDB: 3M0C) H583-D601, H583-L605; PAE: 1.5, 1.5 H583-D579, H583-D601 (PDB: 1IJQ); H583-D579, H583-D601 (PDB: 3M0C) H583-D579, H583-D601; PAE: 1.0, 1.5 584 S Serine Polar/Neutral Beta strand B (strand) E (parallel sheets) 3 -135.6 151.1 94.68 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 105 -0.8 S584-D579 (PDB: 1IJQ); S584-D579 (PDB: 3M0C) S584-D579; PAE: 1.0 S584-D579 (PDB: 1IJQ); S584-D579 (PDB: 3M0C) S584-D579; PAE: 1.0 585 I Isoleucine Aliphatic Beta strand B (strand) E (parallel sheets) 0 -106.7 122.6 97.43 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 131 4.5 I585-L599, I585-I598 (PDB: 1IJQ); I585-L599, I585-I598 (PDB: 3M0C) I585-L599, I585-I598; PAE: 1.0, 1.0 I585-L599, I585-I598 (PDB: 1IJQ); I585-L599, I585-I598 (PDB: 3M0C) I585-L599, I585-I598; PAE: 1.0, 1.0 586 S Serine Polar/Neutral Beta strand B (strand) E (parallel sheets) 1 -119.7 156.3 95.77 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 105 -0.8 S586-W577 (PDB: 1IJQ); S586-W577 (PDB: 3M0C) S586-W577; PAE: 1.0 S586-W577 (PDB: 1IJQ); S586-W577 (PDB: 3M0C) S586-T597, S586-W577; PAE: 1.0, 1.0 587 S Serine Polar/Neutral Beta strand B (strand) E (parallel sheets) 3 -133.1 156.3 94.94 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 105 -0.8 S587-R574, S587-K596 (PDB: 1IJQ); S587-R574, S587-K596 (PDB: 3M0C) S587-R574, S587-K596; PAE: 1.0, 1.0 S587-R574, S587-W577, S587-K596 (PDB: 1IJQ); S587-R574, S587-W577, S587-K596 (PDB: 3M0C) S587-R574, S587-W577, S587-K596; PAE: 1.0, 1.0, 1.0 588 I Isoleucine Aliphatic Beta strand B (strand) E (parallel sheets) 8 -156.4 147.3 94.75 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 131 4.5 I588-L575 (PDB: 1IJQ); I588-L575 (PDB: 3M0C) I588-L575; PAE: 1.0 I588-R574, I588-L575 (PDB: 1IJQ); I588-R574, I588-L575 (PDB: 3M0C) I588-R574, I588-L575; PAE: 1.0, 1.0 589 D Aspartic Acid Negatively-charged Beta strand B (strand) E (parallel sheets) 32 -65.0 151.3 92.68 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 132 -3.5 D589-G593, D589-R574, D589-N594 (PDB: 1IJQ); D589-G593, D589-R574 (PDB: 3M0C) D589-G593, D589-R574, D589-N594; PAE: 2.0, 1.0, 2.0 D589-R574, D589-N594 (PDB: 1IJQ); D589-R574 (PDB: 3M0C) D589-N594; PAE: 2.0 D589-R574 (PDB: 1IJQ); D589-R574 (PDB: 3M0C) D589-R574; PAE: 1.0 590 V Valine Aliphatic C (loop/coil) T (turn) 23 -59.0 -15.2 93.2 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 117 4.2 V590-G573, V590-K544 (PDB: 1IJQ); V590-G573, V590-K544 (PDB: 3M0C) V590-G573, V590-K544; PAE: 2.0, 2.0 V590-G573 (PDB: 1IJQ); V590-G573 (PDB: 3M0C) V590-G573; PAE: 2.0 591 N Asparagine Polar/Neutral C (loop/coil) T (turn) 135 -86.0 -8.8 89.3 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 132 -3.5 592 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible C (loop/coil) S (bend) 35 88.5 8.5 90.01 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 75 -0.4 dbSNP: rs137929307; Variant type: LP/P; AA change: Gly592Glu; PTM type: Ubiquitylation; PTM morphology: NG*GNRkTILED; Var class: II G592-L555 (PDB: 1IJQ); G592-L555 (PDB: 3M0C) G592-L555; PAE: 2.5 593 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible C (loop/coil) C (loop/coil) 32 -97.2 175.0 87.08 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 75 -0.4 G593-D589 (PDB: 1IJQ); G593-D589 (PDB: 3M0C) G593-D589; PAE: 2.0 594 N Asparagine Polar/Neutral C (loop/coil) S (bend) 108 48.1 44.5 86.81 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 132 -3.5 N594-R574, N594-D589 (PDB: 1IJQ); N594-R574 (PDB: 3M0C) N594-R574, N594-D589; PAE: 2.0, 2.0 N594-D589 (PDB: 1IJQ) N594-D589; PAE: 2.0 595 R Arginine Positively-charged C (loop/coil) C (loop/coil) 81 -64.8 136.3 90.3 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 175 -4.5 dbSNP: rs373371572; Variant type: LP/P; AA change: Arg595Trp; PTM type: Ubiquitylation; PTM morphology: NGGNR*kTILED; Var class: II R595-E558, R595-N559 (PDB: 1IJQ); R595-E558, R595-N559 (PDB: 3M0C) R595-E558, R595-N559; PAE: 2.5, 2.5 596 K Lysine Positively-charged Beta strand B (strand) E (parallel sheets) 52 -142.0 138.6 89.1 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 147 -3.9 Morphology: DVNGGNRkTILEDEk; Domain: Ldl_recept_b K596-S587 (PDB: 1IJQ); K596-S587 (PDB: 3M0C) K596-L634, K596-S587; PAE: 2.0, 1.0 K596-S587 (PDB: 1IJQ); K596-S587 (PDB: 3M0C) K596-S587; PAE: 1.0 K596-D362; PAE: 7.0 597 T Threonine Polar/Neutral Beta strand B (strand) E (parallel sheets) 57 -88.0 124.4 91.68 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 119 -0.7 T597-S586; PAE: 1.0 598 I Isoleucine Aliphatic Beta strand B (strand) E (parallel sheets) 14 -90.3 -44.6 92.93 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 131 4.5 I598-I585 (PDB: 1IJQ); I598-I585 (PDB: 3M0C) I598-I585; PAE: 1.0 I598-I585, I598-G636 (PDB: 1IJQ); I598-I585, I598-G636 (PDB: 3M0C) I598-I585, I598-G636; PAE: 1.0, 2.0 599 L Leucine Aliphatic Beta strand B (strand) E (parallel sheets) 21 -145.5 135.0 93.83 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 131 3.8 dbSNP: rs879255025; Variant type: US; AA change: Leu599Ser; PTM type: Ubiquitylation; PTM morphology: NGGNRkTIL*ED; Var class: II&rs879255025 L599-I585 (PDB: 1IJQ); L599-I585 (PDB: 3M0C) L599-I585; PAE: 1.0 L599-I585 (PDB: 1IJQ); L599-I585 (PDB: 3M0C) L599-I585; PAE: 1.0 600 E Glutamic Acid Negatively-charged Beta strand B (strand) E (parallel sheets) 75 -127.9 113.5 92.19 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 146 -3.5 601 D Aspartic Acid Negatively-charged C (loop/coil) C (loop/coil) 30 -153.5 96.2 91.88 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 132 -3.5 dbSNP: rs753707206; Variant type: US; AA change: Asp601His; PTM type: Ubiquitylation; PTM morphology: NGGNRkTILED*; Var class: II&rs753707206 D601-L605, D601-H583 (PDB: 1IJQ); D601-L605, D601-H583 (PDB: 3M0C) D601-L605, D601-H583; PAE: 2.0, 1.5 D601-L605, D601-H583 (PDB: 1IJQ); D601-L605, D601-H583 (PDB: 3M0C) D601-L605, D601-H583; PAE: 2.0, 1.5 D601-R604; PAE: 2.0 602 E Glutamic Acid Negatively-charged Turn C (loop/coil) T (turn) 114 -53.6 -27.1 89.34 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 146 -3.5 E602-A606 (PDB: 1IJQ); E602-A606 (PDB: 3M0C) E602-A606; PAE: 2.0 603 K Lysine Positively-charged Turn C (loop/coil) T (turn) 173 -84.0 -42.5 89.75 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 147 -3.9 Morphology: kTILEDEkRLAHPFS; Domain: Ldl_recept_b K603-N625 (PDB: 1IJQ); K603-N625 (PDB: 3M0C) K603-N625; PAE: 2.0 604 R Arginine Positively-charged Turn C (loop/coil) T (turn) 106 -93.8 -16.1 91.17 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 175 -4.5 R604-W620 (PDB: 1IJQ); R604-W620 (PDB: 3M0C) R604-W620; PAE: 1.5 R604-N625 (PDB: 1IJQ); R604-N625 (PDB: 3M0C) R604-N625; PAE: 2.0 R604-D601; PAE: 2.0 605 L Leucine Aliphatic Turn C (loop/coil) S (bend) 0 -118.2 47.3 92.64 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 131 3.8 L605-D601 (PDB: 1IJQ); L605-D601 (PDB: 3M0C) L605-H583, L605-D601; PAE: 1.5, 2.0 L605-D601 (PDB: 1IJQ); L605-D601 (PDB: 3M0C) L605-D601; PAE: 2.0 606 A Alanine Aliphatic Beta strand C (loop/coil) S (bend) 19 -64.7 -45.3 91.25 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 89 1.8 A606-D622; PAE: 2.0 A606-N625, A606-E602 (PDB: 1IJQ); A606-E602 (PDB: 3M0C) A606-N625, A606-E602; PAE: 2.5, 2.0 607 H Histidine Positively-charged Beta strand C (loop/coil) S (bend) 45 -150.7 68.6 92.64 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 155 -3.2 Pocket 1: Mean pLDDT: 85.7, Volume: 528.09 ų, Druggability score: 0.11 0.1082 H607-I623, H607-D622 (PDB: 1IJQ); H607-I623, H607-D622 (PDB: 3M0C) H607-I623, H607-D622; PAE: 1.5, 1.0 H607-S580, H607-I623 (PDB: 1IJQ); H607-S580, H607-I623 (PDB: 3M0C) H607-I623; PAE: 1.5 608 P Proline Special, No backbone hydrogen Beta strand B (strand) E (parallel sheets) 0 -65.8 139.2 96.63 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 115 1.6 dbSNP: rs879255034; Variant type: LP/P; AA change: Pro608Ser; PTM type: Ubiquitylation; PTM morphology: ILEDEkRLAHP*; Var class: II P608-S580 (PDB: 1IJQ); P608-S580 (PDB: 3M0C) P608-S580, P608-N564; PAE: 1.5, 1.5 609 F Phenylalanine Aromatic