residueId AA Amino acid residues Amino acid properties Secondary structure (PDBe/SIFTS) Secondary structure (DSSP 3-state)* Secondary structure (DSSP 9-state)* Accessible surface area (Ų)* Phi angle (degrees)* Psi angle (degrees)* AlphaFold confidence (pLDDT) Active site (UniProt) Binding site (UniProt) Chain (UniProt) Coiled coil (UniProt) Compositional bias (UniProt) Cross-link (UniProt) Disulfide bond (UniProt) DNA binding (UniProt) Domain (UniProt) Glycosylation (UniProt) Initiator methionine (UniProt) Intramembrane (UniProt) Lipidation (UniProt) Modified residue (UniProt) Motif (UniProt) Mutagenesis (UniProt) Non-adjacent residues (UniProt) Non-standard residue (UniProt) Non-terminal residue (UniProt) Peptide (UniProt) Propeptide (UniProt) Region (UniProt) Repeat (UniProt) Sequence conflict (UniProt) Sequence uncertainty (UniProt) Signal (UniProt) Site (UniProt) Topological domain (UniProt) Transit peptide (UniProt) Transmembrane (UniProt) Zinc finger (UniProt) Molar mass (g/mol) Hydropathy Acetylation Disease-associated PTMs Methylation O-GalNAc O-GlcNAc Phosphorylation SNP-associated PTMs Regulatory sites Substrate genes SUMOylation Ubiquitination Pocket number (fpocket)* Druggability score (fpocket)* Intra-chain Hydrogen bond (PDB) Intra-chain Hydrogen bond (AlphaFold2) Intra-chain Non-bonded interaction (PDB) Intra-chain Non-bonded interaction (AlphaFold2) Intra-chain Disulfide bond (PDB) Intra-chain Disulfide bond (AlphaFold2) Intra-chain Salt bridge (PDB) Intra-chain Salt bridge (AlphaFold2) Inter-chain Hydrogen bond (PDB) Inter-chain Non-bonded interaction (PDB) Inter-chain Disulfide bond (PDB) Inter-chain Salt bridge (PDB) 1 M Methionine Aliphatic C (loop/coil) C (loop/coil) 247 360.0 99.4 38.67 Signal 149 1.9 2 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible C (loop/coil) C (loop/coil) 64 -75.2 141.3 40.45 Signal 75 -0.4 3 P Proline Special, No backbone hydrogen C (loop/coil) T (turn) 125 -82.3 40.8 51.92 Signal 115 1.6 Pocket 5: Mean pLDDT: 33.43, Volume: 178.62 ų, Druggability score: 0.02 0.0167 4 W Tryptophan Aromatic C (loop/coil) T (turn) 235 -103.2 3.3 43.65 Signal 204 -0.9 Pocket 5: Mean pLDDT: 33.43, Volume: 178.62 ų, Druggability score: 0.02 0.0167 5 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible C (loop/coil) S (bend) 51 -78.7 -15.8 48.71 Signal 75 -0.4 6 W Tryptophan Aromatic C (loop/coil) S (bend) 225 -87.4 -23.1 48.43 Signal 204 -0.9 7 K Lysine Positively-charged H (helix) H (α-helix) 178 -75.9 -24.7 49.62 Signal 147 -3.9 Pocket 5: Mean pLDDT: 33.43, Volume: 178.62 ų, Druggability score: 0.02 0.0167 K7-T11; PAE: 5.0 K7-T11; PAE: 5.0 8 L Leucine Aliphatic H (helix) H (α-helix) 124 -78.1 -24.6 51.98 Signal 131 3.8 L8-V12; PAE: 4.5 L8-V12; PAE: 4.5 9 R Arginine Positively-charged H (helix) H (α-helix) 206 -73.0 -33.5 51.86 Signal 175 -4.5 R9-A13; PAE: 5.0 R9-A13; PAE: 5.0 10 W Tryptophan Aromatic H (helix) H (α-helix) 196 -75.1 -34.9 50.05 Signal 204 -0.9 W10-L14; PAE: 4.5 W10-L14; PAE: 4.5 11 T Threonine Polar/Neutral H (helix) H (α-helix) 76 -71.3 -35.9 56.76 Signal 119 -0.7 T11-L15, T11-K7; PAE: 4.5, 5.0 T11-L15, T11-K7; PAE: 4.5, 5.0 12 V Valine Aliphatic H (helix) H (α-helix) 78 -72.9 -35.7 55.25 Signal 117 4.2 V12-L16, V12-L8; PAE: 4.5, 4.5 V12-L16, V12-L8; PAE: 4.5, 4.5 13 A Alanine Aliphatic H (helix) H (α-helix) 56 -66.6 -38.1 52.87 Signal 89 1.8 A13-A17, A13-R9; PAE: 5.0, 5.0 A13-A17, A13-R9; PAE: 5.0, 5.0 14 L Leucine Aliphatic H (helix) H (α-helix) 116 -70.7 -34.6 49.0 Signal 131 3.8 L14-A18, L14-W10; PAE: 5.0, 4.5 L14-A18, L14-W10; PAE: 5.0, 4.5 15 L Leucine Aliphatic H (helix) H (α-helix) 123 -72.9 -31.2 45.82 Signal 131 3.8 L15-A19, L15-T11; PAE: 5.5, 4.5 L15-A19, L15-T11; PAE: 5.5, 4.5 16 L Leucine Aliphatic H (helix) H (α-helix) 126 -76.9 -29.6 43.05 Signal 131 3.8 L16-V12; PAE: 4.5 L16-V12, L16-G20; PAE: 4.5, 6.0 17 A Alanine Aliphatic H (helix) H (α-helix) 75 -73.4 -33.8 43.35 Signal 89 1.8 A17-A13; PAE: 5.0 A17-A13; PAE: 5.0 18 A Alanine Aliphatic H (helix) H (α-helix) 85 -78.6 -16.3 42.38 Signal 89 1.8 A18-L14; PAE: 5.0 A18-L14; PAE: 5.0 19 A Alanine Aliphatic C (loop/coil) T (turn) 65 -94.7 7.7 39.06 Signal 89 1.8 A19-L15; PAE: 5.5 A19-L15; PAE: 5.5 20 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible C (loop/coil) C (loop/coil) 55 -70.4 69.1 35.64 Signal 75 -0.4 G20-L16; PAE: 6.0 21 T Threonine Polar/Neutral C (loop/coil) C (loop/coil) 111 -46.7 118.3 38.18 Signal 119 -0.7 22 A Alanine Aliphatic C (loop/coil) C (loop/coil) 95 -44.4 107.8 39.18 Low-density lipoprotein receptor Extracellular 89 1.8 23 V Valine Aliphatic C (loop/coil) C (loop/coil) 123 -65.0 85.2 38.93 Low-density lipoprotein receptor Extracellular 117 4.2 24 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible C (loop/coil) C (loop/coil) 45 -49.8 124.7 44.92 Low-density lipoprotein receptor Extracellular 75 -0.4 25 D Aspartic Acid Negatively-charged C (loop/coil) C (loop/coil) 141 -43.5 112.8 50.13 Low-density lipoprotein receptor LDL-receptor class A 1 Extracellular 132 -3.5 26 R Arginine Positively-charged C (loop/coil) C (loop/coil) 226 -66.6 115.3 59.32 Low-density lipoprotein receptor LDL-receptor class A 1 Extracellular 175 -4.5 1 interaction 27 C Cysteine Special, a very reactive sulfhydryl group C (loop/coil) C (loop/coil) 24 -47.5 150.0 74.34 Low-density lipoprotein receptor Disulfide bond 27-39 LDL-receptor class A 1 Extracellular 121 2.5 28 E Glutamic Acid Negatively-charged C (loop/coil) C (loop/coil) 145 -59.0 162.8 74.05 Low-density lipoprotein receptor LDL-receptor class A 1 Extracellular 146 -3.5 29 R Arginine Positively-charged Beta strand C (loop/coil) T (turn) 239 -58.1 -15.4 65.28 Low-density lipoprotein receptor LDL-receptor class A 1 Extracellular 175 -4.5 30 N Asparagine Polar/Neutral Beta strand C (loop/coil) T (turn) 119 -108.7 11.4 63.09 Low-density lipoprotein receptor LDL-receptor class A 1 Extracellular 132 -3.5 N30-Y42; PAE: 3.5 1 interaction N30-Y42; PAE: 3.5 31 E Glutamic Acid Negatively-charged Beta strand B (undefined) E (parallel sheets) 66 -119.6 139.9 75.25 Low-density lipoprotein receptor LDL-receptor class A 1 in Ref. 4; BAG58495 Extracellular 146 -3.5 1 interaction 2 interactions 32 F Phenylalanine Aromatic Beta strand B (undefined) E (parallel sheets) 32 -91.2 135.6 76.58 Low-density lipoprotein receptor LDL-receptor class A 1 Extracellular 165 2.8 2 interactions F32-I40; PAE: 2.0 2 interactions F32-I40; PAE: 2.0 33 Q Glutamine Polar/Neutral Beta strand B (undefined) E (parallel sheets) 97 -91.7 112.6 80.05 Low-density lipoprotein receptor LDL-receptor class A 1 Extracellular 146 -3.5 1 interaction 1 interaction 34 C Cysteine Special, a very reactive sulfhydryl group C (loop/coil) C (loop/coil) 4 -59.3 157.8 82.23 Low-density lipoprotein receptor Disulfide bond 34-52 LDL-receptor class A 1 Extracellular 121 2.5 2 interactions C34-K38; PAE: 5.0 3 interactions 35 Q Glutamine Polar/Neutral Beta strand C (loop/coil) T (turn) 173 -70.0 -22.7 79.07 Low-density lipoprotein receptor LDL-receptor class A 1 Extracellular 146 -3.5 Q35-S56; PAE: 6.5 1 interaction Q35-S56; PAE: 6.5 36 D Aspartic Acid Negatively-charged Beta strand C (loop/coil) T (turn) 70 -71.8 -9.0 78.61 Low-density lipoprotein receptor LDL-receptor class A 1 Extracellular 132 -3.5 D36-D54; PAE: 7.5 1 interaction 37 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible Beta strand C (loop/coil) S (bend) 41 90.3 -0.2 78.64 Low-density lipoprotein receptor LDL-receptor class A 1 Extracellular 75 -0.4 1 interaction 38 K Lysine Positively-charged C (loop/coil) C (loop/coil) 109 -71.3 148.0 80.73 Low-density lipoprotein receptor LDL-receptor class A 1 Extracellular 147 -3.9 Morphology: EFQCQDGkCISYKWV; Domain: Ldl_recept_a 2 interactions K38-Q53, K38-C34; PAE: 5.0, 5.0 1 interaction 39 C Cysteine Special, a very reactive sulfhydryl group Beta strand B (undefined) E (parallel sheets) 50 -102.2 127.1 81.31 Low-density lipoprotein receptor Disulfide bond 27-39 LDL-receptor class A 1 Extracellular 121 2.5 40 I Isoleucine Aliphatic Beta strand B (undefined) E (parallel sheets) 23 -118.6 155.8 73.8 Low-density lipoprotein receptor LDL-receptor class A 1 Extracellular 131 4.5 2 interactions I40-F32; PAE: 2.0 4 interactions I40-F32; PAE: 2.0 41 S Serine Polar/Neutral Beta strand B (undefined) E (parallel sheets) 38 -61.9 144.0 71.77 Low-density lipoprotein receptor LDL-receptor class A 1 Extracellular 105 -0.8 1 interaction 2 interactions 42 Y Tyrosine Aromatic Turn H (helix) G (3₁₀-helix) 132 -55.5 -19.2 69.05 Low-density lipoprotein receptor LDL-receptor class A 1 Extracellular 181 -1.3 Y42-N30; PAE: 3.5 1 interaction Y42-N30; PAE: 3.5 43 K Lysine Positively-charged Turn H (helix) G (3₁₀-helix) 154 -65.7 -20.8 62.79 Low-density lipoprotein receptor LDL-receptor class A 1 Extracellular 147 -3.9 44 W Tryptophan Aromatic Turn H (helix) G (3₁₀-helix) 53 -105.1 22.8 65.92 Low-density lipoprotein receptor LDL-receptor class A 1 Extracellular 204 -0.9 45 V Valine Aliphatic Turn C (loop/coil) S (bend) 18 -102.7 119.0 71.09 Low-density lipoprotein receptor LDL-receptor class A 1 Extracellular 117 4.2 3 interactions 46 C Cysteine Special, a very reactive sulfhydryl group Turn C (loop/coil) S (bend) 11 67.1 35.7 67.96 Low-density lipoprotein receptor Disulfide bond 46-63 LDL-receptor class A 1 Extracellular 121 2.5 1 interaction C46-C63; PAE: 6.0 47 D Aspartic Acid Negatively-charged Beta strand C (loop/coil) S (bend) 24 -89.6 -2.4 60.58 Low-density lipoprotein receptor LDL-receptor class A 1 Extracellular 132 -3.5 D47-E58; PAE: 4.0 48 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible Beta strand C (loop/coil) S (bend) 57 92.8 -2.3 63.58 Low-density lipoprotein receptor LDL-receptor class A 1 Extracellular 75 -0.4 1 interaction G48-E58; PAE: 4.0 49 S Serine Polar/Neutral Beta strand C (loop/coil) S (bend) 48 -114.8 144.6 62.2 Low-density lipoprotein receptor LDL-receptor class A 1 Extracellular 105 -0.8 50 A Alanine Aliphatic C (loop/coil) C (loop/coil) 70 -91.6 96.5 70.83 Low-density lipoprotein receptor LDL-receptor class A 1 Extracellular 89 1.8 1 interaction 51 E Glutamic Acid Negatively-charged Beta strand C (loop/coil) C (loop/coil) 56 -78.4 -33.4 68.86 Low-density lipoprotein receptor LDL-receptor class A 1 Extracellular 146 -3.5 2 interactions E51-D57, E51-K376; PAE: 5.0, 29.5 52 C Cysteine Special, a very reactive sulfhydryl group Beta strand C (loop/coil) S (bend) 2 -73.5 129.9 78.07 Low-density lipoprotein receptor Disulfide bond 34-52 LDL-receptor class A 1 Extracellular 121 2.5 1 interaction C52-D57; PAE: 4.0 2 interactions C52-D57, C52-S56; PAE: 4.0, 5.0 53 Q Glutamine Polar/Neutral Beta strand C (loop/coil) T (turn) 160 -65.7 -15.5 74.73 Low-density lipoprotein receptor LDL-receptor class A 1 Extracellular 146 -3.5 Q53-K38; PAE: 5.0 54 D Aspartic Acid Negatively-charged Beta strand C (loop/coil) T (turn) 69 -98.4 -2.5 78.37 Low-density lipoprotein receptor LDL-receptor class A 1 Extracellular 132 -3.5 D54-D36; PAE: 7.5 55 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible Beta strand C (loop/coil) S (bend) 24 68.0 21.6 74.31 Low-density lipoprotein receptor LDL-receptor class A 1 Extracellular 75 -0.4 1 interaction 2 interactions G55-S59; PAE: 3.5 56 S Serine Polar/Neutral Helix C (loop/coil) C (loop/coil) 6 -65.5 -33.4 79.71 Low-density lipoprotein receptor LDL-receptor class A 1 Extracellular 105 -0.8 S56-Q35, S56-T62; PAE: 6.5, 6.5 4 interactions S56-Q35, S56-T62, S56-C52; PAE: 6.5, 6.5, 5.0 57 D Aspartic Acid Negatively-charged Helix C (loop/coil) S (bend) 0 -64.1 -38.9 74.61 Low-density lipoprotein receptor LDL-receptor class A 1 Extracellular 132 -3.5 3 interactions D57-C52, D57-E51; PAE: 4.0, 5.0 3 interactions D57-C52; PAE: 4.0 58 E Glutamic Acid Negatively-charged Helix C (loop/coil) S (bend) 59 -91.0 1.9 76.52 Low-density lipoprotein receptor LDL-receptor class A 1 Extracellular 146 -3.5 1 interaction E58-D47, E58-G48; PAE: 4.0, 4.0 59 S Serine Polar/Neutral C (loop/coil) C (loop/coil) 40 -65.7 135.9 76.62 Low-density lipoprotein receptor LDL-receptor class A 1 Extracellular 105 -0.8 2 interactions S59-C63; PAE: 3.0 2 interactions S59-G55, S59-C63; PAE: 3.5, 3.0 60 Q Glutamine Polar/Neutral Turn H (helix) H (α-helix) 143 -55.8 -31.8 68.36 Low-density lipoprotein receptor LDL-receptor class A 1 Extracellular 146 -3.5 1 interaction Q60-L64; PAE: 3.5 1 interaction Q60-L64; PAE: 3.5 61 E Glutamic Acid Negatively-charged Turn H (helix) H (α-helix) 166 -73.0 -44.3 69.75 Low-density lipoprotein receptor LDL-receptor class A 1 Extracellular 146 -3.5 E61-S65; PAE: 5.0 E61-S65; PAE: 5.0 62 T Threonine Polar/Neutral Turn H (helix) H (α-helix) 23 -58.8 -50.5 69.31 Low-density lipoprotein receptor LDL-receptor class A 1 Extracellular 119 -0.7 T62-S56, T62-V66; PAE: 6.5, 4.5 T62-S56, T62-V66; PAE: 6.5, 4.5 63 C Cysteine Special, a very reactive sulfhydryl group H (helix) H (α-helix) 3 -66.5 -24.5 67.23 Low-density lipoprotein receptor Disulfide bond 46-63 LDL-receptor class A 1 Extracellular 121 2.5 1 interaction C63-N80, C63-S59; PAE: 11.0, 3.0 1 interaction C63-C46, C63-N80, C63-S59; PAE: 6.0, 11.0, 3.0 64 L Leucine Aliphatic H (helix) H (α-helix) 84 -79.3 -26.1 64.0 Low-density lipoprotein receptor LDL-receptor class A 1 Extracellular 131 3.8 2 interactions L64-Q60, L64-N80; PAE: 3.5, 9.0 1 interaction L64-Q60, L64-N80; PAE: 3.5, 9.0 65 S Serine Polar/Neutral Beta strand H (helix) H (α-helix) 83 -87.0 -18.4 60.86 Low-density lipoprotein receptor LDL-receptor class A 1 Extracellular 105 -0.8 1 interaction S65-E61; PAE: 5.0 1 interaction S65-E61; PAE: 5.0 66 V Valine Aliphatic Beta strand C (loop/coil) C (loop/coil) 41 -60.7 115.1 62.92 Low-density lipoprotein receptor LDL-receptor class A 2 Extracellular 117 4.2 V66-T62; PAE: 4.5 V66-T62; PAE: 4.5 67 T Threonine Polar/Neutral Beta strand H (helix) P (polyproline helix) 129 -97.8 121.8 62.64 Low-density lipoprotein receptor LDL-receptor class A 2 Extracellular 119 -0.7 68 C Cysteine Special, a very reactive sulfhydryl group H (helix) P (polyproline helix) 30 -54.6 140.6 67.28 Low-density lipoprotein receptor Disulfide bond 68-82 LDL-receptor class A 2 Extracellular 121 2.5 C68-S74; PAE: 6.5 69 K Lysine Positively-charged H (helix) P (polyproline helix) 160 -62.5 152.8 67.43 Low-density lipoprotein receptor LDL-receptor class A 2 Extracellular 147 -3.9 70 S Serine Polar/Neutral Beta strand C (loop/coil) T (turn) 128 -58.9 109.8 63.77 Low-density lipoprotein receptor LDL-receptor class A 2 Extracellular 105 -0.8 71 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible Beta strand C (loop/coil) T (turn) 52 117.9 -4.0 66.56 Low-density lipoprotein receptor LDL-receptor class A 2 Extracellular 75 -0.4 G71-Q85; PAE: 4.5 G71-Q85; PAE: 4.5 72 D Aspartic Acid Negatively-charged Beta strand B (undefined) E (parallel sheets) 62 -105.6 144.6 74.83 Low-density lipoprotein receptor LDL-receptor class A 2 Extracellular 132 -3.5 73 F Phenylalanine Aromatic B (undefined) E (parallel sheets) 45 -88.2 132.8 77.5 Low-density lipoprotein receptor LDL-receptor class A 2 Extracellular 165 2.8 2 interactions F73-I83; PAE: 2.5 4 interactions F73-R88, F73-I83, F73-D100; PAE: 3.5, 2.5, 4.0 74 S Serine Polar/Neutral B (undefined) E (parallel sheets) 49 -89.7 120.1 79.3 Low-density lipoprotein receptor LDL-receptor class A 2 Extracellular 105 -0.8 1 interaction 1 interaction S74-C68; PAE: 6.5 75 C Cysteine Special, a very reactive sulfhydryl group C (loop/coil) C (loop/coil) 7 -60.0 -25.1 75.58 Low-density lipoprotein receptor Disulfide bond 75-95 LDL-receptor class A 2 Extracellular 121 2.5 4 interactions C75-S99, C75-R81, C75-N97; PAE: 5.0, 7.0, 5.0 3 interactions C75-S99, C75-N97; PAE: 5.0, 5.0 76 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible C (loop/coil) C (loop/coil) 31 62.0 143.1 70.51 Low-density lipoprotein receptor LDL-receptor class A 2 Extracellular 75 -0.4 2 interactions 77 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible Beta strand C (loop/coil) S (bend) 57 150.3 -160.5 62.78 Low-density lipoprotein receptor LDL-receptor class A 2 Extracellular 75 -0.4 2 interactions 78 R Arginine Positively-charged Beta strand C (loop/coil) S (bend) 222 -71.2 -24.6 56.79 Low-density lipoprotein receptor LDL-receptor class A 2 Extracellular 175 -4.5 1 interaction 79 V Valine Aliphatic Beta strand C (loop/coil) S (bend) 55 -119.5 124.1 59.79 Low-density lipoprotein receptor LDL-receptor class A 2 Extracellular 117 4.2 1 interaction 80 N Asparagine Polar/Neutral C (loop/coil) C (loop/coil) 51 -75.5 77.0 62.05 Low-density lipoprotein receptor LDL-receptor class A 2 Extracellular 132 -3.5 N80-L64, N80-C63; PAE: 9.0, 11.0 4 interactions N80-L64, N80-C63; PAE: 9.0, 11.0 81 R Arginine Positively-charged C (loop/coil) C (loop/coil) 33 -77.7 139.0 70.0 Low-density lipoprotein receptor LDL-receptor class A 2 Extracellular 175 -4.5 4 interactions R81-C75, R81-D96; PAE: 7.0, 6.0 1 interaction 82 C Cysteine Special, a very reactive sulfhydryl group B (undefined) E (parallel sheets) 36 -117.4 125.1 74.3 Low-density lipoprotein receptor Disulfide bond 68-82 LDL-receptor class A 2 Extracellular 121 2.5 2 interactions 1 interaction 83 I Isoleucine Aliphatic B (undefined) E (parallel sheets) 0 -109.8 153.9 74.83 Low-density lipoprotein receptor LDL-receptor class A 2 Extracellular 131 4.5 3 interactions I83-F73; PAE: 2.5 3 interactions I83-F73; PAE: 2.5 84 P Proline Special, No backbone hydrogen B (undefined) E (parallel sheets) 7 -59.6 147.6 75.78 Low-density lipoprotein receptor LDL-receptor class A 2 Extracellular 115 1.6 85 Q Glutamine Polar/Neutral Helix H (helix) G (3₁₀-helix) 99 -57.7 -23.5 74.73 Low-density lipoprotein receptor LDL-receptor class A 2 Extracellular 146 -3.5 1 interaction Q85-G71; PAE: 4.5 3 interactions Q85-G71; PAE: 4.5 86 F Phenylalanine Aromatic Helix H (helix) G (3₁₀-helix) 86 -81.0 -12.7 75.67 Low-density lipoprotein receptor LDL-receptor class A 2 Extracellular 165 2.8 F86-G396; PAE: 29.0 1 interaction 1 interaction 87 W Tryptophan Aromatic Helix H (helix) G (3₁₀-helix) 4 -84.1 -7.8 77.85 Low-density lipoprotein receptor LDL-receptor class A 2 Extracellular 204 -0.9 88 R Arginine Positively-charged C (loop/coil) T (turn) 65 -75.9 125.8 78.88 Low-density lipoprotein receptor LDL-receptor class A 2 Extracellular 175 -4.5 2 interactions R88-G103; PAE: 5.5 R88-C104, R88-F73; PAE: 5.5, 3.5 89 C Cysteine Special, a very reactive sulfhydryl group C (loop/coil) T (turn) 22 66.7 32.9 75.81 Low-density lipoprotein receptor Disulfide bond 89-104 LDL-receptor class A 2 Extracellular 121 2.5 2 interactions 1 interaction 1 interaction 90 D Aspartic Acid Negatively-charged Beta strand C (loop/coil) S (bend) 38 -93.1 1.3 70.08 Low-density lipoprotein receptor LDL-receptor class A 2 Extracellular 132 -3.5 2 interactions D90-K393, D90-E101; PAE: 29.0, 3.5 3 interactions 1 interaction 1 interaction 91 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible Beta strand C (loop/coil) S (bend) 46 90.3 1.8 71.19 Low-density lipoprotein receptor LDL-receptor class A 2 Extracellular 75 -0.4 1 interaction G91-E101; PAE: 3.5 92 Q Glutamine Polar/Neutral Beta strand C (loop/coil) S (bend) 62 -109.7 153.1 71.31 Low-density lipoprotein receptor LDL-receptor class A 2 Extracellular 146 -3.5 Q92-K393; PAE: 28.5 1 interaction 1 interaction 93 V Valine Aliphatic Beta strand C (loop/coil) C (loop/coil) 77 -93.8 95.2 77.62 Low-density lipoprotein receptor LDL-receptor class A 2 Extracellular 117 4.2 1 interaction 1 interaction 2 interactions 94 D Aspartic Acid Negatively-charged C (loop/coil) C (loop/coil) 1 -94.8 -19.6 74.45 Low-density lipoprotein receptor LDL-receptor class A 2 Extracellular 132 -3.5 1 interaction D94-D100, D94-K393; PAE: 4.5, 29.0 1 interaction 1 interaction 95 C Cysteine Special, a very reactive sulfhydryl group Beta strand C (loop/coil) S (bend) 0 -94.6 138.7 77.66 Low-density lipoprotein receptor Disulfide bond 75-95 LDL-receptor class A 2 Extracellular 121 2.5 2 interactions C95-D100; PAE: 3.5 3 interactions C95-S99; PAE: 4.5 96 D Aspartic Acid Negatively-charged Beta strand C (loop/coil) T (turn) 96 -53.8 -27.4 71.62 Low-density lipoprotein receptor LDL-receptor class A 2 Extracellular 132 -3.5 D96-H388, D96-R81; PAE: 29.0, 6.0 2 interactions D96-H388; PAE: 29.0 97 N Asparagine Polar/Neutral Beta strand C (loop/coil) T (turn) 74 -101.6 0.6 76.3 Low-density lipoprotein receptor LDL-receptor class A 2 N-linked (GlcNAc...) asparagine Extracellular 132 -3.5 2 interactions N97-C75, N97-Q102; PAE: 5.0, 4.0 5 interactions N97-C75; PAE: 5.0 98 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible C (loop/coil) C (loop/coil) 13 59.6 25.7 76.61 Low-density lipoprotein receptor LDL-receptor class A 2 Extracellular 75 -0.4 2 interactions G98-Q102; PAE: 4.0 3 interactions G98-Q102; PAE: 4.0 99 S Serine Polar/Neutral Helix C (loop/coil) C (loop/coil) 17 -72.5 -26.8 81.5 Low-density lipoprotein receptor LDL-receptor class A 2 Extracellular 105 -0.8 1 interaction S99-C75; PAE: 5.0 5 interactions S99-C95, S99-C75; PAE: 4.5, 5.0 100 D Aspartic Acid Negatively-charged Helix C (loop/coil) T (turn) 0 -56.7 -39.2 78.54 Low-density lipoprotein receptor LDL-receptor class A 2 Extracellular 132 -3.5 5 interactions D100-C95, D100-D94; PAE: 3.5, 4.5 4 interactions D100-F73; PAE: 4.0 101 E Glutamic Acid Negatively-charged Helix C (loop/coil) T (turn) 59 -89.3 -1.3 81.24 Low-density lipoprotein receptor LDL-receptor class A 2 Extracellular 146 -3.5 2 interactions E101-D90, E101-G91; PAE: 3.5, 3.5 102 Q Glutamine Polar/Neutral Beta strand C (loop/coil) T (turn) 114 -89.9 134.0 78.89 Low-density lipoprotein receptor LDL-receptor class A 2 Extracellular 146 -3.5 3 interactions Q102-G98, Q102-N97; PAE: 4.0, 4.0 3 interactions Q102-G98; PAE: 4.0 103 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible Beta strand C (loop/coil) T (turn) 70 62.8 31.2 70.61 Low-density lipoprotein receptor LDL-receptor class A 2 Extracellular 75 -0.4 2 interactions G103-R88; PAE: 5.5 2 interactions 104 C Cysteine Special, a very reactive sulfhydryl group Beta strand H (helix) P (polyproline helix) 36 -55.8 138.6 72.07 Low-density lipoprotein receptor Disulfide bond 89-104 LDL-receptor class A 2 Extracellular 121 2.5 C104-R88; PAE: 5.5 1 interaction 1 interaction 105 P Proline Special, No backbone hydrogen H (helix) P (polyproline helix) 91 -50.4 131.6 67.6 Low-density lipoprotein receptor LDL-receptor class A 2 Extracellular 115 1.6 dbSNP: rs13306510; Variant type: LB/B; AA change: Pro105Ser; PTM type: Phosphorylation; PTM morphology: P*PKTCsQDEFR; Var class: II 106 P Proline Special, No backbone hydrogen H (helix) P (polyproline helix) 105 -51.2 118.7 55.25 Low-density lipoprotein receptor LDL-receptor class A 2 Extracellular 115 1.6 107 K Lysine Positively-charged C (loop/coil) C (loop/coil) 100 -55.0 96.6 57.64 Low-density lipoprotein receptor LDL-receptor class A 3 Extracellular 147 -3.9 1 interaction K107-D415; PAE: 28.5 1 interaction 108 T Threonine Polar/Neutral C (loop/coil) C (loop/coil) 119 -86.1 101.2 60.64 Low-density lipoprotein receptor LDL-receptor class A 3 Extracellular 119 -0.7 109 C Cysteine Special, a very reactive sulfhydryl group C (loop/coil) C (loop/coil) 23 -47.5 135.5 71.86 Low-density lipoprotein receptor Disulfide bond 109-121 LDL-receptor class A 3 Extracellular 121 2.5 dbSNP: rs140807148; Variant type: US; AA change: Cys109Arg; PTM type: Phosphorylation; PTM morphology: PPKTC*sQDEFR; Var class: II 110 S Serine Polar/Neutral C (loop/coil) C (loop/coil) 62 -54.9 163.7 73.13 Low-density lipoprotein receptor LDL-receptor class A 3 Extracellular 105 -0.8 Morphology: GCPPKTCsQDEFRCH; Domain: Ldl_recept_a 111 Q Glutamine Polar/Neutral C (loop/coil) T (turn) 168 -60.5 -18.3 71.17 Low-density lipoprotein receptor LDL-receptor class A 3 Extracellular 146 -3.5 Q111-R124; PAE: 4.0 112 D Aspartic Acid Negatively-charged C (loop/coil) T (turn) 121 -97.5 