Beta strand B (strand) E (parallel sheets) 22 -124.2 -50.4 95.16 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 165 2.8 Pocket 1: Mean pLDDT: 85.7, Volume: 528.09 ų, Druggability score: 0.11 0.1082 F609-T621, F609-G565 (PDB: 1IJQ); F609-T621, F609-G565 (PDB: 3M0C) F609-T621; PAE: 1.0 F609-T621 (PDB: 1IJQ); F609-T621 (PDB: 3M0C) F609-T621; PAE: 1.0 610 S Serine Polar/Neutral Beta strand B (strand) E (parallel sheets) 6 -125.9 158.8 97.46 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 105 -0.8 S610-D651, S610-T621, S610-M652 (PDB: 1IJQ); S610-D651, S610-T621, S610-M652 (PDB: 3M0C) S610-D651, S610-T621, S610-M652; PAE: 2.0, 1.5, 3.5 S610-T621, S610-M652 (PDB: 1IJQ); S610-T621, S610-M652 (PDB: 3M0C) S610-T621, S610-M652; PAE: 1.5, 3.5 611 L Leucine Aliphatic Beta strand B (strand) E (parallel sheets) 3 -147.5 151.7 97.78 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 131 3.8 612 A Alanine Aliphatic Beta strand B (strand) E (parallel sheets) 3 -136.4 152.8 97.36 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 89 1.8 A612-F619 (PDB: 1IJQ); A612-F619 (PDB: 3M0C) A612-F619; PAE: 1.0 A612-F619 (PDB: 1IJQ); A612-F619 (PDB: 3M0C) A612-F619; PAE: 1.0 613 V Valine Aliphatic Beta strand B (strand) E (parallel sheets) 15 -121.9 136.5 95.53 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 117 4.2 Pocket 2: Mean pLDDT: 89.82, Volume: 512.1 ų, Druggability score: 0.1 0.0983 614 F Phenylalanine Aromatic Beta strand B (strand) E (parallel sheets) 13 -150.1 138.0 93.97 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 165 2.8 Pocket 2: Mean pLDDT: 89.82, Volume: 512.1 ų, Druggability score: 0.1 0.0983 615 E Glutamic Acid Negatively-charged C (loop/coil) T (turn) 34 51.8 -124.9 90.26 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 146 -3.5 Pocket 2: Mean pLDDT: 89.82, Volume: 512.1 ų, Druggability score: 0.1 0.0983 E615-R633 (PDB: 1IJQ) E615-A394; PAE: 3.5 616 D Aspartic Acid Negatively-charged C (loop/coil) T (turn) 24 -99.0 14.4 88.96 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 132 -3.5 D616-R633 (PDB: 1IJQ); D616-R633 (PDB: 3M0C) D616-R633; PAE: 1.5 D616-R633 (PDB: 1IJQ); D616-R633 (PDB: 3M0C) D616-N632, D616-R633; PAE: 1.5, 1.5 617 K Lysine Positively-charged Beta strand B (strand) E (parallel sheets) 62 -116.0 140.7 92.85 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 147 -3.9 K617-D638 (PDB: 1IJQ) 618 V Valine Aliphatic Beta strand B (strand) E (parallel sheets) 0 -106.4 134.7 96.22 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 117 4.2 V618-A631 (PDB: 1IJQ); V618-A631 (PDB: 3M0C) V618-A631; PAE: 1.0 V618-A631 (PDB: 1IJQ); V618-A631 (PDB: 3M0C) V618-A631; PAE: 1.0 619 F Phenylalanine Aromatic Beta strand B (strand) E (parallel sheets) 3 -115.6 136.8 97.9 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 165 2.8 F619-A612 (PDB: 1IJQ); F619-A612 (PDB: 3M0C) F619-A612; PAE: 1.0 F619-A612 (PDB: 1IJQ); F619-A612 (PDB: 3M0C) F619-A612; PAE: 1.0 620 W Tryptophan Aromatic Beta strand B (strand) E (parallel sheets) 0 -139.2 150.9 98.15 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 204 -0.9 W620-R604, W620-F629 (PDB: 1IJQ); W620-R604, W620-F629 (PDB: 3M0C) W620-R604, W620-F629; PAE: 1.5, 1.0 W620-F629 (PDB: 1IJQ); W620-F629 (PDB: 3M0C) W620-S630, W620-F629; PAE: 1.5, 1.0 621 T Threonine Polar/Neutral Beta strand B (strand) E (parallel sheets) 0 -92.8 142.4 97.25 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 119 -0.7 T621-F609, T621-P649, T621-S610 (PDB: 1IJQ); T621-F609, T621-P649, T621-S610 (PDB: 3M0C) T621-F609, T621-P649, T621-S610; PAE: 1.0, 2.0, 1.5 T621-F609, T621-S610 (PDB: 1IJQ); T621-F609, T621-S610 (PDB: 3M0C) T621-F609, T621-S610; PAE: 1.0, 1.5 622 D Aspartic Acid Negatively-charged Beta strand B (strand) E (parallel sheets) 0 -128.6 124.6 95.48 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 132 -3.5 D622-H607, D622-A627, D622-E626 (PDB: 1IJQ); D622-H607, D622-A627, D622-E626 (PDB: 3M0C) D622-A606, D622-H607, D622-A627; PAE: 2.0, 1.0, 1.0 D622-A627, D622-E626 (PDB: 1IJQ); D622-A627, D622-E626 (PDB: 3M0C) D622-A627, D622-E626; PAE: 1.0, 1.0 623 I Isoleucine Aliphatic Turn C (loop/coil) T (turn) 37 -77.8 -38.1 92.02 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 131 4.5 Pocket 1: Mean pLDDT: 85.7, Volume: 528.09 ų, Druggability score: 0.11 0.1082 I623-H607 (PDB: 1IJQ); I623-H607 (PDB: 3M0C) I623-H607; PAE: 1.5 I623-H607 (PDB: 1IJQ); I623-H607 (PDB: 3M0C) I623-H607; PAE: 1.5 624 I Isoleucine Aliphatic Turn C (loop/coil) T (turn) 96 -73.2 -38.9 88.87 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 131 4.5 Pocket 1: Mean pLDDT: 85.7, Volume: 528.09 ų, Druggability score: 0.11 0.1082 625 N Asparagine Polar/Neutral Turn C (loop/coil) T (turn) 60 -79.6 -6.6 91.7 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 132 -3.5 N625-K603 (PDB: 1IJQ); N625-K603 (PDB: 3M0C) N625-K603; PAE: 2.0 N625-A606, N625-R604 (PDB: 1IJQ); N625-R604 (PDB: 3M0C) N625-A606, N625-R604; PAE: 2.5, 2.0 626 E Glutamic Acid Negatively-charged Turn C (loop/coil) T (turn) 93 50.7 42.5 91.77 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 146 -3.5 E626-D622, E626-L646 (PDB: 1IJQ); E626-D622, E626-L646 (PDB: 3M0C) E626-L646; PAE: 1.5 E626-N645, E626-D622, E626-L646 (PDB: 1IJQ); E626-N645, E626-D622, E626-L646 (PDB: 3M0C) E626-N645, E626-D622, E626-L646; PAE: 2.0, 1.0, 1.5 627 A Alanine Aliphatic Beta strand B (strand) E (parallel sheets) 1 -146.7 160.6 93.65 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 89 1.8 A627-D622 (PDB: 1IJQ); A627-D622 (PDB: 3M0C) A627-D622; PAE: 1.0 A627-D622 (PDB: 1IJQ); A627-D622 (PDB: 3M0C) A627-D622; PAE: 1.0 628 I Isoleucine Aliphatic Beta strand B (strand) E (parallel sheets) 0 -113.8 130.3 96.58 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 131 4.5 I628-A643, I628-L642 (PDB: 1IJQ); I628-A643, I628-L642 (PDB: 3M0C) I628-A643, I628-L642; PAE: 1.0, 1.0 I628-A643, I628-L642 (PDB: 1IJQ); I628-A643, I628-L642 (PDB: 3M0C) I628-A643, I628-L642; PAE: 1.0, 1.0 629 F Phenylalanine Aromatic Beta strand B (strand) E (parallel sheets) 22 -117.2 164.0 96.68 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 165 2.8 F629-W620 (PDB: 1IJQ); F629-W620 (PDB: 3M0C) F629-W620; PAE: 1.0 F629-W620 (PDB: 1IJQ); F629-W620 (PDB: 3M0C) F629-W620; PAE: 1.0 630 S Serine Polar/Neutral Beta strand B (strand) E (parallel sheets) 3 -136.3 150.2 96.09 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 105 -0.8 S630-N640 (PDB: 1IJQ); S630-N640 (PDB: 3M0C) S630-N640; PAE: 1.0 S630-N640 (PDB: 1IJQ); S630-N640 (PDB: 3M0C) S630-N640, S630-W620; PAE: 1.0, 1.5 631 A Alanine Aliphatic Beta strand B (strand) E (parallel sheets) 1 -146.3 168.6 95.25 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 89 1.8 A631-V618 (PDB: 1IJQ); A631-V618 (PDB: 3M0C) A631-V618; PAE: 1.0 A631-V618 (PDB: 1IJQ); A631-V618 (PDB: 3M0C) A631-V618; PAE: 1.0 632 N Asparagine Polar/Neutral Beta strand B (strand) E (parallel sheets) 42 -64.7 128.2 92.37 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 132 -3.5 N632-S637, N632-G636 (PDB: 1IJQ); N632-S637, N632-G636 (PDB: 3M0C) N632-S637, N632-G636; PAE: 2.0, 2.0 N632-S637, N632-G636 (PDB: 1IJQ); N632-G636 (PDB: 3M0C) N632-D616, N632-S637, N632-G636; PAE: 1.5, 2.0, 2.0 633 R Arginine Positively-charged Turn C (loop/coil) T (turn) 14 -72.6 -18.2 92.28 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 175 -4.5 Pocket 2: Mean pLDDT: 89.82, Volume: 512.1 ų, Druggability score: 0.1 0.0983 R633-Y576, R633-D616, R633-E615 (PDB: 1IJQ); R633-Y576, R633-D616 (PDB: 3M0C) R633-Y576, R633-D569, R633-D616, R633-S365; PAE: 1.5, 3.0, 1.5, 5.0 R633-D616 (PDB: 1IJQ); R633-D616 (PDB: 3M0C) R633-D616; PAE: 1.5 R633-D569; PAE: 3.0 634 L Leucine Aliphatic Turn C (loop/coil) T (turn) 23 -92.3 -56.5 88.11 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 131 3.8 L634-K596; PAE: 2.0 635 T Threonine Polar/Neutral Turn C (loop/coil) T (turn) 78 -94.8 -17.1 87.6 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 119 -0.7 636 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible C (loop/coil) C (loop/coil) 7 71.3 4.8 90.1 