6.1 73.92 Low-density lipoprotein receptor LDL-receptor class A 3 Extracellular 132 -3.5 D112-R124; PAE: 3.5 2 interactions D112-R124; PAE: 3.5 113 E Glutamic Acid Negatively-charged Beta strand B (undefined) E (parallel sheets) 46 -117.3 149.4 81.12 Low-density lipoprotein receptor LDL-receptor class A 3 Extracellular 146 -3.5 1 interaction 1 interaction E113-R124; PAE: 2.5 1 interaction 114 F Phenylalanine Aromatic Beta strand B (undefined) E (parallel sheets) 61 -104.0 137.8 82.21 Low-density lipoprotein receptor LDL-receptor class A 3 Extracellular 165 2.8 2 interactions F114-I122; PAE: 2.0 2 interactions F114-I122; PAE: 2.0 115 R Arginine Positively-charged Beta strand B (undefined) E (parallel sheets) 150 -94.1 112.5 82.06 Low-density lipoprotein receptor LDL-receptor class A 3 Extracellular 175 -4.5 1 interaction 116 C Cysteine Special, a very reactive sulfhydryl group C (loop/coil) C (loop/coil) 0 -60.4 163.1 82.42 Low-density lipoprotein receptor Disulfide bond 116-134 LDL-receptor class A 3 Extracellular 121 2.5 2 interactions C116-K120; PAE: 5.0 2 interactions 117 H Histidine Positively-charged C (loop/coil) T (turn) 157 -67.5 -32.8 81.51 Low-density lipoprotein receptor LDL-receptor class A 3 Extracellular 155 -3.2 2 interactions H117-D136; PAE: 5.5 2 interactions H117-S138; PAE: 6.0 118 D Aspartic Acid Negatively-charged C (loop/coil) T (turn) 74 -64.4 -12.9 78.08 Low-density lipoprotein receptor LDL-receptor class A 3 Extracellular 132 -3.5 1 interaction D118-D136; PAE: 6.5 3 interactions 119 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible C (loop/coil) S (bend) 22 89.7 1.8 75.73 Low-density lipoprotein receptor LDL-receptor class A 3 Extracellular 75 -0.4 1 interaction 120 K Lysine Positively-charged C (loop/coil) C (loop/coil) 69 -72.9 153.3 79.27 Low-density lipoprotein receptor LDL-receptor class A 3 Extracellular 147 -3.9 2 interactions K120-C116, K120-D415; PAE: 5.0, 28.5 121 C Cysteine Special, a very reactive sulfhydryl group Beta strand B (undefined) E (parallel sheets) 5 -106.4 126.3 81.4 Low-density lipoprotein receptor Disulfide bond 109-121 LDL-receptor class A 3 Extracellular 121 2.5 C121-Y419; PAE: 27.5 122 I Isoleucine Aliphatic Beta strand B (undefined) E (parallel sheets) 0 -114.1 162.0 80.94 Low-density lipoprotein receptor LDL-receptor class A 3 Extracellular 131 4.5 2 interactions I122-F114; PAE: 2.0 2 interactions I122-F114; PAE: 2.0 123 S Serine Polar/Neutral Beta strand B (undefined) E (parallel sheets) 13 -60.3 144.6 79.91 Low-density lipoprotein receptor LDL-receptor class A 3 Extracellular 105 -0.8 S123-Y419; PAE: 27.5 1 interaction 1 interaction 124 R Arginine Positively-charged Helix H (helix) G (3₁₀-helix) 156 -62.5 -18.7 77.32 Low-density lipoprotein receptor LDL-receptor class A 3 Extracellular 175 -4.5 1 interaction R124-Q111, R124-D112; PAE: 4.0, 3.5 2 interactions R124-E113, R124-D112; PAE: 2.5, 3.5 125 Q Glutamine Polar/Neutral Helix H (helix) G (3₁₀-helix) 78 -70.8 -21.8 77.17 Low-density lipoprotein receptor LDL-receptor class A 3 Extracellular 146 -3.5 2 interactions 1 interaction 126 F Phenylalanine Aromatic Helix H (helix) G (3₁₀-helix) 2 -88.6 30.8 81.31 Low-density lipoprotein receptor LDL-receptor class A 3 Extracellular 165 2.8 127 V Valine Aliphatic C (loop/coil) S (bend) 48 -118.7 117.0 81.02 Low-density lipoprotein receptor LDL-receptor class A 3 Extracellular 117 4.2 128 C Cysteine Special, a very reactive sulfhydryl group C (loop/coil) S (bend) 48 63.4 36.6 77.24 Low-density lipoprotein receptor Disulfide bond 128-143 LDL-receptor class A 3 Extracellular 121 2.5 1 interaction C128-E140; PAE: 2.5 1 interaction C128-C143; PAE: 7.0 1 interaction 129 D Aspartic Acid Negatively-charged Beta strand C (loop/coil) S (bend) 56 -95.7 6.4 71.26 Low-density lipoprotein receptor LDL-receptor class A 3 Extracellular 132 -3.5 1 interaction 2 interactions 1 interaction 130 S Serine Polar/Neutral Beta strand C (loop/coil) S (bend) 101 77.8 -1.4 71.01 Low-density lipoprotein receptor LDL-receptor class A 3 Extracellular 105 -0.8 2 interactions S130-E140; PAE: 3.0 1 interaction 3 interactions 131 D Aspartic Acid Negatively-charged Beta strand C (loop/coil) S (bend) 42 -105.9 139.6 72.99 Low-density lipoprotein receptor LDL-receptor class A 3 Extracellular 132 -3.5 1 interaction 2 interactions 2 interactions 132 R Arginine Positively-charged C (loop/coil) C (loop/coil) 100 -87.1 89.8 78.98 Low-density lipoprotein receptor LDL-receptor class A 3 Extracellular 175 -4.5 R132-N645; PAE: 26.0 R132-G137, R132-N645; PAE: 3.0, 26.0 1 interaction 133 D Aspartic Acid Negatively-charged C (loop/coil) C (loop/coil) 1 -90.4 -25.3 81.82 Low-density lipoprotein receptor LDL-receptor class A 3 Extracellular 132 -3.5 1 interaction D133-R416, D133-R410, D133-D139; PAE: 28.0, 26.0, 4.0 1 interaction 1 interaction 134 C Cysteine Special, a very reactive sulfhydryl group C (loop/coil) S (bend) 0 -80.2 130.3 81.83 Low-density lipoprotein receptor Disulfide bond 116-134 LDL-receptor class A 3 Extracellular 121 2.5 1 interaction C134-D139; PAE: 3.0 2 interactions C134-S138, C134-D139; PAE: 4.5, 3.0 135 L Leucine Aliphatic C (loop/coil) T (turn) 56 -61.3 -14.2 78.02 Low-density lipoprotein receptor LDL-receptor class A 3 Extracellular 131 3.8 2 interactions 136 D Aspartic Acid Negatively-charged C (loop/coil) T (turn) 56 -100.3 -4.9 82.06 Low-density lipoprotein receptor LDL-receptor class A 3 Extracellular 132 -3.5 1 interaction D136-H117, D136-D118; PAE: 5.5, 6.5 2 interactions 137 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible C (loop/coil) C (loop/coil) 17 68.3 20.8 81.29 Low-density lipoprotein receptor LDL-receptor class A 3 Extracellular 75 -0.4 1 interaction 2 interactions G137-R132, G137-A141; PAE: 3.0, 4.0 138 S Serine Polar/Neutral Turn C (loop/coil) T (turn) 36 -70.8 -26.9 86.48 Low-density lipoprotein receptor LDL-receptor class A 3 Extracellular 105 -0.8 2 interactions 4 interactions S138-H117, S138-C134; PAE: 6.0, 4.5 139 D Aspartic Acid Negatively-charged Turn C (loop/coil) T (turn) 3 -62.1 -41.2 81.91 Low-density lipoprotein receptor LDL-receptor class A 3 Extracellular 132 -3.5 3 interactions D139-D133, D139-C134; PAE: 4.0, 3.0 1 interaction D139-C134; PAE: 3.0 140 E Glutamic Acid Negatively-charged Turn C (loop/coil) T (turn) 51 -95.4 -5.1 85.58 Low-density lipoprotein receptor LDL-receptor class A 3 Extracellular 146 -3.5 2 interactions E140-S130, E140-C128; PAE: 3.0, 2.5 141 A Alanine Aliphatic Turn C (loop/coil) T (turn) 83 -69.2 -18.8 82.49 Low-density lipoprotein receptor LDL-receptor class A 3 Extracellular 89 1.8 1 interaction 2 interactions A141-G137; PAE: 4.0 142 S Serine Polar/Neutral Turn C (loop/coil) T (turn) 111 -139.3 51.1 79.01 Low-density lipoprotein receptor LDL-receptor class A 3 Extracellular 105 -0.8 1 interaction 1 interaction 143 C Cysteine Special, a very reactive sulfhydryl group Helix C (loop/coil) C (loop/coil) 47 -96.1 131.6 75.84 Low-density lipoprotein receptor Disulfide bond 128-143 LDL-receptor class A 3 Extracellular 121 2.5 1 interaction 1 interaction 1 interaction C143-C128; PAE: 7.0 144 P Proline Special, No backbone hydrogen Helix C (loop/coil) C (loop/coil) 112 -69.7 141.0 73.0 Low-density lipoprotein receptor LDL-receptor class A 3 Extracellular 115 1.6 1 interaction 1 interaction 145 V Valine Aliphatic Helix C (loop/coil) C (loop/coil) 141 -54.5 115.2 61.08 Low-density lipoprotein receptor LDL-receptor class A 3 Extracellular 117 4.2 146 L Leucine Aliphatic Helix C (loop/coil) C (loop/coil) 130 -61.0 127.4 60.66 Low-density lipoprotein receptor LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 131 3.8 1 interaction 1 interaction 147 T Threonine Polar/Neutral Helix C (loop/coil) C (loop/coil) 127 -109.2 119.2 55.96 Low-density lipoprotein receptor LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 119 -0.7 2 interactions 3 interactions 148 C Cysteine Special, a very reactive sulfhydryl group Beta strand C (loop/coil) C (loop/coil) 38 -57.0 128.7 67.49 Low-density lipoprotein receptor Disulfide bond 148-160 LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 121 2.5 1 interaction 2 interactions C148-S152; PAE: 6.0 C148-C160; PAE: 5.5 149 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible Beta strand C (loop/coil) C (loop/coil) 38 -82.1 176.6 71.43 Low-density lipoprotein receptor LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 75 -0.4 150 P Proline Special, No backbone hydrogen Beta strand C (loop/coil) T (turn) 144 -69.9 -15.1 68.68 Low-density lipoprotein receptor LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 115 1.6 151 A Alanine Aliphatic Beta strand C (loop/coil) T (turn) 79 -98.0 4.6 70.05 Low-density lipoprotein receptor LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 89 1.8 2 interactions A151-Q163; PAE: 3.5 2 interactions A151-Q163; PAE: 3.5 152 S Serine Polar/Neutral Beta strand B (undefined) E (parallel sheets) 30 -113.5 140.4 77.37 Low-density lipoprotein receptor LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 105 -0.8 1 interaction 4 interactions S152-C148; PAE: 6.0 153 F Phenylalanine Aromatic Beta strand B (undefined) E (parallel sheets) 25 -84.0 139.6 79.46 Low-density lipoprotein receptor LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 165 2.8 3 interactions F153-I161; PAE: 2.0 4 interactions F153-D178, F153-I161; PAE: 2.5, 2.0 154 Q Glutamine Polar/Neutral Beta strand B (undefined) E (parallel sheets) 108 -102.8 115.3 80.7 Low-density lipoprotein receptor LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 146 -3.5 2 interactions Q154-R183; PAE: 4.5 155 C Cysteine Special, a very reactive sulfhydryl group C (loop/coil) C (loop/coil) 3 -62.3 159.9 82.4 Low-density lipoprotein receptor Disulfide bond 155-173 LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 121 2.5 3 interactions C155-T159; PAE: 4.0 3 interactions C155-C173; PAE: 3.5 156 N Asparagine Polar/Neutral Turn C (loop/coil) T (turn) 81 -69.6 -26.2 81.37 Low-density lipoprotein receptor LDL-receptor class A 4 N-linked (GlcNAc...) asparagine Binding to Getah virus E1-E2 spike glycoproteins Extracellular 132 -3.5 3 interactions N156-D175, N156-R183; PAE: 5.5, 5.0 3 interactions N156-S177; PAE: 4.0 157 S Serine Polar/Neutral Turn C (loop/coil) T (turn) 46 -63.2 0.4 76.62 Low-density lipoprotein receptor LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 105 -0.8 2 interactions S157-D175; PAE: 5.0 1 interaction 158 S Serine Polar/Neutral Turn C (loop/coil) S (bend) 85 69.9 1.8 74.15 Low-density lipoprotein receptor LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 105 -0.8 1 interaction 159 T Threonine Polar/Neutral C (loop/coil) C (loop/coil) 69 -67.4 143.8 77.98 Low-density lipoprotein receptor LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 119 -0.7 3 interactions T159-C155; PAE: 4.0 1 interaction 160 C Cysteine Special, a very reactive sulfhydryl group Beta strand B (undefined) E (parallel sheets) 26 -107.2 126.5 78.62 Low-density lipoprotein receptor Disulfide bond 148-160 LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 121 2.5 C160-C148; PAE: 5.5 161 I Isoleucine Aliphatic Beta strand B (undefined) E (parallel sheets) 12 -115.5 154.7 78.92 Low-density lipoprotein receptor LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 131 4.5 3 interactions I161-F153; PAE: 2.0 4 interactions I161-F153; PAE: 2.0 162 P Proline Special, No backbone hydrogen Beta strand B (undefined) E (parallel sheets) 38 -51.2 140.3 78.74 Low-density lipoprotein receptor LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 115 1.6 1 interaction 3 interactions P162-A166; PAE: 2.0 163 Q Glutamine Polar/Neutral Helix H (helix) G (3₁₀-helix) 104 -60.6 -19.4 78.47 Low-density lipoprotein receptor LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 146 -3.5 2 interactions Q163-A151; PAE: 3.5 4 interactions Q163-A151; PAE: 3.5 164 L Leucine Aliphatic Helix H (helix) G (3₁₀-helix) 80 -65.8 -31.5 77.3 Low-density lipoprotein receptor LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 131 3.8 L164-R427; PAE: 14.0 165 W Tryptophan Aromatic Helix H (helix) G (3₁₀-helix) 50 -87.2 -5.7 80.08 Low-density lipoprotein receptor LDL-receptor class A 4 Mutation: W -> I. Partial loss of binding to Getah virus E2-E1 spike glycoproteins. Binding to Getah virus E1-E2 spike glycoproteins Extracellular 204 -0.9 W165-L426; PAE: 17.0 1 interaction 166 A Alanine Aliphatic C (loop/coil) T (turn) 12 -82.0 129.7 81.61 Low-density lipoprotein receptor LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 89 1.8 1 interaction 4 interactions A166-P162; PAE: 2.0 167 C Cysteine Special, a very reactive sulfhydryl group C (loop/coil) T (turn) 37 66.1 41.8 80.03 Low-density lipoprotein receptor Disulfide bond 167-184 LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 121 2.5 2 interactions C167-E179; PAE: 2.5 C167-C184; PAE: 7.5 C167-C184; PAE: 7.5 168 D Aspartic Acid Negatively-charged Beta strand C (loop/coil) S (bend) 6 -109.7 10.1 73.24 Low-density lipoprotein receptor LDL-receptor class A 4 Mutation: D -> K. Partial loss of binding to Getah virus E2-E1 spike glycoproteins. Binding to Getah virus E1-E2 spike glycoproteins Extracellular 132 -3.5 3 interactions D168-E179; PAE: 2.0 D168-R427; PAE: 14.0 3 interactions 1 interaction 169 N Asparagine Polar/Neutral Beta strand C (loop/coil) S (bend) 95 71.0 13.0 73.72 Low-density lipoprotein receptor LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 132 -3.5 2 interactions N169-E179; PAE: 2.5 1 interaction 1 interaction 170 D Aspartic Acid Negatively-charged Beta strand C (loop/coil) S (bend) 29 -116.3 128.1 73.46 Low-density lipoprotein receptor LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 132 -3.5 D170-N428; PAE: 11.0 3 interactions 2 interactions 171 P Proline Special, No backbone hydrogen C (loop/coil) C (loop/coil) 78 -79.4 100.0 79.83 Low-density lipoprotein receptor LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 115 1.6 1 interaction 172 D Aspartic Acid Negatively-charged C (loop/coil) C (loop/coil) 25 -95.4 -26.0 79.08 Low-density lipoprotein receptor LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 132 -3.5 2 interactions D172-D178, D172-H407, D172-R406; PAE: 2.5, 10.5, 11.0 3 interactions 3 interactions 173 C Cysteine Special, a very reactive sulfhydryl group Beta strand C (loop/coil) S (bend) 6 -72.6 136.7 81.64 Low-density lipoprotein receptor Disulfide bond 155-173 LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 121 2.5 3 interactions C173-D178; PAE: 2.5 5 interactions C173-S177, C173-D178; PAE: 3.0, 2.5 C173-C155; PAE: 3.5 1 interaction 174 E Glutamic Acid Negatively-charged Beta strand C (loop/coil) T (turn) 178 -52.8 -24.8 78.05 Low-density lipoprotein receptor LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 146 -3.5 2 interactions 1 interaction 175 D Aspartic Acid Negatively-charged Beta strand C (loop/coil) T (turn) 47 -100.8 -0.5 81.36 Low-density lipoprotein receptor LDL-receptor class A 4 Mutation: D -> K. Partial loss of binding to Getah virus E2-E1 spike glycoproteins. Binding to Getah virus E1-E2 spike glycoproteins Extracellular 132 -3.5 D175-S157, D175-N156; PAE: 5.0, 5.5 176 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible Beta strand C (loop/coil) C (loop/coil) 16 60.5 22.0 81.66 Low-density lipoprotein receptor LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 75 -0.4 1 interaction 3 interactions G176-W180; PAE: 2.5 177 S Serine Polar/Neutral Helix C (loop/coil) C (loop/coil) 0 -68.1 -27.6 84.17 Low-density lipoprotein receptor LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 105 -0.8 2 interactions 7 interactions S177-N156, S177-C173; PAE: 4.0, 3.0 178 D Aspartic Acid Negatively-charged Helix C (loop/coil) S (bend) 0 -59.1 -40.5 80.68 Low-density lipoprotein receptor LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 132 -3.5 5 interactions D178-C173, D178-D172; PAE: 2.5, 2.5 3 interactions D178-C173, D178-F153; PAE: 2.5, 2.5 179 E Glutamic Acid Negatively-charged Helix C (loop/coil) S (bend) 34 -90.7 3.7 84.5 Low-density lipoprotein receptor LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 146 -3.5 4 interactions E179-N169, E179-C167, E179-D168; PAE: 2.5, 2.5, 2.0 180 W Tryptophan Aromatic C (loop/coil) C (loop/coil) 121 -64.7 128.3 81.78 Low-density lipoprotein receptor LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 204 -0.9 1 interaction W180-C184; PAE: 3.0 5 interactions W180-C184, W180-G176; PAE: 3.0, 2.5 181 P Proline Special, No backbone hydrogen Helix C (loop/coil) T (turn) 91 -58.0 -19.2 73.08 Low-density lipoprotein receptor LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 115 1.6 1 interaction 182 Q Glutamine Polar/Neutral Helix C (loop/coil) T (turn) 189 -81.2 -29.3 73.24 Low-density lipoprotein receptor LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 146 -3.5 183 R Arginine Positively-charged Helix C (loop/coil) T (turn) 107 -88.5 -39.8 73.83 Low-density lipoprotein receptor LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 175 -4.5 3 interactions R183-N156, R183-Q154; PAE: 5.0, 4.5 1 interaction 184 C Cysteine Special, a very reactive sulfhydryl group C (loop/coil) T (turn) 5 -74.6 91.7 73.29 Low-density lipoprotein receptor Disulfide bond 167-184 LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 121 2.5 C184-W180; PAE: 3.0 4 interactions C184-W180, C184-C167; PAE: 3.0, 7.5 C184-C167; PAE: 7.5 185 R Arginine Positively-charged C (loop/coil) T (turn) 234 -60.5 65.6 66.8 Low-density lipoprotein receptor LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 175 -4.5 1 interaction 186 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible C (loop/coil) S (bend) 73 62.9 13.0 54.45 Low-density lipoprotein receptor LDL-receptor class A 4 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 75 -0.4 187 L Leucine Aliphatic C (loop/coil) S (bend) 115 -80.5 98.9 46.72 Low-density lipoprotein receptor Binding to Getah virus E1-E2 spike glycoproteins Extracellular 131 3.8 188 Y Tyrosine Aromatic C (loop/coil) C (loop/coil) 160 65.1 45.7 41.57 Low-density lipoprotein receptor Binding to Getah virus E1-E2 spike glycoproteins Extracellular 181 -1.3 3 interactions 189 V Valine Aliphatic Turn C (loop/coil) C (loop/coil) 82 -84.2 90.8 38.18 Low-density lipoprotein receptor Binding to Getah virus E1-E2 spike glycoproteins Extracellular 117 4.2 190 F Phenylalanine Aromatic Turn C (loop/coil) C (loop/coil) 153 -67.6 117.3 41.47 Low-density lipoprotein receptor Binding to Getah virus E1-E2 spike glycoproteins Extracellular 165 2.8 191 Q Glutamine Polar/Neutral Turn C (loop/coil) C (loop/coil) 192 -66.7 79.9 34.96 Low-density lipoprotein receptor Binding to Getah virus E1-E2 spike glycoproteins Extracellular 146 -3.5 192 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible C (loop/coil) C (loop/coil) 65 -72.8 141.7 40.07 Low-density lipoprotein receptor Binding to Getah virus E1-E2 spike glycoproteins Extracellular 75 -0.4 1 interaction 193 D Aspartic Acid Negatively-charged C (loop/coil) C (loop/coil) 146 -46.5 133.4 38.7 Low-density lipoprotein receptor Binding to Getah virus E1-E2 spike glycoproteins Extracellular 132 -3.5 194 S Serine Polar/Neutral C (loop/coil) S (bend) 121 -78.0 56.3 46.98 Low-density lipoprotein receptor Binding to Getah virus E1-E2 spike glycoproteins Extracellular 105 -0.8 1 interaction 195 S Serine Polar/Neutral C (loop/coil) C (loop/coil) 69 -126.9 112.9 52.94 Low-density lipoprotein receptor LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 105 -0.8 196 P Proline Special, No backbone hydrogen C (loop/coil) S (bend) 101 -62.2 -23.8 64.14 Low-density lipoprotein receptor LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 115 1.6 1 interaction P196-H203; PAE: 6.5 197 C Cysteine Special, a very reactive sulfhydryl group C (loop/coil) S (bend) 15 -127.7 152.6 71.19 Low-density lipoprotein receptor Disulfide bond 197-209 LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 121 2.5 2 interactions C197-H203; PAE: 5.5 C197-C209; PAE: 5.0 198 S Serine Polar/Neutral C (loop/coil) C (loop/coil) 63 -63.3 163.0 70.38 Low-density lipoprotein receptor LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 105 -0.8 Pocket 4: Mean pLDDT: 80.74, Volume: 495.81 ų, Druggability score: 0.03 0.0258 199 A Alanine Aliphatic C (loop/coil) T (turn) 98 -60.3 -15.6 66.68 Low-density lipoprotein receptor LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 89 1.8 200 F Phenylalanine Aromatic C (loop/coil) T (turn) 141 -105.6 10.3 65.63 Low-density lipoprotein receptor LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 165 2.8 Pocket 4: Mean pLDDT: 80.74, Volume: 495.81 ų, Druggability score: 0.03 0.0258 F200-S212; PAE: 3.0 1 interaction F200-H211, F200-S212; PAE: 3.0, 3.0 201 E Glutamic Acid Negatively-charged Beta strand B (undefined) E (parallel sheets) 40 -118.4 139.3 74.05 Low-density lipoprotein receptor LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 146 -3.5 Pocket 4: Mean pLDDT: 80.74, Volume: 495.81 ų, Druggability score: 0.03 0.0258 E201-K518; PAE: 26.5 1 interaction E201-S212; PAE: 2.5 202 F Phenylalanine Aromatic Beta strand B (undefined) E (parallel sheets) 49 -92.4 130.0 79.23 Low-density lipoprotein receptor LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 165 2.8 2 interactions F202-I210; PAE: 2.0 4 interactions F202-I210; PAE: 2.0 203 H Histidine Positively-charged Beta strand B (undefined) E (parallel sheets) 83 -83.7 114.8 78.42 Low-density lipoprotein receptor LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 155 -3.2 1 interaction 3 interactions H203-P196, H203-C197; PAE: 6.5, 5.5 204 C Cysteine Special, a very reactive sulfhydryl group Beta strand C (loop/coil) C (loop/coil) 0 -63.0 150.1 81.86 Low-density lipoprotein receptor Disulfide bond 204-222 LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 121 2.5 2 interactions C204-E208; PAE: 4.0 2 interactions C204-C222; PAE: 3.5 205 L Leucine Aliphatic Turn C (loop/coil) T (turn) 144 -67.3 -18.8 78.17 Low-density lipoprotein receptor LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 131 3.8 1 interaction 2 interactions L205-S226; PAE: 4.0 206 S Serine Polar/Neutral Turn C (loop/coil) T (turn) 49 -70.3 -10.0 75.1 Low-density lipoprotein receptor LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 105 -0.8 S206-D224; PAE: 4.0 3 interactions S206-K223; PAE: 4.5 207 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible Turn C (loop/coil) S (bend) 40 102.9 -17.9 72.73 Low-density lipoprotein receptor LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 75 -0.4 1 interaction 208 E Glutamic Acid Negatively-charged Beta strand C (loop/coil) C (loop/coil) 84 -69.3 152.5 71.71 Low-density lipoprotein receptor LDL-receptor class A 5 Mutation: E -> R. Partial loss of binding to Getah virus E2-E1 spike glycoproteins. Binding to Getah virus E1-E2 spike glycoproteins Extracellular 146 -3.5 Pocket 1: Mean pLDDT: 85.7, Volume: 528.09 ų, Druggability score: 0.11 0.1082 2 interactions E208-K223, E208-C204; PAE: 3.5, 4.0 1 interaction E208-K223; PAE: 3.5 209 C Cysteine Special, a very reactive sulfhydryl group Beta strand B (undefined) E (parallel sheets) 45 -110.1 109.4 76.49 Low-density lipoprotein receptor Disulfide bond 197-209 LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 121 2.5 Pocket 1: Mean pLDDT: 85.7, Volume: 528.09 ų, Druggability score: 0.11 0.1082 C209-C197; PAE: 5.0 210 I Isoleucine Aliphatic Beta strand B (undefined) E (parallel sheets) 11 -102.4 164.7 73.19 Low-density lipoprotein receptor LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 131 4.5 Pocket 1: Mean pLDDT: 85.7, Volume: 528.09 ų, Druggability score: 0.11 0.1082 2 interactions I210-F202; PAE: 2.0 2 interactions I210-F202; PAE: 2.0 211 H Histidine Positively-charged Beta strand B (undefined) E (parallel sheets) 25 -71.6 147.6 72.47 Low-density lipoprotein receptor LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 155 -3.2 Pocket 4: Mean pLDDT: 80.74, Volume: 495.81 ų, Druggability score: 0.03 0.0258 H211-T538; PAE: 25.0 2 interactions H211-F200; PAE: 3.0 212 S Serine Polar/Neutral Helix H (helix) G (3₁₀-helix) 57 -61.5 -26.3 75.23 Low-density lipoprotein receptor LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 105 -0.8 S212-F200; PAE: 3.0 2 interactions S212-F200, S212-E201; PAE: 3.0, 2.5 213 S Serine Polar/Neutral Helix H (helix) G (3₁₀-helix) 69 -71.8 -8.8 73.66 Low-density lipoprotein receptor LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 105 -0.8 214 W Tryptophan Aromatic Helix H (helix) G (3₁₀-helix) 14 -103.0 0.4 72.09 Low-density lipoprotein receptor LDL-receptor class A 5 Mutation: W -> I. Partial loss of binding to Getah virus E2-E1 spike glycoproteins. Binding to Getah virus E1-E2 spike glycoproteins Extracellular 204 -0.9 Pocket 1: Mean pLDDT: 85.7, Volume: 528.09 ų, Druggability score: 0.11 0.1082 215 R Arginine Positively-charged C (loop/coil) T (turn) 111 -71.2 119.2 79.09 Low-density lipoprotein receptor LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 175 -4.5 2 interactions R215-N230; PAE: 5.0 3 interactions 216 C Cysteine Special, a very reactive sulfhydryl group C (loop/coil) T (turn) 27 65.6 41.1 79.3 Low-density lipoprotein receptor Disulfide bond 216-231 LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 121 2.5 1 interaction C216-D227; PAE: 2.5 C216-C231; PAE: 7.0 217 D Aspartic Acid Negatively-charged Beta strand C (loop/coil) S (bend) 16 -92.7 -4.6 73.13 Low-density lipoprotein receptor LDL-receptor class A 5 Mutation: D -> K. Partial loss of binding to Getah virus E2-E1 spike glycoproteins. Binding to Getah virus E1-E2 spike glycoproteins Extracellular 132 -3.5 2 interactions D217-R237, D217-E228, D217-K581; PAE: 18.0, 3.5, 24.5 D217-R237, D217-K581; PAE: 18.0, 24.5 218 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible Beta strand C (loop/coil) S (bend) 46 100.0 -8.3 71.4 Low-density lipoprotein receptor LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 75 -0.4 2 interactions G218-E228; PAE: 3.5 219 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible Beta strand C (loop/coil) S (bend) 19 -120.6 139.3 74.09 Low-density lipoprotein receptor LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 75 -0.4 220 P Proline Special, No backbone hydrogen C (loop/coil) C (loop/coil) 78 -73.4 102.8 77.71 Low-density lipoprotein receptor LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 115 1.6 221 D Aspartic Acid Negatively-charged C (loop/coil) C (loop/coil) 31 -93.4 -25.7 75.82 Low-density lipoprotein receptor LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 132 -3.5 Pocket 1: Mean pLDDT: 85.7, Volume: 528.09 ų, Druggability score: 0.11 0.1082 1 interaction D221-D227, D221-K581; PAE: 3.0, 22.5 D221-K581; PAE: 22.5 D221-K581; PAE: 22.5 222 C Cysteine Special, a very reactive sulfhydryl group Beta strand C (loop/coil) S (bend) 6 -82.3 143.9 80.45 Low-density lipoprotein receptor Disulfide bond 204-222 LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 121 2.5 1 interaction C222-D227; PAE: 2.5 2 interactions C222-S226, C222-D227; PAE: 3.0, 2.5 C222-C204; PAE: 3.5 223 K Lysine Positively-charged Beta strand C (loop/coil) T (turn) 147 -52.3 -32.0 73.42 Low-density lipoprotein receptor LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 147 -3.9 Pocket 1: Mean pLDDT: 85.7, Volume: 528.09 ų, Druggability score: 0.11 0.1082 1 interaction K223-E208; PAE: 3.5 2 interactions K223-S206; PAE: 4.5 K223-E208; PAE: 3.5 224 D Aspartic Acid Negatively-charged Beta strand C (loop/coil) T (turn) 62 -101.4 5.5 81.65 Low-density lipoprotein receptor LDL-receptor class A 5 Mutation: D -> K. Partial loss of binding to Getah virus E2-E1 spike glycoproteins. Binding to Getah virus E1-E2 spike glycoproteins Extracellular 132 -3.5 D224-S206; PAE: 4.0 2 interactions 225 K Lysine Positively-charged C (loop/coil) C (loop/coil) 133 59.6 22.6 79.21 Low-density lipoprotein receptor LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 147 -3.9 1 interaction 2 interactions K225-E229; PAE: 3.5 226 S Serine Polar/Neutral Helix H (helix) G (3₁₀-helix) 19 -69.2 -21.5 85.71 Low-density lipoprotein receptor LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 105 -0.8 2 interactions 3 interactions S226-L205, S226-C222; PAE: 4.0, 3.0 227 D Aspartic Acid Negatively-charged Helix H (helix) G (3₁₀-helix) 0 -67.4 -28.7 80.81 Low-density lipoprotein receptor LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 132 -3.5 3 interactions D227-D221, D227-C222, D227-C216; PAE: 3.0, 2.5, 2.5 2 interactions D227-C222; PAE: 2.5 228 E Glutamic Acid Negatively-charged Helix H (helix) G (3₁₀-helix) 52 -96.6 0.8 85.49 Low-density lipoprotein receptor LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 146 -3.5 4 interactions E228-G218, E228-D217; PAE: 3.5, 3.5 1 interaction 229 E Glutamic Acid Negatively-charged C (loop/coil) T (turn) 126 -83.5 134.7 79.48 Low-density lipoprotein receptor LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 146 -3.5 2 interactions 2 interactions E229-K225; PAE: 3.5 230 N Asparagine Polar/Neutral C (loop/coil) T (turn) 136 59.0 53.7 75.47 Low-density lipoprotein receptor LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 132 -3.5 2 interactions N230-R215; PAE: 5.0 1 interaction 231 C Cysteine Special, a very reactive sulfhydryl group C (loop/coil) C (loop/coil) 43 -99.0 132.5 75.27 Low-density lipoprotein receptor Disulfide bond 216-231 LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 121 2.5 1 interaction C231-C216; PAE: 7.0 232 A Alanine Aliphatic C (loop/coil) S (bend) 105 -80.5 -33.1 67.16 Low-density lipoprotein receptor LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 89 1.8 1 interaction 1 interaction 233 V Valine Aliphatic C (loop/coil) C (loop/coil) 111 -159.4 119.3 59.62 Low-density lipoprotein receptor LDL-receptor class A 5 Binding to Getah virus E1-E2 spike glycoproteins Extracellular 117 4.2 234 A Alanine Aliphatic C (loop/coil) C (loop/coil) 43 -67.7 121.2 56.38 Low-density lipoprotein receptor LDL-receptor class A 6 Extracellular 89 1.8 235 T Threonine Polar/Neutral C (loop/coil) C (loop/coil) 105 -110.2 112.1 62.73 Low-density lipoprotein receptor LDL-receptor class A 6 Extracellular 119 -0.7 236 C Cysteine Special, a very reactive sulfhydryl group C (loop/coil) C (loop/coil) 20 -66.1 151.4 69.19 Low-density lipoprotein receptor Disulfide bond 236-248 LDL-receptor class A 6 Extracellular 121 2.5 C236-C248; PAE: 6.0 C236-C248; PAE: 6.0 237 R Arginine Positively-charged C (loop/coil) C (loop/coil) 38 -72.6 164.0 59.37 Low-density lipoprotein receptor LDL-receptor class A 6 Extracellular 175 -4.5 R237-D217; PAE: 18.0 R237-D217; PAE: 18.0 238 P Proline Special, No backbone hydrogen C (loop/coil) T (turn) 140 -64.6 -26.4 59.2 Low-density lipoprotein receptor LDL-receptor class A 6 Extracellular 115 1.6 239 D Aspartic Acid Negatively-charged C (loop/coil) T (turn) 35 -91.9 -4.6 54.63 Low-density lipoprotein receptor LDL-receptor class A 6 Extracellular 132 -3.5 1 interaction D239-G251; PAE: 4.5 2 interactions D239-G251; PAE: 4.5 240 E Glutamic Acid Negatively-charged B (undefined) E (parallel sheets) 53 -106.7 142.6 71.51 Low-density lipoprotein receptor LDL-receptor class A 6 Extracellular 146 -3.5 1 interaction 241 F Phenylalanine Aromatic Beta strand B (undefined) E (parallel sheets) 47 -86.4 124.0 77.12 Low-density lipoprotein receptor LDL-receptor class A 6 Extracellular 165 2.8 1 interaction F241-I249; PAE: 2.5 2 interactions F241-Q254, F241-D266, F241-I249; PAE: 3.5, 3.5, 2.5 242 Q Glutamine Polar/Neutral Beta strand B (undefined) E (parallel sheets) 102 -79.3 110.5 79.22 Low-density lipoprotein receptor LDL-receptor class A 6 Extracellular 146 -3.5 243 C Cysteine Special, a very reactive sulfhydryl group Beta strand C (loop/coil) C (loop/coil) 2 -58.2 155.1 82.42 Low-density lipoprotein receptor Disulfide bond 243-261 LDL-receptor class A 6 Extracellular 121 2.5 1 interaction C243-N247; PAE: 4.0 2 interactions C243-C261; PAE: 4.0 244 S Serine Polar/Neutral Turn C (loop/coil) T (turn) 97 -65.7 -25.5 79.35 Low-density lipoprotein receptor LDL-receptor class A 6 Extracellular 105 -0.8 S244-D263, S244-S265; PAE: 5.5, 5.0 1 interaction S244-S265; PAE: 5.0 245 D Aspartic Acid Negatively-charged Turn C (loop/coil) T (turn) 97 -68.5 -12.0 77.99 Low-density lipoprotein receptor LDL-receptor class A 6 Extracellular 132 -3.5 D245-D263; PAE: 6.0 1 interaction D245-D263; PAE: 6.0 246 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible Turn C (loop/coil) S (bend) 25 92.2 -1.6 74.41 Low-density lipoprotein receptor LDL-receptor class A 6 Extracellular 75 -0.4 247 N Asparagine Polar/Neutral Beta strand C (loop/coil) C (loop/coil) 77 -72.2 151.8 78.06 Low-density lipoprotein receptor LDL-receptor class A 6 Extracellular 132 -3.5 1 interaction N247-C243; PAE: 4.0 248 C Cysteine Special, a very reactive sulfhydryl group Beta strand B (undefined) E (parallel sheets) 41 -110.1 133.1 78.63 Low-density lipoprotein receptor Disulfide bond 236-248 LDL-receptor class A 6 Extracellular 121 2.5 C248-C236; PAE: 6.0 C248-C236; PAE: 6.0 249 I Isoleucine Aliphatic Beta strand B (undefined) E (parallel sheets) 16 -119.4 155.0 76.69 Low-density lipoprotein receptor LDL-receptor class A 6 Extracellular 131 4.5 1 interaction I249-F241; PAE: 2.5 3 interactions I249-F241; PAE: 2.5 250 H Histidine Positively-charged B (undefined) E (parallel sheets) 54 -63.8 143.1 72.48 Low-density lipoprotein receptor LDL-receptor class A 6 Extracellular 155 -3.2 2 interactions 251 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible Helix H (helix) G (3₁₀-helix) 34 -62.3 -16.6 70.74 Low-density lipoprotein receptor LDL-receptor class A 6 Extracellular 75 -0.4 1 interaction G251-D239; PAE: 4.5 1 interaction G251-D239; PAE: 4.5 252 S Serine Polar/Neutral Helix H (helix) G (3₁₀-helix) 71 -73.0 -22.6 72.75 Low-density lipoprotein receptor LDL-receptor class A 6 Extracellular 105 -0.8 253 R Arginine Positively-charged Helix H (helix) G (3₁₀-helix) 71 -86.1 8.4 78.48 Low-density lipoprotein receptor LDL-receptor class A 6 Extracellular 175 -4.5 1 interaction 254 Q Glutamine Polar/Neutral Beta strand C (loop/coil) S (bend) 93 -89.3 122.0 75.17 Low-density lipoprotein receptor LDL-receptor class A 6 Extracellular 146 -3.5 3 interactions Q254-F241; PAE: 3.5 255 C Cysteine Special, a very reactive sulfhydryl group Beta strand C (loop/coil) S (bend) 58 64.0 35.5 76.7 Low-density lipoprotein receptor Disulfide bond 255-270 LDL-receptor class A 6 Extracellular 121 2.5 1 interaction C255-D266; PAE: 3.0 C255-C270; PAE: 7.0 256 D Aspartic Acid Negatively-charged Beta strand C (loop/coil) S (bend) 65 -93.4 1.8 71.92 Low-density lipoprotein receptor LDL-receptor class A 6 Extracellular 132 -3.5 1 interaction D256-E267; PAE: 4.0 257 R Arginine Positively-charged Beta strand C (loop/coil) S (bend) 211 78.1 2.9 69.81 Low-density lipoprotein receptor LDL-receptor class A 6 Extracellular 175 -4.5 1 interaction R257-E267; PAE: 3.0 258 E Glutamic Acid Negatively-charged Beta strand C (loop/coil) S (bend) 132 -103.0 157.0 75.87 Low-density lipoprotein receptor LDL-receptor class A 6 Extracellular 146 -3.5 1 interaction 259 Y Tyrosine Aromatic C (loop/coil) C (loop/coil) 154 -103.0 86.4 81.35 Low-density lipoprotein receptor LDL-receptor class A 6 Extracellular 181 -1.3 1 interaction 260 D Aspartic Acid Negatively-charged Beta strand C (loop/coil) C (loop/coil) 60 -83.2 -33.5 79.81 Low-density lipoprotein receptor LDL-receptor class A 6 Extracellular 132 -3.5 D260-D266; PAE: 4.0 261 C Cysteine Special, a very reactive sulfhydryl group Beta strand C (loop/coil) S (bend) 3 -74.8 132.6 82.16 Low-density lipoprotein receptor Disulfide bond 243-261 LDL-receptor class A 6 Extracellular 121 2.5 1 interaction C261-D266; PAE: 3.5 C261-D266, C261-S265; PAE: 3.5, 5.0 C261-C243; PAE: 4.0 262 K Lysine Positively-charged Beta strand C (loop/coil) T (turn) 186 -60.1 -26.8 79.57 Low-density lipoprotein receptor LDL-receptor class A 6 Extracellular 147 -3.9 263 D Aspartic Acid Negatively-charged Beta strand C (loop/coil) T (turn) 40 -94.2 3.7 83.41 Low-density lipoprotein receptor LDL-receptor class A 6 Extracellular 132 -3.5 D263-S244, D263-D245; PAE: 5.5, 6.0 1 interaction D263-D245; PAE: 6.0 264 M Methionine Aliphatic Beta strand C (loop/coil) C (loop/coil) 99 62.2 19.1 79.05 Low-density lipoprotein receptor LDL-receptor class A 6 Extracellular 149 1.9 2 interactions M264-V268; PAE: 3.0 265 S Serine Polar/Neutral Helix H (helix) G (3₁₀-helix) 16 -62.3 -31.0 85.28 Low-density lipoprotein receptor LDL-receptor class A 6 Extracellular 105 -0.8 S265-S244; PAE: 5.0 2 interactions S265-C261, S265-S244; PAE: 5.0, 5.0 266 D Aspartic Acid Negatively-charged Helix H (helix) G (3₁₀-helix) 1 -60.6 -33.0 81.17 Low-density lipoprotein receptor LDL-receptor class A 6 Extracellular 132 -3.5 1 interaction D266-C261, D266-C255, D266-D260; PAE: 3.5, 3.0, 4.0 1 interaction D266-C261, D266-F241; PAE: 3.5, 3.5 267 E Glutamic Acid Negatively-charged Helix H (helix) G (3₁₀-helix) 34 -98.0 -2.0 83.69 Low-density lipoprotein receptor LDL-receptor class A 6 Extracellular 146 -3.5 3 interactions E267-R257, E267-D256; PAE: 3.0, 4.0 268 V Valine Aliphatic Beta strand C (loop/coil) T (turn) 107 -91.7 125.7 78.43 Low-density lipoprotein receptor LDL-receptor class A 6 Extracellular 117 4.2 2 interactions V268-M264; PAE: 3.0 269 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible Beta strand C (loop/coil) T (turn) 75 84.5 5.2 72.21 Low-density lipoprotein receptor LDL-receptor class A 6 Extracellular 75 -0.4 270 C Cysteine Special, a very reactive sulfhydryl group Beta strand C (loop/coil) C (loop/coil) 21 -54.1 135.8 70.37 Low-density lipoprotein receptor Disulfide bond 255-270 LDL-receptor class A 6 Extracellular 121 2.5 C270-C255; PAE: 7.0 271 V Valine Aliphatic C (loop/coil) C (loop/coil) 139 -69.9 83.4 65.63 Low-density lipoprotein receptor LDL-receptor class A 6 Extracellular 117 4.2 272 N Asparagine Polar/Neutral C (loop/coil) C (loop/coil) 129 -70.1 91.5 46.22 Low-density lipoprotein receptor LDL-receptor class A 6 N-linked (GlcNAc...) asparagine Extracellular 132 -3.5 1 interaction 273 V Valine Aliphatic C (loop/coil) C (loop/coil) 105 -60.4 106.1 43.47 Low-density lipoprotein receptor Extracellular 117 4.2 274 T Threonine Polar/Neutral C (loop/coil) C (loop/coil) 129 -70.2 76.3 42.57 Low-density lipoprotein receptor LDL-receptor class A 7 Extracellular 119 -0.7 275 L Leucine Aliphatic C (loop/coil) C (loop/coil) 105 -69.7 137.5 51.9 Low-density lipoprotein receptor LDL-receptor class A 7 Extracellular 131 3.8 276 C Cysteine Special, a very reactive sulfhydryl group C (loop/coil) C (loop/coil) 31 -66.9 78.9 63.57 Low-density lipoprotein receptor Disulfide bond 276-289 LDL-receptor class A 7 Extracellular 121 2.5 1 interaction 1 interaction C276-C289; PAE: 5.5 277 E Glutamic Acid Negatively-charged C (loop/coil) C (loop/coil) 142 -83.6 123.0 58.53 Low-density lipoprotein receptor LDL-receptor class A 7 Extracellular 146 -3.5 278 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible C (loop/coil) S (bend) 36 164.0 138.4 63.96 Low-density lipoprotein receptor LDL-receptor class A 7 Extracellular 75 -0.4 279 P Proline Special, No backbone hydrogen C (loop/coil) T (turn) 125 -61.0 -15.9 65.61 Low-density lipoprotein receptor LDL-receptor class A 7 Extracellular 115 1.6 280 N Asparagine Polar/Neutral C (loop/coil) T (turn) 106 -118.4 23.1 72.18 Low-density lipoprotein receptor LDL-receptor class A 7 Extracellular 132 -3.5 1 interaction N280-L292; PAE: 4.0 2 interactions N280-L292; PAE: 4.0 281 K Lysine Positively-charged Beta strand B (undefined) E (parallel sheets) 123 -118.6 134.3 77.49 Low-density lipoprotein receptor LDL-receptor class A 7 Extracellular 147 -3.9 1 interaction 282 F Phenylalanine Aromatic Beta strand B (undefined) E (parallel sheets) 48 -110.1 133.6 79.16 Low-density lipoprotein receptor LDL-receptor class A 7 Extracellular 165 2.8 1 interaction F282-I290; PAE: 2.0 5 interactions F282-I290; PAE: 2.0 283 K Lysine Positively-charged Beta strand B (undefined) E (parallel sheets) 127 -91.9 113.9 79.42 Low-density lipoprotein receptor LDL-receptor class A 7 Extracellular 147 -3.9 284 C Cysteine Special, a very reactive sulfhydryl group C (loop/coil) C (loop/coil) 1 -61.4 146.9 79.55 Low-density lipoprotein receptor Disulfide bond 284-302 LDL-receptor class A 7 Extracellular 121 2.5 2 interactions C284-E288; PAE: 6.5 2 interactions 1 interaction C284-C302; PAE: 3.5 285 H Histidine Positively-charged C (loop/coil) T (turn) 174 -61.2 -24.8 79.44 Low-density lipoprotein receptor LDL-receptor class A 7 Extracellular 155 -3.2 2 interactions H285-S306; PAE: 4.5 286 S Serine Polar/Neutral C (loop/coil) T (turn) 52 -72.0 -5.0 78.14 Low-density lipoprotein receptor LDL-receptor class A 7 Extracellular 105 -0.8 S286-D304; PAE: 4.5 S286-R303; PAE: 5.0 287 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible C (loop/coil) S (bend) 47 93.5 -3.6 76.99 Low-density lipoprotein receptor LDL-receptor class A 7 Extracellular 75 -0.4 288 E Glutamic Acid Negatively-charged C (loop/coil) C (loop/coil) 89 -78.6 143.4 76.52 Low-density lipoprotein receptor LDL-receptor class A 7 Extracellular 146 -3.5 2 interactions E288-C284; PAE: 6.5 2 interactions E288-R303; PAE: 4.5 289 C Cysteine Special, a very reactive sulfhydryl group Beta strand B (undefined) E (parallel sheets) 69 -102.3 118.4 81.21 Low-density lipoprotein receptor Disulfide bond 276-289 LDL-receptor class A 7 Extracellular 121 2.5 2 interactions 1 interaction C289-C276; PAE: 5.5 290 I Isoleucine Aliphatic Beta strand B (undefined) E (parallel sheets) 18 -106.1 170.4 80.36 Low-density lipoprotein receptor LDL-receptor class A 7 Extracellular 131 4.5 1 interaction I290-F282; PAE: 2.0 2 interactions I290-F282; PAE: 2.0 291 T Threonine Polar/Neutral Beta strand B (undefined) E (parallel sheets) 63 -88.6 144.5 81.57 Low-density lipoprotein receptor LDL-receptor class A 7 Extracellular 119 -0.7 3 interactions T291-V295; PAE: 3.0 292 L Leucine Aliphatic Beta strand H (helix) G (3₁₀-helix) 67 -56.6 -26.3 80.15 Low-density lipoprotein receptor LDL-receptor class A 7 Extracellular 131 3.8 1 interaction L292-N280; PAE: 4.0 2 interactions L292-N280; PAE: 4.0 293 D Aspartic Acid Negatively-charged Turn H (helix) G (3₁₀-helix) 116 -65.6 -19.0 82.31 Low-density lipoprotein receptor LDL-receptor class A 7 Extracellular 132 -3.5 294 K Lysine Positively-charged Turn H (helix) G (3₁₀-helix) 74 -92.3 -6.3 82.99 Low-density lipoprotein receptor LDL-receptor class A 7 Extracellular 147 -3.9 K294-D301; PAE: 4.0 1 interaction K294-D301; PAE: 4.0 295 V Valine Aliphatic Turn C (loop/coil) T (turn) 8 -80.4 128.2 83.33 Low-density lipoprotein receptor LDL-receptor class A 7 Extracellular 117 4.2 V295-T291; PAE: 3.0 296 C Cysteine Special, a very reactive sulfhydryl group Turn C (loop/coil) T (turn) 33 61.1 42.6 82.96 Low-density lipoprotein receptor Disulfide bond 296-313 LDL-receptor class A 7 Extracellular 121 2.5 C296-D307; PAE: 3.0 C296-G314; PAE: 5.5 1 interaction C296-C313; PAE: 5.0 297 N Asparagine Polar/Neutral C (loop/coil) S (bend) 65 -104.6 9.3 84.36 Low-density lipoprotein receptor LDL-receptor class A 7 Extracellular 132 -3.5 2 interactions N297-D301; PAE: 3.0 298 M Methionine Aliphatic C (loop/coil) S (bend) 178 64.8 19.6 78.03 Low-density lipoprotein receptor LDL-receptor class A 7 Extracellular 149 1.9 M298-E308; PAE: 4.5 299 A Alanine Aliphatic C (loop/coil) S (bend) 43 -129.6 136.7 81.31 Low-density lipoprotein receptor LDL-receptor class A 7 Extracellular 89 1.8 1 interaction A299-E308; PAE: 3.5 300 R Arginine Positively-charged C (loop/coil) C (loop/coil) 131 -75.3 92.2 83.53 Low-density lipoprotein receptor LDL-receptor class A 7 Extracellular 175 -4.5 1 interaction R300-W305; PAE: 2.5 301 D Aspartic Acid Negatively-charged C (loop/coil) C (loop/coil) 53 -92.0 -31.4 83.5 Low-density lipoprotein receptor LDL-receptor class A 7 Extracellular 132 -3.5 2 interactions D301-K294, D301-N297, D301-D307; PAE: 4.0, 3.0, 3.5 1 interaction D301-K294; PAE: 4.0 302 C Cysteine Special, a very reactive sulfhydryl group C (loop/coil) S (bend) 0 -86.0 145.5 82.07 Low-density lipoprotein receptor Disulfide bond 284-302 LDL-receptor class A 7 Extracellular 121 2.5 C302-D307, C302-S306; PAE: 3.0, 4.0 1 interaction C302-C284; PAE: 3.5 303 R Arginine Positively-charged C (loop/coil) T (turn) 188 -64.1 -29.3 78.89 Low-density lipoprotein receptor LDL-receptor class A 7 Extracellular 175 -4.5 R303-E288, R303-S286; PAE: 4.5, 5.0 304 D Aspartic Acid Negatively-charged C (loop/coil) T (turn) 55 -103.7 6.4 82.02 Low-density lipoprotein receptor LDL-receptor class A 7 Extracellular 132 -3.5 D304-S286; PAE: 4.5 305 W Tryptophan Aromatic C (loop/coil) S (bend) 152 64.0 19.1 76.66 Low-density lipoprotein receptor LDL-receptor class A 7 Extracellular 204 -0.9 1 interaction W305-R300; PAE: 2.5 306 S Serine Polar/Neutral Beta strand C (loop/coil) T (turn) 34 -63.4 -21.3 81.14 Low-density lipoprotein receptor LDL-receptor class A 7 Extracellular 105 -0.8 2 interactions S306-H285, S306-C302; PAE: 4.5, 4.0 307 D Aspartic Acid Negatively-charged Beta strand C (loop/coil) T (turn) 0 -78.5 -16.4 81.8 Low-density lipoprotein receptor LDL-receptor class A 7 Extracellular 132 -3.5 1 interaction D307-D301, D307-C296; PAE: 3.5, 3.0 D307-C302; PAE: 3.0 308 E Glutamic Acid Negatively-charged Beta strand C (loop/coil) C (loop/coil) 26 -135.7 61.7 84.47 Low-density lipoprotein receptor LDL-receptor class A 7 Extracellular 146 -3.5 2 interactions E308-A299, E308-M298; PAE: 3.5, 4.5 309 P Proline Special, No backbone hydrogen C (loop/coil) C (loop/coil) 36 -68.3 121.2 78.24 Low-density lipoprotein receptor LDL-receptor class A 7 Extracellular 115 1.6 1 interaction P309-C313; PAE: 4.5 1 interaction P309-C313; PAE: 4.5 310 I Isoleucine Aliphatic Turn C (loop/coil) T (turn) 182 -53.8 -28.2 75.28 Low-density lipoprotein receptor LDL-receptor class A 7 Extracellular 131 4.5 1 interaction 311 K Lysine Positively-charged Turn C (loop/coil) T (turn) 165 -106.3 -33.3 75.31 Low-density lipoprotein receptor LDL-receptor class A 7 Extracellular 147 -3.9 K311-T315; PAE: 5.0 1 interaction K311-T315; PAE: 5.0 312 E Glutamic Acid Negatively-charged Turn C (loop/coil) T (turn) 84 -98.8 -11.6 72.75 Low-density lipoprotein receptor LDL-receptor class A 7 Extracellular 146 -3.5 1 interaction 3 interactions 313 C Cysteine Special, a very reactive sulfhydryl group B (undefined) B (beta bridge) 39 -73.5 112.4 82.17 Low-density lipoprotein receptor Disulfide bond 296-313 LDL-receptor class A 7 Extracellular 121 2.5 1 interaction C313-P309; PAE: 4.5 1 interaction C313-P309; PAE: 4.5 1 interaction C313-C296; PAE: 5.0 314 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible C (loop/coil) T (turn) 58 70.3 12.9 77.25 Low-density lipoprotein receptor EGF-like 1 Extracellular 75 -0.4 5 interactions G314-K333; PAE: 4.5 G314-C296; PAE: 5.5 315 T Threonine Polar/Neutral C (loop/coil) C (loop/coil) 65 -79.3 134.1 82.27 Low-density lipoprotein receptor EGF-like 1 Extracellular 119 -0.7 1 interaction T315-K311; PAE: 5.0 2 interactions T315-K311; PAE: 5.0 316 N Asparagine Polar/Neutral C (loop/coil) C (loop/coil) 62 -97.3 96.1 82.79 Low-density lipoprotein receptor EGF-like 1 Extracellular 132 -3.5 N316-D331; PAE: 2.5 1 interaction 8 interactions 7 interactions 317 E Glutamic Acid Negatively-charged Helix H (helix) G (3₁₀-helix) 30 -70.8 -20.7 85.15 Low-density lipoprotein receptor EGF-like 1 Extracellular 146 -3.5 2 interactions 13 interactions E317-G323; PAE: 4.5 318 C Cysteine Special, a very reactive sulfhydryl group Helix H (helix) G (3₁₀-helix) 24 -64.6 -19.6 87.13 Low-density lipoprotein receptor