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 75 -0.4 G636-N632 (PDB: 1IJQ); G636-N632 (PDB: 3M0C) G636-N632; PAE: 2.0 G636-N632, G636-I598 (PDB: 1IJQ); G636-N632, G636-I598 (PDB: 3M0C) G636-N632, G636-I598; PAE: 2.0, 2.0 637 S Serine Polar/Neutral C (loop/coil) C (loop/coil) 64 -78.6 173.2 89.4 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 105 -0.8 S637-N632 (PDB: 1IJQ); S637-N632 (PDB: 3M0C) S637-N632; PAE: 2.0 S637-N632 (PDB: 1IJQ) S637-N632; PAE: 2.0 638 D Aspartic Acid Negatively-charged C (loop/coil) S (bend) 102 57.7 52.9 87.89 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 132 -3.5 D638-K617 (PDB: 1IJQ) 639 V Valine Aliphatic C (loop/coil) C (loop/coil) 31 -74.1 117.3 93.65 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 117 4.2 640 N Asparagine Polar/Neutral Beta strand B (strand) E (parallel sheets) 64 -120.9 141.7 92.08 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 132 -3.5 N640-S630 (PDB: 1IJQ); N640-S630 (PDB: 3M0C) N640-S630; PAE: 1.0 N640-S630 (PDB: 1IJQ); N640-S630 (PDB: 3M0C) N640-S630; PAE: 1.0 641 L Leucine Aliphatic Beta strand B (strand) E (parallel sheets) 72 -88.2 122.9 92.2 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 131 3.8 L641-R416 (PDB: 1IJQ); L641-R416 (PDB: 3M0C) 642 L Leucine Aliphatic Beta strand B (strand) E (parallel sheets) 21 -104.1 -36.8 91.21 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 131 3.8 L642-Y419, L642-I628 (PDB: 1IJQ); L642-Y419, L642-I628 (PDB: 3M0C) L642-R416, L642-I628; PAE: 4.0, 1.0 L642-I628 (PDB: 1IJQ); L642-I628 (PDB: 3M0C) L642-I628; PAE: 1.0 643 A Alanine Aliphatic Beta strand B (strand) E (parallel sheets) 0 -146.5 149.9 90.98 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 89 1.8 A643-I628 (PDB: 1IJQ); A643-I628 (PDB: 3M0C) A643-I628; PAE: 1.0 A643-I628, A643-R416 (PDB: 1IJQ); A643-I628, A643-R416 (PDB: 3M0C) A643-I628; PAE: 1.0 644 E Glutamic Acid Negatively-charged C (loop/coil) C (loop/coil) 35 -142.3 170.2 89.72 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 146 -3.5 E644-R416 (PDB: 1IJQ); E644-R416 (PDB: 3M0C) E644-R416 (PDB: 3M0C) 645 N Asparagine Polar/Neutral C (loop/coil) S (bend) 49 55.9 39.5 84.9 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 132 -3.5 N645-R132; PAE: 26.0 N645-E626 (PDB: 1IJQ); N645-E626 (PDB: 3M0C) N645-R132, N645-E626; PAE: 26.0, 2.0 646 L Leucine Aliphatic C (loop/coil) C (loop/coil) 0 -85.4 134.8 90.67 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 131 3.8 L646-E626 (PDB: 1IJQ); L646-E626 (PDB: 3M0C) L646-E626; PAE: 1.5 L646-E626 (PDB: 1IJQ); L646-E626 (PDB: 3M0C) L646-E626; PAE: 1.5 647 L Leucine Aliphatic C (loop/coil) S (bend) 56 -87.9 98.8 87.16 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 131 3.8 L647-N405 (PDB: 1IJQ); L647-N405 (PDB: 3M0C) L647-N405; PAE: 2.0 L647-N405 (PDB: 1IJQ); L647-N405 (PDB: 3M0C) L647-N405; PAE: 2.0 648 S Serine Polar/Neutral C (loop/coil) C (loop/coil) 26 53.8 68.3 87.49 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 105 -0.8 S648-R406 (PDB: 1IJQ); S648-R406 (PDB: 3M0C) S648-R406 (PDB: 1IJQ); S648-R406 (PDB: 3M0C) 649 P Proline Special, No backbone hydrogen C (loop/coil) C (loop/coil) 0 -75.7 73.4 94.33 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 115 1.6 P649-T621 (PDB: 1IJQ); P649-T621 (PDB: 3M0C) P649-T621; PAE: 2.0 650 E Glutamic Acid Negatively-charged C (loop/coil) C (loop/coil) 36 -78.2 -28.0 94.46 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 146 -3.5 E650-T404; PAE: 2.0 E650-T404 (PDB: 1IJQ); E650-T404 (PDB: 3M0C) E650-T404; PAE: 2.0 651 D Aspartic Acid Negatively-charged C (loop/coil) C (loop/coil) 22 -143.8 149.9 97.11 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 132 -3.5 D651-L432, D651-T404, D651-S610 (PDB: 1IJQ); D651-L432, D651-T404, D651-S610 (PDB: 3M0C) D651-L432, D651-T404, D651-S610; PAE: 2.0, 1.0, 2.0 D651-T404 (PDB: 1IJQ); D651-T404 (PDB: 3M0C) D651-T404, D651-V430; PAE: 1.0, 1.5 652 M Methionine Aliphatic Beta strand B (strand) E (parallel sheets) 3 -149.7 128.0 97.55 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 149 1.9 M652-S610 (PDB: 1IJQ); M652-S610 (PDB: 3M0C) M652-S610; PAE: 3.5 M652-L432, M652-S610 (PDB: 1IJQ); M652-S610 (PDB: 3M0C) M652-S610; PAE: 3.5 653 V Valine Aliphatic Beta strand B (strand) E (parallel sheets) 22 -126.6 154.5 97.24 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 117 4.2 V653-F402 (PDB: 1IJQ); V653-F402 (PDB: 3M0C) V653-F402; PAE: 1.0 V653-F402 (PDB: 1IJQ); V653-F402 (PDB: 3M0C) V653-F402; PAE: 1.0 654 L Leucine Aliphatic Beta strand B (strand) E (parallel sheets) 18 -100.0 121.2 96.51 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 131 3.8 L654-T659; PAE: 2.0 655 F Phenylalanine Aromatic Beta strand B (strand) E (parallel sheets) 31 -98.7 102.3 95.32 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 165 2.8 F655-Y400 (PDB: 1IJQ); F655-Y400 (PDB: 3M0C) F655-Y400; PAE: 1.0 F655-Y400 (PDB: 1IJQ); F655-Y400 (PDB: 3M0C) F655-Y400; PAE: 1.0 656 H Histidine Positively-charged Beta strand C (loop/coil) C (loop/coil) 5 -157.4 150.3 94.85 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 155 -3.2 H656-G396 (PDB: 3M0C) H656-S397; PAE: 3.5 H656-G396 (PDB: 3M0C) H656-S397; PAE: 3.5 657 N Asparagine Polar/Neutral Helix C (loop/coil) T (turn) 89 -65.3 -29.5 91.45 Low-density lipoprotein receptor N-linked (GlcNAc...) asparagine LDL-receptor class B 6 Extracellular 132 -3.5 N657-S397; PAE: 6.0 N657-V436 (PDB: 1IJQ); N657-V436 (PDB: 3M0C) N657-S397; PAE: 6.0 658 L Leucine Aliphatic Helix C (loop/coil) T (turn) 45 -78.9 -15.8 91.18 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 131 3.8 Pocket 2: Mean pLDDT: 89.82, Volume: 512.1 ų, Druggability score: 0.1 0.0983 659 T Threonine Polar/Neutral Helix C (loop/coil) T (turn) 41 -78.5 -21.1 91.36 Low-density lipoprotein receptor Extracellular 119 -0.7 Pocket 2: Mean pLDDT: 89.82, Volume: 512.1 ų, Druggability score: 0.1 0.0983 T659-L654; PAE: 2.0 660 Q Glutamine Polar/Neutral C (loop/coil) S (bend) 20 -121.8 75.9 94.09 Low-density lipoprotein receptor Extracellular 146 -3.5 Q660-V436, Q660-T434 (PDB: 1IJQ); Q660-V436, Q660-T434 (PDB: 3M0C) Q660-V436, Q660-T434; PAE: 2.0, 1.5 Q660-W483 (PDB: 1IJQ); Q660-W483 (PDB: 3M0C) Q660-W483; PAE: 1.5 661 P Proline Special, No backbone hydrogen C (loop/coil) C (loop/coil) 42 -59.9 148.7 90.72 Low-density lipoprotein receptor Extracellular 115 1.6 P661-W483 (PDB: 1IJQ); P661-W483 (PDB: 3M0C) P661-W483; PAE: 2.0 662 R Arginine Positively-charged C (loop/coil) C (loop/coil) 251 -70.7 125.8 89.31 Low-density lipoprotein receptor Extracellular 175 -4.5 663 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible C (loop/coil) C (loop/coil) 38 -125.8 -175.4 88.41 Low-density lipoprotein receptor EGF-like 3 Extracellular 75 -0.4 G663-I484 (PDB: 1IJQ) G663-I484; PAE: 2.0 664 V Valine Aliphatic C (loop/coil) C (loop/coil) 65 -94.2 117.1 91.56 Low-density lipoprotein receptor EGF-like 3 Extracellular 117 4.2 V664-R669 (PDB: 3M0C) 665 N Asparagine Polar/Neutral C (loop/coil) C (loop/coil) 25 -70.0 102.8 93.68 Low-density lipoprotein receptor EGF-like 3 Extracellular 132 -3.5 N665-I484 (PDB: 3M0C) N665-R669; PAE: 3.0 N665-I484, N665-R669, N665-H485 (PDB: 1IJQ); N665-I484, N665-R669, N665-P526, N665-H485 (PDB: 3M0C) N665-I484, N665-R669, N665-H485; PAE: 2.0, 3.0, 1.5 666 W Tryptophan Aromatic C (loop/coil) T (turn) 80 -71.1 -23.7 90.32 Low-density lipoprotein receptor EGF-like 3 Extracellular 204 -0.9 W666-H485 (PDB: 1IJQ) W666-K693, W666-H485 (PDB: 1IJQ); W666-V527 (PDB: 3M0C) W666-H485; PAE: 2.0 667 C Cysteine Special, a very reactive sulfhydryl group C (loop/coil) T (turn) 6 -71.6 -32.3 90.94 Low-density lipoprotein receptor Disulfide bond 667-681 EGF-like 3 Extracellular 121 2.5 C667-G675 (PDB: 1IJQ); C667-G675, C667-H485 (PDB: 3M0C) C667-G675; PAE: 2.5 C667-G675, C667-N674 (PDB: 1IJQ); C667-G675, C667-N674, C667-H485 (PDB: 3M0C) C667-G675; PAE: 2.5 C667-C681 (PDB: 3M0C) C667-C681; PAE: 2.5 668 E Glutamic Acid Negatively-charged Beta strand C (loop/coil) T (turn) 147 -94.8 -17.4 89.92 Low-density lipoprotein receptor EGF-like 3 Extracellular 146 -3.5 E668-N674 (PDB: 1IJQ); E668-N674 (PDB: 3M0C) 669 R Arginine Positively-charged Beta strand C (loop/coil) S (bend) 178 -65.8 -25.2 87.1 Low-density lipoprotein receptor EGF-like 3 Extracellular 175 -4.5 R669-N665; PAE: 3.0 R669-N665 (PDB: 1IJQ); R669-N665, R669-V664 (PDB: 3M0C) R669-N665; PAE: 3.0 670 T Threonine Polar/Neutral Beta strand C (loop/coil) S (bend) 46 -76.7 156.9 84.49 Low-density lipoprotein receptor EGF-like 3 Extracellular 119 -0.7 671 T Threonine Polar/Neutral Beta strand C (loop/coil) S (bend) 152 -66.3 -12.3 84.87 Low-density lipoprotein receptor EGF-like 3 Extracellular 119 -0.7 672 L Leucine Aliphatic Beta strand C (loop/coil) S (bend) 92 -97.1 134.7 86.45 Low-density lipoprotein receptor EGF-like 3 Extracellular 131 3.8 L672-G676 (PDB: 1IJQ); L672-G676 (PDB: 3M0C) L672-G676; PAE: 3.5 673 S Serine Polar/Neutral Helix H (helix) G (3₁₀-helix) 116 -56.0 137.8 88.84 Low-density lipoprotein receptor EGF-like 3 Extracellular 105 -0.8 674 N Asparagine Polar/Neutral Helix H (helix) G (3₁₀-helix) 45 55.4 39.0 91.03 Low-density lipoprotein receptor EGF-like 3 Extracellular 132 -3.5 N674-Y679 (PDB: 1IJQ); N674-Y679 (PDB: 3M0C) N674-Y679; PAE: 2.5 N674-E668, N674-C667 (PDB: 1IJQ); N674-E668, N674-C667 (PDB: 3M0C) N674-C681; PAE: 2.0 675 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible Helix H (helix) G (3₁₀-helix) 0 67.0 2.0 87.7 Low-density lipoprotein receptor EGF-like 3 Extracellular 75 -0.4 G675-C667 (PDB: 1IJQ); G675-C667 (PDB: 3M0C) G675-C667, G675-R709; PAE: 2.5, 2.5 G675-C667 (PDB: 1IJQ); G675-C667 (PDB: 3M0C) G675-C667; PAE: 2.5 676 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible Helix H (helix) G (3₁₀-helix) 21 76.7 22.8 90.95 Low-density lipoprotein receptor EGF-like 3 Extracellular 75 -0.4 G676-L672 (PDB: 1IJQ); G676-L672 (PDB: 3M0C) G676-L672, G676-R709; PAE: 3.5, 2.0 677 C Cysteine Special, a very reactive sulfhydryl group C (loop/coil) C (loop/coil) 10 -85.8 137.1 93.63 Low-density lipoprotein receptor Disulfide bond 677-696 EGF-like 3 Extracellular 121 2.5 C677-C696; PAE: 2.5 C677-C696 (PDB: 3M0C) C677-C696; PAE: 2.5 678 Q Glutamine Polar/Neutral Beta strand C (loop/coil) S (bend) 122 -66.1 -33.9 93.33 Low-density lipoprotein receptor EGF-like 3 Extracellular 146 -3.5 Q678-R709, Q678-C711 (PDB: 1IJQ); Q678-R709, Q678-C711 (PDB: 3M0C) Q678-R709, Q678-C711; PAE: 2.0, 2.5 Q678-C711 (PDB: 1IJQ); Q678-C711 (PDB: 3M0C) Q678-C711; PAE: 2.5 679 Y Tyrosine Aromatic Beta strand C (loop/coil) S (bend) 50 -123.8 -97.0 94.35 Low-density lipoprotein receptor EGF-like 3 Extracellular 181 -1.3 Y679-R508, Y679-N674 (PDB: 1IJQ); Y679-R508, Y679-N674 (PDB: 3M0C) Y679-K507, Y679-R508, Y679-N674; PAE: 1.0, 2.0, 2.5 Y679-K507 (PDB: 1IJQ); Y679-K507 (PDB: 3M0C) Y679-K507; PAE: 1.0 680 L Leucine Aliphatic Beta strand B (strand) E (parallel sheets) 4 -96.8 142.0 95.23 Low-density lipoprotein receptor EGF-like 3 Extracellular 131 3.8 L680-A697 (PDB: 1IJQ); L680-A697 (PDB: 3M0C) L680-A697; PAE: 1.0 L680-A697 (PDB: 1IJQ); L680-A697 (PDB: 3M0C) L680-A697; PAE: 1.0 681 C Cysteine Special, a very reactive sulfhydryl group Beta strand B (strand) E (parallel sheets) 4 -113.8 113.5 95.38 Low-density lipoprotein receptor Disulfide bond 667-681 EGF-like 3 Extracellular 121 2.5 C681-N674; PAE: 2.0 C681-C667 (PDB: 3M0C) C681-C667; PAE: 2.5 682 L Leucine Aliphatic Beta strand B (strand) E (parallel sheets) 0 -114.6 137.6 96.48 Low-density lipoprotein receptor EGF-like 3 Extracellular 131 3.8 L682-T695 (PDB: 1IJQ); L682-T695 (PDB: 3M0C) L682-T695; PAE: 1.0 L682-T695 (PDB: 1IJQ); L682-T695 (PDB: 3M0C) L682-T695; PAE: 1.0 683 P Proline Special, No backbone hydrogen Beta strand B (strand) E (parallel sheets) 3 -60.0 141.3 95.08 Low-density lipoprotein receptor EGF-like 3 Extracellular 115 1.6 684 A Alanine Aliphatic H (helix) P (polyproline helix) 2 -102.1 148.0 93.93 Low-density lipoprotein receptor EGF-like 3 Extracellular 89 1.8 A684-K693 (PDB: 1IJQ); A684-K693 (PDB: 3M0C) A684-K693; PAE: 1.5 A684-F694 (PDB: 1IJQ) 685 P Proline Special, No backbone hydrogen H (helix) P (polyproline helix) 7 -64.7 127.3 93.92 Low-density lipoprotein receptor EGF-like 3 Extracellular 115 1.6 P685-S691; PAE: 2.0 P685-S691 (PDB: 1IJQ); P685-S691 (PDB: 3M0C) P685-S691; PAE: 2.0 686 Q Glutamine Polar/Neutral C (loop/coil) C (loop/coil) 45 -82.4 60.2 90.34 Low-density lipoprotein receptor EGF-like 3 Extracellular 146 -3.5 Q686-H528, Q686-K693, Q686-P692 (PDB: 1IJQ); Q686-K693, Q686-P692 (PDB: 3M0C) Q686-H528, Q686-K693, Q686-P692; PAE: 2.0, 2.5, 2.0 Q686-H528, Q686-K693, Q686-F530 (PDB: 1IJQ); Q686-K693 (PDB: 3M0C) Q686-H528, Q686-K693; PAE: 2.0, 2.5 687 I Isoleucine Aliphatic C (loop/coil) S (bend) 94 -63.7 -38.9 87.56 Low-density lipoprotein receptor EGF-like 3 Extracellular 131 4.5 I687-S691 (PDB: 1IJQ); I687-S691 (PDB: 3M0C) I687-S691 (PDB: 1IJQ); I687-S691 (PDB: 3M0C) I687-S691; PAE: 3.0 688 N Asparagine Polar/Neutral C (loop/coil) S (bend) 77 -142.8 166.4 87.21 Low-density lipoprotein receptor EGF-like 3 Extracellular 132 -3.5 689 P Proline Special, No backbone hydrogen C (loop/coil) T (turn) 117 -59.9 -18.4 85.74 Low-density lipoprotein receptor EGF-like 3 Extracellular 115 1.6 690 H Histidine Positively-charged C (loop/coil) T (turn) 176 -96.7 -1.0 87.95 Low-density lipoprotein receptor EGF-like 3 Extracellular 155 -3.2 691 S Serine Polar/Neutral C (loop/coil) S (bend) 15 -57.4 139.0 89.18 Low-density lipoprotein receptor EGF-like 3 Extracellular 105 -0.8 S691-I687 (PDB: 1IJQ); S691-I687 (PDB: 3M0C) S691-P685; PAE: 2.0 S691-I687, S691-P685 (PDB: 1IJQ); S691-P685, S691-I687 (PDB: 3M0C) S691-I687, S691-P685; PAE: 3.0, 2.0 692 P Proline Special, No backbone hydrogen C (loop/coil) C (loop/coil) 76 -57.3 146.4 91.15 Low-density lipoprotein receptor EGF-like 3 Extracellular 115 1.6 P692-Q686 (PDB: 1IJQ); P692-Q686 (PDB: 3M0C) P692-Q686; PAE: 2.0 693 K Lysine Positively-charged Beta strand C (loop/coil) S (bend) 84 -77.0 -34.3 91.02 Low-density lipoprotein receptor EGF-like 3 Extracellular 147 -3.9 K693-A684, K693-Q686 (PDB: 1IJQ); K693-A684, K693-Q686 (PDB: 3M0C) K693-A684, K693-Q686; PAE: 1.5, 2.5 K693-W666, K693-Q686 (PDB: 1IJQ); K693-Q686 (PDB: 3M0C) K693-Q686; PAE: 2.5 694 F Phenylalanine Aromatic Beta strand B (strand) E (parallel sheets) 40 -147.6 162.4 93.86 Low-density lipoprotein receptor EGF-like 3 Extracellular 165 2.8 F694-A684 (PDB: 1IJQ) 695 T Threonine Polar/Neutral Beta strand B (strand) E (parallel sheets) 31 -136.1 147.5 93.98 Low-density lipoprotein receptor EGF-like 3 Extracellular 119 -0.7 T695-L682, T695-N548 (PDB: 1IJQ); T695-L682, T695-N548 (PDB: 3M0C) T695-L682, T695-N548; PAE: 1.0, 2.0 T695-L682, T695-N548 (PDB: 1IJQ); T695-L682, T695-N548 (PDB: 3M0C) T695-L682, T695-N548; PAE: 1.0, 2.0 696 C Cysteine Special, a very reactive sulfhydryl group Beta strand B (strand) E (parallel sheets) 13 -82.9 140.3 94.99 Low-density lipoprotein receptor Disulfide bond 677-696 EGF-like 3 Extracellular 121 2.5 C696-C677; PAE: 2.5 C696-C677 (PDB: 3M0C) C696-C677; PAE: 2.5 697 A Alanine Aliphatic Beta strand B (strand) E (parallel sheets) 10 -125.5 137.9 94.7 Low-density lipoprotein receptor EGF-like 3 Extracellular 89 1.8 A697-L680 (PDB: 1IJQ); A697-L680 (PDB: 3M0C) A697-L680; PAE: 1.0 A697-L680 (PDB: 1IJQ); A697-L680 (PDB: 3M0C) A697-L680; PAE: 1.0 698 C Cysteine Special, a very reactive sulfhydryl group H (helix) P (polyproline helix) 4 -103.5 157.8 94.88 Low-density lipoprotein receptor Disulfide bond 698-711 EGF-like 3 Extracellular 121 2.5 C698-K509 (PDB: 1IJQ); C698-K509 (PDB: 3M0C) C698-K509; PAE: 1.5 C698-L704 (PDB: 1IJQ); C698-L704 (PDB: 3M0C) C698-C711 (PDB: 3M0C) C698-C711; PAE: 2.5 699 P Proline Special, No backbone hydrogen H (helix) P (polyproline helix) 28 -55.2 159.7 93.66 Low-density lipoprotein receptor EGF-like 3 Extracellular 115 1.6 700 D Aspartic Acid Negatively-charged C (loop/coil) T (turn) 82 -60.8 133.7 91.61 Low-density lipoprotein receptor EGF-like 3 Extracellular 132 -3.5 D700-T510 (PDB: 1IJQ); D700-T510 (PDB: 3M0C) D700-T510; PAE: 2.0 D700-K509 (PDB: 3M0C) 