Disulfide bond 318-329 EGF-like 1 Extracellular 121 2.5 8 interactions 16 interactions C318-G323, C318-N322, C318-D331; PAE: 3.0, 2.5, 2.5 4 interactions C318-C329; PAE: 2.5 319 L Leucine Aliphatic Helix H (helix) G (3₁₀-helix) 155 -71.9 -21.7 87.2 Low-density lipoprotein receptor EGF-like 1 Extracellular 131 3.8 320 D Aspartic Acid Negatively-charged C (loop/coil) T (turn) 132 -103.5 107.4 86.55 Low-density lipoprotein receptor EGF-like 1 Extracellular 132 -3.5 4 interactions 1 interaction 2 interactions 321 N Asparagine Polar/Neutral Helix H (helix) G (3₁₀-helix) 135 47.9 37.6 87.43 Low-density lipoprotein receptor EGF-like 1 Extracellular 132 -3.5 3 interactions 4 interactions 322 N Asparagine Polar/Neutral Helix H (helix) G (3₁₀-helix) 58 55.2 32.6 85.26 Low-density lipoprotein receptor EGF-like 1 Extracellular 132 -3.5 10 interactions N322-H327; PAE: 3.0 14 interactions N322-C318, N322-C329; PAE: 2.5, 2.0 9 interactions 323 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible Helix H (helix) G (3₁₀-helix) 11 64.2 5.9 82.9 Low-density lipoprotein receptor EGF-like 1 Extracellular 75 -0.4 13 interactions 17 interactions G323-E317, G323-C318, G323-Y336; PAE: 4.5, 3.0, 2.5 324 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible Helix H (helix) G (3₁₀-helix) 27 78.1 11.6 84.4 Low-density lipoprotein receptor EGF-like 1 Extracellular 75 -0.4 2 interactions 7 interactions 325 C Cysteine Special, a very reactive sulfhydryl group C (loop/coil) C (loop/coil) 10 -75.5 139.7 87.57 Low-density lipoprotein receptor Disulfide bond 325-338 EGF-like 1 Extracellular 121 2.5 4 interactions 4 interactions C325-C338; PAE: 3.5 326 S Serine Polar/Neutral Beta strand C (loop/coil) S (bend) 60 -66.9 -38.0 86.21 Low-density lipoprotein receptor EGF-like 1 Extracellular 105 -0.8 7 interactions S326-C352, S326-R350; PAE: 3.5, 3.5 11 interactions S326-C352; PAE: 3.5 327 H Histidine Positively-charged Beta strand C (loop/coil) S (bend) 82 -122.3 -101.3 87.75 Low-density lipoprotein receptor EGF-like 1 Extracellular 155 -3.2 5 interactions H327-N322; PAE: 3.0 2 interactions 328 V Valine Aliphatic Beta strand B (undefined) E (parallel sheets) 78 -95.0 127.0 89.29 Low-density lipoprotein receptor EGF-like 1 Extracellular 117 4.2 12 interactions V328-L339; PAE: 2.0 13 interactions V328-L339; PAE: 2.0 329 C Cysteine Special, a very reactive sulfhydryl group Beta strand B (undefined) E (parallel sheets) 20 -101.7 116.9 89.64 Low-density lipoprotein receptor Disulfide bond 318-329 EGF-like 1 Extracellular 121 2.5 2 interactions 10 interactions C329-N322; PAE: 2.0 4 interactions C329-C318; PAE: 2.5 8 interactions 8 interactions 330 N Asparagine Polar/Neutral Beta strand B (undefined) E (parallel sheets) 62 -98.5 121.7 87.52 Low-density lipoprotein receptor EGF-like 1 Extracellular 132 -3.5 13 interactions N330-E337; PAE: 2.0 14 interactions N330-E337; PAE: 2.0 8 interactions 5 interactions 331 D Aspartic Acid Negatively-charged B (undefined) E (parallel sheets) 57 -82.7 117.2 84.17 Low-density lipoprotein receptor EGF-like 1 Extracellular 132 -3.5 1 interaction D331-N316; PAE: 2.5 10 interactions D331-C318; PAE: 2.5 8 interactions 8 interactions 7 interactions 332 L Leucine Aliphatic H (helix) P (polyproline helix) 70 -95.0 166.4 83.01 Low-density lipoprotein receptor EGF-like 1 Extracellular 131 3.8 3 interactions 333 K Lysine Positively-charged Beta strand C (loop/coil) S (bend) 135 -61.9 -27.3 80.97 Low-density lipoprotein receptor EGF-like 1 Extracellular 147 -3.9 4 interactions K333-G314; PAE: 4.5 1 interaction 334 I Isoleucine Aliphatic Beta strand B (undefined) B (beta bridge) 49 -132.9 113.9 77.88 Low-density lipoprotein receptor EGF-like 1 Extracellular 131 4.5 1 interaction 335 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible Beta strand C (loop/coil) S (bend) 14 72.4 -164.7 82.75 Low-density lipoprotein receptor EGF-like 1 Extracellular 75 -0.4 4 interactions 6 interactions 336 Y Tyrosine Aromatic B (undefined) E (parallel sheets) 75 -138.7 156.8 84.82 Low-density lipoprotein receptor EGF-like 1 Extracellular 181 -1.3 12 interactions Y336-R350; PAE: 4.0 13 interactions Y336-G323; PAE: 2.5 337 E Glutamic Acid Negatively-charged Beta strand B (undefined) E (parallel sheets) 81 -125.0 143.0 85.69 Low-density lipoprotein receptor EGF-like 1 Extracellular 146 -3.5 13 interactions E337-N330; PAE: 2.0 13 interactions E337-N330; PAE: 2.0 338 C Cysteine Special, a very reactive sulfhydryl group Beta strand B (undefined) E (parallel sheets) 10 -90.6 129.4 89.58 Low-density lipoprotein receptor Disulfide bond 325-338 EGF-like 1 Extracellular 121 2.5 1 interaction 4 interactions C338-C325; PAE: 3.5 339 L Leucine Aliphatic Beta strand B (undefined) E (parallel sheets) 74 -110.5 142.1 87.53 Low-density lipoprotein receptor EGF-like 1 Extracellular 131 3.8 12 interactions L339-V328; PAE: 2.0 13 interactions L339-V328; PAE: 2.0 340 C Cysteine Special, a very reactive sulfhydryl group H (helix) P (polyproline helix) 31 -95.9 148.3 88.8 Low-density lipoprotein receptor Disulfide bond 340-352 EGF-like 1 Extracellular 121 2.5 6 interactions C340-L346; PAE: 2.0 3 interactions C340-C352; PAE: 2.5 1 interaction 341 P Proline Special, No backbone hydrogen Beta strand H (helix) P (polyproline helix) 49 -58.2 161.8 87.14 Low-density lipoprotein receptor EGF-like 1 Extracellular 115 1.6 342 D Aspartic Acid Negatively-charged Beta strand C (loop/coil) T (turn) 158 -54.3 140.7 83.61 Low-density lipoprotein receptor EGF-like 1 Extracellular 132 -3.5 343 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible Beta strand C (loop/coil) T (turn) 17 84.7 1.3 83.31 Low-density lipoprotein receptor EGF-like 1 Extracellular 75 -0.4 1 interaction G343-I355; PAE: 3.0 2 interactions G343-I355; PAE: 3.0 344 F Phenylalanine Aromatic B (undefined) E (parallel sheets) 37 -127.3 141.9 88.62 Low-density lipoprotein receptor EGF-like 1 Extracellular 165 2.8 10 interactions F344-D354, F344-G373; PAE: 1.0, 2.5 345 Q Glutamine Polar/Neutral Beta strand B (undefined) E (parallel sheets) 131 -103.0 136.8 84.75 Low-density lipoprotein receptor EGF-like 1 Extracellular 146 -3.5 10 interactions Q345-E353; PAE: 2.0 11 interactions Q345-E353; PAE: 2.0 346 L Leucine Aliphatic Beta strand B (undefined) E (parallel sheets) 70 -76.0 104.1 85.32 Low-density lipoprotein receptor EGF-like 1 Extracellular 131 3.8 11 interactions L346-C340, L346-R350; PAE: 2.0, 2.0 347 V Valine Aliphatic Beta strand B (undefined) E (parallel sheets) 47 -94.4 132.6 84.98 Low-density lipoprotein receptor EGF-like 1 Extracellular 117 4.2 8 interactions V347-R351; PAE: 3.5 9 interactions V347-R351; PAE: 3.5 348 A Alanine Aliphatic Turn C (loop/coil) T (turn) 67 53.3 35.0 83.07 Low-density lipoprotein receptor EGF-like 1 Extracellular 89 1.8 349 Q Glutamine Polar/Neutral Turn C (loop/coil) T (turn) 161 61.1 5.8 79.78 Low-density lipoprotein receptor EGF-like 1 Extracellular 146 -3.5 350 R Arginine Positively-charged Turn C (loop/coil) T (turn) 125 -143.5 -34.8 84.86 Low-density lipoprotein receptor EGF-like 1 Extracellular 175 -4.5 9 interactions R350-Y336, R350-S326; PAE: 4.0, 3.5 9 interactions R350-L346; PAE: 2.0 351 R Arginine Positively-charged Beta strand B (undefined) E (parallel sheets) 155 -95.7 142.8 86.18 Low-density lipoprotein receptor EGF-like 1 Extracellular 175 -4.5 8 interactions R351-V347; PAE: 3.5 10 interactions R351-V347; PAE: 3.5 352 C Cysteine Special, a very reactive sulfhydryl group Beta strand B (undefined) E (parallel sheets) 19 -105.8 119.7 87.48 Low-density lipoprotein receptor Disulfide bond 340-352 EGF-like 1 Extracellular 121 2.5 1 interaction C352-S326; PAE: 3.5 8 interactions C352-S326; PAE: 3.5 3 interactions C352-C340; PAE: 2.5 353 E Glutamic Acid Negatively-charged Beta strand B (undefined) E (parallel sheets) 102 -105.6 147.3 87.27 Low-density lipoprotein receptor EGF-like 1 Extracellular 146 -3.5 10 interactions E353-Q345; PAE: 2.0 12 interactions E353-Q345; PAE: 2.0 354 D Aspartic Acid Negatively-charged B (undefined) E (parallel sheets) 50 -60.6 134.8 87.81 Low-density lipoprotein receptor EGF-like 2; calcium-binding Extracellular 132 -3.5 D354-G373, D354-N370; PAE: 3.5, 2.5 6 interactions D354-G373, D354-F344; PAE: 3.5, 1.0 355 I Isoleucine Aliphatic C (loop/coil) C (loop/coil) 66 -81.0 114.9 87.07 Low-density lipoprotein receptor EGF-like 2; calcium-binding Extracellular 131 4.5 1 interaction I355-G343; PAE: 3.0 2 interactions I355-G343; PAE: 3.0 356 D Aspartic Acid Negatively-charged C (loop/coil) C (loop/coil) 60 -74.8 88.3 83.93 Low-density lipoprotein receptor EGF-like 2; calcium-binding Extracellular 132 -3.5 5 interactions D356-N370; PAE: 2.0 357 E Glutamic Acid Negatively-charged Helix H (helix) G (3₁₀-helix) 32 -64.9 -18.5 86.03 Low-density lipoprotein receptor EGF-like 2; calcium-binding Extracellular 146 -3.5 1 interaction E357-T363; PAE: 4.5 4 interactions E357-Y375, E357-T363; PAE: 2.0, 4.5 358 C Cysteine Special, a very reactive sulfhydryl group Helix H (helix) G (3₁₀-helix) 35 -72.6 -8.1 84.32 Low-density lipoprotein receptor Disulfide bond 358-368 EGF-like 2; calcium-binding Extracellular 121 2.5 8 interactions C358-N370, C358-V369; PAE: 2.0, 1.5 1 interaction C358-C368; PAE: 2.5 359 Q Glutamine Polar/Neutral Helix H (helix) G (3₁₀-helix) 145 -73.3 -22.9 82.25 Low-density lipoprotein receptor EGF-like 2; calcium-binding Extracellular 146 -3.5 1 interaction 360 D Aspartic Acid Negatively-charged C (loop/coil) S (bend) 79 -85.3 116.5 77.25 Low-density lipoprotein receptor EGF-like 2; calcium-binding Extracellular 132 -3.5 1 interaction 361 P Proline Special, No backbone hydrogen C (loop/coil) T (turn) 54 -63.4 -14.7 70.22 Low-density lipoprotein receptor EGF-like 2; calcium-binding Extracellular 115 1.6 362 D Aspartic Acid Negatively-charged C (loop/coil) T (turn) 53 -82.2 -11.9 72.04 Low-density lipoprotein receptor EGF-like 2; calcium-binding Extracellular 132 -3.5 D362-K596; PAE: 7.0 363 T Threonine Polar/Neutral Beta strand C (loop/coil) S (bend) 26 -66.9 -39.4 79.41 Low-density lipoprotein receptor EGF-like 2; calcium-binding Extracellular 119 -0.7 1 interaction T363-E357; PAE: 4.5 6 interactions T363-E357; PAE: 4.5 364 C Cysteine Special, a very reactive sulfhydryl group Beta strand C (loop/coil) C (loop/coil) 11 -133.8 146.4 79.39 Low-density lipoprotein receptor Disulfide bond 364-377 EGF-like 2; calcium-binding Extracellular 121 2.5 3 interactions C364-C377; PAE: 3.5 1 interaction C364-C377; PAE: 3.5 365 S Serine Polar/Neutral Beta strand C (loop/coil) S (bend) 9 -58.0 -40.7 77.64 Low-density lipoprotein receptor EGF-like 2; calcium-binding Extracellular 105 -0.8 S365-R633; PAE: 5.0 S365-C392; PAE: 4.5 366 Q Glutamine Polar/Neutral Beta strand C (loop/coil) S (bend) 45 -131.5 -102.8 83.35 Low-density lipoprotein receptor EGF-like 2; calcium-binding Extracellular 146 -3.5 Pocket 2: Mean pLDDT: 89.82, Volume: 512.1 ų, Druggability score: 0.1 0.0983 1 interaction Q366-E380; PAE: 3.5 3 interactions Q366-E380; PAE: 3.5 367 L Leucine Aliphatic Beta strand B (undefined) E (parallel sheets) 92 -89.6 121.6 84.14 Low-density lipoprotein receptor EGF-like 2; calcium-binding Extracellular 131 3.8 Pocket 2: Mean pLDDT: 89.82, Volume: 512.1 ų, Druggability score: 0.1 0.0983 4 interactions L367-Q378; PAE: 2.0 5 interactions L367-Q378; PAE: 2.0 368 C Cysteine Special, a very reactive sulfhydryl group Beta strand B (undefined) E (parallel sheets) 32 -98.1 131.8 84.54 Low-density lipoprotein receptor Disulfide bond 358-368 EGF-like 2; calcium-binding Extracellular 121 2.5 2 interactions 1 interaction C368-C358; PAE: 2.5 369 V Valine Aliphatic Beta strand B (undefined) E (parallel sheets) 49 -116.5 115.4 84.94 Low-density lipoprotein receptor EGF-like 2; calcium-binding Extracellular 117 4.2 3 interactions V369-K376; PAE: 1.5 6 interactions V369-C358, V369-Q378, V369-K376; PAE: 1.5, 3.0, 1.5 370 N Asparagine Polar/Neutral B (undefined) E (parallel sheets) 54 -73.7 132.6 84.26 Low-density lipoprotein receptor EGF-like 2; calcium-binding Extracellular 132 -3.5 N370-D354; PAE: 2.5 7 interactions N370-C358, N370-D356; PAE: 2.0, 2.0 371 L Leucine Aliphatic B (undefined) E (parallel sheets) 87 -122.9 156.0 85.69 Low-density lipoprotein receptor EGF-like 2; calcium-binding Extracellular 131 3.8 2 interactions 372 E Glutamic Acid Negatively-charged Beta strand C (loop/coil) T (turn) 175 -68.0 110.8 81.82 Low-density lipoprotein receptor EGF-like 2; calcium-binding Extracellular 146 -3.5 1 interaction 373 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible Beta strand C (loop/coil) T (turn) 29 91.6 12.9 80.41 Low-density lipoprotein receptor EGF-like 2; calcium-binding Extracellular 75 -0.4 G373-D354; PAE: 3.5 2 interactions G373-D354, G373-F344; PAE: 3.5, 2.5 374 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible Beta strand B (undefined) E (parallel sheets) 17 162.8 -170.6 82.31 Low-density lipoprotein receptor EGF-like 2; calcium-binding Extracellular 75 -0.4 375 Y Tyrosine Aromatic B (undefined) E (parallel sheets) 115 -128.3 161.7 85.01 Low-density lipoprotein receptor EGF-like 2; calcium-binding Extracellular 181 -1.3 2 interactions Y375-E357; PAE: 2.0 376 K Lysine Positively-charged Beta strand B (undefined) E (parallel sheets) 37 -127.4 126.1 77.32 Low-density lipoprotein receptor EGF-like 2; calcium-binding Extracellular 147 -3.9 3 interactions K376-V369, K376-E51; PAE: 1.5, 29.5 4 interactions K376-V369; PAE: 1.5 377 C Cysteine Special, a very reactive sulfhydryl group Beta strand B (undefined) E (parallel sheets) 26 -87.0 138.0 83.64 Low-density lipoprotein receptor Disulfide bond 364-377 EGF-like 2; calcium-binding Extracellular 121 2.5 1 interaction C377-C364; PAE: 3.5 1 interaction C377-C364; PAE: 3.5 378 Q Glutamine Polar/Neutral Beta strand B (undefined) E (parallel sheets) 72 -126.1 151.0 82.53 Low-density lipoprotein receptor EGF-like 2; calcium-binding Extracellular 146 -3.5 4 interactions Q378-L367; PAE: 2.0 5 interactions Q378-L367, Q378-V369; PAE: 2.0, 3.0 379 C Cysteine Special, a very reactive sulfhydryl group H (helix) P (polyproline helix) 34 -101.1 146.7 85.04 Low-density lipoprotein receptor Disulfide bond 379-392 EGF-like 2; calcium-binding Extracellular 121 2.5 5 interactions C379-L385; PAE: 3.0 1 interaction C379-C392; PAE: 3.5 380 E Glutamic Acid Negatively-charged H (helix) P (polyproline helix) 86 -76.1 171.0 83.87 Low-density lipoprotein receptor EGF-like 2; calcium-binding Extracellular 146 -3.5 Pocket 2: Mean pLDDT: 89.82, Volume: 512.1 ų, Druggability score: 0.1 0.0983 E380-Q366; PAE: 3.5 1 interaction E380-Q366; PAE: 3.5 381 E Glutamic Acid Negatively-charged Beta strand C (loop/coil) T (turn) 185 -59.5 126.7 82.81 Low-density lipoprotein receptor EGF-like 2; calcium-binding Extracellular 146 -3.5 382 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible Beta strand C (loop/coil) T (turn) 28 94.2 -8.8 81.3 Low-density lipoprotein receptor EGF-like 2; calcium-binding Extracellular 75 -0.4 2 interactions G382-V395; PAE: 5.0 2 interactions G382-V395; PAE: 5.0 383 F Phenylalanine Aromatic Beta strand B (undefined) E (parallel sheets) 18 -108.7 149.9 85.62 Low-density lipoprotein receptor EGF-like 2; calcium-binding Extracellular 165 2.8 Pocket 2: Mean pLDDT: 89.82, Volume: 512.1 ų, Druggability score: 0.1 0.0983 5 interactions F383-A394; PAE: 1.5 384 Q Glutamine Polar/Neutral Beta strand B (undefined) E (parallel sheets) 74 -124.3 139.6 79.19 Low-density lipoprotein receptor EGF-like 2; calcium-binding Extracellular 146 -3.5 3 interactions Q384-K393; PAE: 2.0 6 interactions Q384-K393; PAE: 2.0 385 L Leucine Aliphatic Beta strand B (undefined) E (parallel sheets) 51 -67.8 121.1 77.64 Low-density lipoprotein receptor EGF-like 2; calcium-binding Extracellular 131 3.8 3 interactions L385-C379; PAE: 3.0 386 D Aspartic Acid Negatively-charged C (loop/coil) C (loop/coil) 1 -69.2 116.2 72.05 Low-density lipoprotein receptor EGF-like 2; calcium-binding Extracellular 132 -3.5 4 interactions D386-A391, D386-K390; PAE: 2.5, 2.0 4 interactions D386-A391, D386-K390; PAE: 2.5, 2.0 387 P Proline Special, No backbone hydrogen Turn C (loop/coil) T (turn) 34 -64.3 -20.9 66.16 Low-density lipoprotein receptor EGF-like 2; calcium-binding Extracellular 115 1.6 388 H Histidine Positively-charged Turn C (loop/coil) T (turn) 81 -84.7 -56.6 62.18 Low-density lipoprotein receptor EGF-like 2; calcium-binding Extracellular 155 -3.2 H388-D96; PAE: 29.0 H388-D96; PAE: 29.0 389 T Threonine Polar/Neutral Turn C (loop/coil) T (turn) 79 -82.4 -12.8 69.71 Low-density lipoprotein receptor EGF-like 2; calcium-binding Extracellular 119 -0.7 390 K Lysine Positively-charged C (loop/coil) C (loop/coil) 139 56.3 18.7 71.49 Low-density lipoprotein receptor EGF-like 2; calcium-binding Extracellular 147 -3.9 Morphology: FQLDPHTkACKAVGS; Domain: EGF_CA 2 interactions K390-D386; PAE: 2.0 3 interactions K390-D386; PAE: 2.0 391 A Alanine Aliphatic C (loop/coil) C (loop/coil) 22 -87.9 152.7 77.62 Low-density lipoprotein receptor EGF-like 2; calcium-binding Extracellular 89 1.8 dbSNP: rs11669576; Variant type: LB/B; AA change: Ala391Thr; PTM type: Ubiquitylation; PTM morphology: LDPHTkA*CKAV; Var class: II 3 interactions A391-D386; PAE: 2.5 4 interactions A391-D386; PAE: 2.5 392 C Cysteine Special, a very reactive sulfhydryl group Beta strand B (undefined) E (parallel sheets) 0 -91.5 111.2 85.08 Low-density lipoprotein receptor Disulfide bond 379-392 EGF-like 2; calcium-binding Extracellular 121 2.5 1 interaction 2 interactions C392-S365; PAE: 4.5 1 interaction C392-C379; PAE: 3.5 393 K Lysine Positively-charged Beta strand B (undefined) E (parallel sheets) 13 -108.4 141.2 83.23 Low-density lipoprotein receptor EGF-like 2; calcium-binding Extracellular 147 -3.9 3 interactions K393-Q384, K393-D94, K393-D90, K393-Q92; PAE: 2.0, 29.0, 29.0, 28.5 5 interactions K393-Q384; PAE: 2.0 394 A Alanine Aliphatic Beta strand B (undefined) E (parallel sheets) 8 -70.2 149.2 86.01 Low-density lipoprotein receptor Extracellular 89 1.8 A394-E615; PAE: 3.5 2 interactions A394-F383; PAE: 1.5 395 V Valine Aliphatic C (loop/coil) C (loop/coil) 48 -107.0 125.3 79.91 Low-density lipoprotein receptor Extracellular 117 4.2 2 interactions V395-G382; PAE: 5.0 3 interactions V395-G382; PAE: 5.0 396 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible C (loop/coil) S (bend) 57 97.4 -24.2 73.95 Low-density lipoprotein receptor Extracellular 75 -0.4 1 interaction 1 interaction G396-F86; PAE: 29.0 397 S Serine Polar/Neutral C (loop/coil) S (bend) 54 -124.0 145.3 79.95 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 105 -0.8 S397-N657, S397-H656; PAE: 6.0, 3.5 S397-N657, S397-H656; PAE: 6.0, 3.5 398 I Isoleucine Aliphatic C (loop/coil) C (loop/coil) 114 -79.1 132.5 85.57 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 131 4.5 399 A Alanine Aliphatic C (loop/coil) C (loop/coil) 9 -85.8 135.8 92.29 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 89 1.8 2 interactions A399-L414; PAE: 2.0 400 Y Tyrosine Aromatic Beta strand B (undefined) E (parallel sheets) 48 -120.9 143.7 94.91 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 181 -1.3 2 interactions Y400-E418, Y400-F655; PAE: 2.5, 1.0 2 interactions Y400-F655; PAE: 1.0 401 L Leucine Aliphatic Beta strand B (undefined) E (parallel sheets) 0 -96.3 124.7 97.03 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 131 3.8 2 interactions L401-M412; PAE: 1.0 2 interactions L401-M412; PAE: 1.0 402 F Phenylalanine Aromatic Beta strand B (undefined) E (parallel sheets) 7 -106.2 129.6 96.89 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 165 2.8 2 interactions F402-V653; PAE: 1.0 2 interactions F402-V653; PAE: 1.0 403 F Phenylalanine Aromatic Beta strand B (undefined) E (parallel sheets) 0 -144.5 154.3 97.27 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 165 2.8 2 interactions F403-R410; PAE: 1.0 2 interactions F403-R410; PAE: 1.0 404 T Threonine Polar/Neutral Beta strand B (undefined) E (parallel sheets) 0 -77.8 147.2 95.76 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 119 -0.7 2 interactions T404-D651, T404-E650; PAE: 1.0, 2.0 3 interactions T404-E650, T404-D651; PAE: 2.0, 1.0 405 N Asparagine Polar/Neutral C (loop/coil) C (loop/coil) 5 -141.9 58.3 92.75 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 132 -3.5 2 interactions N405-L647; PAE: 2.0 3 interactions N405-L647, N405-R410; PAE: 2.0, 1.5 406 R Arginine Positively-charged Beta strand C (loop/coil) S (bend) 67 54.7 -69.0 87.99 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 175 -4.5 3 interactions R406-V429, R406-D172; PAE: 1.5, 11.0 4 interactions R406-V429; PAE: 1.5 407 H Histidine Positively-charged Beta strand C (loop/coil) S (bend) 9 -102.6 7.1 88.34 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 155 -3.2 2 interactions H407-L426, H407-D172, H407-R427; PAE: 1.5, 10.5, 2.0 3 interactions H407-L426, H407-N425; PAE: 1.5, 2.0 408 E Glutamic Acid Negatively-charged Beta strand C (loop/coil) C (loop/coil) 25 -154.5 165.5 89.43 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 146 -3.5 2 interactions E408-S421; PAE: 2.0 2 interactions E408-S421; PAE: 2.0 1 interaction E408-R410; PAE: 1.5 409 V Valine Aliphatic Beta strand B (undefined) E (parallel sheets) 0 -106.0 125.7 93.76 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 117 4.2 3 interactions V409-I423, V409-L422; PAE: 1.0, 1.0 3 interactions V409-S421, V409-I423, V409-L422; PAE: 1.5, 1.0, 1.0 410 R Arginine Positively-charged Beta strand B (undefined) E (parallel sheets) 1 -98.9 156.1 93.25 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 175 -4.5 2 interactions R410-Y419, R410-D133, R410-F403; PAE: 1.5, 26.0, 1.0 3 interactions R410-Y419, R410-N405, R410-F403; PAE: 1.5, 1.5, 1.0 1 interaction R410-E408; PAE: 1.5 411 K Lysine Positively-charged Beta strand B (undefined) E (parallel sheets) 39 -126.5 140.3 93.01 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 147 -3.9 2 interactions K411-E418, K411-T420; PAE: 2.5, 2.0 2 interactions K411-T420; PAE: 2.0 K411-E418; PAE: 2.5 412 M Methionine Aliphatic Beta strand B (undefined) E (parallel sheets) 1 -146.1 153.8 92.43 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 149 1.9 2 interactions M412-L401; PAE: 1.0 2 interactions M412-L401; PAE: 1.0 413 T Threonine Polar/Neutral Beta strand B (undefined) E (parallel sheets) 6 -76.7 159.2 91.14 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 119 -0.7 2 interactions T413-E418, T413-S417; PAE: 2.0, 3.0 2 interactions T413-E418, T413-S417; PAE: 2.0, 3.0 414 L Leucine Aliphatic C (loop/coil) T (turn) 34 -62.0 -26.7 90.53 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 131 3.8 2 interactions L414-A399; PAE: 2.0 415 D Aspartic Acid Negatively-charged C (loop/coil) T (turn) 39 -90.9 2.5 82.43 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 132 -3.5 D415-K120, D415-K107; PAE: 28.5, 28.5 416 R Arginine Positively-charged C (loop/coil) S (bend) 12 57.3 21.7 84.09 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 175 -4.5 3 interactions R416-D133, R416-L642; PAE: 28.0, 4.0 2 interactions 1 interaction 417 S Serine Polar/Neutral C (loop/coil) S (bend) 20 -71.3 -30.0 77.67 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 105 -0.8 2 interactions S417-T413; PAE: 3.0 2 interactions S417-T413; PAE: 3.0 418 E Glutamic Acid Negatively-charged B (undefined) E (parallel sheets) 43 -114.6 126.8 83.15 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 146 -3.5 1 interaction E418-T413, E418-K411, E418-Y400; PAE: 2.0, 2.5, 2.5 1 interaction E418-T413; PAE: 2.0 E418-K411; PAE: 2.5 419 Y Tyrosine Aromatic B (undefined) E (parallel sheets) 1 -141.0 109.6 88.67 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 181 -1.3 2 interactions Y419-S123, Y419-R410; PAE: 27.5, 1.5 1 interaction Y419-C121, Y419-R410; PAE: 27.5, 1.5 420 T Threonine Polar/Neutral Beta strand B (undefined) E (parallel sheets) 8 -148.7 159.1 88.14 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 119 -0.7 2 interactions T420-K411; PAE: 2.0 2 interactions T420-K411; PAE: 2.0 421 S Serine Polar/Neutral Beta strand B (undefined) E (parallel sheets) 0 -76.1 129.8 87.74 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 105 -0.8 2 interactions S421-E408; PAE: 2.0 2 interactions S421-E408, S421-H460, S421-V409; PAE: 2.0, 8.0, 1.5 422 L Leucine Aliphatic Beta strand B (undefined) E (parallel sheets) 9 -90.4 -47.6 90.84 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 131 3.8 2 interactions L422-V409; PAE: 1.0 2 interactions L422-H460, L422-V409; PAE: 7.5, 1.0 423 I Isoleucine Aliphatic Beta strand B (undefined) E (parallel sheets) 0 -128.5 99.2 91.0 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 131 4.5 2 interactions I423-V409; PAE: 1.0 2 interactions I423-V409; PAE: 1.0 424 P Proline Special, No backbone hydrogen C (loop/coil) C (loop/coil) 21 -84.8 165.7 86.13 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 115 1.6 2 interactions 425 N Asparagine Polar/Neutral C (loop/coil) S (bend) 97 59.5 40.0 81.78 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 132 -3.5 2 interactions N425-H407; PAE: 2.0 426 L Leucine Aliphatic C (loop/coil) C (loop/coil) 8 -79.7 172.8 87.95 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 131 3.8 2 interactions L426-H407, L426-W165; PAE: 1.5, 17.0 2 interactions L426-H407; PAE: 1.5 427 R Arginine Positively-charged Beta strand C (loop/coil) S (bend) 64 -97.6 -68.5 84.49 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 175 -4.5 4 interactions R427-H407; PAE: 2.0 2 interactions R427-D168, R427-L164, R427-Q448, R427-S447; PAE: 14.0, 14.0, 2.5, 3.0 428 N Asparagine Polar/Neutral Beta strand C (loop/coil) C (loop/coil) 22 -146.2 90.3 88.57 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 132 -3.5 2 interactions N428-L446; PAE: 2.0 4 interactions N428-D170, N428-L446; PAE: 11.0, 2.0 429 V Valine Aliphatic Beta strand B (undefined) E (parallel sheets) 0 -87.7 126.0 93.51 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 117 4.2 2 interactions V429-R406; PAE: 1.5 2 interactions V429-R406; PAE: 1.5 430 V Valine Aliphatic Beta strand B (undefined) E (parallel sheets) 2 -118.5 -49.8 93.23 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 117 4.2 2 interactions V430-S444; PAE: 2.0 V430-D651; PAE: 1.5 431 A Alanine Aliphatic Beta strand B (undefined) E (parallel sheets) 0 -121.0 150.1 96.67 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 89 1.8 2 interactions A431-S444; PAE: 1.0 2 interactions A431-G478, A431-S444; PAE: 2.0, 1.0 432 L Leucine Aliphatic Beta strand B (undefined) E (parallel sheets) 0 -146.4 154.1 96.7 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 131 3.8 2 interactions L432-D651; PAE: 2.0 1 interaction 433 D Aspartic Acid Negatively-charged Beta strand B (undefined) E (parallel sheets) 23 -155.8 166.5 97.67 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 132 -3.5 3 interactions D433-Y442, D433-V481; PAE: 1.0, 1.0 3 interactions D433-Y442, D433-V481; PAE: 1.0, 1.0 434 T Threonine Polar/Neutral Beta strand B (undefined) E (parallel sheets) 1 -130.3 155.8 96.59 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 119 -0.7 2 interactions T434-Q660; PAE: 1.5 435 E Glutamic Acid Negatively-charged Beta strand B (undefined) E (parallel sheets) 15 -115.1 99.4 96.14 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 146 -3.5 4 interactions E435-Y442, E435-R440; PAE: 1.0, 1.0 3 interactions E435-N439, E435-R440; PAE: 1.0, 1.0 1 interaction 436 V Valine Aliphatic Turn C (loop/coil) T (turn) 10 -63.5 -46.6 94.33 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 117 4.2 2 interactions V436-Q660; PAE: 2.0 2 interactions 437 A Alanine Aliphatic Turn C (loop/coil) T (turn) 91 -62.5 -34.7 92.34 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 89 1.8 438 S Serine Polar/Neutral Turn C (loop/coil) T (turn) 54 -93.4 1.5 92.44 Low-density lipoprotein receptor LDL-receptor class B 1 Extracellular 105 -0.8 2 interactions S438-Q455; PAE: 2.0 439 N Asparagine Polar/Neutral Turn C (loop/coil) T (turn) 39 50.3 44.8 93.48 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 132 -3.5 3 interactions N439-L456; PAE: 2.0 4 interactions N439-D457, N439-E435, N439-L456, N439-Q455; PAE: 3.5, 1.0, 2.0, 2.0 440 R Arginine Positively-charged Beta strand B (undefined) E (parallel sheets) 32 -122.9 143.8 94.33 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 175 -4.5 3 interactions R440-D466, R440-E435, R440-S453; PAE: 2.5, 1.0, 1.5 3 interactions R440-E435, R440-S453; PAE: 1.0, 1.5 1 interaction R440-D466; PAE: 2.5 441 I Isoleucine Aliphatic Beta strand B (undefined) E (parallel sheets) 0 -120.2 143.1 95.78 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 131 4.5 2 interactions I441-T454; PAE: 1.0 2 interactions I441-T454; PAE: 1.0 442 Y Tyrosine Aromatic Beta strand B (undefined) E (parallel sheets) 1 -122.0 142.3 97.05 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 181 -1.3 3 interactions Y442-E435, Y442-D433; PAE: 1.0, 1.0 2 interactions Y442-D433; PAE: 1.0 443 W Tryptophan Aromatic Beta strand B (undefined) E (parallel sheets) 2 -147.8 155.4 96.58 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 204 -0.9 2 interactions W443-C452; PAE: 1.0 2 interactions W443-S453, W443-C452; PAE: 1.5, 1.0 444 S Serine Polar/Neutral Beta strand B (undefined) E (parallel sheets) 0 -100.6 140.6 95.45 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 105 -0.8 4 interactions S444-V430, S444-P476, S444-A431; PAE: 2.0, 2.0, 1.0 2 interactions S444-A431; PAE: 1.0 445 D Aspartic Acid Negatively-charged Beta strand B (undefined) E (parallel sheets) 1 -119.1 116.5 90.86 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 132 -3.5 3 interactions D445-M450, D445-R449; PAE: 1.0, 1.0 3 interactions D445-M450, D445-R449; PAE: 1.0, 1.0 446 L Leucine Aliphatic Turn C (loop/coil) T (turn) 49 -72.2 -38.1 87.86 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 131 3.8 2 interactions L446-N428; PAE: 2.0 2 interactions L446-N428; PAE: 2.0 447 S Serine Polar/Neutral Turn C (loop/coil) T (turn) 25 -62.4 -40.3 84.06 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 105 -0.8 2 interactions 3 interactions S447-R427; PAE: 3.0 448 Q Glutamine Polar/Neutral Turn C (loop/coil) T (turn) 88 -90.2 -16.4 83.87 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 146 -3.5 2 interactions Q448-R427; PAE: 2.5 449 R Arginine Positively-charged Turn C (loop/coil) T (turn) 104 51.9 55.7 89.67 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 175 -4.5 2 interactions R449-D445; PAE: 1.0 2 interactions R449-D445; PAE: 1.0 450 M Methionine Aliphatic Beta strand B (undefined) E (parallel sheets) 34 -140.1 158.1 93.05 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 149 1.9 2 interactions M450-D445; PAE: 1.0 2 interactions M450-D445; PAE: 1.0 451 I Isoleucine Aliphatic Beta strand B (undefined) E (parallel sheets) 0 -109.7 127.3 96.08 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 131 4.5 3 interactions I451-I469, I451-V468; PAE: 1.0, 1.0 3 interactions I451-I469, I451-V468; PAE: 1.0, 1.0 452 C Cysteine Special, a very reactive sulfhydryl group Beta strand B (undefined) E (parallel sheets) 4 -118.0 161.5 94.49 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 121 2.5 2 interactions C452-W443; PAE: 1.0 2 interactions C452-W443; PAE: 1.0 453 S Serine Polar/Neutral Beta strand B (undefined) E (parallel sheets) 4 -144.4 156.2 94.58 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 105 -0.8 2 interactions S453-D466, S453-R440; PAE: 2.0, 1.5 2 interactions S453-R440, S453-D466, S453-W443; PAE: 1.5, 2.0, 1.5 454 T Threonine Polar/Neutral Beta strand B (undefined) E (parallel sheets) 4 -153.3 160.0 93.9 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 119 -0.7 2 interactions T454-I441; PAE: 1.0 2 interactions T454-I441; PAE: 1.0 455 Q Glutamine Polar/Neutral Beta strand B (undefined) E (parallel sheets) 45 -74.0 130.6 92.91 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 146 -3.5 3 interactions Q455-S438; PAE: 2.0 3 interactions Q455-N439, Q455-A459; PAE: 2.0, 5.0 456 L Leucine Aliphatic H (helix) G (3₁₀-helix) 15 -58.5 -39.0 90.06 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 131 3.8 2 interactions L456-N439; PAE: 2.0 2 interactions L456-N439; PAE: 2.0 457 D Aspartic Acid Negatively-charged H (helix) G (3₁₀-helix) 134 -60.7 -20.3 85.89 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 132 -3.5 D457-N439; PAE: 3.5 458 R Arginine Positively-charged H (helix) G (3₁₀-helix) 142 -100.2 -10.2 80.31 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 175 -4.5 R458-V462; PAE: 8.0 459 A Alanine Aliphatic H (helix) G (3₁₀-helix) 1 -54.7 -44.1 76.14 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 89 1.8 A459-Q455; PAE: 5.0 460 H Histidine Positively-charged H (helix) G (3₁₀-helix) 102 -66.5 -11.9 70.52 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 155 -3.2 H460-S421, H460-L422; PAE: 8.0, 7.5 461 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible H (helix) G (3₁₀-helix) 75 -141.3 6.9 65.58 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 75 -0.4 462 V Valine Aliphatic C (loop/coil) C (loop/coil) 25 -96.5 134.6 66.61 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 117 4.2 V462-R458; PAE: 8.0 463 S Serine Polar/Neutral C (loop/coil) S (bend) 128 -84.9 -0.1 64.71 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 105 -0.8 464 S Serine Polar/Neutral C (loop/coil) C (loop/coil) 77 -145.7 128.1 76.35 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 105 -0.8 465 Y Tyrosine Aromatic C (loop/coil) C (loop/coil) 62 -108.1 160.7 86.82 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 181 -1.3 Morphology: RAHGVSSyDTVIsRD; Domain: Ldl_recept_b 2 interactions 466 D Aspartic Acid Negatively-charged Beta strand B (undefined) E (parallel sheets) 79 -79.8 114.6 91.09 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 132 -3.5 2 interactions D466-R440, D466-S453; PAE: 2.5, 2.0 2 interactions D466-S453; PAE: 2.0 D466-R440; PAE: 2.5 467 T Threonine Polar/Neutral Beta strand B (undefined) E (parallel sheets) 73 -75.6 119.5 92.01 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 119 -0.7 1 interaction 468 V Valine Aliphatic Beta strand B (undefined) E (parallel sheets) 12 -87.3 -56.5 93.96 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 117 4.2 dbSNP: rs5932; Variant type: LB/B; AA change: Val468Ile; PTM type: Phosphorylation; PTM morphology: HGVSSyDTV*Is; Var class: II&rs5932 2 interactions V468-I451; PAE: 1.0 3 interactions V468-I451, V468-G505; PAE: 1.0, 2.0 469 I Isoleucine Aliphatic Beta strand B (undefined) E (parallel sheets) 6 -126.2 134.9 94.93 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 131 4.5 2 interactions I469-I451; PAE: 1.0 2 interactions I469-I451; PAE: 1.0 470 S Serine Polar/Neutral C (loop/coil) C (loop/coil) 70 -135.3 2.5 90.02 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 105 -0.8 Morphology: SSyDTVIsRDIQAPD; Domain: Ldl_recept_b 471 R Arginine Positively-charged C (loop/coil) S (bend) 187 -141.3 149.6 87.86 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 175 -4.5 dbSNP: rs879254891; Variant type: US; AA change: Arg471Gly; PTM type: Phosphorylation; PTM morphology: yDTVIsR*DIQA; Var class: II 2 interactions 472 D Aspartic Acid Negatively-charged C (loop/coil) S (bend) 111 51.7 43.6 85.88 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 132 -3.5 2 interactions D472-R508; PAE: 4.0 D472-R508; PAE: 4.0 473 I Isoleucine Aliphatic C (loop/coil) C (loop/coil) 4 -133.1 136.3 90.7 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 131 4.5 2 interactions 474 Q Glutamine Polar/Neutral C (loop/coil) S (bend) 70 -120.1 -61.8 90.0 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 146 -3.5 2 interactions Q474-D492; PAE: 2.0 475 A Alanine Aliphatic C (loop/coil) C (loop/coil) 13 -137.7 80.8 90.03 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 89 1.8 3 interactions A475-S493; PAE: 2.0 2 interactions A475-S493; PAE: 2.0 476 P Proline Special, No backbone hydrogen C (loop/coil) C (loop/coil) 0 -76.5 83.3 93.88 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 115 1.6 2 interactions P476-S444; PAE: 2.0 477 D Aspartic Acid Negatively-charged C (loop/coil) C (loop/coil) 25 -83.6 -2.3 93.13 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 132 -3.5 3 interactions D477-S493; PAE: 2.5 3 interactions D477-T491, D477-S493; PAE: 2.0, 2.5 1 interaction 478 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible Beta strand B (undefined) E (parallel sheets) 2 -154.9 140.3 96.35 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 75 -0.4 2 interactions G478-T491; PAE: 1.0 2 interactions G478-T491, G478-A431; PAE: 1.0, 2.0 479 L Leucine Aliphatic Beta strand B (undefined) E (parallel sheets) 8 -127.5 142.4 97.73 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 131 3.8 480 A Alanine Aliphatic Beta strand B (undefined) E (parallel sheets) 2 -145.5 131.5 98.26 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 89 1.8 2 interactions A480-Y489; PAE: 1.0 2 interactions A480-Y489; PAE: 1.0 481 V Valine Aliphatic Beta strand B (undefined) E (parallel sheets) 0 -105.2 127.0 97.79 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 117 4.2 2 interactions V481-D433; PAE: 1.0 2 interactions V481-D433; PAE: 1.0 482 D Aspartic Acid Negatively-charged Beta strand B (undefined) E (parallel sheets) 0 -86.3 97.6 97.13 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 132 -3.5 3 interactions D482-S486, D482-N487; PAE: 1.0, 1.0 3 interactions D482-S486, D482-N487; PAE: 1.0, 1.0 483 W Tryptophan Aromatic Turn C (loop/coil) T (turn) 39 -71.4 -13.5 96.15 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 204 -0.9 2 interactions W483-P661; PAE: 2.0 2 interactions W483-Q660; PAE: 1.5 484 I Isoleucine Aliphatic Turn C (loop/coil) T (turn) 16 -85.8 -45.1 95.91 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 131 4.5 1 interaction 2 interactions I484-N665, I484-G663; PAE: 2.0, 2.0 485 H Histidine Positively-charged Turn C (loop/coil) T (turn) 16 -103.7 1.0 95.36 Low-density lipoprotein receptor LDL-receptor class B 2 Extracellular 155 -3.2 2 interactions 3 interactions H485-N665, H485-W666; PAE: 1.5, 2.0 486 S Serine Polar/Neutral Turn C (loop/coil) T (turn) 47 57.4 47.9 95.01 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 105 -0.8 3 interactions S486-D482, S486-T503; PAE: 1.0, 2.0 3 interactions S486-D482, S486-T503; PAE: 1.0, 2.0 487 N Asparagine Polar/Neutral Beta strand B (undefined) E (parallel sheets) 7 -113.8 156.3 97.08 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 132 -3.5 2 interactions N487-D482; PAE: 1.0 3 interactions N487-D482; PAE: 1.0 488 I Isoleucine Aliphatic Beta strand B (undefined) E (parallel sheets) 0 -123.5 132.9 97.66 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 131 4.5 2 interactions I488-A501; PAE: 1.0 2 interactions I488-A501; PAE: 1.0 489 Y Tyrosine Aromatic Beta strand B (undefined) E (parallel sheets) 0 -112.9 141.7 98.36 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 181 -1.3 3 interactions Y489-A480, Y489-L547; PAE: 1.0, 1.0 2 interactions Y489-A480; PAE: 1.0 490 W Tryptophan Aromatic Beta strand B (undefined) E (parallel sheets) 5 -144.7 149.7 98.02 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 204 -0.9 2 interactions W490-S499; PAE: 1.0 2 interactions W490-V500, W490-S499; PAE: 1.0, 1.0 491 T Threonine Polar/Neutral Beta strand B (undefined) E (parallel sheets) 0 -93.4 149.6 97.3 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 119 -0.7 3 interactions T491-G478, T491-R520; PAE: 1.0, 1.5 2 interactions T491-G478, T491-D477; PAE: 1.0, 2.0 492 D Aspartic Acid Negatively-charged Beta strand B (undefined) E (parallel sheets) 0 -130.8 114.1 95.68 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 132 -3.5 5 interactions D492-G496, D492-T497, D492-Q474; PAE: 1.0, 1.0, 2.0 3 interactions D492-G496, D492-T497; PAE: 1.0, 1.0 493 S Serine Polar/Neutral Turn C (loop/coil) T (turn) 18 -75.2 -26.4 91.62 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 105 -0.8 3 interactions S493-A475, S493-D477; PAE: 2.0, 2.5 3 interactions S493-A475, S493-D477; PAE: 2.0, 2.5 494 V Valine Aliphatic Turn C (loop/coil) T (turn) 100 -82.4 -40.3 89.81 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 117 4.2 495 L Leucine Aliphatic Turn C (loop/coil) T (turn) 55 -82.1 -15.2 91.79 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 131 3.8 L495-R513; PAE: 2.0 496 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible Turn C (loop/coil) T (turn) 2 62.3 43.2 94.18 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 75 -0.4 3 interactions G496-E514, G496-D492; PAE: 2.0, 1.0 4 interactions G496-E514, G496-D492, G496-S517; PAE: 2.0, 1.0, 3.0 497 T Threonine Polar/Neutral Beta strand B (undefined) E (parallel sheets) 2 -126.5 152.9 96.03 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 119 -0.7 2 interactions T497-D492; PAE: 1.0 3 interactions T497-D492, T497-R513; PAE: 1.0, 1.5 498 V Valine Aliphatic Beta strand B (undefined) E (parallel sheets) 0 -114.1 125.3 97.78 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 117 4.2 3 interactions V498-F512, V498-L511; PAE: 1.0, 1.0 3 interactions V498-F512, V498-L511; PAE: 1.0, 1.0 499 S Serine Polar/Neutral Beta strand B (undefined) E (parallel sheets) 6 -126.5 158.2 97.26 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 105 -0.8 2 interactions S499-T510, S499-W490; PAE: 1.0, 1.0 2 interactions S499-T510, S499-W490; PAE: 1.0, 1.0 500 V Valine Aliphatic Beta strand B (undefined) E (parallel sheets) 0 -129.7 146.3 97.51 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 117 4.2 2 interactions V500-K509; PAE: 1.0 2 interactions V500-K509, V500-W490; PAE: 1.0, 1.0 501 A Alanine Aliphatic Beta strand B (undefined) E (parallel sheets) 0 -140.9 166.7 96.8 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 89 1.8 2 interactions A501-I488; PAE: 1.0 2 interactions A501-I488; PAE: 1.0 502 D Aspartic Acid Negatively-charged Beta strand B (undefined) E (parallel sheets) 28 -66.8 156.2 94.89 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 132 -3.5 3 interactions D502-K507, D502-V506; PAE: 1.5, 1.5 4 interactions D502-K507, D502-V506; PAE: 1.5, 1.5 503 T Threonine Polar/Neutral C (loop/coil) T (turn) 16 -61.7 -10.8 94.46 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 119 -0.7 2 interactions T503-S486; PAE: 2.0 2 interactions T503-S486; PAE: 2.0 504 K Lysine Positively-charged C (loop/coil) T (turn) 128 -95.6 -6.7 92.73 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 147 -3.9 505 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible Beta strand C (loop/coil) S (bend) 20 68.2 12.8 92.16 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 75 -0.4 2 interactions G505-V468; PAE: 2.0 506 V Valine Aliphatic Beta strand C (loop/coil) S (bend) 110 -73.5 -37.2 92.61 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 117 4.2 2 interactions V506-D502; PAE: 1.5 2 interactions V506-D502; PAE: 1.5 507 K Lysine Positively-charged Beta strand C (loop/coil) S (bend) 61 -123.9 124.0 94.16 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 147 -3.9 2 interactions K507-Y679, K507-D502; PAE: 1.0, 1.5 3 interactions K507-Y679, K507-D502; PAE: 1.0, 1.5 508 R Arginine Positively-charged Beta strand B (undefined) E (parallel sheets) 76 -140.0 160.6 94.79 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 175 -4.5 4 interactions R508-D472, R508-Y679; PAE: 4.0, 2.0 R508-D472; PAE: 4.0 509 K Lysine Positively-charged Beta strand B (undefined) E (parallel sheets) 48 -155.7 140.4 94.95 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 147 -3.9 3 interactions K509-V500, K509-C698; PAE: 1.0, 1.5 3 interactions K509-V500; PAE: 1.0 510 T Threonine Polar/Neutral Beta strand B (undefined) E (parallel sheets) 27 -79.9 122.7 95.75 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 119 -0.7 2 interactions T510-D700, T510-S499; PAE: 2.0, 1.0 T510-S499; PAE: 1.0 511 L Leucine Aliphatic Beta strand B (undefined) E (parallel sheets) 23 -90.6 -35.8 96.07 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 131 3.8 2 interactions L511-V498; PAE: 1.0 2 interactions L511-V498; PAE: 1.0 512 F Phenylalanine Aromatic Beta strand B (undefined) E (parallel sheets) 25 -138.8 140.0 96.42 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 165 2.8 2 interactions F512-V498; PAE: 1.0 2 interactions F512-V498; PAE: 1.0 513 R Arginine Positively-charged Beta strand B (undefined) E (parallel sheets) 135 -149.0 121.5 95.33 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 175 -4.5 2 interactions R513-T497, R513-L495; PAE: 1.5, 2.0 514 E Glutamic Acid Negatively-charged C (loop/coil) C (loop/coil) 72 -138.1 122.2 92.85 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 146 -3.5 Pocket 4: Mean pLDDT: 80.74, Volume: 495.81 ų, Druggability score: 0.03 0.0258 3 interactions E514-G496, E514-K543, E514-K541; PAE: 2.0, 2.5, 3.0 2 interactions E514-G496; PAE: 2.0 1 interaction E514-K543, E514-K541; PAE: 2.5, 3.0 515 N Asparagine Polar/Neutral C (loop/coil) T (turn) 151 -66.5 126.8 86.3 Low-density lipoprotein receptor N-linked (GlcNAc...) asparagine LDL-receptor class B 3 Extracellular 132 -3.5 Pocket 4: Mean pLDDT: 80.74, Volume: 495.81 ų, Druggability score: 0.03 0.0258 516 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible C (loop/coil) T (turn) 66 87.4 -6.1 83.91 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 75 -0.4 Pocket 4: Mean pLDDT: 80.74, Volume: 495.81 ų, Druggability score: 0.03 0.0258 517 S Serine Polar/Neutral C (loop/coil) C (loop/coil) 4 -69.0 143.4 91.0 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 105 -0.8 Morphology: TLFRENGsKPRAIVV; Domain: Ldl_recept_b Pocket 4: Mean pLDDT: 80.74, Volume: 495.81 ų, Druggability score: 0.03 0.0258 2 interactions S517-G496; PAE: 3.0 518 K Lysine Positively-charged C (loop/coil) C (loop/coil) 48 -126.2 70.9 93.43 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 147 -3.9 Pocket 4: Mean pLDDT: 80.74, Volume: 495.81 ų, Druggability score: 0.03 0.0258 3 interactions K518-D535, K518-W536, K518-E201; PAE: 1.0, 1.5, 26.5 3 interactions K518-W536, K518-G537; PAE: 1.5, 1.5 519 P Proline Special, No backbone hydrogen Beta strand B (undefined) E (parallel sheets) 0 -67.0 142.8 96.7 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 115 1.6 520 R Arginine Positively-charged Beta strand B (undefined) E (parallel sheets) 29 -127.5 -106.5 95.43 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 175 -4.5 Pocket 1: Mean pLDDT: 85.7, Volume: 528.09 ų, Druggability score: 0.11 0.1082 4 interactions R520-T491, R520-T534; PAE: 1.5, 1.0 3 interactions R520-W536, R520-N564, R520-T534; PAE: 2.5, 2.0, 1.0 1 interaction 521 A Alanine Aliphatic Beta strand B (undefined) E (parallel sheets) 15 -65.8 143.5 97.69 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 89 1.8 2 interactions A521-T534; PAE: 1.0 3 interactions A521-T534, A521-I566; PAE: 1.0, 2.0 522 I Isoleucine Aliphatic Beta strand B (undefined) E (parallel sheets) 6 -136.7 141.1 98.36 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 131 4.5 523 V Valine Aliphatic Beta strand B (undefined) E (parallel sheets) 24 -135.0 150.9 98.25 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 117 4.2 2 interactions V523-Y532; PAE: 1.0 2 interactions V523-Y532; PAE: 1.0 524 V Valine Aliphatic Beta strand B (undefined) E (parallel sheets) 9 -120.4 146.2 97.88 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 117 4.2 525 D Aspartic Acid Negatively-charged Beta strand B (undefined) E (parallel sheets) 7 -115.9 90.0 96.89 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 132 -3.5 3 interactions D525-G529, D525-F530; PAE: 1.0, 1.0 3 interactions D525-G529, D525-F530; PAE: 1.0, 1.0 526 P Proline Special, No backbone hydrogen Turn C (loop/coil) T (turn) 3 -65.5 -21.1 95.7 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 115 1.6 1 interaction 527 V Valine Aliphatic Turn C (loop/coil) T (turn) 62 -77.6 -46.3 93.73 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 117 4.2 1 interaction 528 H Histidine Positively-charged Turn C (loop/coil) T (turn) 93 -96.7 -9.1 93.52 Low-density lipoprotein receptor LDL-receptor class B 3 Extracellular 155 -3.2 1 interaction H528-Q686; PAE: 2.0 1 interaction H528-Q686; PAE: 2.0 529 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible Turn C (loop/coil) T (turn) 2 85.5 27.4 95.37 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 75 -0.4 3 interactions G529-D525, G529-L547; PAE: 1.0, 2.0 3 interactions G529-D525, G529-L547; PAE: 1.0, 2.0 530 F Phenylalanine Aromatic Beta strand B (undefined) E (parallel sheets) 22 -116.1 158.4 97.45 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 165 2.8 2 interactions F530-D525; PAE: 1.0 2 interactions F530-D525; PAE: 1.0 531 M Methionine Aliphatic Beta strand B (undefined) E (parallel sheets) 0 -134.6 150.4 97.71 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 149 1.9 2 interactions M531-G545; PAE: 1.0 2 interactions M531-G545; PAE: 1.0 532 Y Tyrosine Aromatic Beta strand B (undefined) E (parallel sheets) 2 -133.6 136.0 98.5 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 181 -1.3 2 interactions Y532-V523; PAE: 1.0 3 interactions Y532-V523; PAE: 1.0 533 W Tryptophan Aromatic Beta strand B (undefined) E (parallel sheets) 0 -145.6 152.3 98.34 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 204 -0.9 2 interactions W533-K543; PAE: 1.0 2 interactions W533-K543; PAE: 1.0 534 T Threonine Polar/Neutral Beta strand B (undefined) E (parallel sheets) 0 -86.8 143.1 97.95 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 119 -0.7 4 interactions T534-A521, T534-N564, T534-P563, T534-R520; PAE: 1.0, 2.0, 1.5, 1.0 3 interactions T534-A521, T534-R520; PAE: 1.0, 1.0 535 D Aspartic Acid Negatively-charged Beta strand B (undefined) E (parallel sheets) 1 -134.7 112.4 96.21 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 132 -3.5 Pocket 4: Mean pLDDT: 80.74, Volume: 495.81 ų, Druggability score: 0.03 0.0258 3 interactions D535-K541, D535-K518; PAE: 1.0, 1.0 3 interactions D535-K541; PAE: 1.0 536 W Tryptophan Aromatic C (loop/coil) C (loop/coil) 42 -94.0 11.1 93.36 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 204 -0.9 Pocket 1: Mean pLDDT: 85.7, Volume: 528.09 ų, Druggability score: 0.11 0.1082 2 interactions W536-K518; PAE: 1.5 2 interactions W536-K518, W536-R520; PAE: 1.5, 2.5 537 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible Beta strand C (loop/coil) S (bend) 6 -62.6 -179.6 88.78 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 75 -0.4 Pocket 4: Mean pLDDT: 80.74, Volume: 495.81 ų, Druggability score: 0.03 0.0258 2 interactions G537-K518; PAE: 1.5 538 T Threonine Polar/Neutral Beta strand C (loop/coil) S (bend) 85 -107.7 109.1 85.55 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 119 -0.7 Pocket 4: Mean pLDDT: 80.74, Volume: 495.81 ų, Druggability score: 0.03 0.0258 T538-H211; PAE: 25.0 539 P Proline Special, No backbone hydrogen Beta strand C (loop/coil) S (bend) 97 -82.2 148.3 89.94 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 115 1.6 Pocket 4: Mean pLDDT: 80.74, Volume: 495.81 ų, Druggability score: 0.03 0.0258 540 A Alanine Aliphatic C (loop/coil) C (loop/coil) 14 -74.6 144.8 93.54 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 89 1.8 541 K Lysine Positively-charged Beta strand B (undefined) E (parallel sheets) 17 -162.3 154.8 95.71 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 147 -3.9 Pocket 4: Mean pLDDT: 80.74, Volume: 495.81 ų, Druggability score: 0.03 0.0258 2 interactions K541-E514, K541-D535; PAE: 3.0, 1.0 3 interactions K541-S554, K541-D535; PAE: 2.0, 1.0 K541-E514; PAE: 3.0 542 I Isoleucine Aliphatic Beta strand B (undefined) E (parallel sheets) 1 -103.1 126.9 97.99 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 131 4.5 3 interactions I542-V556, I542-L555; PAE: 1.0, 1.0 3 interactions I542-L555, I542-V556; PAE: 1.0, 1.0 543 K Lysine Positively-charged Beta strand B (undefined) E (parallel sheets) 12 -101.5 148.1 97.63 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 147 -3.9 3 interactions K543-W533, K543-E514; PAE: 1.0, 2.5 3 interactions K543-W533; PAE: 1.0 1 interaction K543-E514; PAE: 2.5 544 K Lysine Positively-charged Beta strand B (undefined) E (parallel sheets) 12 -121.4 140.7 97.45 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 147 -3.9 3 interactions K544-V590, K544-Y553; PAE: 2.0, 1.0 3 interactions K544-Y553; PAE: 1.0 545 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible Beta strand B (undefined) E (parallel sheets) 0 -159.6 168.8 96.16 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 75 -0.4 2 interactions G545-M531; PAE: 1.0 2 interactions G545-M531; PAE: 1.0 546 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible Beta strand B (undefined) E (parallel sheets) 0 -69.9 149.5 96.37 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 75 -0.4 2 interactions G546-V550; PAE: 1.5 547 L Leucine Aliphatic C (loop/coil) T (turn) 0 -62.1 -12.5 97.16 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 131 3.8 3 interactions L547-Y489, L547-G529; PAE: 1.0, 2.0 2 interactions L547-G529; PAE: 2.0 548 N Asparagine Polar/Neutral C (loop/coil) T (turn) 19 -96.9 3.8 94.54 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 132 -3.5 2 interactions N548-T695; PAE: 2.0 2 interactions N548-T695; PAE: 2.0 549 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible C (loop/coil) S (bend) 21 81.1 10.3 93.74 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 75 -0.4 550 V Valine Aliphatic C (loop/coil) C (loop/coil) 79 -90.6 149.6 91.73 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 117 4.2 1 interaction V550-G546; PAE: 1.5 551 D Aspartic Acid Negatively-charged C (loop/coil) S (bend) 84 57.2 47.4 91.3 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 132 -3.5 2 interactions 552 I Isoleucine Aliphatic Beta strand C (loop/coil) C (loop/coil) 47 -81.3 122.8 95.94 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 131 4.5 553 Y Tyrosine Aromatic Beta strand B (undefined) E (parallel sheets) 93 -143.0 164.5 94.8 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 181 -1.3 2 interactions Y553-K544; PAE: 1.0 2 interactions Y553-K544; PAE: 1.0 554 S Serine Polar/Neutral Beta strand B (undefined) E (parallel sheets) 52 -80.9 117.5 95.41 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 105 -0.8 2 interactions S554-K541; PAE: 2.0 555 L Leucine Aliphatic Beta strand B (undefined) E (parallel sheets) 25 -80.3 -43.9 95.77 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 131 3.8 2 interactions L555-I542; PAE: 1.0 3 interactions L555-I542, L555-G592; PAE: 1.0, 2.5 556 V Valine Aliphatic Beta strand B (undefined) E (parallel sheets) 6 -125.5 128.1 95.95 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 117 4.2 2 interactions V556-I542; PAE: 1.0 2 interactions V556-I542; PAE: 1.0 557 T Threonine Polar/Neutral C (loop/coil) C (loop/coil) 89 -135.7 -6.2 92.79 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 119 -0.7 558 E Glutamic Acid Negatively-charged C (loop/coil) S (bend) 143 -109.1 150.9 89.39 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 146 -3.5 2 interactions E558-R595; PAE: 2.5 559 N Asparagine Polar/Neutral C (loop/coil) S (bend) 84 42.3 50.8 88.44 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 132 -3.5 2 interactions N559-R595; PAE: 2.5 560 I Isoleucine Aliphatic C (loop/coil) C (loop/coil) 8 -144.3 131.2 91.87 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 131 4.5 561 Q Glutamine Polar/Neutral C (loop/coil) S (bend) 50 -131.6 -72.5 89.47 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 146 -3.5 2 interactions Q561-D579; PAE: 1.5 562 W Tryptophan Aromatic C (loop/coil) C (loop/coil) 20 -118.0 73.5 90.44 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 204 -0.9 Pocket 1: Mean pLDDT: 85.7, Volume: 528.09 ų, Druggability score: 0.11 0.1082 3 interactions W562-S580, W562-D579; PAE: 2.0, 1.0 3 interactions W562-S580; PAE: 2.0 563 P Proline Special, No backbone hydrogen Beta strand B (undefined) E (parallel sheets) 0 -68.3 103.5 96.5 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 115 1.6 1 interaction P563-T534; PAE: 1.5 564 N Asparagine Polar/Neutral Beta strand B (undefined) E (parallel sheets) 2 -88.0 -76.9 95.21 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 132 -3.5 Pocket 1: Mean pLDDT: 85.7, Volume: 528.09 ų, Druggability score: 0.11 0.1082 4 interactions N564-T534, N564-V578, N564-P608; PAE: 2.0, 2.0, 1.5 2 interactions N564-R520, N564-S580; PAE: 2.0, 2.0 565 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible Beta strand B (undefined) E (parallel sheets) 1 -89.7 144.8 96.31 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 75 -0.4 3 interactions G565-V578; PAE: 1.5 2 interactions G565-V578; PAE: 1.5 566 I Isoleucine Aliphatic Beta strand B (undefined) E (parallel sheets) 8 -135.7 141.1 98.02 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 131 4.5 2 interactions I566-A521; PAE: 2.0 567 T Threonine Polar/Neutral Beta strand B (undefined) E (parallel sheets) 23 -133.7 152.3 97.67 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 119 -0.7 2 interactions T567-Y576; PAE: 1.0 2 interactions T567-Y576; PAE: 1.0 568 L Leucine Aliphatic Beta strand B (undefined) E (parallel sheets) 23 -118.9 120.8 96.47 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 131 3.8 Pocket 2: Mean pLDDT: 89.82, Volume: 512.1 ų, Druggability score: 0.1 0.0983 569 D Aspartic Acid Negatively-charged Beta strand B (undefined) E (parallel sheets) 25 -81.9 100.7 93.37 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 132 -3.5 Pocket 2: Mean pLDDT: 89.82, Volume: 512.1 ų, Druggability score: 0.1 0.0983 3 interactions D569-G573, D569-R574, D569-R633; PAE: 1.5, 1.0, 3.0 3 interactions D569-G573, D569-R574; PAE: 1.5, 1.0 D569-R633; PAE: 3.0 570 L Leucine Aliphatic Turn C (loop/coil) T (turn) 31 -62.5 -27.9 91.37 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 131 3.8 Pocket 2: Mean pLDDT: 89.82, Volume: 512.1 ų, Druggability score: 0.1 0.0983 571 L Leucine Aliphatic Turn C (loop/coil) T (turn) 62 -78.9 -49.9 85.73 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 131 3.8 Pocket 2: Mean pLDDT: 89.82, Volume: 512.1 ų, Druggability score: 0.1 0.0983 572 S Serine Polar/Neutral Turn C (loop/coil) T (turn) 60 -79.9 -13.5 85.76 Low-density lipoprotein receptor LDL-receptor class B 4 Extracellular 105 -0.8 Pocket 2: Mean pLDDT: 89.82, Volume: 512.1 ų, Druggability score: 0.1 0.0983 573 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible Turn C (loop/coil) T (turn) 21 64.1 40.5 91.22 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 75 -0.4 3 interactions G573-D569, G573-V590; PAE: 1.5, 2.0 3 interactions G573-D569, G573-V590; PAE: 1.5, 2.0 574 R Arginine Positively-charged Beta strand B (undefined) E (parallel sheets) 19 -125.6 134.2 93.0 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 175 -4.5 5 interactions R574-D569, R574-N594, R574-D589, R574-S587; PAE: 1.0, 2.0, 1.0, 1.0 5 interactions R574-I588, R574-D569, R574-S587; PAE: 1.0, 1.0, 1.0 2 interactions R574-D589; PAE: 1.0 575 L Leucine Aliphatic Beta strand B (undefined) E (parallel sheets) 1 -94.2 141.3 97.18 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 131 3.8 2 interactions L575-I588; PAE: 1.0 2 interactions L575-I588; PAE: 1.0 576 Y Tyrosine Aromatic Beta strand B (undefined) E (parallel sheets) 4 -124.5 139.5 97.74 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 181 -1.3 3 interactions Y576-T567, Y576-R633; PAE: 1.0, 1.5 2 interactions Y576-T567; PAE: 1.0 577 W Tryptophan Aromatic Beta strand B (undefined) E (parallel sheets) 1 -143.0 155.1 98.15 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 204 -0.9 2 interactions W577-S586; PAE: 1.0 3 interactions W577-S586, W577-S587; PAE: 1.0, 1.0 578 V Valine Aliphatic Beta strand B (undefined) E (parallel sheets) 0 -99.9 139.3 97.73 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 117 4.2 3 interactions V578-N564, V578-G565; PAE: 2.0, 1.5 2 interactions V578-G565; PAE: 1.5 579 D Aspartic Acid Negatively-charged Beta strand B (undefined) E (parallel sheets) 0 -119.4 115.9 95.92 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 132 -3.5 5 interactions D579-W562, D579-Q561, D579-S584; PAE: 1.0, 1.5, 1.0 3 interactions D579-H583, D579-S584; PAE: 1.0, 1.0 580 S Serine Polar/Neutral Turn C (loop/coil) T (turn) 2 -77.1 -24.8 93.34 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 105 -0.8 4 interactions S580-P608, S580-W562; PAE: 1.5, 2.0 4 interactions S580-N564, S580-W562; PAE: 2.0, 2.0 581 K Lysine Positively-charged Turn C (loop/coil) T (turn) 22 -83.8 -33.1 85.81 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 147 -3.9 K581-D217, K581-D221; PAE: 24.5, 22.5 2 interactions K581-D221; PAE: 22.5 K581-D217, K581-D221; PAE: 24.5, 22.5 582 L Leucine Aliphatic Turn C (loop/coil) T (turn) 34 -84.9 -1.0 90.07 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 131 3.8 583 H Histidine Positively-charged Turn C (loop/coil) T (turn) 56 47.8 41.3 93.68 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 155 -3.2 3 interactions H583-D601, H583-L605; PAE: 1.5, 1.5 3 interactions H583-D579, H583-D601; PAE: 1.0, 1.5 584 S Serine Polar/Neutral Beta strand B (undefined) E (parallel sheets) 3 -135.6 151.1 94.68 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 105 -0.8 2 interactions S584-D579; PAE: 1.0 2 interactions S584-D579; PAE: 1.0 585 I Isoleucine Aliphatic Beta strand B (undefined) E (parallel sheets) 0 -106.7 122.6 97.43 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 131 4.5 3 interactions I585-L599, I585-I598; PAE: 1.0, 1.0 3 interactions I585-L599, I585-I598; PAE: 1.0, 1.0 586 S Serine Polar/Neutral Beta strand B (undefined) E (parallel sheets) 1 -119.7 156.3 95.77 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 105 -0.8 2 interactions S586-W577; PAE: 1.0 2 interactions S586-T597, S586-W577; PAE: 1.0, 1.0 587 S Serine Polar/Neutral Beta strand B (undefined) E (parallel sheets) 3 -133.1 156.3 94.94 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 105 -0.8 3 interactions S587-R574, S587-K596; PAE: 1.0, 1.0 4 interactions S587-R574, S587-W577, S587-K596; PAE: 1.0, 1.0, 1.0 588 I Isoleucine Aliphatic Beta strand B (undefined) E (parallel sheets) 8 -156.4 147.3 94.75 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 131 4.5 2 interactions I588-L575; PAE: 1.0 3 interactions I588-R574, I588-L575; PAE: 1.0, 1.0 589 D Aspartic Acid Negatively-charged Beta strand B (undefined) E (parallel sheets) 32 -65.0 151.3 92.68 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 132 -3.5 3 interactions D589-G593, D589-R574, D589-N594; PAE: 2.0, 1.0, 2.0 2 interactions D589-N594; PAE: 2.0 2 interactions D589-R574; PAE: 1.0 590 V Valine Aliphatic C (loop/coil) T (turn) 23 -59.0 -15.2 93.2 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 117 4.2 3 interactions V590-G573, V590-K544; PAE: 2.0, 2.0 2 interactions V590-G573; PAE: 2.0 591 N Asparagine Polar/Neutral C (loop/coil) T (turn) 135 -86.0 -8.8 89.3 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 132 -3.5 592 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible C (loop/coil) S (bend) 35 88.5 8.5 90.01 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 75 -0.4 dbSNP: rs137929307; Variant type: LP/P; AA change: Gly592Glu; PTM type: Ubiquitylation; PTM morphology: NG*GNRkTILED; Var class: II 2 interactions G592-L555; PAE: 2.5 593 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible C (loop/coil) C (loop/coil) 32 -97.2 175.0 87.08 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 75 -0.4 2 interactions G593-D589; PAE: 2.0 594 N Asparagine Polar/Neutral C (loop/coil) S (bend) 108 48.1 44.5 86.81 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 132 -3.5 2 interactions N594-R574, N594-D589; PAE: 2.0, 2.0 1 interaction N594-D589; PAE: 2.0 595 R Arginine Positively-charged C (loop/coil) C (loop/coil) 81 -64.8 136.3 90.3 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 175 -4.5 dbSNP: rs373371572; Variant type: LP/P; AA change: Arg595Trp; PTM type: Ubiquitylation; PTM morphology: NGGNR*kTILED; Var class: II 3 interactions R595-E558, R595-N559; PAE: 2.5, 2.5 596 K Lysine Positively-charged Beta strand B (undefined) E (parallel sheets) 52 -142.0 138.6 89.1 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 147 -3.9 Morphology: DVNGGNRkTILEDEk; Domain: Ldl_recept_b 2 interactions K596-L634, K596-S587; PAE: 2.0, 1.0 2 interactions K596-S587; PAE: 1.0 K596-D362; PAE: 7.0 597 T Threonine Polar/Neutral Beta strand B (undefined) E (parallel sheets) 57 -88.0 124.4 91.68 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 119 -0.7 T597-S586; PAE: 1.0 598 I Isoleucine Aliphatic Beta strand B (undefined) E (parallel sheets) 14 -90.3 -44.6 92.93 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 131 4.5 2 interactions I598-I585; PAE: 1.0 3 interactions I598-I585, I598-G636; PAE: 1.0, 2.0 599 L Leucine Aliphatic Beta strand B (undefined) E (parallel sheets) 21 -145.5 135.0 93.83 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 131 3.8 dbSNP: rs879255025; Variant type: US; AA change: Leu599Ser; PTM type: Ubiquitylation; PTM morphology: NGGNRkTIL*ED; Var class: II&rs879255025 2 interactions L599-I585; PAE: 1.0 2 interactions L599-I585; PAE: 1.0 600 E Glutamic Acid Negatively-charged Beta strand B (undefined) E (parallel sheets) 75 -127.9 113.5 92.19 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 146 -3.5 601 D Aspartic Acid Negatively-charged C (loop/coil) C (loop/coil) 30 -153.5 96.2 91.88 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 132 -3.5 dbSNP: rs753707206; Variant type: US; AA change: Asp601His; PTM type: Ubiquitylation; PTM morphology: NGGNRkTILED*; Var class: II&rs753707206 3 interactions D601-L605, D601-H583; PAE: 2.0, 1.5 3 interactions D601-L605, D601-H583; PAE: 2.0, 1.5 D601-R604; PAE: 2.0 602 E Glutamic Acid Negatively-charged Turn C (loop/coil) T (turn) 114 -53.6 -27.1 89.34 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 146 -3.5 2 interactions E602-A606; PAE: 2.0 603 K Lysine Positively-charged Turn C (loop/coil) T (turn) 173 -84.0 -42.5 89.75 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 147 -3.9 Morphology: kTILEDEkRLAHPFS; Domain: Ldl_recept_b 2 interactions K603-N625; PAE: 2.0 604 R Arginine Positively-charged Turn C (loop/coil) T (turn) 106 -93.8 -16.1 91.17 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 175 -4.5 2 interactions R604-W620; PAE: 1.5 2 interactions R604-N625; PAE: 2.0 R604-D601; PAE: 2.0 605 L Leucine Aliphatic Turn C (loop/coil) S (bend) 0 -118.2 47.3 92.64 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 131 3.8 2 interactions L605-H583, L605-D601; PAE: 1.5, 2.0 2 interactions L605-D601; PAE: 2.0 606 A Alanine Aliphatic Beta strand C (loop/coil) S (bend) 19 -64.7 -45.3 91.25 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 89 1.8 A606-D622; PAE: 2.0 2 interactions A606-N625, A606-E602; PAE: 2.5, 2.0 607 H Histidine Positively-charged Beta strand C (loop/coil) S (bend) 45 -150.7 68.6 92.64 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 155 -3.2 Pocket 1: Mean pLDDT: 85.7, Volume: 528.09 ų, Druggability score: 0.11 0.1082 3 interactions H607-I623, H607-D622; PAE: 1.5, 1.0 3 interactions H607-I623; PAE: 1.5 608 P Proline Special, No backbone hydrogen Beta strand B (undefined) E (parallel sheets) 0 -65.8 139.2 96.63 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 115 1.6 dbSNP: rs879255034; Variant type: LP/P; AA change: Pro608Ser; PTM type: Ubiquitylation; PTM morphology: ILEDEkRLAHP*; Var class: II 2 interactions P608-S580, P608-N564; PAE: 1.5, 1.5 609 F Phenylalanine Aromatic Beta strand B (undefined) E (parallel sheets) 22 -124.2 -50.4 95.16 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 165 2.8 Pocket 1: Mean pLDDT: 85.7, Volume: 528.09 ų, Druggability score: 0.11 0.1082 3 interactions F609-T621; PAE: 1.0 2 interactions F609-T621; PAE: 1.0 610 S Serine Polar/Neutral Beta strand B (undefined) E (parallel sheets) 6 -125.9 158.8 97.46 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 105 -0.8 4 interactions S610-D651, S610-T621, S610-M652; PAE: 2.0, 1.5, 3.5 3 interactions S610-T621, S610-M652; PAE: 1.5, 3.5 611 L Leucine Aliphatic Beta strand B (undefined) E (parallel sheets) 3 -147.5 151.7 97.78 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 131 3.8 612 A Alanine Aliphatic Beta strand B (undefined) E (parallel sheets) 3 -136.4 152.8 97.36 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 89 1.8 2 interactions A612-F619; PAE: 1.0 2 interactions A612-F619; PAE: 1.0 613 V Valine Aliphatic Beta strand B (undefined) E (parallel sheets) 15 -121.9 136.5 95.53 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 117 4.2 Pocket 2: Mean pLDDT: 89.82, Volume: 512.1 ų, Druggability score: 0.1 0.0983 614 F Phenylalanine Aromatic Beta strand B (undefined) E (parallel sheets) 13 -150.1 138.0 93.97 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 165 2.8 Pocket 2: Mean pLDDT: 89.82, Volume: 512.1 ų, Druggability score: 0.1 0.0983 615 E Glutamic Acid Negatively-charged C (loop/coil) T (turn) 34 51.8 -124.9 90.26 Low-density lipoprotein receptor LDL-receptor class B 5 Extracellular 146 -3.5 Pocket 2: Mean pLDDT: 89.82, Volume: 512.1 ų, Druggability score: 0.1 0.0983 1 interaction E615-A394; PAE: 3.5 616 D Aspartic Acid Negatively-charged C (loop/coil) T (turn) 24 -99.0 14.4 88.96 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 132 -3.5 2 interactions D616-R633; PAE: 1.5 2 interactions D616-N632, D616-R633; PAE: 1.5, 1.5 617 K Lysine Positively-charged Beta strand B (undefined) E (parallel sheets) 62 -116.0 140.7 92.85 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 147 -3.9 1 interaction 618 V Valine Aliphatic Beta strand B (undefined) E (parallel sheets) 0 -106.4 134.7 96.22 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 117 4.2 2 interactions V618-A631; PAE: 1.0 2 interactions V618-A631; PAE: 1.0 619 F Phenylalanine Aromatic Beta strand B (undefined) E (parallel sheets) 3 -115.6 136.8 97.9 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 165 2.8 2 interactions F619-A612; PAE: 1.0 2 interactions F619-A612; PAE: 1.0 620 W Tryptophan Aromatic Beta strand B (undefined) E (parallel sheets) 0 -139.2 150.9 98.15 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 204 -0.9 3 interactions W620-R604, W620-F629; PAE: 1.5, 1.0 2 interactions W620-S630, W620-F629; PAE: 1.5, 1.0 621 T Threonine Polar/Neutral Beta strand B (undefined) E (parallel sheets) 0 -92.8 142.4 97.25 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 119 -0.7 4 interactions T621-F609, T621-P649, T621-S610; PAE: 1.0, 2.0, 1.5 3 interactions T621-F609, T621-S610; PAE: 1.0, 1.5 622 D Aspartic Acid Negatively-charged Beta strand B (undefined) E (parallel sheets) 0 -128.6 124.6 95.48 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 132 -3.5 4 interactions D622-A606, D622-H607, D622-A627; PAE: 2.0, 1.0, 1.0 3 interactions D622-A627, D622-E626; PAE: 1.0, 1.0 623 I Isoleucine Aliphatic Turn C (loop/coil) T (turn) 37 -77.8 -38.1 92.02 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 131 4.5 Pocket 1: Mean pLDDT: 85.7, Volume: 528.09 ų, Druggability score: 0.11 0.1082 2 interactions I623-H607; PAE: 1.5 2 interactions I623-H607; PAE: 1.5 624 I Isoleucine Aliphatic Turn C (loop/coil) T (turn) 96 -73.2 -38.9 88.87 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 131 4.5 Pocket 1: Mean pLDDT: 85.7, Volume: 528.09 ų, Druggability score: 0.11 0.1082 625 N Asparagine Polar/Neutral Turn C (loop/coil) T (turn) 60 -79.6 -6.6 