701 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible C (loop/coil) T (turn) 57 84.3 -1.8 88.88 Low-density lipoprotein receptor EGF-like 3 Extracellular 75 -0.4 702 M Methionine Aliphatic B (strand) E (parallel sheets) 56 -111.4 146.8 93.43 Low-density lipoprotein receptor EGF-like 3 Extracellular 149 1.9 M702-T713, M702-L712 (PDB: 1IJQ); M702-L712 (PDB: 3M0C) M702-T713; PAE: 2.0 703 L Leucine Aliphatic B (strand) E (parallel sheets) 92 -104.6 146.3 90.64 Low-density lipoprotein receptor EGF-like 3 Extracellular 131 3.8 L703-L712 (PDB: 1IJQ); L703-L712 (PDB: 3M0C) L703-L712; PAE: 2.0 L703-L712 (PDB: 1IJQ); L703-L712 (PDB: 3M0C) L703-L712; PAE: 2.0 704 L Leucine Aliphatic B (strand) E (parallel sheets) 59 -73.6 131.0 90.52 Low-density lipoprotein receptor EGF-like 3 Extracellular 131 3.8 L704-R709, L704-C698 (PDB: 1IJQ); L704-C698 (PDB: 3M0C) L704-R709; PAE: 2.0 705 A Alanine Aliphatic C (loop/coil) C (loop/coil) 13 -69.4 169.4 88.72 Low-density lipoprotein receptor EGF-like 3 Extracellular 89 1.8 A705-S710 (PDB: 1IJQ); A705-S710 (PDB: 3M0C) A705-S710; PAE: 3.5 706 R Arginine Positively-charged C (loop/coil) T (turn) 183 -63.7 -18.0 88.44 Low-density lipoprotein receptor EGF-like 3 Extracellular 175 -4.5 R706-T724; PAE: 11.5 707 D Aspartic Acid Negatively-charged C (loop/coil) T (turn) 78 -76.8 -4.5 88.54 Low-density lipoprotein receptor EGF-like 3 Extracellular 132 -3.5 708 M Methionine Aliphatic Beta strand C (loop/coil) S (bend) 116 59.3 23.1 88.86 Low-density lipoprotein receptor EGF-like 3 Extracellular 149 1.9 709 R Arginine Positively-charged Beta strand C (loop/coil) S (bend) 88 -137.3 -41.7 90.89 Low-density lipoprotein receptor EGF-like 3 Extracellular 175 -4.5 R709-Q678 (PDB: 1IJQ); R709-Q678 (PDB: 3M0C) R709-G675, R709-Q678; PAE: 2.5, 2.0 R709-L704 (PDB: 1IJQ) R709-G676, R709-L704; PAE: 2.0, 2.0 710 S Serine Polar/Neutral Beta strand C (loop/coil) C (loop/coil) 41 -91.2 153.7 92.96 Low-density lipoprotein receptor EGF-like 3 Extracellular 105 -0.8 S710-A705 (PDB: 1IJQ); S710-A705 (PDB: 3M0C) S710-A705; PAE: 3.5 711 C Cysteine Special, a very reactive sulfhydryl group Beta strand B (strand) E (parallel sheets) 11 -107.8 128.3 93.42 Low-density lipoprotein receptor Disulfide bond 698-711 EGF-like 3 Extracellular 121 2.5 C711-Q678 (PDB: 1IJQ); C711-Q678 (PDB: 3M0C) C711-Q678; PAE: 2.5 C711-Q678 (PDB: 1IJQ); C711-Q678 (PDB: 3M0C) C711-Q678; PAE: 2.5 C711-C698 (PDB: 3M0C) C711-C698; PAE: 2.5 712 L Leucine Aliphatic Beta strand B (strand) E (parallel sheets) 49 -112.7 141.0 92.69 Low-density lipoprotein receptor EGF-like 3 Extracellular 131 3.8 L712-L703 (PDB: 1IJQ); L712-L703 (PDB: 3M0C) L712-L703; PAE: 2.0 L712-M702, L712-L703 (PDB: 1IJQ); L712-M702, L712-L703 (PDB: 3M0C) L712-L703; PAE: 2.0 713 T Threonine Polar/Neutral Beta strand B (strand) E (parallel sheets) 55 -66.3 157.5 89.65 Low-density lipoprotein receptor Extracellular 119 -0.7 Morphology: RDMRSCLtEAEAAVA T713-A717; PAE: 4.0 T713-M702 (PDB: 1IJQ) T713-A717, T713-M702; PAE: 4.0, 2.0 714 E Glutamic Acid Negatively-charged H (helix) H (α-helix) 135 -54.3 -35.1 81.27 Low-density lipoprotein receptor Extracellular 146 -3.5 dbSNP: rs869320652; Variant type: LP/P; AA change: Glu714Lys; PTM type: Phosphorylation; PTM morphology: MRSCLtE*AEAA; Var class: II E714-A718; PAE: 2.5 E714-A718; PAE: 2.5 715 A Alanine Aliphatic H (helix) H (α-helix) 71 -66.1 -45.1 81.82 Low-density lipoprotein receptor Extracellular 89 1.8 A715-V719; PAE: 3.5 A715-V719; PAE: 3.5 716 E Glutamic Acid Negatively-charged H (helix) H (α-helix) 98 -67.7 -37.4 81.98 Low-density lipoprotein receptor Extracellular 146 -3.5 E716-A720; PAE: 4.5 E716-A720; PAE: 4.5 717 A Alanine Aliphatic H (helix) H (α-helix) 22 -63.5 -38.4 74.48 Low-density lipoprotein receptor Extracellular 89 1.8 A717-T713, A717-T721; PAE: 4.0, 5.0 A717-T713, A717-T721; PAE: 4.0, 5.0 718 A Alanine Aliphatic H (helix) H (α-helix) 52 -64.5 -35.2 75.57 Low-density lipoprotein receptor Extracellular 89 1.8 A718-E714; PAE: 2.5 A718-E714, A718-Q722; PAE: 2.5, 6.0 719 V Valine Aliphatic H (helix) H (α-helix) 83 -72.6 -44.6 76.63 Low-density lipoprotein receptor Extracellular 117 4.2 V719-E723, V719-A715; PAE: 6.0, 3.5 V719-E723, V719-A715; PAE: 6.0, 3.5 720 A Alanine Aliphatic H (helix) H (α-helix) 39 -61.2 -30.6 65.35 Low-density lipoprotein receptor Extracellular 89 1.8 A720-E716; PAE: 4.5 A720-T724, A720-E716; PAE: 7.0, 4.5 721 T Threonine Polar/Neutral H (helix) H (α-helix) 76 -73.2 -35.3 62.54 Low-density lipoprotein receptor Clustered O-linked oligosaccharides Extracellular 119 -0.7 Morphology: EAEAAVAtQEtstVR T721-A717; PAE: 5.0 T721-S725, T721-A717; PAE: 6.5, 5.0 722 Q Glutamine Polar/Neutral H (helix) H (α-helix) 136 -70.1 -35.7 59.34 Low-density lipoprotein receptor Clustered O-linked oligosaccharides Extracellular 146 -3.5 Q722-T726; PAE: 6.5 Q722-T726, Q722-A718; PAE: 6.5, 6.0 723 E Glutamic Acid Negatively-charged H (helix) H (α-helix) 123 -64.7 -34.7 55.77 Low-density lipoprotein receptor Clustered O-linked oligosaccharides Extracellular 146 -3.5 E723-V719, E723-V727; PAE: 6.0, 7.0 E723-V719, E723-V727; PAE: 6.0, 7.0 724 T Threonine Polar/Neutral H (helix) H (α-helix) 65 -72.1 -25.5 52.7 Low-density lipoprotein receptor Phosphothreonine Clustered O-linked oligosaccharides Extracellular 119 -0.7 Morphology: AAVAtQEtstVRLkV T724-R706; PAE: 11.5 T724-A720; PAE: 7.0 725 S Serine Polar/Neutral H (helix) H (α-helix) 87 -76.8 -31.2 50.71 Low-density lipoprotein receptor Clustered O-linked oligosaccharides Extracellular 105 -0.8 Morphology: AVAtQEtstVRLkVs S725-T721; PAE: 6.5 726 T Threonine Polar/Neutral H (helix) H (α-helix) 95 -83.5 -23.6 45.95 Low-density lipoprotein receptor Clustered O-linked oligosaccharides Extracellular 119 -0.7 Morphology: VAtQEtstVRLkVss dbSNP: rs45508991; Variant type: LP/P; AA change: Thr726Ile; PTM type: Phosphorylation; PTM morphology: VAtQEtst*VRL; Var class: II&rs45508991 T726-Q722; PAE: 6.5 T726-Q722; PAE: 6.5 727 V Valine Aliphatic C (loop/coil) T (turn) 122 -71.2 -15.3 43.93 Low-density lipoprotein receptor Clustered O-linked oligosaccharides Extracellular 117 4.2 V727-E723; PAE: 7.0 V727-E723; PAE: 7.0 728 R Arginine Positively-charged C (loop/coil) T (turn) 231 -87.5 1.1 38.58 Low-density lipoprotein receptor Clustered O-linked oligosaccharides Extracellular 175 -4.5 729 L Leucine Aliphatic C (loop/coil) C (loop/coil) 150 -116.3 55.3 39.48 Low-density lipoprotein receptor Clustered O-linked oligosaccharides Extracellular 131 3.8 730 K Lysine Positively-charged C (loop/coil) C (loop/coil) 203 -140.9 64.1 30.68 Low-density lipoprotein receptor Clustered O-linked oligosaccharides Extracellular 147 -3.9 Morphology: EtstVRLkVsstAVR 731 V Valine Aliphatic C (loop/coil) S (bend) 149 -131.9 134.0 35.15 Low-density lipoprotein receptor Clustered O-linked oligosaccharides Extracellular 117 4.2 732 S Serine Polar/Neutral C (loop/coil) C (loop/coil) 106 -65.6 142.5 32.97 Low-density lipoprotein receptor Clustered O-linked oligosaccharides Extracellular 105 -0.8 Morphology: stVRLkVsstAVRtQ 733 S Serine Polar/Neutral C (loop/coil) C (loop/coil) 111 -61.9 118.1 30.05 Low-density lipoprotein receptor Clustered O-linked oligosaccharides Extracellular 105 -0.8 Morphology: tVRLkVsstAVRtQH 734 T Threonine Polar/Neutral C (loop/coil) C (loop/coil) 139 -127.3 115.8 30.84 Low-density lipoprotein receptor Polar residues Clustered O-linked oligosaccharides; Disordered Extracellular 119 -0.7 Morphology: VRLkVsstAVRtQHt 735 A Alanine Aliphatic C (loop/coil) C (loop/coil) 102 -67.2 128.1 26.82 Low-density lipoprotein receptor Polar residues Clustered O-linked oligosaccharides; Disordered Extracellular 89 1.8 736 V Valine Aliphatic C (loop/coil) C (loop/coil) 147 -133.3 127.5 30.1 Low-density lipoprotein receptor Polar residues Clustered O-linked oligosaccharides; Disordered Extracellular 117 4.2 737 R Arginine Positively-charged C (loop/coil) C (loop/coil) 222 -87.5 136.9 22.03 Low-density lipoprotein receptor Polar residues Clustered O-linked oligosaccharides; Disordered Extracellular 175 -4.5 738 T Threonine Polar/Neutral C (loop/coil) C (loop/coil) 111 162.7 127.1 25.27 Low-density lipoprotein receptor Polar residues Clustered O-linked oligosaccharides; Disordered Extracellular 119 -0.7 Morphology: VsstAVRtQHtttRP 739 Q Glutamine Polar/Neutral C (loop/coil) C (loop/coil) 173 63.6 115.1 26.2 Low-density lipoprotein receptor Polar residues Clustered O-linked oligosaccharides; Disordered Extracellular 146 -3.5 740 H Histidine Positively-charged C (loop/coil) C (loop/coil) 183 72.4 100.6 23.62 Low-density lipoprotein receptor Polar residues Clustered O-linked oligosaccharides; Disordered Extracellular 155 -3.2 741 T Threonine Polar/Neutral C (loop/coil) C (loop/coil) 131 -166.8 101.8 28.8 Low-density lipoprotein receptor Polar residues Clustered O-linked oligosaccharides; Disordered Extracellular 119 -0.7 Morphology: tAVRtQHtttRPVPD 742 T Threonine Polar/Neutral C (loop/coil) C (loop/coil) 113 61.4 124.9 23.2 Low-density lipoprotein receptor Polar residues Clustered O-linked oligosaccharides; Disordered Extracellular 119 -0.7 Morphology: AVRtQHtttRPVPDT 743 T Threonine Polar/Neutral C (loop/coil) C (loop/coil) 128 81.1 116.1 25.72 Low-density lipoprotein receptor Polar residues Clustered O-linked oligosaccharides; Disordered Extracellular 119 -0.7 Morphology: VRtQHtttRPVPDTs 744 R Arginine Positively-charged C (loop/coil) C (loop/coil) 234 93.9 154.3 26.9 Low-density lipoprotein receptor Polar residues Clustered O-linked oligosaccharides; Disordered Extracellular 175 -4.5 745 P Proline Special, No backbone hydrogen C (loop/coil) C (loop/coil) 110 -140.7 178.1 34.7 Low-density lipoprotein receptor Clustered O-linked oligosaccharides; Disordered Extracellular 115 1.6 746 V Valine Aliphatic C (loop/coil) C (loop/coil) 116 -37.3 154.2 23.93 Low-density lipoprotein receptor Clustered O-linked oligosaccharides; Disordered Extracellular 117 4.2 747 P Proline Special, No backbone hydrogen C (loop/coil) C (loop/coil) 129 -114.2 126.5 31.03 Low-density lipoprotein receptor Clustered O-linked oligosaccharides; Disordered Extracellular 115 1.6 748 D Aspartic Acid Negatively-charged C (loop/coil) C (loop/coil) 134 -79.2 151.3 22.61 Low-density lipoprotein receptor Clustered O-linked oligosaccharides; Disordered Extracellular 132 -3.5 749 T Threonine Polar/Neutral C (loop/coil) C (loop/coil) 146 -167.7 117.1 29.0 Low-density lipoprotein receptor Clustered O-linked oligosaccharides; Disordered Extracellular 119 -0.7 750 S Serine Polar/Neutral C (loop/coil) C (loop/coil) 99 -87.6 151.7 22.66 Low-density lipoprotein receptor Clustered O-linked oligosaccharides; Disordered Extracellular 105 -0.8 Morphology: tRPVPDTsRLPGATP 751 R Arginine Positively-charged C (loop/coil) C (loop/coil) 250 -164.2 113.3 26.69 Low-density lipoprotein receptor Clustered O-linked oligosaccharides; Disordered Extracellular 175 -4.5 752 L Leucine Aliphatic C (loop/coil) C (loop/coil) 160 -62.8 171.6 24.64 Low-density lipoprotein receptor Clustered O-linked oligosaccharides; Disordered Extracellular 131 3.8 753 P Proline Special, No backbone hydrogen C (loop/coil) C (loop/coil) 122 -139.3 179.7 29.61 Low-density lipoprotein receptor Clustered O-linked oligosaccharides; Disordered Extracellular 115 1.6 754 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible C (loop/coil) C (loop/coil) 70 110.8 101.9 21.09 Low-density lipoprotein receptor Clustered O-linked oligosaccharides; Disordered Extracellular 75 -0.4 755 A Alanine Aliphatic C (loop/coil) C (loop/coil) 106 162.1 129.5 26.42 Low-density lipoprotein receptor Clustered O-linked oligosaccharides; Disordered Extracellular 89 1.8 756 T Threonine Polar/Neutral C (loop/coil) C (loop/coil) 134 -75.1 -168.6 23.68 Low-density lipoprotein receptor Clustered O-linked oligosaccharides Extracellular 119 -0.7 757 P Proline Special, No backbone hydrogen C (loop/coil) C (loop/coil) 125 -137.1 -178.5 38.12 Low-density lipoprotein receptor Clustered O-linked oligosaccharides Extracellular 115 1.6 758 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible C (loop/coil) C (loop/coil) 76 131.8 103.3 24.33 Low-density lipoprotein receptor Clustered O-linked oligosaccharides Extracellular 75 -0.4 759 L Leucine Aliphatic C (loop/coil) C (loop/coil) 181 -127.3 118.2 25.44 Low-density lipoprotein receptor Clustered O-linked oligosaccharides Extracellular 131 3.8 760 T Threonine Polar/Neutral C (loop/coil) C (loop/coil) 127 -114.2 126.1 23.98 Low-density lipoprotein receptor Clustered O-linked oligosaccharides Extracellular 119 -0.7 761 T Threonine Polar/Neutral C (loop/coil) C (loop/coil) 143 48.9 120.5 22.55 Low-density lipoprotein receptor Clustered O-linked oligosaccharides Extracellular 119 -0.7 762 V Valine Aliphatic H (helix) P (polyproline helix) 129 -85.2 127.8 22.91 Low-density lipoprotein receptor Clustered O-linked oligosaccharides Extracellular 117 4.2 763 E Glutamic Acid Negatively-charged H (helix) P (polyproline helix) 190 -101.4 131.4 24.28 Low-density lipoprotein receptor Clustered O-linked oligosaccharides Extracellular 146 -3.5 764 I Isoleucine Aliphatic H (helix) P (polyproline helix) 147 -87.9 127.1 20.4 Low-density lipoprotein receptor Clustered O-linked oligosaccharides Extracellular 131 4.5 765 V Valine Aliphatic C (loop/coil) C (loop/coil) 135 -128.6 109.3 23.98 Low-density lipoprotein receptor Clustered O-linked oligosaccharides Extracellular 117 4.2 766 T Threonine Polar/Neutral C (loop/coil) C (loop/coil) 116 -73.5 149.3 18.89 Low-density lipoprotein receptor Clustered O-linked oligosaccharides Extracellular 119 -0.7 767 M Methionine Aliphatic C (loop/coil) C (loop/coil) 170 179.4 99.1 24.12 Low-density lipoprotein receptor Clustered O-linked oligosaccharides Extracellular 149 1.9 768 S Serine Polar/Neutral C (loop/coil) C (loop/coil) 97 82.2 121.4 25.47 Low-density lipoprotein receptor Clustered O-linked oligosaccharides Extracellular 105 -0.8 769 H Histidine Positively-charged C (loop/coil) C (loop/coil) 184 -61.1 157.3 22.33 Low-density lipoprotein receptor Extracellular 155 -3.2 770 Q Glutamine Polar/Neutral C (loop/coil) C (loop/coil) 194 141.1 145.7 25.37 Low-density lipoprotein receptor Extracellular 146 -3.5 771 A Alanine Aliphatic C (loop/coil) C (loop/coil) 85 -174.0 153.0 24.91 Low-density lipoprotein receptor Extracellular 89 1.8 772 L Leucine Aliphatic C (loop/coil) C (loop/coil) 179 30.9 136.3 21.77 Low-density lipoprotein receptor Extracellular 131 3.8 773 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible C (loop/coil) C (loop/coil) 65 127.2 119.4 22.81 Low-density lipoprotein receptor Extracellular 75 -0.4 774 D Aspartic Acid Negatively-charged C (loop/coil) C (loop/coil) 154 78.2 100.9 25.58 Low-density lipoprotein receptor Extracellular 132 -3.5 775 V Valine Aliphatic C (loop/coil) C (loop/coil) 138 40.9 128.6 21.28 Low-density lipoprotein receptor Extracellular 117 4.2 776 A Alanine Aliphatic C (loop/coil) C (loop/coil) 103 104.9 125.7 24.36 Low-density lipoprotein receptor Extracellular 89 1.8 777 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible C (loop/coil) C (loop/coil) 76 127.1 79.3 24.9 Low-density lipoprotein receptor Extracellular 75 -0.4 778 R Arginine Positively-charged C (loop/coil) C (loop/coil) 262 26.4 124.7 21.4 Low-density lipoprotein receptor Extracellular 175 -4.5 779 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible C (loop/coil) C (loop/coil) 72 146.4 101.7 25.44 Low-density lipoprotein receptor Extracellular 75 -0.4 780 N Asparagine Polar/Neutral C (loop/coil) C (loop/coil) 146 42.7 121.3 24.42 Low-density lipoprotein receptor Extracellular 132 -3.5 781 E Glutamic Acid Negatively-charged C (loop/coil) C (loop/coil) 169 57.1 106.1 25.49 Low-density lipoprotein receptor Extracellular 146 -3.5 782 K Lysine Positively-charged C (loop/coil) C (loop/coil) 218 -157.3 133.2 32.45 Low-density lipoprotein receptor Extracellular 147 -3.9 783 K Lysine Positively-charged C (loop/coil) C (loop/coil) 203 -90.2 179.6 27.47 Low-density lipoprotein receptor Extracellular 147 -3.9 784 P Proline Special, No backbone hydrogen C (loop/coil) C (loop/coil) 113 -119.3 166.3 43.13 Low-density lipoprotein receptor Extracellular 115 1.6 785 S Serine Polar/Neutral C (loop/coil) C (loop/coil) 127 -160.6 62.5 35.76 Low-density lipoprotein receptor Extracellular 105 -0.8 786 S Serine Polar/Neutral C (loop/coil) C (loop/coil) 86 -127.3 77.3 41.23 Low-density lipoprotein receptor Extracellular 105 -0.8 787 V Valine Aliphatic C (loop/coil) S (bend) 121 -112.8 -9.8 46.19 Low-density lipoprotein receptor Extracellular 117 4.2 788 R Arginine Positively-charged C (loop/coil) S (bend) 226 -84.4 -25.2 50.38 Low-density lipoprotein receptor Extracellular 175 -4.5 789 A Alanine Aliphatic C (loop/coil) T (turn) 52 -71.3 -30.2 55.72 Low-density lipoprotein receptor Helical 89 1.8 A789-V793; PAE: 5.5 A789-V793; PAE: 5.5 790 L Leucine Aliphatic H (helix) H (α-helix) 116 -66.3 -27.2 56.5 Low-density lipoprotein receptor Helical 131 3.8 L790-L794; PAE: 4.0 L790-L794; PAE: 4.0 791 S Serine Polar/Neutral H (helix) H (α-helix) 90 -77.4 -19.7 65.91 Low-density lipoprotein receptor Helical 105 -0.8 792 I Isoleucine Aliphatic H (helix) H (α-helix) 115 -98.2 -35.5 75.3 Low-density lipoprotein receptor Helical 131 4.5 I792-I796; PAE: 2.5 793 V Valine Aliphatic H (helix) H (α-helix) 85 -69.9 -39.0 80.83 Low-density lipoprotein receptor Helical 117 4.2 V793-A789, V793-V797; PAE: 5.5, 2.0 V793-A789, V793-V797; PAE: 5.5, 2.0 794 L Leucine Aliphatic H (helix) H (α-helix) 111 -58.1 -48.7 82.92 Low-density lipoprotein receptor Helical 131 3.8 L794-L790, L794-L798; PAE: 4.0, 2.0 L794-L790, L794-L798; PAE: 4.0, 2.0 795 P Proline Special, No backbone hydrogen H (helix) H (α-helix) 70 -68.4 -33.9 85.4 Low-density lipoprotein receptor Helical 115 1.6 P795-L799; PAE: 2.0 P795-L799; PAE: 2.0 796 I Isoleucine Aliphatic H (helix) H (α-helix) 102 -65.4 -46.0 87.85 Low-density lipoprotein receptor Helical 131 4.5 I796-V800; PAE: 1.0 I796-V800, I796-I792; PAE: 1.0, 2.5 797 V Valine Aliphatic H (helix) H (α-helix) 66 -61.1 -43.7 88.63 Low-density lipoprotein receptor Helical 117 4.2 V797-V793, V797-F801; PAE: 2.0, 1.0 V797-V793, V797-F801; PAE: 2.0, 1.0 798 L Leucine Aliphatic H (helix) H (α-helix) 110 -60.2 -40.9 91.21 Low-density lipoprotein receptor Helical 131 3.8 L798-L794, L798-L802; PAE: 2.0, 1.0 L798-L794, L798-L802; PAE: 2.0, 1.0 799 L Leucine Aliphatic H (helix) H (α-helix) 113 -68.3 -39.2 92.12 Low-density lipoprotein receptor Helical 131 3.8 L799-C803, L799-P795; PAE: 1.0, 2.0 L799-C803, L799-P795; PAE: 1.0, 2.0 800 V Valine Aliphatic H (helix) H (α-helix) 79 -62.7 -44.3 92.19 Low-density lipoprotein receptor Helical 117 4.2 V800-I796, V800-L804; PAE: 1.0, 1.0 V800-I796, V800-L804; PAE: 1.0, 1.0 801 F Phenylalanine Aromatic H (helix) H (α-helix) 143 -64.3 -34.9 93.33 Low-density lipoprotein receptor Helical 165 2.8 F801-V797, F801-G805; PAE: 1.0, 1.0 F801-V797, F801-G805; PAE: 1.0, 1.0 802 L Leucine Aliphatic H (helix) H (α-helix) 119 -68.5 -43.8 93.61 Low-density lipoprotein receptor Helical 131 3.8 Pocket 3: Mean pLDDT: 93.04, Volume: 279.55 ų, Druggability score: 0.04 0.036 L802-L798, L802-V806; PAE: 1.0, 1.0 L802-L798, L802-V806; PAE: 1.0, 1.0 803 C Cysteine Special, a very reactive sulfhydryl group H (helix) H (α-helix) 76 -62.9 -43.2 91.81 Low-density lipoprotein receptor Helical 121 2.5 Pocket 3: Mean pLDDT: 93.04, Volume: 279.55 ų, Druggability score: 0.04 0.036 C803-F807, C803-L799; PAE: 1.0, 1.0 C803-F807, C803-L799; PAE: 1.0, 1.0 804 L Leucine Aliphatic H (helix) H (α-helix) 89 -62.0 -41.1 91.73 Low-density lipoprotein receptor Helical 131 3.8 L804-V800, L804-L808; PAE: 1.0, 1.0 L804-V800, L804-L808; PAE: 1.0, 1.0 805 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible H (helix) H (α-helix) 29 -62.3 -44.3 90.76 Low-density lipoprotein receptor Helical 75 -0.4 G805-L809, G805-F801; PAE: 1.0, 1.0 G805-L809, G805-F801; PAE: 1.0, 1.0 806 V Valine Aliphatic H (helix) H (α-helix) 86 -66.1 -40.8 90.85 Low-density lipoprotein receptor Helical 117 4.2 Pocket 3: Mean pLDDT: 93.04, Volume: 279.55 ų, Druggability score: 0.04 0.036 V806-L802, V806-W810; PAE: 1.0, 1.0 V806-L802, V806-W810; PAE: 1.0, 1.0 807 F Phenylalanine Aromatic H (helix) H (α-helix) 111 -64.0 -41.6 91.55 Low-density lipoprotein receptor Helical 165 2.8 Pocket 3: Mean pLDDT: 93.04, Volume: 279.55 ų, Druggability score: 0.04 0.036 F807-C803, F807-K811; PAE: 1.0, 1.0 F807-C803, F807-K811; PAE: 1.0, 1.0 808 L Leucine Aliphatic H (helix) H (α-helix) 104 -68.0 -38.4 87.48 Low-density lipoprotein receptor Helical 131 3.8 L808-N812, L808-L804; PAE: 1.5, 1.0 L808-N812, L808-L804; PAE: 1.5, 1.0 809 L Leucine Aliphatic H (helix) H (α-helix) 123 -65.0 -41.4 83.93 Low-density lipoprotein receptor Helical 131 3.8 L809-G805, L809-W813; PAE: 1.0, 2.0 L809-G805, L809-W813; PAE: 1.0, 2.0 810 W Tryptophan Aromatic H (helix) H (α-helix) 130 -65.4 -45.4 88.16 Low-density lipoprotein receptor Helical 204 -0.9 Pocket 3: Mean pLDDT: 93.04, Volume: 279.55 ų, Druggability score: 0.04 0.036 W810-V806, W810-R814; PAE: 1.0, 1.5 W810-V806, W810-R814; PAE: 1.0, 1.5 811 K Lysine Positively-charged H (helix) H (α-helix) 112 -61.6 -41.3 78.13 Low-density lipoprotein receptor Mutation: K -> R. No change. No change; when associated with R-816 and R-830. Insensitive to MYLIP-triggered degradation; when associated with R-816; R-830 and A-839. Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 147 -3.9 K811-L815, K811-F807; PAE: 2.0, 1.0 K811-L815, K811-F807; PAE: 2.0, 1.0 812 N Asparagine Polar/Neutral H (helix) H (α-helix) 90 -73.5 -34.9 78.45 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 132 -3.5 N812-L808, N812-K816; PAE: 1.5, 2.0 N812-L808, N812-K816; PAE: 1.5, 2.0 813 W Tryptophan Aromatic H (helix) H (α-helix) 155 -66.4 -40.2 78.1 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 204 -0.9 W813-L809, W813-N817; PAE: 2.0, 2.0 W813-L809, W813-N817; PAE: 2.0, 2.0 814 R Arginine Positively-charged H (helix) H (α-helix) 134 -67.7 -40.7 71.14 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 175 -4.5 R814-W810, R814-I818; PAE: 1.5, 3.5 R814-W810, R814-I818; PAE: 1.5, 3.5 815 L Leucine Aliphatic H (helix) H (α-helix) 97 -64.5 -39.2 63.67 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 131 3.8 L815-K811; PAE: 2.0 L815-N819, L815-K811; PAE: 4.0, 2.0 816 K Lysine Positively-charged H (helix) H (α-helix) 145 -67.7 -29.9 61.88 Low-density lipoprotein receptor Mutation: K -> R. No change. No change; when associated with R-830. No change; when associated with R-811 and R-830. Insensitive to MYLIP-triggered degradation; when associated with R-830 and A-839. Insensitive to MYLIP-triggered degradation; when associated with R-811; R-830 and A-839. Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 147 -3.9 K816-N812; PAE: 2.0 K816-N812; PAE: 2.0 817 N Asparagine Polar/Neutral H (helix) H (α-helix) 99 -90.9 -6.2 50.25 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 132 -3.5 N817-W813; PAE: 2.0 N817-W813; PAE: 2.0 818 I Isoleucine Aliphatic C (loop/coil) C (loop/coil) 98 -117.5 57.3 40.61 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 131 4.5 I818-R814; PAE: 3.5 I818-R814; PAE: 3.5 819 N Asparagine Polar/Neutral C (loop/coil) C (loop/coil) 124 -83.1 92.5 39.36 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 132 -3.5 N819-L815; PAE: 4.0 820 S Serine Polar/Neutral C (loop/coil) C (loop/coil) 70 49.0 98.8 35.64 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 105 -0.8 Morphology: WRLKNINsINFDNPV Q:S820-A:E44 (PDB: 3SO6) 821 I Isoleucine Aliphatic Beta strand C (loop/coil) C (loop/coil) 156 -63.8 70.2 34.06 Low-density lipoprotein receptor Mutation: I -> A. 3-fold decreased affinity for LDLRAP1.; Mutation: I -> R. 10-fold decreased affinity for LDLRAP1. Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 131 4.5 Q:I821-A:A101 (PDB: 3SO6) Q:I821-A:A101 (PDB: 3SO6) 822 N Asparagine Polar/Neutral Beta strand C (loop/coil) C (loop/coil) 129 -96.9 111.8 29.66 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 132 -3.5 Q:N822-A:Y98, Q:N822-A:T100 (PDB: 3SO6) Q:N822-A:E44 (PDB: 3SO6) 823 F Phenylalanine Aromatic Beta strand C (loop/coil) C (loop/coil) 194 -64.6 76.5 32.57 Low-density lipoprotein receptor NPXY motif Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 165 2.8 Q:F823-A:C99 (PDB: 3SO6) Q:F823-A:C99 (PDB: 3SO6) 824 D Aspartic Acid Negatively-charged Beta strand C (loop/coil) C (loop/coil) 152 -143.8 112.7 31.16 Low-density lipoprotein receptor NPXY motif Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 132 -3.5 825 N Asparagine Polar/Neutral C (loop/coil) C (loop/coil) 111 -92.7 116.9 25.94 Low-density lipoprotein receptor NPXY motif Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 132 -3.5 dbSNP: rs374045590; Variant type: LP/P; AA change: Asn825Lys; PTM type: Phosphorylation; PTM morphology: LKNINsINFDN*; Var class: II&rs374045590 Q:N825-A:I96, Q:N825-A:I93, Q:N825-A:S97 (PDB: 3SO6) Q:N825-A:I96, Q:N825-A:F145, Q:N825-A:S97 (PDB: 3SO6) 826 P Proline Special, No backbone hydrogen Turn C (loop/coil) C (loop/coil) 104 -122.6 33.6 41.28 Low-density lipoprotein receptor NPXY motif Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 115 1.6 dbSNP: rs879255217; Variant type: LP/P; AA change: Pro826Ser; PTM type: Ubiquitylation; PTM morphology: NP*VyQkTTEDE; Var class: II&rs879255217 827 V Valine Aliphatic Turn C (loop/coil) C (loop/coil) 128 -97.6 11.4 30.02 Low-density lipoprotein receptor NPXY motif Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 117 4.2 dbSNP: rs137853964; Variant type: US; AA change: Val827Ile; PTM type: Ubiquitylation; PTM morphology: NPV*yQkTTEDE; Var class: II&rs137853964 828 Y Tyrosine Aromatic Turn C (loop/coil) C (loop/coil) 207 -107.2 41.6 30.97 Low-density lipoprotein receptor NPXY motif Mutation: Y -> A. Abolishes interaction with ARRB2. Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 181 -1.3 Morphology: INFDNPVyQkTTEDE dbSNP: rs28942085; Variant type: LP/P; AA change: Tyr828Cys; PTM type: Ubiquitylation; PTM morphology: NPVy*QkTTEDE; Var class: II&rs28942085 829 Q Glutamine Polar/Neutral Turn C (loop/coil) C (loop/coil) 175 -90.7 104.7 30.79 Low-density lipoprotein receptor Mutation: Q -> A. Decreased affinity for LDLRAP1. Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 146 -3.5 Q:Q829-A:Q114, Q:Q829-A:Y94 (PDB: 3SO6) Q:Q829-A:Y94 (PDB: 3SO6) 830 K Lysine Positively-charged C (loop/coil) C (loop/coil) 202 -50.6 104.9 27.68 Low-density lipoprotein receptor Mutation: K -> R. No change. No change; when associated with R-816. No change; when associated with R-811 and R-816. Insensitive to MYLIP-triggered degradation; when associated with A-839. Insensitive to MYLIP-triggered degradation; when associated with R-816 and A-839. Insensitive to MYLIP-triggered degradation; when associated with R-811; R-816 and A-839. Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 147 -3.9 Morphology: FDNPVyQkTTEDEVH Q:K830-A:W152 (PDB: 3SO6) 831 T Threonine Polar/Neutral C (loop/coil) C (loop/coil) 120 -157.1 100.8 32.19 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 119 -0.7 832 T Threonine Polar/Neutral C (loop/coil) C (loop/coil) 122 40.6 120.2 28.51 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 119 -0.7 833 E Glutamic Acid Negatively-charged C (loop/coil) C (loop/coil) 181 83.8 89.7 32.3 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 146 -3.5 834 D Aspartic Acid Negatively-charged C (loop/coil) C (loop/coil) 170 -160.0 129.3 32.61 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 132 -3.5 835 E Glutamic Acid Negatively-charged C (loop/coil) C (loop/coil) 190 -69.2 138.9 30.26 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 146 -3.5 836 V Valine Aliphatic C (loop/coil) C (loop/coil) 124 -69.4 113.5 27.68 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 117 4.2 837 H Histidine Positively-charged C (loop/coil) C (loop/coil) 186 -82.9 101.8 28.6 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 155 -3.2 838 I Isoleucine Aliphatic C (loop/coil) C (loop/coil) 129 -81.6 104.6 28.56 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 131 4.5 839 C Cysteine Special, a very reactive sulfhydryl group C (loop/coil) C (loop/coil) 122 -91.3 112.8 24.7 Low-density lipoprotein receptor Mutation: C -> A. No change. Insensitive to MYLIP-triggered degradation; when associated with R-830. Insensitive to MYLIP-triggered degradation; when associated with R-816 and R-830. Insensitive to MYLIP-triggered degradation; when associated with R-811; R-816 and R-830. Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 121 2.5 840 H Histidine Positively-charged C (loop/coil) C (loop/coil) 171 -74.7 125.9 30.05 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 155 -3.2 841 N Asparagine Polar/Neutral C (loop/coil) C (loop/coil) 161 -118.6 147.9 31.98 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 132 -3.5 842 Q Glutamine Polar/Neutral C (loop/coil) S (bend) 195 -83.9 16.4 40.27 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 146 -3.5 843 D Aspartic Acid Negatively-charged C (loop/coil) C (loop/coil) 144 -107.3 97.6 35.91 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 132 -3.5 844 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible C (loop/coil) C (loop/coil) 81 -66.8 57.8 31.73 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 75 -0.4 dbSNP: rs121908037; Variant type: LP/P; AA change: Gly844Asp; PTM type: Phosphorylation; PTM morphology: G*ysyPsRQMVS; Var class: II&rs121908037 845 Y Tyrosine Aromatic C (loop/coil) C (loop/coil) 192 -106.4 108.3 32.9 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 181 -1.3 Morphology: ICHNQDGysyPsRQM 846 S Serine Polar/Neutral C (loop/coil) C (loop/coil) 116 -94.2 114.7 30.23 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 105 -0.8 Morphology: CHNQDGysyPsRQMV 847 Y Tyrosine Aromatic H (helix) P (polyproline helix) 196 -90.6 127.4 32.07 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 181 -1.3 Morphology: HNQDGysyPsRQMVS 848 P Proline Special, No backbone hydrogen H (helix) P (polyproline helix) 134 -71.0 117.6 32.54 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 115 1.6 dbSNP: -; Variant type: Disease; AA change: Pro848Leu; PTM type: Phosphorylation; PTM morphology: GysyP*sRQMVS; Var class: II&- 849 S Serine Polar/Neutral H (helix) P (polyproline helix) 115 -79.5 132.4 30.03 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 105 -0.8 Morphology: QDGysyPsRQMVSLE 850 R Arginine Positively-charged C (loop/coil) C (loop/coil) 208 17.8 103.8 29.79 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 175 -4.5 851 Q Glutamine Polar/Neutral C (loop/coil) C (loop/coil) 186 -94.7 104.7 29.29 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 146 -3.5 852 M Methionine Aliphatic C (loop/coil) C (loop/coil) 148 -72.3 101.4 32.51 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 149 1.9 853 V Valine Aliphatic C (loop/coil) C (loop/coil) 116 -75.8 107.8 31.6 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 117 4.2 854 S Serine Polar/Neutral C (loop/coil) C (loop/coil) 97 -63.4 119.7 32.51 Low-density lipoprotein receptor Mutation: S -> A. No effect on receptor internalization.; Mutation: S -> D. Enhances interaction with ARRB2 and receptor internalization. Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 105 -0.8 855 L Leucine Aliphatic C (loop/coil) S (bend) 166 -86.4 77.3 32.67 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 131 3.8 856 E Glutamic Acid Negatively-charged C (loop/coil) C (loop/coil) 167 -163.8 52.6 35.99 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 146 -3.5 857 D Aspartic Acid Negatively-charged C (loop/coil) C (loop/coil) 162 -151.6 71.1 35.67 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 132 -3.5 858 D Aspartic Acid Negatively-charged C (loop/coil) C (loop/coil) 167 -149.8 47.0 31.74 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 132 -3.5 859 V Valine Aliphatic C (loop/coil) C (loop/coil) 152 -145.8 85.6 32.17 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 117 4.2 860 A Alanine Aliphatic C (loop/coil) C (loop/coil) 179 -140.4 360.0 43.48 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 89 1.8