91.7 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 132 -3.5 2 interactions N625-K603; PAE: 2.0 2 interactions N625-A606, N625-R604; PAE: 2.5, 2.0 626 E Glutamic Acid Negatively-charged Turn C (loop/coil) T (turn) 93 50.7 42.5 91.77 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 146 -3.5 3 interactions E626-L646; PAE: 1.5 4 interactions E626-N645, E626-D622, E626-L646; PAE: 2.0, 1.0, 1.5 627 A Alanine Aliphatic Beta strand B (undefined) E (parallel sheets) 1 -146.7 160.6 93.65 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 89 1.8 2 interactions A627-D622; PAE: 1.0 2 interactions A627-D622; PAE: 1.0 628 I Isoleucine Aliphatic Beta strand B (undefined) E (parallel sheets) 0 -113.8 130.3 96.58 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 131 4.5 3 interactions I628-A643, I628-L642; PAE: 1.0, 1.0 3 interactions I628-A643, I628-L642; PAE: 1.0, 1.0 629 F Phenylalanine Aromatic Beta strand B (undefined) E (parallel sheets) 22 -117.2 164.0 96.68 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 165 2.8 2 interactions F629-W620; PAE: 1.0 2 interactions F629-W620; PAE: 1.0 630 S Serine Polar/Neutral Beta strand B (undefined) E (parallel sheets) 3 -136.3 150.2 96.09 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 105 -0.8 2 interactions S630-N640; PAE: 1.0 2 interactions S630-N640, S630-W620; PAE: 1.0, 1.5 631 A Alanine Aliphatic Beta strand B (undefined) E (parallel sheets) 1 -146.3 168.6 95.25 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 89 1.8 2 interactions A631-V618; PAE: 1.0 2 interactions A631-V618; PAE: 1.0 632 N Asparagine Polar/Neutral Beta strand B (undefined) E (parallel sheets) 42 -64.7 128.2 92.37 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 132 -3.5 3 interactions N632-S637, N632-G636; PAE: 2.0, 2.0 2 interactions N632-D616, N632-S637, N632-G636; PAE: 1.5, 2.0, 2.0 633 R Arginine Positively-charged Turn C (loop/coil) T (turn) 14 -72.6 -18.2 92.28 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 175 -4.5 Pocket 2: Mean pLDDT: 89.82, Volume: 512.1 ų, Druggability score: 0.1 0.0983 3 interactions R633-Y576, R633-D569, R633-D616, R633-S365; PAE: 1.5, 3.0, 1.5, 5.0 2 interactions R633-D616; PAE: 1.5 R633-D569; PAE: 3.0 634 L Leucine Aliphatic Turn C (loop/coil) T (turn) 23 -92.3 -56.5 88.11 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 131 3.8 L634-K596; PAE: 2.0 635 T Threonine Polar/Neutral Turn C (loop/coil) T (turn) 78 -94.8 -17.1 87.6 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 119 -0.7 636 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible C (loop/coil) C (loop/coil) 7 71.3 4.8 90.1 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 75 -0.4 2 interactions G636-N632; PAE: 2.0 3 interactions G636-N632, G636-I598; PAE: 2.0, 2.0 637 S Serine Polar/Neutral C (loop/coil) C (loop/coil) 64 -78.6 173.2 89.4 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 105 -0.8 2 interactions S637-N632; PAE: 2.0 1 interaction S637-N632; PAE: 2.0 638 D Aspartic Acid Negatively-charged C (loop/coil) S (bend) 102 57.7 52.9 87.89 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 132 -3.5 1 interaction 639 V Valine Aliphatic C (loop/coil) C (loop/coil) 31 -74.1 117.3 93.65 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 117 4.2 640 N Asparagine Polar/Neutral Beta strand B (undefined) E (parallel sheets) 64 -120.9 141.7 92.08 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 132 -3.5 2 interactions N640-S630; PAE: 1.0 2 interactions N640-S630; PAE: 1.0 641 L Leucine Aliphatic Beta strand B (undefined) E (parallel sheets) 72 -88.2 122.9 92.2 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 131 3.8 2 interactions 642 L Leucine Aliphatic Beta strand B (undefined) E (parallel sheets) 21 -104.1 -36.8 91.21 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 131 3.8 3 interactions L642-R416, L642-I628; PAE: 4.0, 1.0 2 interactions L642-I628; PAE: 1.0 643 A Alanine Aliphatic Beta strand B (undefined) E (parallel sheets) 0 -146.5 149.9 90.98 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 89 1.8 2 interactions A643-I628; PAE: 1.0 3 interactions A643-I628; PAE: 1.0 644 E Glutamic Acid Negatively-charged C (loop/coil) C (loop/coil) 35 -142.3 170.2 89.72 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 146 -3.5 2 interactions 1 interaction 645 N Asparagine Polar/Neutral C (loop/coil) S (bend) 49 55.9 39.5 84.9 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 132 -3.5 N645-R132; PAE: 26.0 2 interactions N645-R132, N645-E626; PAE: 26.0, 2.0 646 L Leucine Aliphatic C (loop/coil) C (loop/coil) 0 -85.4 134.8 90.67 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 131 3.8 2 interactions L646-E626; PAE: 1.5 2 interactions L646-E626; PAE: 1.5 647 L Leucine Aliphatic C (loop/coil) S (bend) 56 -87.9 98.8 87.16 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 131 3.8 2 interactions L647-N405; PAE: 2.0 2 interactions L647-N405; PAE: 2.0 648 S Serine Polar/Neutral C (loop/coil) C (loop/coil) 26 53.8 68.3 87.49 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 105 -0.8 2 interactions 2 interactions 649 P Proline Special, No backbone hydrogen C (loop/coil) C (loop/coil) 0 -75.7 73.4 94.33 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 115 1.6 2 interactions P649-T621; PAE: 2.0 650 E Glutamic Acid Negatively-charged C (loop/coil) C (loop/coil) 36 -78.2 -28.0 94.46 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 146 -3.5 E650-T404; PAE: 2.0 2 interactions E650-T404; PAE: 2.0 651 D Aspartic Acid Negatively-charged C (loop/coil) C (loop/coil) 22 -143.8 149.9 97.11 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 132 -3.5 4 interactions D651-L432, D651-T404, D651-S610; PAE: 2.0, 1.0, 2.0 2 interactions D651-T404, D651-V430; PAE: 1.0, 1.5 652 M Methionine Aliphatic Beta strand B (undefined) E (parallel sheets) 3 -149.7 128.0 97.55 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 149 1.9 2 interactions M652-S610; PAE: 3.5 2 interactions M652-S610; PAE: 3.5 653 V Valine Aliphatic Beta strand B (undefined) E (parallel sheets) 22 -126.6 154.5 97.24 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 117 4.2 2 interactions V653-F402; PAE: 1.0 2 interactions V653-F402; PAE: 1.0 654 L Leucine Aliphatic Beta strand B (undefined) E (parallel sheets) 18 -100.0 121.2 96.51 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 131 3.8 L654-T659; PAE: 2.0 655 F Phenylalanine Aromatic Beta strand B (undefined) E (parallel sheets) 31 -98.7 102.3 95.32 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 165 2.8 2 interactions F655-Y400; PAE: 1.0 2 interactions F655-Y400; PAE: 1.0 656 H Histidine Positively-charged Beta strand C (loop/coil) C (loop/coil) 5 -157.4 150.3 94.85 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 155 -3.2 1 interaction H656-S397; PAE: 3.5 1 interaction H656-S397; PAE: 3.5 657 N Asparagine Polar/Neutral Helix C (loop/coil) T (turn) 89 -65.3 -29.5 91.45 Low-density lipoprotein receptor N-linked (GlcNAc...) asparagine LDL-receptor class B 6 Extracellular 132 -3.5 N657-S397; PAE: 6.0 2 interactions N657-S397; PAE: 6.0 658 L Leucine Aliphatic Helix C (loop/coil) T (turn) 45 -78.9 -15.8 91.18 Low-density lipoprotein receptor LDL-receptor class B 6 Extracellular 131 3.8 Pocket 2: Mean pLDDT: 89.82, Volume: 512.1 ų, Druggability score: 0.1 0.0983 659 T Threonine Polar/Neutral Helix C (loop/coil) T (turn) 41 -78.5 -21.1 91.36 Low-density lipoprotein receptor Extracellular 119 -0.7 Pocket 2: Mean pLDDT: 89.82, Volume: 512.1 ų, Druggability score: 0.1 0.0983 T659-L654; PAE: 2.0 660 Q Glutamine Polar/Neutral C (loop/coil) S (bend) 20 -121.8 75.9 94.09 Low-density lipoprotein receptor Extracellular 146 -3.5 3 interactions Q660-V436, Q660-T434; PAE: 2.0, 1.5 2 interactions Q660-W483; PAE: 1.5 661 P Proline Special, No backbone hydrogen C (loop/coil) C (loop/coil) 42 -59.9 148.7 90.72 Low-density lipoprotein receptor Extracellular 115 1.6 2 interactions P661-W483; PAE: 2.0 662 R Arginine Positively-charged C (loop/coil) C (loop/coil) 251 -70.7 125.8 89.31 Low-density lipoprotein receptor Extracellular 175 -4.5 663 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible C (loop/coil) C (loop/coil) 38 -125.8 -175.4 88.41 Low-density lipoprotein receptor EGF-like 3 Extracellular 75 -0.4 1 interaction G663-I484; PAE: 2.0 664 V Valine Aliphatic C (loop/coil) C (loop/coil) 65 -94.2 117.1 91.56 Low-density lipoprotein receptor EGF-like 3 Extracellular 117 4.2 1 interaction 665 N Asparagine Polar/Neutral C (loop/coil) C (loop/coil) 25 -70.0 102.8 93.68 Low-density lipoprotein receptor EGF-like 3 Extracellular 132 -3.5 1 interaction N665-R669; PAE: 3.0 5 interactions N665-I484, N665-R669, N665-H485; PAE: 2.0, 3.0, 1.5 666 W Tryptophan Aromatic C (loop/coil) T (turn) 80 -71.1 -23.7 90.32 Low-density lipoprotein receptor EGF-like 3 Extracellular 204 -0.9 1 interaction 2 interactions W666-H485; PAE: 2.0 667 C Cysteine Special, a very reactive sulfhydryl group C (loop/coil) T (turn) 6 -71.6 -32.3 90.94 Low-density lipoprotein receptor Disulfide bond 667-681 EGF-like 3 Extracellular 121 2.5 3 interactions C667-G675; PAE: 2.5 4 interactions C667-G675; PAE: 2.5 1 interaction C667-C681; PAE: 2.5 668 E Glutamic Acid Negatively-charged Beta strand C (loop/coil) T (turn) 147 -94.8 -17.4 89.92 Low-density lipoprotein receptor EGF-like 3 Extracellular 146 -3.5 2 interactions 669 R Arginine Positively-charged Beta strand C (loop/coil) S (bend) 178 -65.8 -25.2 87.1 Low-density lipoprotein receptor EGF-like 3 Extracellular 175 -4.5 R669-N665; PAE: 3.0 3 interactions R669-N665; PAE: 3.0 670 T Threonine Polar/Neutral Beta strand C (loop/coil) S (bend) 46 -76.7 156.9 84.49 Low-density lipoprotein receptor EGF-like 3 Extracellular 119 -0.7 671 T Threonine Polar/Neutral Beta strand C (loop/coil) S (bend) 152 -66.3 -12.3 84.87 Low-density lipoprotein receptor EGF-like 3 Extracellular 119 -0.7 672 L Leucine Aliphatic Beta strand C (loop/coil) S (bend) 92 -97.1 134.7 86.45 Low-density lipoprotein receptor EGF-like 3 Extracellular 131 3.8 2 interactions L672-G676; PAE: 3.5 673 S Serine Polar/Neutral Helix H (helix) G (3₁₀-helix) 116 -56.0 137.8 88.84 Low-density lipoprotein receptor EGF-like 3 Extracellular 105 -0.8 674 N Asparagine Polar/Neutral Helix H (helix) G (3₁₀-helix) 45 55.4 39.0 91.03 Low-density lipoprotein receptor EGF-like 3 Extracellular 132 -3.5 2 interactions N674-Y679; PAE: 2.5 3 interactions N674-C681; PAE: 2.0 675 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible Helix H (helix) G (3₁₀-helix) 0 67.0 2.0 87.7 Low-density lipoprotein receptor EGF-like 3 Extracellular 75 -0.4 2 interactions G675-C667, G675-R709; PAE: 2.5, 2.5 2 interactions G675-C667; PAE: 2.5 676 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible Helix H (helix) G (3₁₀-helix) 21 76.7 22.8 90.95 Low-density lipoprotein receptor EGF-like 3 Extracellular 75 -0.4 2 interactions G676-L672, G676-R709; PAE: 3.5, 2.0 677 C Cysteine Special, a very reactive sulfhydryl group C (loop/coil) C (loop/coil) 10 -85.8 137.1 93.63 Low-density lipoprotein receptor Disulfide bond 677-696 EGF-like 3 Extracellular 121 2.5 C677-C696; PAE: 2.5 1 interaction C677-C696; PAE: 2.5 678 Q Glutamine Polar/Neutral Beta strand C (loop/coil) S (bend) 122 -66.1 -33.9 93.33 Low-density lipoprotein receptor EGF-like 3 Extracellular 146 -3.5 3 interactions Q678-R709, Q678-C711; PAE: 2.0, 2.5 2 interactions Q678-C711; PAE: 2.5 679 Y Tyrosine Aromatic Beta strand C (loop/coil) S (bend) 50 -123.8 -97.0 94.35 Low-density lipoprotein receptor EGF-like 3 Extracellular 181 -1.3 3 interactions Y679-K507, Y679-R508, Y679-N674; PAE: 1.0, 2.0, 2.5 2 interactions Y679-K507; PAE: 1.0 680 L Leucine Aliphatic Beta strand B (undefined) E (parallel sheets) 4 -96.8 142.0 95.23 Low-density lipoprotein receptor EGF-like 3 Extracellular 131 3.8 2 interactions L680-A697; PAE: 1.0 2 interactions L680-A697; PAE: 1.0 681 C Cysteine Special, a very reactive sulfhydryl group Beta strand B (undefined) E (parallel sheets) 4 -113.8 113.5 95.38 Low-density lipoprotein receptor Disulfide bond 667-681 EGF-like 3 Extracellular 121 2.5 C681-N674; PAE: 2.0 1 interaction C681-C667; PAE: 2.5 682 L Leucine Aliphatic Beta strand B (undefined) E (parallel sheets) 0 -114.6 137.6 96.48 Low-density lipoprotein receptor EGF-like 3 Extracellular 131 3.8 2 interactions L682-T695; PAE: 1.0 2 interactions L682-T695; PAE: 1.0 683 P Proline Special, No backbone hydrogen Beta strand B (undefined) E (parallel sheets) 3 -60.0 141.3 95.08 Low-density lipoprotein receptor EGF-like 3 Extracellular 115 1.6 684 A Alanine Aliphatic H (helix) P (polyproline helix) 2 -102.1 148.0 93.93 Low-density lipoprotein receptor EGF-like 3 Extracellular 89 1.8 2 interactions A684-K693; PAE: 1.5 1 interaction 685 P Proline Special, No backbone hydrogen H (helix) P (polyproline helix) 7 -64.7 127.3 93.92 Low-density lipoprotein receptor EGF-like 3 Extracellular 115 1.6 P685-S691; PAE: 2.0 2 interactions P685-S691; PAE: 2.0 686 Q Glutamine Polar/Neutral C (loop/coil) C (loop/coil) 45 -82.4 60.2 90.34 Low-density lipoprotein receptor EGF-like 3 Extracellular 146 -3.5 3 interactions Q686-H528, Q686-K693, Q686-P692; PAE: 2.0, 2.5, 2.0 2 interactions Q686-H528, Q686-K693; PAE: 2.0, 2.5 687 I Isoleucine Aliphatic C (loop/coil) S (bend) 94 -63.7 -38.9 87.56 Low-density lipoprotein receptor EGF-like 3 Extracellular 131 4.5 2 interactions 2 interactions I687-S691; PAE: 3.0 688 N Asparagine Polar/Neutral C (loop/coil) S (bend) 77 -142.8 166.4 87.21 Low-density lipoprotein receptor EGF-like 3 Extracellular 132 -3.5 689 P Proline Special, No backbone hydrogen C (loop/coil) T (turn) 117 -59.9 -18.4 85.74 Low-density lipoprotein receptor EGF-like 3 Extracellular 115 1.6 690 H Histidine Positively-charged C (loop/coil) T (turn) 176 -96.7 -1.0 87.95 Low-density lipoprotein receptor EGF-like 3 Extracellular 155 -3.2 691 S Serine Polar/Neutral C (loop/coil) S (bend) 15 -57.4 139.0 89.18 Low-density lipoprotein receptor EGF-like 3 Extracellular 105 -0.8 2 interactions S691-P685; PAE: 2.0 3 interactions S691-I687, S691-P685; PAE: 3.0, 2.0 692 P Proline Special, No backbone hydrogen C (loop/coil) C (loop/coil) 76 -57.3 146.4 91.15 Low-density lipoprotein receptor EGF-like 3 Extracellular 115 1.6 2 interactions P692-Q686; PAE: 2.0 693 K Lysine Positively-charged Beta strand C (loop/coil) S (bend) 84 -77.0 -34.3 91.02 Low-density lipoprotein receptor EGF-like 3 Extracellular 147 -3.9 3 interactions K693-A684, K693-Q686; PAE: 1.5, 2.5 2 interactions K693-Q686; PAE: 2.5 694 F Phenylalanine Aromatic Beta strand B (undefined) E (parallel sheets) 40 -147.6 162.4 93.86 Low-density lipoprotein receptor EGF-like 3 Extracellular 165 2.8 1 interaction 695 T Threonine Polar/Neutral Beta strand B (undefined) E (parallel sheets) 31 -136.1 147.5 93.98 Low-density lipoprotein receptor EGF-like 3 Extracellular 119 -0.7 3 interactions T695-L682, T695-N548; PAE: 1.0, 2.0 3 interactions T695-L682, T695-N548; PAE: 1.0, 2.0 696 C Cysteine Special, a very reactive sulfhydryl group Beta strand B (undefined) E (parallel sheets) 13 -82.9 140.3 94.99 Low-density lipoprotein receptor Disulfide bond 677-696 EGF-like 3 Extracellular 121 2.5 C696-C677; PAE: 2.5 1 interaction C696-C677; PAE: 2.5 697 A Alanine Aliphatic Beta strand B (undefined) E (parallel sheets) 10 -125.5 137.9 94.7 Low-density lipoprotein receptor EGF-like 3 Extracellular 89 1.8 2 interactions A697-L680; PAE: 1.0 2 interactions A697-L680; PAE: 1.0 698 C Cysteine Special, a very reactive sulfhydryl group H (helix) P (polyproline helix) 4 -103.5 157.8 94.88 Low-density lipoprotein receptor Disulfide bond 698-711 EGF-like 3 Extracellular 121 2.5 2 interactions C698-K509; PAE: 1.5 2 interactions 1 interaction C698-C711; PAE: 2.5 699 P Proline Special, No backbone hydrogen H (helix) P (polyproline helix) 28 -55.2 159.7 93.66 Low-density lipoprotein receptor EGF-like 3 Extracellular 115 1.6 700 D Aspartic Acid Negatively-charged C (loop/coil) T (turn) 82 -60.8 133.7 91.61 Low-density lipoprotein receptor EGF-like 3 Extracellular 132 -3.5 2 interactions D700-T510; PAE: 2.0 1 interaction 701 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible C (loop/coil) T (turn) 57 84.3 -1.8 88.88 Low-density lipoprotein receptor EGF-like 3 Extracellular 75 -0.4 702 M Methionine Aliphatic B (undefined) E (parallel sheets) 56 -111.4 146.8 93.43 Low-density lipoprotein receptor EGF-like 3 Extracellular 149 1.9 2 interactions M702-T713; PAE: 2.0 703 L Leucine Aliphatic B (undefined) E (parallel sheets) 92 -104.6 146.3 90.64 Low-density lipoprotein receptor EGF-like 3 Extracellular 131 3.8 2 interactions L703-L712; PAE: 2.0 2 interactions L703-L712; PAE: 2.0 704 L Leucine Aliphatic B (undefined) E (parallel sheets) 59 -73.6 131.0 90.52 Low-density lipoprotein receptor EGF-like 3 Extracellular 131 3.8 2 interactions L704-R709; PAE: 2.0 705 A Alanine Aliphatic C (loop/coil) C (loop/coil) 13 -69.4 169.4 88.72 Low-density lipoprotein receptor EGF-like 3 Extracellular 89 1.8 2 interactions A705-S710; PAE: 3.5 706 R Arginine Positively-charged C (loop/coil) T (turn) 183 -63.7 -18.0 88.44 Low-density lipoprotein receptor EGF-like 3 Extracellular 175 -4.5 R706-T724; PAE: 11.5 707 D Aspartic Acid Negatively-charged C (loop/coil) T (turn) 78 -76.8 -4.5 88.54 Low-density lipoprotein receptor EGF-like 3 Extracellular 132 -3.5 708 M Methionine Aliphatic Beta strand C (loop/coil) S (bend) 116 59.3 23.1 88.86 Low-density lipoprotein receptor EGF-like 3 Extracellular 149 1.9 709 R Arginine Positively-charged Beta strand C (loop/coil) S (bend) 88 -137.3 -41.7 90.89 Low-density lipoprotein receptor EGF-like 3 Extracellular 175 -4.5 2 interactions R709-G675, R709-Q678; PAE: 2.5, 2.0 1 interaction R709-G676, R709-L704; PAE: 2.0, 2.0 710 S Serine Polar/Neutral Beta strand C (loop/coil) C (loop/coil) 41 -91.2 153.7 92.96 Low-density lipoprotein receptor EGF-like 3 Extracellular 105 -0.8 2 interactions S710-A705; PAE: 3.5 711 C Cysteine Special, a very reactive sulfhydryl group Beta strand B (undefined) E (parallel sheets) 11 -107.8 128.3 93.42 Low-density lipoprotein receptor Disulfide bond 698-711 EGF-like 3 Extracellular 121 2.5 2 interactions C711-Q678; PAE: 2.5 2 interactions C711-Q678; PAE: 2.5 1 interaction C711-C698; PAE: 2.5 712 L Leucine Aliphatic Beta strand B (undefined) E (parallel sheets) 49 -112.7 141.0 92.69 Low-density lipoprotein receptor EGF-like 3 Extracellular 131 3.8 2 interactions L712-L703; PAE: 2.0 3 interactions L712-L703; PAE: 2.0 713 T Threonine Polar/Neutral Beta strand B (undefined) E (parallel sheets) 55 -66.3 157.5 89.65 Low-density lipoprotein receptor Extracellular 119 -0.7 Morphology: RDMRSCLtEAEAAVA T713-A717; PAE: 4.0 1 interaction T713-A717, T713-M702; PAE: 4.0, 2.0 714 E Glutamic Acid Negatively-charged H (helix) H (α-helix) 135 -54.3 -35.1 81.27 Low-density lipoprotein receptor Extracellular 146 -3.5 dbSNP: rs869320652; Variant type: LP/P; AA change: Glu714Lys; PTM type: Phosphorylation; PTM morphology: MRSCLtE*AEAA; Var class: II E714-A718; PAE: 2.5 E714-A718; PAE: 2.5 715 A Alanine Aliphatic H (helix) H (α-helix) 71 -66.1 -45.1 81.82 Low-density lipoprotein receptor Extracellular 89 1.8 A715-V719; PAE: 3.5 A715-V719; PAE: 3.5 716 E Glutamic Acid Negatively-charged H (helix) H (α-helix) 98 -67.7 -37.4 81.98 Low-density lipoprotein receptor Extracellular 146 -3.5 E716-A720; PAE: 4.5 E716-A720; PAE: 4.5 717 A Alanine Aliphatic H (helix) H (α-helix) 22 -63.5 -38.4 74.48 Low-density lipoprotein receptor Extracellular 89 1.8 A717-T713, A717-T721; PAE: 4.0, 5.0 A717-T713, A717-T721; PAE: 4.0, 5.0 718 A Alanine Aliphatic H (helix) H (α-helix) 52 -64.5 -35.2 75.57 Low-density lipoprotein receptor Extracellular 89 1.8 A718-E714; PAE: 2.5 A718-E714, A718-Q722; PAE: 2.5, 6.0 719 V Valine Aliphatic H (helix) H (α-helix) 83 -72.6 -44.6 76.63 Low-density lipoprotein receptor Extracellular 117 4.2 V719-E723, V719-A715; PAE: 6.0, 3.5 V719-E723, V719-A715; PAE: 6.0, 3.5 720 A Alanine Aliphatic H (helix) H (α-helix) 39 -61.2 -30.6 65.35 Low-density lipoprotein receptor Extracellular 89 1.8 A720-E716; PAE: 4.5 A720-T724, A720-E716; PAE: 7.0, 4.5 721 T Threonine Polar/Neutral H (helix) H (α-helix) 76 -73.2 -35.3 62.54 Low-density lipoprotein receptor Clustered O-linked oligosaccharides Extracellular 119 -0.7 Morphology: EAEAAVAtQEtstVR T721-A717; PAE: 5.0 T721-S725, T721-A717; PAE: 6.5, 5.0 722 Q Glutamine Polar/Neutral H (helix) H (α-helix) 136 -70.1 -35.7 59.34 Low-density lipoprotein receptor Clustered O-linked oligosaccharides Extracellular 146 -3.5 Q722-T726; PAE: 6.5 Q722-T726, Q722-A718; PAE: 6.5, 6.0 723 E Glutamic Acid Negatively-charged H (helix) H (α-helix) 123 -64.7 -34.7 55.77 Low-density lipoprotein receptor Clustered O-linked oligosaccharides Extracellular 146 -3.5 E723-V719, E723-V727; PAE: 6.0, 7.0 E723-V719, E723-V727; PAE: 6.0, 7.0 724 T Threonine Polar/Neutral H (helix) H (α-helix) 65 -72.1 -25.5 52.7 Low-density lipoprotein receptor Phosphothreonine Clustered O-linked oligosaccharides Extracellular 119 -0.7 Morphology: AAVAtQEtstVRLkV T724-R706; PAE: 11.5 T724-A720; PAE: 7.0 725 S Serine Polar/Neutral H (helix) H (α-helix) 87 -76.8 -31.2 50.71 Low-density lipoprotein receptor Clustered O-linked oligosaccharides Extracellular 105 -0.8 Morphology: AVAtQEtstVRLkVs S725-T721; PAE: 6.5 726 T Threonine Polar/Neutral H (helix) H (α-helix) 95 -83.5 -23.6 45.95 Low-density lipoprotein receptor Clustered O-linked oligosaccharides Extracellular 119 -0.7 Morphology: VAtQEtstVRLkVss dbSNP: rs45508991; Variant type: LP/P; AA change: Thr726Ile; PTM type: Phosphorylation; PTM morphology: VAtQEtst*VRL; Var class: II&rs45508991 T726-Q722; PAE: 6.5 T726-Q722; PAE: 6.5 727 V Valine Aliphatic C (loop/coil) T (turn) 122 -71.2 -15.3 43.93 Low-density lipoprotein receptor Clustered O-linked oligosaccharides Extracellular 117 4.2 V727-E723; PAE: 7.0 V727-E723; PAE: 7.0 728 R Arginine Positively-charged C (loop/coil) T (turn) 231 -87.5 1.1 38.58 Low-density lipoprotein receptor Clustered O-linked oligosaccharides Extracellular 175 -4.5 729 L Leucine Aliphatic C (loop/coil) C (loop/coil) 150 -116.3 55.3 39.48 Low-density lipoprotein receptor Clustered O-linked oligosaccharides Extracellular 131 3.8 730 K Lysine Positively-charged C (loop/coil) C (loop/coil) 203 -140.9 64.1 30.68 Low-density lipoprotein receptor Clustered O-linked oligosaccharides Extracellular 147 -3.9 Morphology: EtstVRLkVsstAVR 731 V Valine Aliphatic C (loop/coil) S (bend) 149 -131.9 134.0 35.15 Low-density lipoprotein receptor Clustered O-linked oligosaccharides Extracellular 117 4.2 732 S Serine Polar/Neutral C (loop/coil) C (loop/coil) 106 -65.6 142.5 32.97 Low-density lipoprotein receptor Clustered O-linked oligosaccharides Extracellular 105 -0.8 Morphology: stVRLkVsstAVRtQ 733 S Serine Polar/Neutral C (loop/coil) C (loop/coil) 111 -61.9 118.1 30.05 Low-density lipoprotein receptor Clustered O-linked oligosaccharides Extracellular 105 -0.8 Morphology: tVRLkVsstAVRtQH 734 T Threonine Polar/Neutral C (loop/coil) C (loop/coil) 139 -127.3 115.8 30.84 Low-density lipoprotein receptor Polar residues Clustered O-linked oligosaccharides; Disordered Extracellular 119 -0.7 Morphology: VRLkVsstAVRtQHt 735 A Alanine Aliphatic C (loop/coil) C (loop/coil) 102 -67.2 128.1 26.82 Low-density lipoprotein receptor Polar residues Clustered O-linked oligosaccharides; Disordered Extracellular 89 1.8 736 V Valine Aliphatic C (loop/coil) C (loop/coil) 147 -133.3 127.5 30.1 Low-density lipoprotein receptor Polar residues Clustered O-linked oligosaccharides; Disordered Extracellular 117 4.2 737 R Arginine Positively-charged C (loop/coil) C (loop/coil) 222 -87.5 136.9 22.03 Low-density lipoprotein receptor Polar residues Clustered O-linked oligosaccharides; Disordered Extracellular 175 -4.5 738 T Threonine Polar/Neutral C (loop/coil) C (loop/coil) 111 162.7 127.1 25.27 Low-density lipoprotein receptor Polar residues Clustered O-linked oligosaccharides; Disordered Extracellular 119 -0.7 Morphology: VsstAVRtQHtttRP 739 Q Glutamine Polar/Neutral C (loop/coil) C (loop/coil) 173 63.6 115.1 26.2 Low-density lipoprotein receptor Polar residues Clustered O-linked oligosaccharides; Disordered Extracellular 146 -3.5 740 H Histidine Positively-charged C (loop/coil) C (loop/coil) 183 72.4 100.6 23.62 Low-density lipoprotein receptor Polar residues Clustered O-linked oligosaccharides; Disordered Extracellular 155 -3.2 741 T Threonine Polar/Neutral C (loop/coil) C (loop/coil) 131 -166.8 101.8 28.8 Low-density lipoprotein receptor Polar residues Clustered O-linked oligosaccharides; Disordered Extracellular 119 -0.7 Morphology: tAVRtQHtttRPVPD 742 T Threonine Polar/Neutral C (loop/coil) C (loop/coil) 113 61.4 124.9 23.2 Low-density lipoprotein receptor Polar residues Clustered O-linked oligosaccharides; Disordered Extracellular 119 -0.7 Morphology: AVRtQHtttRPVPDT 743 T Threonine Polar/Neutral C (loop/coil) C (loop/coil) 128 81.1 116.1 25.72 Low-density lipoprotein receptor Polar residues Clustered O-linked oligosaccharides; Disordered Extracellular 119 -0.7 Morphology: VRtQHtttRPVPDTs 744 R Arginine Positively-charged C (loop/coil) C (loop/coil) 234 93.9 154.3 26.9 Low-density lipoprotein receptor Polar residues Clustered O-linked oligosaccharides; Disordered Extracellular 175 -4.5 745 P Proline Special, No backbone hydrogen C (loop/coil) C (loop/coil) 110 -140.7 178.1 34.7 Low-density lipoprotein receptor Clustered O-linked oligosaccharides; Disordered Extracellular 115 1.6 746 V Valine Aliphatic C (loop/coil) C (loop/coil) 116 -37.3 154.2 23.93 Low-density lipoprotein receptor Clustered O-linked oligosaccharides; Disordered Extracellular 117 4.2 747 P Proline Special, No backbone hydrogen C (loop/coil) C (loop/coil) 129 -114.2 126.5 31.03 Low-density lipoprotein receptor Clustered O-linked oligosaccharides; Disordered Extracellular 115 1.6 748 D Aspartic Acid Negatively-charged C (loop/coil) C (loop/coil) 134 -79.2 151.3 22.61 Low-density lipoprotein receptor Clustered O-linked oligosaccharides; Disordered Extracellular 132 -3.5 749 T Threonine Polar/Neutral C (loop/coil) C (loop/coil) 146 -167.7 117.1 29.0 Low-density lipoprotein receptor Clustered O-linked oligosaccharides; Disordered Extracellular 119 -0.7 750 S Serine Polar/Neutral C (loop/coil) C (loop/coil) 99 -87.6 151.7 22.66 Low-density lipoprotein receptor Clustered O-linked oligosaccharides; Disordered Extracellular 105 -0.8 Morphology: tRPVPDTsRLPGATP 751 R Arginine Positively-charged C (loop/coil) C (loop/coil) 250 -164.2 113.3 26.69 Low-density lipoprotein receptor Clustered O-linked oligosaccharides; Disordered Extracellular 175 -4.5 752 L Leucine Aliphatic C (loop/coil) C (loop/coil) 160 -62.8 171.6 24.64 Low-density lipoprotein receptor Clustered O-linked oligosaccharides; Disordered Extracellular 131 3.8 753 P Proline Special, No backbone hydrogen C (loop/coil) C (loop/coil) 122 -139.3 179.7 29.61 Low-density lipoprotein receptor Clustered O-linked oligosaccharides; Disordered Extracellular 115 1.6 754 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible C (loop/coil) C (loop/coil) 70 110.8 101.9 21.09 Low-density lipoprotein receptor Clustered O-linked oligosaccharides; Disordered Extracellular 75 -0.4 755 A Alanine Aliphatic C (loop/coil) C (loop/coil) 106 162.1 129.5 26.42 Low-density lipoprotein receptor Clustered O-linked oligosaccharides; Disordered Extracellular 89 1.8 756 T Threonine Polar/Neutral C (loop/coil) C (loop/coil) 134 -75.1 -168.6 23.68 Low-density lipoprotein receptor Clustered O-linked oligosaccharides Extracellular 119 -0.7 757 P Proline Special, No backbone hydrogen C (loop/coil) C (loop/coil) 125 -137.1 -178.5 38.12 Low-density lipoprotein receptor Clustered O-linked oligosaccharides Extracellular 115 1.6 758 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible C (loop/coil) C (loop/coil) 76 131.8 103.3 24.33 Low-density lipoprotein receptor Clustered O-linked oligosaccharides Extracellular 75 -0.4 759 L Leucine Aliphatic C (loop/coil) C (loop/coil) 181 -127.3 118.2 25.44 Low-density lipoprotein receptor Clustered O-linked oligosaccharides Extracellular 131 3.8 760 T Threonine Polar/Neutral C (loop/coil) C (loop/coil) 127 -114.2 126.1 23.98 Low-density lipoprotein receptor Clustered O-linked oligosaccharides Extracellular 119 -0.7 761 T Threonine Polar/Neutral C (loop/coil) C (loop/coil) 143 48.9 120.5 22.55 Low-density lipoprotein receptor Clustered O-linked oligosaccharides Extracellular 119 -0.7 762 V Valine Aliphatic H (helix) P (polyproline helix) 129 -85.2 127.8 22.91 Low-density lipoprotein receptor Clustered O-linked oligosaccharides Extracellular 117 4.2 763 E Glutamic Acid Negatively-charged H (helix) P (polyproline helix) 190 -101.4 131.4 24.28 Low-density lipoprotein receptor Clustered O-linked oligosaccharides Extracellular 146 -3.5 764 I Isoleucine Aliphatic H (helix) P (polyproline helix) 147 -87.9 127.1 20.4 Low-density lipoprotein receptor Clustered O-linked oligosaccharides Extracellular 131 4.5 765 V Valine Aliphatic C (loop/coil) C (loop/coil) 135 -128.6 109.3 23.98 Low-density lipoprotein receptor Clustered O-linked oligosaccharides Extracellular 117 4.2 766 T Threonine Polar/Neutral C (loop/coil) C (loop/coil) 116 -73.5 149.3 18.89 Low-density lipoprotein receptor Clustered O-linked oligosaccharides Extracellular 119 -0.7 767 M Methionine Aliphatic C (loop/coil) C (loop/coil) 170 179.4 99.1 24.12 Low-density lipoprotein receptor Clustered O-linked oligosaccharides Extracellular 149 1.9 768 S Serine Polar/Neutral C (loop/coil) C (loop/coil) 97 82.2 121.4 25.47 Low-density lipoprotein receptor Clustered O-linked oligosaccharides Extracellular 105 -0.8 769 H Histidine Positively-charged C (loop/coil) C (loop/coil) 184 -61.1 157.3 22.33 Low-density lipoprotein receptor Extracellular 155 -3.2 770 Q Glutamine Polar/Neutral C (loop/coil) C (loop/coil) 194 141.1 145.7 25.37 Low-density lipoprotein receptor Extracellular 146 -3.5 771 A Alanine Aliphatic C (loop/coil) C (loop/coil) 85 -174.0 153.0 24.91 Low-density lipoprotein receptor Extracellular 89 1.8 772 L Leucine Aliphatic C (loop/coil) C (loop/coil) 179 30.9 136.3 21.77 Low-density lipoprotein receptor Extracellular 131 3.8 773 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible C (loop/coil) C (loop/coil) 65 127.2 119.4 22.81 Low-density lipoprotein receptor Extracellular 75 -0.4 774 D Aspartic Acid Negatively-charged C (loop/coil) C (loop/coil) 154 78.2 100.9 25.58 Low-density lipoprotein receptor Extracellular 132 -3.5 775 V Valine Aliphatic C (loop/coil) C (loop/coil) 138 40.9 128.6 21.28 Low-density lipoprotein receptor Extracellular 117 4.2 776 A Alanine Aliphatic C (loop/coil) C (loop/coil) 103 104.9 125.7 24.36 Low-density lipoprotein receptor Extracellular 89 1.8 777 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible C (loop/coil) C (loop/coil) 76 127.1 79.3 24.9 Low-density lipoprotein receptor Extracellular 75 -0.4 778 R Arginine Positively-charged C (loop/coil) C (loop/coil) 262 26.4 124.7 21.4 Low-density lipoprotein receptor Extracellular 175 -4.5 779 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible C (loop/coil) C (loop/coil) 72 146.4 101.7 25.44 Low-density lipoprotein receptor Extracellular 75 -0.4 780 N Asparagine Polar/Neutral C (loop/coil) C (loop/coil) 146 42.7 121.3 24.42 Low-density lipoprotein receptor Extracellular 132 -3.5 781 E Glutamic Acid Negatively-charged C (loop/coil) C (loop/coil) 169 57.1 106.1 25.49 Low-density lipoprotein receptor Extracellular 146 -3.5 782 K Lysine Positively-charged C (loop/coil) C (loop/coil) 218 -157.3 133.2 32.45 Low-density lipoprotein receptor Extracellular 147 -3.9 783 K Lysine Positively-charged C (loop/coil) C (loop/coil) 203 -90.2 179.6 27.47 Low-density lipoprotein receptor Extracellular 147 -3.9 784 P Proline Special, No backbone hydrogen C (loop/coil) C (loop/coil) 113 -119.3 166.3 43.13 Low-density lipoprotein receptor Extracellular 115 1.6 785 S Serine Polar/Neutral C (loop/coil) C (loop/coil) 127 -160.6 62.5 35.76 Low-density lipoprotein receptor Extracellular 105 -0.8 786 S Serine Polar/Neutral C (loop/coil) C (loop/coil) 86 -127.3 77.3 41.23 Low-density lipoprotein receptor Extracellular 105 -0.8 787 V Valine Aliphatic C (loop/coil) S (bend) 121 -112.8 -9.8 46.19 Low-density lipoprotein receptor Extracellular 117 4.2 788 R Arginine Positively-charged C (loop/coil) S (bend) 226 -84.4 -25.2 50.38 Low-density lipoprotein receptor Extracellular 175 -4.5 789 A Alanine Aliphatic C (loop/coil) T (turn) 52 -71.3 -30.2 55.72 Low-density lipoprotein receptor Helical 89 1.8 A789-V793; PAE: 5.5 A789-V793; PAE: 5.5 790 L Leucine Aliphatic H (helix) H (α-helix) 116 -66.3 -27.2 56.5 Low-density lipoprotein receptor Helical 131 3.8 L790-L794; PAE: 4.0 L790-L794; PAE: 4.0 791 S Serine Polar/Neutral H (helix) H (α-helix) 90 -77.4 -19.7 65.91 Low-density lipoprotein receptor Helical 105 -0.8 792 I Isoleucine Aliphatic H (helix) H (α-helix) 115 -98.2 -35.5 75.3 Low-density lipoprotein receptor Helical 131 4.5 I792-I796; PAE: 2.5 793 V Valine Aliphatic H (helix) H (α-helix) 85 -69.9 -39.0 80.83 Low-density lipoprotein receptor Helical 117 4.2 V793-A789, V793-V797; PAE: 5.5, 2.0 V793-A789, V793-V797; PAE: 5.5, 2.0 794 L Leucine Aliphatic H (helix) H (α-helix) 111 -58.1 -48.7 82.92 Low-density lipoprotein receptor Helical 131 3.8 L794-L790, L794-L798; PAE: 4.0, 2.0 L794-L790, L794-L798; PAE: 4.0, 2.0 795 P Proline Special, No backbone hydrogen H (helix) H (α-helix) 70 -68.4 -33.9 85.4 Low-density lipoprotein receptor Helical 115 1.6 P795-L799; PAE: 2.0 P795-L799; PAE: 2.0 796 I Isoleucine Aliphatic H (helix) H (α-helix) 102 -65.4 -46.0 87.85 Low-density lipoprotein receptor Helical 131 4.5 I796-V800; PAE: 1.0 I796-V800, I796-I792; PAE: 1.0, 2.5 797 V Valine Aliphatic H (helix) H (α-helix) 66 -61.1 -43.7 88.63 Low-density lipoprotein receptor Helical 117 4.2 V797-V793, V797-F801; PAE: 2.0, 1.0 V797-V793, V797-F801; PAE: 2.0, 1.0 798 L Leucine Aliphatic H (helix) H (α-helix) 110 -60.2 -40.9 91.21 Low-density lipoprotein receptor Helical 131 3.8 L798-L794, L798-L802; PAE: 2.0, 1.0 L798-L794, L798-L802; PAE: 2.0, 1.0 799 L Leucine Aliphatic H (helix) H (α-helix) 113 -68.3 -39.2 92.12 Low-density lipoprotein receptor Helical 131 3.8 L799-C803, L799-P795; PAE: 1.0, 2.0 L799-C803, L799-P795; PAE: 1.0, 2.0 800 V Valine Aliphatic H (helix) H (α-helix) 79 -62.7 -44.3 92.19 Low-density lipoprotein receptor Helical 117 4.2 V800-I796, V800-L804; PAE: 1.0, 1.0 V800-I796, V800-L804; PAE: 1.0, 1.0 801 F Phenylalanine Aromatic H (helix) H (α-helix) 143 -64.3 -34.9 93.33 Low-density lipoprotein receptor Helical 165 2.8 F801-V797, F801-G805; PAE: 1.0, 1.0 F801-V797, F801-G805; PAE: 1.0, 1.0 802 L Leucine Aliphatic H (helix) H (α-helix) 119 -68.5 -43.8 93.61 Low-density lipoprotein receptor Helical 131 3.8 Pocket 3: Mean pLDDT: 93.04, Volume: 279.55 ų, Druggability score: 0.04 0.036 L802-L798, L802-V806; PAE: 1.0, 1.0 L802-L798, L802-V806; PAE: 1.0, 1.0 803 C Cysteine Special, a very reactive sulfhydryl group H (helix) H (α-helix) 76 -62.9 -43.2 91.81 Low-density lipoprotein receptor Helical 121 2.5 Pocket 3: Mean pLDDT: 93.04, Volume: 279.55 ų, Druggability score: 0.04 0.036 C803-F807, C803-L799; PAE: 1.0, 1.0 C803-F807, C803-L799; PAE: 1.0, 1.0 804 L Leucine Aliphatic H (helix) H (α-helix) 89 -62.0 -41.1 91.73 Low-density lipoprotein receptor Helical 131 3.8 L804-V800, L804-L808; PAE: 1.0, 1.0 L804-V800, L804-L808; PAE: 1.0, 1.0 805 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible H (helix) H (α-helix) 29 -62.3 -44.3 90.76 Low-density lipoprotein receptor Helical 75 -0.4 G805-L809, G805-F801; PAE: 1.0, 1.0 G805-L809, G805-F801; PAE: 1.0, 1.0 806 V Valine Aliphatic H (helix) H (α-helix) 86 -66.1 -40.8 90.85 Low-density lipoprotein receptor Helical 117 4.2 Pocket 3: Mean pLDDT: 93.04, Volume: 279.55 ų, Druggability score: 0.04 0.036 V806-L802, V806-W810; PAE: 1.0, 1.0 V806-L802, V806-W810; PAE: 1.0, 1.0 807 F Phenylalanine Aromatic H (helix) H (α-helix) 111 -64.0 -41.6 91.55 Low-density lipoprotein receptor Helical 165 2.8 Pocket 3: Mean pLDDT: 93.04, Volume: 279.55 ų, Druggability score: 0.04 0.036 F807-C803, F807-K811; PAE: 1.0, 1.0 F807-C803, F807-K811; PAE: 1.0, 1.0 808 L Leucine Aliphatic H (helix) H (α-helix) 104 -68.0 -38.4 87.48 Low-density lipoprotein receptor Helical 131 3.8 L808-N812, L808-L804; PAE: 1.5, 1.0 L808-N812, L808-L804; PAE: 1.5, 1.0 809 L Leucine Aliphatic H (helix) H (α-helix) 123 -65.0 -41.4 83.93 Low-density lipoprotein receptor Helical 131 3.8 L809-G805, L809-W813; PAE: 1.0, 2.0 L809-G805, L809-W813; PAE: 1.0, 2.0 810 W Tryptophan Aromatic H (helix) H (α-helix) 130 -65.4 -45.4 88.16 Low-density lipoprotein receptor Helical 204 -0.9 Pocket 3: Mean pLDDT: 93.04, Volume: 279.55 ų, Druggability score: 0.04 0.036 W810-V806, W810-R814; PAE: 1.0, 1.5 W810-V806, W810-R814; PAE: 1.0, 1.5 811 K Lysine Positively-charged H (helix) H (α-helix) 112 -61.6 -41.3 78.13 Low-density lipoprotein receptor Mutation: K -> R. No change. No change; when associated with R-816 and R-830. Insensitive to MYLIP-triggered degradation; when associated with R-816; R-830 and A-839. Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 147 -3.9 K811-L815, K811-F807; PAE: 2.0, 1.0 K811-L815, K811-F807; PAE: 2.0, 1.0 812 N Asparagine Polar/Neutral H (helix) H (α-helix) 90 -73.5 -34.9 78.45 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 132 -3.5 N812-L808, N812-K816; PAE: 1.5, 2.0 N812-L808, N812-K816; PAE: 1.5, 2.0 813 W Tryptophan Aromatic H (helix) H (α-helix) 155 -66.4 -40.2 78.1 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 204 -0.9 W813-L809, W813-N817; PAE: 2.0, 2.0 W813-L809, W813-N817; PAE: 2.0, 2.0 814 R Arginine Positively-charged H (helix) H (α-helix) 134 -67.7 -40.7 71.14 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 175 -4.5 R814-W810, R814-I818; PAE: 1.5, 3.5 R814-W810, R814-I818; PAE: 1.5, 3.5 815 L Leucine Aliphatic H (helix) H (α-helix) 97 -64.5 -39.2 63.67 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 131 3.8 L815-K811; PAE: 2.0 L815-N819, L815-K811; PAE: 4.0, 2.0 816 K Lysine Positively-charged H (helix) H (α-helix) 145 -67.7 -29.9 61.88 Low-density lipoprotein receptor Mutation: K -> R. No change. No change; when associated with R-830. No change; when associated with R-811 and R-830. Insensitive to MYLIP-triggered degradation; when associated with R-830 and A-839. Insensitive to MYLIP-triggered degradation; when associated with R-811; R-830 and A-839. Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 147 -3.9 K816-N812; PAE: 2.0 K816-N812; PAE: 2.0 817 N Asparagine Polar/Neutral H (helix) H (α-helix) 99 -90.9 -6.2 50.25 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 132 -3.5 N817-W813; PAE: 2.0 N817-W813; PAE: 2.0 818 I Isoleucine Aliphatic C (loop/coil) C (loop/coil) 98 -117.5 57.3 40.61 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 131 4.5 I818-R814; PAE: 3.5 I818-R814; PAE: 3.5 819 N Asparagine Polar/Neutral C (loop/coil) C (loop/coil) 124 -83.1 92.5 39.36 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 132 -3.5 N819-L815; PAE: 4.0 820 S Serine Polar/Neutral C (loop/coil) C (loop/coil) 70 49.0 98.8 35.64 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 105 -0.8 Morphology: WRLKNINsINFDNPV 1 interaction 821 I Isoleucine Aliphatic Beta strand C (loop/coil) C (loop/coil) 156 -63.8 70.2 34.06 Low-density lipoprotein receptor Mutation: I -> A. 3-fold decreased affinity for LDLRAP1.; Mutation: I -> R. 10-fold decreased affinity for LDLRAP1. Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 131 4.5 1 interaction 1 interaction 822 N Asparagine Polar/Neutral Beta strand C (loop/coil) C (loop/coil) 129 -96.9 111.8 29.66 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 132 -3.5 2 interactions 1 interaction 823 F Phenylalanine Aromatic Beta strand C (loop/coil) C (loop/coil) 194 -64.6 76.5 32.57 Low-density lipoprotein receptor NPXY motif Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 165 2.8 1 interaction 1 interaction 824 D Aspartic Acid Negatively-charged Beta strand C (loop/coil) C (loop/coil) 152 -143.8 112.7 31.16 Low-density lipoprotein receptor NPXY motif Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 132 -3.5 825 N Asparagine Polar/Neutral C (loop/coil) C (loop/coil) 111 -92.7 116.9 25.94 Low-density lipoprotein receptor NPXY motif Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 132 -3.5 dbSNP: rs374045590; Variant type: LP/P; AA change: Asn825Lys; PTM type: Phosphorylation; PTM morphology: LKNINsINFDN*; Var class: II&rs374045590 3 interactions 3 interactions 826 P Proline Special, No backbone hydrogen Turn C (loop/coil) C (loop/coil) 104 -122.6 33.6 41.28 Low-density lipoprotein receptor NPXY motif Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 115 1.6 dbSNP: rs879255217; Variant type: LP/P; AA change: Pro826Ser; PTM type: Ubiquitylation; PTM morphology: NP*VyQkTTEDE; Var class: II&rs879255217 827 V Valine Aliphatic Turn C (loop/coil) C (loop/coil) 128 -97.6 11.4 30.02 Low-density lipoprotein receptor NPXY motif Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 117 4.2 dbSNP: rs137853964; Variant type: US; AA change: Val827Ile; PTM type: Ubiquitylation; PTM morphology: NPV*yQkTTEDE; Var class: II&rs137853964 828 Y Tyrosine Aromatic Turn C (loop/coil) C (loop/coil) 207 -107.2 41.6 30.97 Low-density lipoprotein receptor NPXY motif Mutation: Y -> A. Abolishes interaction with ARRB2. Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 181 -1.3 Morphology: INFDNPVyQkTTEDE dbSNP: rs28942085; Variant type: LP/P; AA change: Tyr828Cys; PTM type: Ubiquitylation; PTM morphology: NPVy*QkTTEDE; Var class: II&rs28942085 829 Q Glutamine Polar/Neutral Turn C (loop/coil) C (loop/coil) 175 -90.7 104.7 30.79 Low-density lipoprotein receptor Mutation: Q -> A. Decreased affinity for LDLRAP1. Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 146 -3.5 2 interactions 1 interaction 830 K Lysine Positively-charged C (loop/coil) C (loop/coil) 202 -50.6 104.9 27.68 Low-density lipoprotein receptor Mutation: K -> R. No change. No change; when associated with R-816. No change; when associated with R-811 and R-816. Insensitive to MYLIP-triggered degradation; when associated with A-839. Insensitive to MYLIP-triggered degradation; when associated with R-816 and A-839. Insensitive to MYLIP-triggered degradation; when associated with R-811; R-816 and A-839. Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 147 -3.9 Morphology: FDNPVyQkTTEDEVH 1 interaction 831 T Threonine Polar/Neutral C (loop/coil) C (loop/coil) 120 -157.1 100.8 32.19 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 119 -0.7 832 T Threonine Polar/Neutral C (loop/coil) C (loop/coil) 122 40.6 120.2 28.51 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 119 -0.7 833 E Glutamic Acid Negatively-charged C (loop/coil) C (loop/coil) 181 83.8 89.7 32.3 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 146 -3.5 834 D Aspartic Acid Negatively-charged C (loop/coil) C (loop/coil) 170 -160.0 129.3 32.61 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 132 -3.5 835 E Glutamic Acid Negatively-charged C (loop/coil) C (loop/coil) 190 -69.2 138.9 30.26 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 146 -3.5 836 V Valine Aliphatic C (loop/coil) C (loop/coil) 124 -69.4 113.5 27.68 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 117 4.2 837 H Histidine Positively-charged C (loop/coil) C (loop/coil) 186 -82.9 101.8 28.6 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 155 -3.2 838 I Isoleucine Aliphatic C (loop/coil) C (loop/coil) 129 -81.6 104.6 28.56 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 131 4.5 839 C Cysteine Special, a very reactive sulfhydryl group C (loop/coil) C (loop/coil) 122 -91.3 112.8 24.7 Low-density lipoprotein receptor Mutation: C -> A. No change. Insensitive to MYLIP-triggered degradation; when associated with R-830. Insensitive to MYLIP-triggered degradation; when associated with R-816 and R-830. Insensitive to MYLIP-triggered degradation; when associated with R-811; R-816 and R-830. Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 121 2.5 840 H Histidine Positively-charged C (loop/coil) C (loop/coil) 171 -74.7 125.9 30.05 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 155 -3.2 841 N Asparagine Polar/Neutral C (loop/coil) C (loop/coil) 161 -118.6 147.9 31.98 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 132 -3.5 842 Q Glutamine Polar/Neutral C (loop/coil) S (bend) 195 -83.9 16.4 40.27 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 146 -3.5 843 D Aspartic Acid Negatively-charged C (loop/coil) C (loop/coil) 144 -107.3 97.6 35.91 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 132 -3.5 844 G Glycine Special, lack of a chiral carbon, smallest amino acid, very flexible C (loop/coil) C (loop/coil) 81 -66.8 57.8 31.73 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 75 -0.4 dbSNP: rs121908037; Variant type: LP/P; AA change: Gly844Asp; PTM type: Phosphorylation; PTM morphology: G*ysyPsRQMVS; Var class: II&rs121908037 845 Y Tyrosine Aromatic C (loop/coil) C (loop/coil) 192 -106.4 108.3 32.9 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 181 -1.3 Morphology: ICHNQDGysyPsRQM 846 S Serine Polar/Neutral C (loop/coil) C (loop/coil) 116 -94.2 114.7 30.23 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 105 -0.8 Morphology: CHNQDGysyPsRQMV 847 Y Tyrosine Aromatic H (helix) P (polyproline helix) 196 -90.6 127.4 32.07 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 181 -1.3 Morphology: HNQDGysyPsRQMVS 848 P Proline Special, No backbone hydrogen H (helix) P (polyproline helix) 134 -71.0 117.6 32.54 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 115 1.6 dbSNP: -; Variant type: Disease; AA change: Pro848Leu; PTM type: Phosphorylation; PTM morphology: GysyP*sRQMVS; Var class: II&- 849 S Serine Polar/Neutral H (helix) P (polyproline helix) 115 -79.5 132.4 30.03 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 105 -0.8 Morphology: QDGysyPsRQMVSLE 850 R Arginine Positively-charged C (loop/coil) C (loop/coil) 208 17.8 103.8 29.79 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 175 -4.5 851 Q Glutamine Polar/Neutral C (loop/coil) C (loop/coil) 186 -94.7 104.7 29.29 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 146 -3.5 852 M Methionine Aliphatic C (loop/coil) C (loop/coil) 148 -72.3 101.4 32.51 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 149 1.9 853 V Valine Aliphatic C (loop/coil) C (loop/coil) 116 -75.8 107.8 31.6 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 117 4.2 854 S Serine Polar/Neutral C (loop/coil) C (loop/coil) 97 -63.4 119.7 32.51 Low-density lipoprotein receptor Mutation: S -> A. No effect on receptor internalization.; Mutation: S -> D. Enhances interaction with ARRB2 and receptor internalization. Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 105 -0.8 855 L Leucine Aliphatic C (loop/coil) S (bend) 166 -86.4 77.3 32.67 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 131 3.8 856 E Glutamic Acid Negatively-charged C (loop/coil) C (loop/coil) 167 -163.8 52.6 35.99 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 146 -3.5 857 D Aspartic Acid Negatively-charged C (loop/coil) C (loop/coil) 162 -151.6 71.1 35.67 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 132 -3.5 858 D Aspartic Acid Negatively-charged C (loop/coil) C (loop/coil) 167 -149.8 47.0 31.74 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 132 -3.5 859 V Valine Aliphatic C (loop/coil) C (loop/coil) 152 -145.8 85.6 32.17 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 117 4.2 860 A Alanine Aliphatic C (loop/coil) C (loop/coil) 179 -140.4 360.0 43.48 Low-density lipoprotein receptor Required for MYLIP-triggered down-regulation of LDLR Cytoplasmic 89 1.8